GREMLIN Database
HEM1 - Glutamyl-tRNA reductase
UniProt: P16618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (418)
Sequences: 2475 (1647)
Seq/√Len: 80.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_M285_L6.8431.00
102_R322_E6.7561.00
151_R155_E4.9281.00
280_A284_D4.3771.00
152_T321_V4.0091.00
184_H208_K3.7921.00
184_H210_T3.7121.00
248_S284_D3.6891.00
45_I142_F3.5871.00
43_E135_G3.5251.00
208_K229_E3.4451.00
248_S285_L3.1731.00
7_G89_T2.9301.00
98_E326_E2.8461.00
356_Q382_T2.8441.00
371_S374_E2.7881.00
188_L257_V2.7511.00
353_L356_Q2.7511.00
317_T320_K2.7461.00
235_Q238_S2.6461.00
212_I231_R2.5891.00
14_P87_F2.5451.00
151_R328_T2.5101.00
262_M276_M2.4051.00
186_L212_I2.3601.00
259_K288_A2.3081.00
216_Y230_A2.2481.00
151_R327_E2.2391.00
174_K204_Q2.2301.00
259_K263_E2.2291.00
100_L121_V2.1971.00
216_Y232_S2.1821.00
255_F286_D2.1621.00
276_M295_V2.1591.00
352_A389_M2.1481.00
239_A242_E2.1181.00
359_T362_S2.0921.00
19_E283_R2.0831.00
185_I206_I2.0821.00
216_Y220_K2.0771.00
312_K315_R2.0651.00
57_A69_I2.0271.00
328_T331_E2.0181.00
372_T375_K1.9811.00
349_R394_I1.9701.00
102_R108_D1.9591.00
248_S280_A1.9501.00
220_K224_D1.9401.00
94_D333_K1.9311.00
199_E225_R1.9291.00
285_L289_L1.9211.00
116_Q196_L1.9071.00
32_M133_T1.8981.00
141_L332_F1.8711.00
14_P17_I1.8471.00
349_R387_N1.8431.00
353_L357_S1.8261.00
231_R239_A1.8011.00
56_Y142_F1.7901.00
129_Q139_N1.7791.00
258_S261_M1.7591.00
359_T384_S1.7461.00
260_E263_E1.7401.00
157_D160_S1.7181.00
262_M265_A1.7111.00
259_K291_D1.7101.00
190_A213_N1.7101.00
128_A133_T1.7021.00
5_V56_Y1.6901.00
210_T231_R1.6861.00
36_K133_T1.6741.00
146_V149_G1.6641.00
250_T284_D1.6421.00
370_L374_E1.6351.00
266_N292_L1.6341.00
95_A98_E1.6241.00
288_A291_D1.6231.00
105_C152_T1.6161.00
17_I87_F1.6141.00
405_D408_E1.5931.00
281_V300_I1.5681.00
23_F31_A1.5480.99
262_M289_L1.5360.99
363_I377_L1.5280.99
8_V21_V1.5240.99
348_L419_I1.5220.99
80_S83_E1.5120.99
369_H374_E1.5040.99
97_V141_L1.5010.99
240_L246_L1.5000.99
103_V108_D1.4960.99
118_L149_G1.4740.99
47_V121_V1.4660.99
31_A46_I1.4640.99
409_K416_I1.4620.99
162_A167_Y1.4530.99
359_T388_Q1.4500.99
70_K88_L1.4450.99
356_Q379_N1.4440.99
125_F139_N1.4430.99
162_A168_A1.4410.99
185_I201_L1.4370.99
344_V414_M1.4240.99
298_Y302_D1.4200.99
364_E375_K1.4160.99
237_E261_M1.4150.99
319_E322_E1.4110.99
212_I236_L1.3990.99
195_E225_R1.3970.99
344_V419_I1.3910.99
304_E308_E1.3870.99
125_F129_Q1.3810.99
43_E58_V1.3740.99
53_T106_G1.3690.99
198_A226_F1.3610.99
356_Q383_K1.3600.99
260_E288_A1.3570.99
148_V325_I1.3500.99
169_A279_I1.3430.99
105_C321_V1.3410.99
182_S207_G1.3330.98
352_A390_L1.3310.98
212_I233_L1.3130.98
71_K75_D1.3090.98
386_I389_M1.3040.98
261_M286_D1.3020.98
121_V142_F1.2990.98
97_V329_I1.2970.98
42_L60_D1.2960.98
176_I296_F1.2900.98
18_R301_D1.2860.98
