HEMX - BACSU - GREMLIN Contacts

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HEMX - Protein HemX

UniProt:	P16645	Sequences: MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLSIVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNVIGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQYHLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFDAKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	276 (263)
Sequences:	3045 (1962)
Seq/√Len:	121.0

ECOLI - YPJD
BACSU - HEMX RESC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_T	78_W	7.020	1.00
139_A	199_S	5.240	1.00
47_W	82_T	4.958	1.00
197_L	228_L	4.458	1.00
17_Y	50_Q	4.201	1.00
213_T	216_W	4.060	1.00
193_V	232_S	3.858	1.00
150_F	253_T	3.532	1.00
147_S	256_F	3.525	1.00
43_L	101_N	3.306	1.00
149_S	189_N	2.882	1.00
54_L	78_W	2.581	1.00
81_V	104_G	2.487	1.00
230_L	255_C	2.443	1.00
230_L	258_V	2.433	1.00
182_D	238_R	2.334	1.00
24_Y	97_V	2.292	1.00
160_Y	246_K	2.288	1.00
47_W	78_W	2.259	1.00
156_Y	249_A	2.182	1.00
153_S	185_A	2.157	1.00
146_F	192_G	2.063	1.00
65_P	71_E	2.038	1.00
243_L	247_V	2.017	1.00
44_S	85_L	2.011	1.00
227_V	259_L	1.977	1.00
23_F	39_A	1.935	1.00
51_T	54_L	1.903	1.00
47_W	81_V	1.901	1.00
198_L	202_L	1.897	1.00
154_V	253_T	1.846	1.00
84_S	97_V	1.777	1.00
46_V	81_V	1.774	1.00
55_A	59_W	1.762	1.00
52_V	55_A	1.745	1.00
152_F	181_L	1.725	1.00
48_T	52_V	1.715	1.00
234_Y	255_C	1.695	1.00
262_N	265_L	1.693	1.00
229_L	233_Y	1.684	1.00
99_F	155_L	1.671	1.00
9_L	52_V	1.649	1.00
193_V	228_L	1.630	1.00
13_T	17_Y	1.621	1.00
270_S	273_H	1.612	1.00
61_T	120_S	1.610	1.00
16_I	46_V	1.567	1.00
79_V	144_G	1.544	1.00
22_L	26_I	1.499	1.00
82_T	86_V	1.487	1.00
207_A	211_L	1.486	1.00
207_A	215_Y	1.463	1.00
242_E	245_G	1.454	1.00
150_F	154_V	1.447	1.00
189_N	252_N	1.418	1.00
104_G	107_M	1.382	1.00
256_F	260_M	1.380	1.00
153_S	253_T	1.369	1.00
143_Y	196_L	1.358	1.00
170_K	173_L	1.358	1.00
52_V	56_Y	1.341	1.00
182_D	248_A	1.332	1.00
153_S	252_N	1.330	1.00
40_F	88_T	1.330	1.00
47_W	50_Q	1.320	1.00
98_F	102_V	1.307	1.00
12_G	49_L	1.306	1.00
180_K	183_Y	1.302	1.00
192_G	231_Y	1.298	1.00
196_L	227_V	1.293	1.00
47_W	51_T	1.287	1.00
20_S	43_L	1.252	0.99
163_L	178_L	1.252	0.99
23_F	42_L	1.231	0.99
47_W	85_L	1.221	0.99
17_Y	46_V	1.219	0.99
145_A	192_G	1.211	0.99
89_K	92_R	1.206	0.99
217_F	221_V	1.202	0.99
183_Y	187_V	1.202	0.99
44_S	48_T	1.193	0.99
163_L	166_K	1.188	0.99
193_V	197_L	1.185	0.99
143_Y	220_K	1.183	0.99
138_M	199_S	1.169	0.99
214_L	263_Y	1.164	0.99
