GREMLIN Database
DIVIB - Cell division protein DivIB
UniProt: P16655 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (219)
Sequences: 3427 (2836)
Seq/√Len: 191.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_Y139_L4.4151.00
111_S117_N3.4241.00
68_S71_E3.0491.00
216_T219_D2.9721.00
62_T119_A2.8801.00
76_S118_I2.6781.00
98_Q106_A2.6691.00
90_K110_K2.5851.00
60_S117_N2.5571.00
61_V72_I2.5481.00
58_T115_K2.5261.00
62_T117_N2.4471.00
75_L100_N2.3991.00
104_K121_E2.3751.00
60_S115_K2.3711.00
90_K108_I2.3481.00
123_Y143_S2.2411.00
104_K141_N2.2281.00
210_V224_Y2.1801.00
67_V100_N2.1601.00
69_K73_I2.1051.00
98_Q105_K2.0341.00
89_D92_K1.9481.00
203_Y209_V1.9461.00
105_K121_E1.8701.00
97_I120_I1.8231.00
104_K123_Y1.8101.00
139_L143_S1.7961.00
104_K140_E1.7941.00
204_M207_G1.7811.00
224_Y241_L1.7461.00
70_K74_D1.7401.00
57_S114_N1.7381.00
43_V47_V1.7371.00
97_I103_V1.7311.00
109_S119_A1.7131.00
44_L47_V1.7051.00
93_T108_I1.6961.00
204_M210_V1.6951.00
227_I247_F1.6821.00
201_K209_V1.6681.00
78_I96_K1.6621.00
85_F112_L1.6471.00
76_S97_I1.6321.00
92_K96_K1.6281.00
107_E119_A1.6281.00
109_S117_N1.5991.00
184_S205_N1.5951.00
94_E98_Q1.5641.00
238_I250_F1.5451.00
224_Y239_I1.5441.00
61_V73_I1.4941.00
33_I37_M1.4801.00
66_N102_L1.4561.00
126_I140_E1.4551.00
237_G250_F1.4241.00
127_A158_L1.3741.00
54_S86_W1.3731.00
159_V187_E1.3511.00
131_K134_V1.3441.00
85_F110_K1.3441.00
209_V238_I1.3181.00
42_M46_I1.3101.00
159_V189_Y1.3071.00
90_K94_E1.3071.00
94_E108_I1.3051.00
186_S203_Y1.2941.00
91_Q94_E1.2841.00
73_I76_S1.2821.00
213_S220_R1.2811.00
127_A138_V1.2721.00
187_E203_Y1.2651.00
186_S205_N1.2611.00
54_S84_E1.2491.00
100_N103_V1.2431.00
64_N69_K1.2331.00
70_K73_I1.2311.00
157_I187_E1.2241.00
212_A220_R1.2231.00
136_Y144_V1.2211.00
102_L145_L1.2161.00
76_S116_I1.2121.00
64_N122_E1.2101.00
103_V106_A1.1901.00
135_Y157_I1.1601.00
170_M190_Y1.1581.00
130_E157_I1.1441.00
40_F44_L1.1361.00
191_T199_R1.1351.00
49_L52_P1.1331.00
124_K140_E1.1191.00
64_N72_I1.1131.00
72_I120_I1.1041.00
103_V120_I1.0991.00
196_D199_R1.0911.00
111_S115_K1.0761.00
78_I116_I1.0741.00
128_Y157_I1.0671.00
48_Y51_T1.0671.00
173_Q218_A1.0631.00
66_N122_E1.0541.00
71_E75_L1.0491.00
125_A155_G1.0441.00
58_T114_N1.0391.00
34_S37_M1.0381.00
168_S172_K1.0361.00
223_T227_I1.0101.00
158_L167_R1.0081.00
170_M188_I0.9971.00
188_I202_L0.9920.99
