GREMLIN Database
HEMX - Protein HemX
UniProt: P16645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (263)
Sequences: 3045 (1962)
Seq/√Len: 121.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_T78_W7.0201.00
139_A199_S5.2401.00
47_W82_T4.9581.00
197_L228_L4.4581.00
17_Y50_Q4.2011.00
213_T216_W4.0601.00
193_V232_S3.8581.00
150_F253_T3.5321.00
147_S256_F3.5251.00
43_L101_N3.3061.00
149_S189_N2.8821.00
54_L78_W2.5811.00
81_V104_G2.4871.00
230_L255_C2.4431.00
230_L258_V2.4331.00
182_D238_R2.3341.00
24_Y97_V2.2921.00
160_Y246_K2.2881.00
47_W78_W2.2591.00
156_Y249_A2.1821.00
153_S185_A2.1571.00
146_F192_G2.0631.00
65_P71_E2.0381.00
243_L247_V2.0171.00
44_S85_L2.0111.00
227_V259_L1.9771.00
23_F39_A1.9351.00
51_T54_L1.9031.00
47_W81_V1.9011.00
198_L202_L1.8971.00
154_V253_T1.8461.00
84_S97_V1.7771.00
46_V81_V1.7741.00
55_A59_W1.7621.00
52_V55_A1.7451.00
152_F181_L1.7251.00
48_T52_V1.7151.00
234_Y255_C1.6951.00
262_N265_L1.6931.00
229_L233_Y1.6841.00
99_F155_L1.6711.00
9_L52_V1.6491.00
193_V228_L1.6301.00
13_T17_Y1.6211.00
270_S273_H1.6121.00
61_T120_S1.6101.00
16_I46_V1.5671.00
79_V144_G1.5441.00
22_L26_I1.4991.00
82_T86_V1.4871.00
207_A211_L1.4861.00
207_A215_Y1.4631.00
242_E245_G1.4541.00
150_F154_V1.4471.00
189_N252_N1.4181.00
104_G107_M1.3821.00
256_F260_M1.3801.00
153_S253_T1.3691.00
143_Y196_L1.3581.00
170_K173_L1.3581.00
52_V56_Y1.3411.00
182_D248_A1.3321.00
153_S252_N1.3301.00
40_F88_T1.3301.00
47_W50_Q1.3201.00
98_F102_V1.3071.00
12_G49_L1.3061.00
180_K183_Y1.3021.00
192_G231_Y1.2981.00
196_L227_V1.2931.00
47_W51_T1.2871.00
20_S43_L1.2520.99
163_L178_L1.2520.99
23_F42_L1.2310.99
47_W85_L1.2210.99
17_Y46_V1.2190.99
145_A192_G1.2110.99
89_K92_R1.2060.99
217_F221_V1.2020.99
183_Y187_V1.2020.99
44_S48_T1.1930.99
163_L166_K1.1880.99
193_V197_L1.1850.99
143_Y220_K1.1830.99
138_M199_S1.1690.99
214_L263_Y1.1640.99
185_A252_N1.1590.99
11_E15_V1.1510.99
50_Q74_Y1.1510.99
105_F110_I1.1470.99
27_D36_G1.1400.99
182_D186_Y1.1370.99
221_V236_Y1.1360.99
211_L217_F1.1320.99
21_V25_F1.1310.99
12_G16_I1.1300.99
223_G266_L1.1070.99
17_Y21_V1.1050.99
33_R37_K1.0990.99
24_Y39_A1.0870.99
215_Y221_V1.0870.99
65_P68_N1.0810.98
57_F71_E1.0680.98
160_Y178_L1.0680.98
250_L253_T1.0640.98
10_N112_T1.0630.98
24_Y40_F1.0610.98
233_Y237_I1.0610.98
168_W172_L1.0570.98
265_L269_L1.0560.98
211_L221_V1.0530.98
140_I143_Y1.0450.98
72_A199_S1.0400.98
36_G94_D1.0380.98
43_L81_V1.0360.98
104_G108_I1.0300.98
214_L217_F1.0280.98
41_W45_I1.0230.98
72_A263_Y1.0130.98
11_E14_I1.0130.98
19_L42_L1.0000.97
37_K41_W0.9960.97
19_L32_N0.9950.97
80_L147_S0.9920.97
227_V262_N0.9890.97
161_H165_K0.9860.97
12_G19_L0.9820.97
237_I243_L0.9800.97
149_S252_N0.9800.97
158_F161_H0.9660.97
223_G226_V0.9620.97
200_L204_V0.9570.97
182_D245_G0.9570.97
177_D180_K0.9540.97