185_A	252_N	1.159	0.99
11_E	15_V	1.151	0.99
50_Q	74_Y	1.151	0.99
105_F	110_I	1.147	0.99
27_D	36_G	1.140	0.99
182_D	186_Y	1.137	0.99
221_V	236_Y	1.136	0.99
211_L	217_F	1.132	0.99
21_V	25_F	1.131	0.99
12_G	16_I	1.130	0.99
223_G	266_L	1.107	0.99
17_Y	21_V	1.105	0.99
33_R	37_K	1.099	0.99
24_Y	39_A	1.087	0.99
215_Y	221_V	1.087	0.99
65_P	68_N	1.081	0.98
57_F	71_E	1.068	0.98
160_Y	178_L	1.068	0.98
250_L	253_T	1.064	0.98
10_N	112_T	1.063	0.98
24_Y	40_F	1.061	0.98
233_Y	237_I	1.061	0.98
168_W	172_L	1.057	0.98
265_L	269_L	1.056	0.98
211_L	221_V	1.053	0.98
140_I	143_Y	1.045	0.98
72_A	199_S	1.040	0.98
36_G	94_D	1.038	0.98
43_L	81_V	1.036	0.98
104_G	108_I	1.030	0.98
214_L	217_F	1.028	0.98
41_W	45_I	1.023	0.98
72_A	263_Y	1.013	0.98
11_E	14_I	1.013	0.98
19_L	42_L	1.000	0.97
37_K	41_W	0.996	0.97
19_L	32_N	0.995	0.97
80_L	147_S	0.992	0.97
227_V	262_N	0.989	0.97
161_H	165_K	0.986	0.97
12_G	19_L	0.982	0.97
237_I	243_L	0.980	0.97
149_S	252_N	0.980	0.97
158_F	161_H	0.966	0.97
223_G	226_V	0.962	0.97
200_L	204_V	0.957	0.97
182_D	245_G	0.957	0.97
177_D	180_K	0.954	0.97
186_Y	238_R	0.952	0.97
238_R	242_E	0.948	0.96
77_A	108_I	0.940	0.96
265_L	268_S	0.939	0.96
196_L	202_L	0.939	0.96
158_F	172_L	0.938	0.96
77_A	107_M	0.925	0.96
131_L	209_V	0.919	0.96
63_R	71_E	0.909	0.96
196_L	200_L	0.909	0.96
237_I	248_A	0.909	0.96
196_L	259_L	0.908	0.95
80_L	144_G	0.895	0.95
259_L	265_L	0.894	0.95
207_A	218_D	0.891	0.95
190_V	235_L	0.890	0.95
215_Y	236_Y	0.889	0.95
109_A	113_F	0.883	0.95
20_S	24_Y	0.881	0.95
159_Q	175_I	0.881	0.95
207_A	210_S	0.878	0.95
37_K	158_F	0.876	0.95
43_L	46_V	0.871	0.94
15_V	19_L	0.869	0.94
217_F	225_F	0.867	0.94
103_I	147_S	0.865	0.94
27_D	39_A	0.864	0.94
20_S	46_V	0.861	0.94
14_I	21_V	0.860	0.94
65_P	70_T	0.859	0.94
73_L	107_M	0.858	0.94
168_W	171_W	0.857	0.94
18_A	105_F	0.855	0.94
199_S	224_S	0.849	0.94
84_S	100_T	0.848	0.94
182_D	185_A	0.843	0.93
214_L	221_V	0.843	0.93
246_K	249_A	0.840	0.93
128_V	201_I	0.835	0.93
21_V	102_V	0.829	0.93
125_G	204_V	0.828	0.93
74_Y	108_I	0.827	0.93
74_Y	77_A	0.827	0.93
126_Q	210_S	0.822	0.92
18_A	25_F	0.821	0.92
227_V	265_L	0.820	0.92
212_E	221_V	0.818	0.92
252_N	265_L	0.815	0.92
217_F	236_Y	0.812	0.92
150_F	256_F	0.810	0.92
231_Y	252_N	0.808	0.92
211_L	236_Y	0.802	0.91
159_Q	178_L	0.801	0.91
24_Y	88_T	0.799	0.91
211_L	216_W	0.797	0.91
58_M	64_F	0.787	0.91
149_S	188_L	0.786	0.91
266_L	271_Q	0.783	0.90
61_T	68_N	0.781	0.90
204_V	225_F	0.780	0.90
130_E	134_I	0.777	0.90
200_L	228_L	0.776	0.90