185_I202_L0.9850.99
106_A118_I0.9710.99
46_I50_Q0.9690.99
170_M173_Q0.9650.99
64_N120_I0.9590.99
56_V88_L0.9570.99
67_V102_L0.9550.99
208_Y211_T0.9540.99
94_E105_K0.9480.99
38_L42_M0.9440.99
176_A218_A0.9440.99
48_Y53_I0.9390.99
67_V72_I0.9380.99
173_Q221_M0.9370.99
73_I77_D0.9280.99
41_I45_I0.9260.99
75_L97_I0.9230.99
88_L93_T0.9190.99
211_T240_H0.9170.99
67_V97_I0.9130.99
35_F39_F0.9080.99
130_E135_Y0.9040.99
97_I106_A0.9020.99
76_S93_T0.8870.99
125_A145_L0.8840.99
190_Y197_E0.8630.99
95_K98_Q0.8580.98
211_T238_I0.8560.98
79_N96_K0.8560.98
136_Y147_N0.8550.98
170_M178_S0.8480.98
93_T96_K0.8390.98
91_Q95_K0.8340.98
212_A242_E0.8340.98
208_Y239_I0.8330.98
130_E133_D0.8300.98
243_V246_Y0.8300.98
191_T201_K0.8240.98
171_A175_D0.8210.98
224_Y228_I0.8200.98
108_I118_I0.8180.98
137_E145_L0.8100.98
212_A216_T0.8060.98
134_V147_N0.8050.98
27_K30_R0.8000.98
79_N82_D0.7990.98
208_Y236_K0.7980.98
34_S38_L0.7920.97
29_N33_I0.7910.97
198_N213_S0.7910.97
226_S229_S0.7880.97
102_L146_P0.7880.97
200_I214_I0.7830.97
166_K190_Y0.7820.97
102_L221_M0.7780.97
106_A110_K0.7710.97
189_Y203_Y0.7700.97
189_Y201_K0.7690.97
60_S111_S0.7670.97
37_M49_L0.7640.97
96_K99_Q0.7600.97
223_T244_A0.7580.97
30_R37_M0.7580.97
36_I39_F0.7560.97
72_I97_I0.7520.97
199_R213_S0.7500.97
93_T97_I0.7490.96
231_L239_I0.7450.96
222_K226_S0.7430.96
178_S181_L0.7430.96
99_Q149_V0.7410.96
39_F46_I0.7390.96
65_E122_E0.7370.96
200_I212_A0.7370.96
51_T54_S0.7360.96
33_I36_I0.7270.96
88_L116_I0.7250.96
67_V120_I0.7250.96
33_I38_L0.7240.96
122_E224_Y0.7210.96
75_L99_Q0.7200.96
128_Y135_Y0.7200.96
93_T116_I0.7180.96
72_I103_V0.7150.95
41_I44_L0.7140.95
102_L110_K0.7120.95
190_Y199_R0.7090.95
172_K176_A0.7080.95
42_M174_L0.7070.95
222_K225_P0.7060.95
176_A217_F0.7050.95
37_M40_F0.7010.95
50_Q84_E0.7000.95
163_N166_K0.6950.95
35_F42_M0.6920.95
204_M208_Y0.6900.94
58_T118_I0.6880.94
28_A32_L0.6870.94
84_E87_S0.6860.94
71_E74_D0.6820.94
230_Q233_S0.6810.94
85_F114_N0.6760.94
27_K31_R0.6760.94
240_H243_V0.6750.94
236_K239_I0.6740.94
76_S96_K0.6720.94
52_P57_S0.6700.94
201_K211_T0.6700.94
72_I75_L0.6680.93
49_L53_I0.6660.93
56_V78_I0.6610.93
173_Q177_L0.6590.93
169_Q173_Q0.6590.93
186_S207_G0.6590.93
176_A179_N0.6560.93
54_S139_L0.6540.93
74_D77_D0.6520.93
202_L212_A0.6520.93
232_S235_K0.6510.93
180_S225_P0.6490.92
137_E224_Y0.6490.92