186_Y238_R0.9520.97
238_R242_E0.9480.96
77_A108_I0.9400.96
265_L268_S0.9390.96
196_L202_L0.9390.96
158_F172_L0.9380.96
77_A107_M0.9250.96
131_L209_V0.9190.96
63_R71_E0.9090.96
196_L200_L0.9090.96
237_I248_A0.9090.96
196_L259_L0.9080.95
80_L144_G0.8950.95
259_L265_L0.8940.95
207_A218_D0.8910.95
190_V235_L0.8900.95
215_Y236_Y0.8890.95
109_A113_F0.8830.95
20_S24_Y0.8810.95
159_Q175_I0.8810.95
207_A210_S0.8780.95
37_K158_F0.8760.95
43_L46_V0.8710.94
15_V19_L0.8690.94
217_F225_F0.8670.94
103_I147_S0.8650.94
27_D39_A0.8640.94
20_S46_V0.8610.94
14_I21_V0.8600.94
65_P70_T0.8590.94
73_L107_M0.8580.94
168_W171_W0.8570.94
18_A105_F0.8550.94
199_S224_S0.8490.94
84_S100_T0.8480.94
182_D185_A0.8430.93
214_L221_V0.8430.93
246_K249_A0.8400.93
128_V201_I0.8350.93
21_V102_V0.8290.93
125_G204_V0.8280.93
74_Y108_I0.8270.93
74_Y77_A0.8270.93
126_Q210_S0.8220.92
18_A25_F0.8210.92
227_V265_L0.8200.92
212_E221_V0.8180.92
252_N265_L0.8150.92
217_F236_Y0.8120.92
150_F256_F0.8100.92
231_Y252_N0.8080.92
211_L236_Y0.8020.91
159_Q178_L0.8010.91
24_Y88_T0.7990.91
211_L216_W0.7970.91
58_M64_F0.7870.91
149_S188_L0.7860.91
266_L271_Q0.7830.90
61_T68_N0.7810.90
204_V225_F0.7800.90
130_E134_I0.7770.90
200_L228_L0.7760.90
220_K267_G0.7720.90
207_A221_V0.7700.90
57_F70_T0.7700.90
66_V75_F0.7670.90
145_A191_I0.7600.89
71_E225_F0.7590.89
40_F44_S0.7580.89
162_L165_K0.7560.89
165_K173_L0.7560.89
211_L215_Y0.7550.89
64_F67_L0.7540.89
34_K37_K0.7530.89
69_V268_S0.7530.89
76_Y140_I0.7520.89
34_K38_M0.7520.89
66_V137_T0.7480.88
143_Y202_L0.7450.88
142_S196_L0.7450.88
12_G51_T0.7440.88
143_Y265_L0.7430.88
147_S150_F0.7400.88
27_D32_N0.7380.88
204_V210_S0.7350.88
17_Y24_Y0.7340.87
36_G39_A0.7310.87
226_V233_Y0.7310.87
50_Q81_V0.7300.87
20_S25_F0.7230.87
167_K170_K0.7220.87
234_Y262_N0.7210.86
234_Y251_W0.7210.86
252_N255_C0.7200.86
75_F199_S0.7190.86
50_Q78_W0.7180.86
207_A212_E0.7150.86
21_V105_F0.7060.85
182_D249_A0.7040.85
138_M198_L0.6980.85
54_L75_F0.6970.85
183_Y186_Y0.6940.84
40_F48_T0.6930.84
152_F185_A0.6910.84
30_Q33_R0.6900.84
25_F98_F0.6900.84
185_A249_A0.6830.83
30_Q34_K0.6820.83
53_Y70_T0.6760.83
83_L148_L0.6750.83
78_W82_T0.6750.83
72_A75_F0.6720.82
26_I29_L0.6700.82
17_Y81_V0.6700.82
33_R165_K0.6690.82
225_F229_L0.6680.82
58_M65_P0.6680.82
74_Y111_H0.6660.82
224_S265_L0.6660.82
20_S23_F0.6650.82
207_A214_L0.6640.82
227_V268_S0.6640.82
216_W221_V0.6620.81
177_D182_D0.6620.81
195_M199_S0.6610.81
125_G217_F0.6610.81
217_F223_G0.6590.81
24_Y28_F0.6590.81
142_S195_M0.6590.81
11_E106_S0.6590.81
186_Y235_L0.6580.81
257_L261_I0.6540.81
169_G173_L0.6500.80
127_L207_A0.6490.80
111_H263_Y0.6430.80
70_T132_L0.6410.79
237_I244_Q0.6390.79
142_S154_V0.6380.79
211_L214_L0.6380.79
23_F35_A0.6380.79
206_W236_Y0.6370.79
81_V101_N0.6360.79
38_M42_L0.6330.79