220_K	267_G	0.772	0.90
207_A	221_V	0.770	0.90
57_F	70_T	0.770	0.90
66_V	75_F	0.767	0.90
145_A	191_I	0.760	0.89
71_E	225_F	0.759	0.89
40_F	44_S	0.758	0.89
162_L	165_K	0.756	0.89
165_K	173_L	0.756	0.89
211_L	215_Y	0.755	0.89
64_F	67_L	0.754	0.89
34_K	37_K	0.753	0.89
69_V	268_S	0.753	0.89
76_Y	140_I	0.752	0.89
34_K	38_M	0.752	0.89
66_V	137_T	0.748	0.88
143_Y	202_L	0.745	0.88
142_S	196_L	0.745	0.88
12_G	51_T	0.744	0.88
143_Y	265_L	0.743	0.88
147_S	150_F	0.740	0.88
27_D	32_N	0.738	0.88
204_V	210_S	0.735	0.88
17_Y	24_Y	0.734	0.87
36_G	39_A	0.731	0.87
226_V	233_Y	0.731	0.87
50_Q	81_V	0.730	0.87
20_S	25_F	0.723	0.87
167_K	170_K	0.722	0.87
234_Y	262_N	0.721	0.86
234_Y	251_W	0.721	0.86
252_N	255_C	0.720	0.86
75_F	199_S	0.719	0.86
50_Q	78_W	0.718	0.86
207_A	212_E	0.715	0.86
21_V	105_F	0.706	0.85
182_D	249_A	0.704	0.85
138_M	198_L	0.698	0.85
54_L	75_F	0.697	0.85
183_Y	186_Y	0.694	0.84
40_F	48_T	0.693	0.84
152_F	185_A	0.691	0.84
30_Q	33_R	0.690	0.84
25_F	98_F	0.690	0.84
185_A	249_A	0.683	0.83
30_Q	34_K	0.682	0.83
53_Y	70_T	0.676	0.83
83_L	148_L	0.675	0.83
78_W	82_T	0.675	0.83
72_A	75_F	0.672	0.82
26_I	29_L	0.670	0.82
17_Y	81_V	0.670	0.82
33_R	165_K	0.669	0.82
225_F	229_L	0.668	0.82
58_M	65_P	0.668	0.82
74_Y	111_H	0.666	0.82
224_S	265_L	0.666	0.82
20_S	23_F	0.665	0.82
207_A	214_L	0.664	0.82
227_V	268_S	0.664	0.82
216_W	221_V	0.662	0.81
177_D	182_D	0.662	0.81
195_M	199_S	0.661	0.81
125_G	217_F	0.661	0.81
217_F	223_G	0.659	0.81
24_Y	28_F	0.659	0.81
142_S	195_M	0.659	0.81
11_E	106_S	0.659	0.81
186_Y	235_L	0.658	0.81
257_L	261_I	0.654	0.81
169_G	173_L	0.650	0.80
127_L	207_A	0.649	0.80
111_H	263_Y	0.643	0.80
70_T	132_L	0.641	0.79
237_I	244_Q	0.639	0.79
142_S	154_V	0.638	0.79
211_L	214_L	0.638	0.79
23_F	35_A	0.638	0.79
206_W	236_Y	0.637	0.79
81_V	101_N	0.636	0.79
38_M	42_L	0.633	0.79
224_S	264_F	0.633	0.79
33_R	36_G	0.632	0.78
236_Y	240_I	0.632	0.78
229_L	232_S	0.630	0.78
39_A	43_L	0.623	0.77
72_A	139_A	0.623	0.77
233_Y	251_W	0.620	0.77
193_V	235_L	0.618	0.77
244_Q	248_A	0.613	0.76
122_A	192_G	0.611	0.76
123_F	225_F	0.611	0.76
20_S	42_L	0.611	0.76
16_I	42_L	0.610	0.76
156_Y	194_P	0.607	0.76
182_D	242_E	0.607	0.76
19_L	254_A	0.606	0.75
149_S	248_A	0.606	0.75
98_F	101_N	0.605	0.75
154_V	158_F	0.605	0.75
143_Y	259_L	0.603	0.75
40_F	89_K	0.601	0.75
27_D	254_A	0.600	0.75
10_N	74_Y	0.599	0.75
198_L	230_L	0.599	0.75
177_D	183_Y	0.598	0.75
219_A	224_S	0.598	0.75
67_L	124_S	0.594	0.74
227_V	258_V	0.593	0.74
95_F	142_S	0.592	0.74
82_T	164_K	0.592	0.74