169_A277_V1.2850.98
380_K384_S1.2760.98
239_A243_A1.2680.98
140_E335_W1.2630.98
165_V193_M1.2590.98
58_V135_G1.2580.98
351_K392_D1.2550.98
177_F245_I1.2500.98
246_L276_M1.2420.98
262_M274_L1.2270.97
56_Y103_V1.2260.97
9_D108_D1.2210.97
21_V84_L1.2190.97
250_T256_V1.2180.97
332_F335_W1.2170.97
89_T108_D1.2070.97
165_V279_I1.2040.97
363_I381_H1.1980.97
4_L57_A1.1900.97
134_I139_N1.1790.97
11_K108_D1.1740.97
376_K380_K1.1710.97
97_V333_K1.1680.96
186_L239_A1.1540.96
255_F287_P1.1530.96
229_E239_A1.1530.96
210_T229_E1.1510.96
258_S286_D1.1440.96
217_L221_E1.1330.96
179_N182_S1.1320.96
375_K379_N1.1230.96
184_H242_E1.1220.96
71_K81_K1.1210.96
8_V88_L1.1130.95
231_R235_Q1.1110.95
149_G161_N1.1090.95
396_K399_E1.1090.95
392_D418_D1.1040.95
256_V284_D1.1020.95
148_V324_L1.0980.95
27_E77_F1.0970.95
187_I201_L1.0960.95
254_E258_S1.0930.95
286_D290_N1.0860.95
36_K44_N1.0810.95
105_C148_V1.0710.94
400_L404_A1.0710.94
106_G112_I1.0700.94
368_P375_K1.0660.94
201_L206_I1.0630.94
139_N143_K1.0620.94
326_E330_V1.0610.94
31_A72_F1.0600.94
238_S242_E1.0550.94
271_G294_G1.0460.94
186_L243_A1.0430.93
101_F329_I1.0410.93
56_Y106_G1.0300.93
186_L231_R1.0280.93
210_T243_A1.0200.93
348_L417_F1.0180.93
144_Q148_V1.0130.92
254_E260_E1.0090.92
171_E204_Q1.0040.92
183_K245_I1.0020.92
162_A171_E0.9900.92
260_E264_N0.9860.91
257_V261_M0.9850.91
10_Y110_M0.9820.91
15_I281_V0.9770.91
254_E286_D0.9710.91
214_R282_P0.9700.91
257_V276_M0.9700.91
348_L390_L0.9670.91
370_L375_K0.9610.90
45_I134_I0.9600.90
221_E224_D0.9570.90
144_Q328_T0.9570.90
216_Y233_L0.9550.90
7_G18_R0.9520.90
409_K412_L0.9510.90
399_E403_D0.9500.90
194_G222_L0.9470.90
207_G229_E0.9470.90
126_K130_Q0.9400.89
359_T380_K0.9390.89
290_N297_L0.9360.89
33_V131_E0.9360.89
111_V305_G0.9330.89
299_D302_D0.9330.89
360_M379_N0.9330.89
122_R150_K0.9330.89
187_I198_A0.9300.89
46_I55_I0.9300.89
47_V124_S0.9270.89
196_L200_N0.9260.89
153_H363_I0.9250.88
143_K146_V0.9230.88
188_L285_L0.9230.88
357_S379_N0.9210.88
210_T239_A0.9200.88
144_Q147_T0.9140.88
339_L342_V0.9120.88
276_M297_L0.9090.88
269_R274_L0.9080.88
74_A79_L0.9070.87
219_A223_A0.9050.87
172_L298_Y0.9040.87
408_E412_L0.9030.87
363_I382_T0.9020.87
126_K129_Q0.9020.87
3_I137_I0.8980.87
165_V300_I0.8910.87
232_S235_Q0.8900.86
184_H207_G0.8870.86
143_K147_T0.8850.86
382_T385_I0.8840.86
94_D330_V0.8760.86
110_M300_I0.8750.86
128_A134_I0.8740.85
378_L381_H0.8730.85
6_V70_K0.8690.85
252_A284_D0.8620.85
98_E329_I0.8570.84
35_L44_N0.8530.84
28_L127_T0.8520.84
99_H108_D0.8520.84
231_R236_L0.8500.84
175_K309_A0.8490.84
41_I44_N0.8460.84
127_T130_Q0.8460.84
413_F416_I0.8440.83
360_M378_L0.8440.83
29_A131_E0.8390.83
178_G182_S0.8380.83
286_D289_L0.8360.83
61_Q67_Y0.8350.83
266_N269_R0.8350.83
104_A121_V0.8340.83
105_C324_L0.8300.82
367_L377_L0.8270.82
217_L220_K0.8260.82