227_I239_I0.6460.92
221_M244_A0.6410.92
61_V64_N0.6400.92
37_M41_I0.6390.92
73_I78_I0.6380.92
56_V145_L0.6380.92
172_K175_D0.6380.92
82_D86_W0.6380.92
150_T154_A0.6370.92
67_V146_P0.6370.92
131_K136_Y0.6360.92
65_E124_K0.6360.92
129_L200_I0.6360.92
173_Q176_A0.6340.92
110_K116_I0.6330.92
95_K176_A0.6310.91
181_L204_M0.6300.91
57_S60_S0.6290.91
128_Y155_G0.6260.91
66_N125_A0.6250.91
86_W244_A0.6230.91
169_Q172_K0.6210.91
80_S88_L0.6170.90
64_N67_V0.6140.90
55_K87_S0.6130.90
97_I100_N0.6120.90
112_L127_A0.6120.90
207_G211_T0.6060.90
144_V164_A0.6050.90
183_Q206_D0.6030.89
202_L210_V0.6010.89
37_M44_L0.5970.89
242_E248_E0.5970.89
85_F116_I0.5960.89
199_R212_A0.5950.89
219_D223_T0.5950.89
164_A170_M0.5920.89
78_I93_T0.5900.88
35_F38_L0.5900.88
161_W190_Y0.5890.88
200_I213_S0.5890.88
190_Y241_L0.5890.88
230_Q234_N0.5850.88
77_D96_K0.5840.88
55_K82_D0.5830.88
81_G93_T0.5810.88
185_I204_M0.5790.87
28_A31_R0.5750.87
125_A137_E0.5710.87
173_Q178_S0.5690.87
29_N32_L0.5670.86
45_I48_Y0.5640.86
107_E121_E0.5620.86
163_N167_R0.5620.86
227_I233_S0.5600.86
165_K169_Q0.5590.86
44_L48_Y0.5590.86
50_Q53_I0.5570.85
67_V135_Y0.5510.85
29_N34_S0.5500.85
78_I88_L0.5500.85
243_V248_E0.5480.84
90_K112_L0.5460.84
164_A167_R0.5450.84
84_E112_L0.5440.84
175_D183_Q0.5400.84
220_R241_L0.5400.84
244_A247_F0.5350.83
247_F250_F0.5340.83
138_V230_Q0.5330.83
60_S119_A0.5330.83
228_I232_S0.5330.83
191_T220_R0.5320.83
110_K145_L0.5270.82
133_D146_P0.5270.82
38_L41_I0.5270.82
36_I43_V0.5260.82
157_I186_S0.5260.82
236_K242_E0.5240.82
41_I149_V0.5220.82
197_E225_P0.5210.81
32_L40_F0.5210.81
175_D182_K0.5180.81
86_W110_K0.5180.81
198_N201_K0.5150.81
32_L36_I0.5150.81
217_F221_M0.5150.81
220_R242_E0.5140.81
103_V202_L0.5120.80
123_Y141_N0.5100.80
239_I243_V0.5090.80
92_K95_K0.5060.80
212_A241_L0.5040.79
125_A149_V0.5030.79
131_K172_K0.5030.79
177_L206_D0.5020.79
127_A206_D0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vh2A 1 0.7376 100 0.358 Contact Map
2vh1A 1 0.7262 100 0.372 Contact Map
1yr1A 1 0.4449 99.7 0.663 Contact Map
3j00Z 1 0.346 98.9 0.779 Contact Map
4k3bA 1 0.7681 96.8 0.864 Contact Map
3efcA 1 0.7338 93.3 0.893 Contact Map
2qdfA 1 0.7452 91.5 0.898 Contact Map
2x8xX 1 0.7338 78.7 0.915 Contact Map
3q6bA 1 0.4601 75.3 0.918 Contact Map
4bzaA 1 0.5095 69.1 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.