201_I	210_S	0.591	0.74
15_V	37_K	0.591	0.74
221_V	267_G	0.588	0.73
133_V	136_I	0.588	0.73
185_A	234_Y	0.588	0.73
17_Y	20_S	0.587	0.73
125_G	226_V	0.586	0.73
219_A	271_Q	0.586	0.73
225_F	271_Q	0.585	0.73
239_L	242_E	0.582	0.73
65_P	123_F	0.582	0.73
136_I	266_L	0.578	0.72
136_I	267_G	0.575	0.72
153_S	248_A	0.575	0.72
145_A	188_L	0.573	0.71
219_A	263_Y	0.569	0.71
76_Y	147_S	0.568	0.71
238_R	248_A	0.566	0.70
177_D	181_L	0.566	0.70
9_L	13_T	0.565	0.70
210_S	214_L	0.565	0.70
261_I	265_L	0.564	0.70
235_L	272_F	0.562	0.70
253_T	257_L	0.561	0.70
69_V	72_A	0.560	0.70
131_L	136_I	0.560	0.70
13_T	46_V	0.559	0.69
206_W	211_L	0.557	0.69
155_L	181_L	0.556	0.69
178_L	182_D	0.556	0.69
115_P	150_F	0.556	0.69
13_T	28_F	0.555	0.69
175_I	179_S	0.553	0.69
211_L	225_F	0.552	0.69
242_E	246_K	0.552	0.69
24_Y	84_S	0.551	0.68
53_Y	113_F	0.551	0.68
126_Q	225_F	0.550	0.68
209_V	212_E	0.550	0.68
138_M	184_M	0.550	0.68
131_L	206_W	0.549	0.68
210_S	261_I	0.545	0.68
17_Y	22_L	0.545	0.68
204_V	222_L	0.544	0.67
211_L	218_D	0.544	0.67
95_F	101_N	0.543	0.67
176_E	197_L	0.541	0.67
204_V	207_A	0.540	0.67
255_C	259_L	0.539	0.67
221_V	271_Q	0.538	0.67
203_G	220_K	0.537	0.66
83_L	146_F	0.536	0.66
223_G	227_V	0.534	0.66
204_V	208_Y	0.533	0.66
196_L	199_S	0.533	0.66
259_L	263_Y	0.530	0.65
148_L	151_V	0.530	0.65
229_L	239_L	0.530	0.65
127_L	206_W	0.529	0.65
77_A	111_H	0.528	0.65
25_F	35_A	0.528	0.65
125_G	256_F	0.528	0.65
219_A	236_Y	0.526	0.65
112_T	148_L	0.525	0.65
30_Q	35_A	0.524	0.65
223_G	265_L	0.523	0.64
13_T	20_S	0.520	0.64
210_S	221_V	0.520	0.64
161_H	176_E	0.520	0.64
11_E	25_F	0.519	0.64
207_A	236_Y	0.519	0.64
46_V	176_E	0.518	0.64
80_L	258_V	0.516	0.63
46_V	101_N	0.515	0.63
165_K	169_G	0.515	0.63
205_I	208_Y	0.515	0.63
263_Y	266_L	0.514	0.63
35_A	38_M	0.513	0.63
145_A	263_Y	0.512	0.63
21_V	24_Y	0.512	0.63
37_K	40_F	0.510	0.63
48_T	176_E	0.504	0.62
84_S	91_L	0.502	0.61
40_F	85_L	0.502	0.61
189_N	234_Y	0.502	0.61
223_G	264_F	0.501	0.61
212_E	236_Y	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bg9A	1	0.558	12.4	0.96	Contact Map
4qndA	2	0.3297	9.2	0.962	Contact Map
1fftA	1	0.8442	7.2	0.964	Contact Map
2m20A	2	0.2029	6.6	0.965	Contact Map
1q16C	2	0.5109	4.9	0.967	Contact Map
3wxwA	1	0.2391	4.5	0.967	Contact Map
1zcdA	1	0.3297	4.4	0.968	Contact Map
2l2tA	2	0.1594	3.4	0.969	Contact Map
3b5dA	2	0.3587	3.4	0.969	Contact Map
2hi7B	1	0.3949	3.1	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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