224_S264_F0.6330.79
33_R36_G0.6320.78
236_Y240_I0.6320.78
229_L232_S0.6300.78
39_A43_L0.6230.77
72_A139_A0.6230.77
233_Y251_W0.6200.77
193_V235_L0.6180.77
244_Q248_A0.6130.76
122_A192_G0.6110.76
123_F225_F0.6110.76
20_S42_L0.6110.76
16_I42_L0.6100.76
156_Y194_P0.6070.76
182_D242_E0.6070.76
19_L254_A0.6060.75
149_S248_A0.6060.75
98_F101_N0.6050.75
154_V158_F0.6050.75
143_Y259_L0.6030.75
40_F89_K0.6010.75
27_D254_A0.6000.75
10_N74_Y0.5990.75
198_L230_L0.5990.75
177_D183_Y0.5980.75
219_A224_S0.5980.75
67_L124_S0.5940.74
227_V258_V0.5930.74
95_F142_S0.5920.74
82_T164_K0.5920.74
201_I210_S0.5910.74
15_V37_K0.5910.74
221_V267_G0.5880.73
133_V136_I0.5880.73
185_A234_Y0.5880.73
17_Y20_S0.5870.73
125_G226_V0.5860.73
219_A271_Q0.5860.73
225_F271_Q0.5850.73
239_L242_E0.5820.73
65_P123_F0.5820.73
136_I266_L0.5780.72
136_I267_G0.5750.72
153_S248_A0.5750.72
145_A188_L0.5730.71
219_A263_Y0.5690.71
76_Y147_S0.5680.71
238_R248_A0.5660.70
177_D181_L0.5660.70
9_L13_T0.5650.70
210_S214_L0.5650.70
261_I265_L0.5640.70
235_L272_F0.5620.70
253_T257_L0.5610.70
69_V72_A0.5600.70
131_L136_I0.5600.70
13_T46_V0.5590.69
206_W211_L0.5570.69
155_L181_L0.5560.69
178_L182_D0.5560.69
115_P150_F0.5560.69
13_T28_F0.5550.69
175_I179_S0.5530.69
211_L225_F0.5520.69
242_E246_K0.5520.69
24_Y84_S0.5510.68
53_Y113_F0.5510.68
126_Q225_F0.5500.68
209_V212_E0.5500.68
138_M184_M0.5500.68
131_L206_W0.5490.68
210_S261_I0.5450.68
17_Y22_L0.5450.68
204_V222_L0.5440.67
211_L218_D0.5440.67
95_F101_N0.5430.67
176_E197_L0.5410.67
204_V207_A0.5400.67
255_C259_L0.5390.67
221_V271_Q0.5380.67
203_G220_K0.5370.66
83_L146_F0.5360.66
223_G227_V0.5340.66
204_V208_Y0.5330.66
196_L199_S0.5330.66
259_L263_Y0.5300.65
148_L151_V0.5300.65
229_L239_L0.5300.65
127_L206_W0.5290.65
77_A111_H0.5280.65
25_F35_A0.5280.65
125_G256_F0.5280.65
219_A236_Y0.5260.65
112_T148_L0.5250.65
30_Q35_A0.5240.65
223_G265_L0.5230.64
13_T20_S0.5200.64
210_S221_V0.5200.64
161_H176_E0.5200.64
11_E25_F0.5190.64
207_A236_Y0.5190.64
46_V176_E0.5180.64
80_L258_V0.5160.63
46_V101_N0.5150.63
165_K169_G0.5150.63
205_I208_Y0.5150.63
263_Y266_L0.5140.63
35_A38_M0.5130.63
145_A263_Y0.5120.63
21_V24_Y0.5120.63
37_K40_F0.5100.63
48_T176_E0.5040.62
84_S91_L0.5020.61
40_F85_L0.5020.61
189_N234_Y0.5020.61
223_G264_F0.5010.61
212_E236_Y0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bg9A 1 0.558 12.4 0.96 Contact Map
4qndA 2 0.3297 9.2 0.962 Contact Map
1fftA 1 0.8442 7.2 0.964 Contact Map
2m20A 2 0.2029 6.6 0.965 Contact Map
1q16C 2 0.5109 4.9 0.967 Contact Map
3wxwA 1 0.2391 4.5 0.967 Contact Map
1zcdA 1 0.3297 4.4 0.968 Contact Map
2l2tA 2 0.1594 3.4 0.969 Contact Map
3b5dA 2 0.3587 3.4 0.969 Contact Map
2hi7B 1 0.3949 3.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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