259_K286_D0.8250.82
173_A275_F0.8240.82
179_N404_A0.8220.82
411_A415_Q0.8210.82
240_L265_A0.8200.82
335_W338_T0.8160.81
156_T324_L0.8160.81
140_E339_L0.8150.81
188_L246_L0.8140.81
91_Y95_A0.8120.81
250_T280_A0.8110.81
258_S288_A0.8080.81
115_T153_H0.8070.81
56_Y121_V0.8060.81
18_R281_V0.8060.81
158_I352_A0.8050.80
136_T339_L0.8020.80
7_G150_K0.8020.80
177_F296_F0.8010.80
186_L233_L0.8000.80
21_V79_L0.7990.80
335_W342_V0.7930.79
176_I245_I0.7870.79
166_S197_A0.7870.79
212_I232_S0.7870.79
150_K154_A0.7860.79
20_K83_E0.7810.78
158_I303_L0.7790.78
127_T131_E0.7770.78
215_T219_A0.7740.78
356_Q385_I0.7740.78
123_D246_L0.7730.78
221_E225_R0.7730.78
247_I279_I0.7720.78
183_K244_D0.7710.78
145_A149_G0.7710.78
44_N55_I0.7700.77
323_L327_E0.7670.77
9_D344_V0.7650.77
325_I351_K0.7620.77
240_L243_A0.7620.77
19_E43_E0.7560.76
408_E411_A0.7540.76
238_S268_L0.7490.75
241_A268_L0.7470.75
12_S89_T0.7450.75
347_A414_M0.7440.75
9_D112_I0.7420.75
30_E33_V0.7340.74
155_E324_L0.7320.74
100_L142_F0.7310.74
246_L274_L0.7310.74
106_G159_G0.7310.74
141_L335_W0.7290.73
163_V314_R0.7270.73
323_L326_E0.7260.73
111_V165_V0.7250.73
3_I96_A0.7230.73
344_V347_A0.7220.73
260_E266_N0.7200.73
41_I59_V0.7180.72
235_Q260_E0.7170.72
237_E254_E0.7160.72
35_L69_I0.7150.72
289_L292_L0.7140.72
355_I385_I0.7110.72
253_S280_A0.7110.72
348_L393_P0.7090.71
381_H385_I0.7070.71
360_M364_E0.7070.71
149_G153_H0.7060.71
362_S384_S0.7050.71
379_N383_K0.7040.71
248_S289_L0.7040.71
41_I65_G0.7030.71
177_F275_F0.7030.71
115_T149_G0.7020.71
33_V37_E0.7020.71
215_T218_K0.7020.71
111_V168_A0.7010.71
184_H243_A0.7000.70
355_I381_H0.7000.70
67_Y85_S0.6990.70
251_G255_F0.6980.70
152_T324_L0.6970.70
209_V228_G0.6970.70
259_K264_N0.6960.70
162_A310_N0.6950.70
70_K85_S0.6950.70
264_N288_A0.6940.70
31_A76_W0.6940.70
37_E60_D0.6930.70
59_V65_G0.6920.70
249_S279_I0.6920.70
348_L413_F0.6910.69
32_M44_N0.6900.69
16_E19_E0.6890.69
137_I335_W0.6890.69
389_M394_I0.6890.69
362_S391_R0.6880.69
156_T321_V0.6860.69
367_L378_L0.6850.69
344_V348_L0.6850.69
344_V397_V0.6840.69
283_R300_I0.6820.68
165_V324_L0.6810.68
244_D272_R0.6790.68
252_A280_A0.6780.68
213_N219_A0.6760.68
23_F77_F0.6760.68
401_A404_A0.6760.68
349_R391_R0.6700.67
269_R273_P0.6700.67
171_E279_I0.6680.67
354_A357_S0.6680.67
318_A321_V0.6680.67
79_L84_L0.6650.66
320_K323_L0.6650.66
250_T282_P0.6650.66
162_A318_A0.6650.66
121_V245_I0.6640.66
186_L236_L0.6620.66
366_K371_S0.6620.66
190_A222_L0.6610.66
99_H103_V0.6590.66
21_V77_F0.6590.66
34_Q75_D0.6580.66
38_E75_D0.6560.65
273_P296_F0.6550.65
396_K415_Q0.6550.65
248_S276_M0.6530.65
337_N401_A0.6520.65
279_I306_I0.6490.65
190_A211_V0.6490.65
18_R166_S0.6480.64
206_I209_V0.6480.64
81_K85_S0.6480.64
283_R301_D0.6460.64
197_A247_I0.6460.64
394_I398_K0.6450.64
228_G275_F0.6450.64
45_I124_S0.6430.64
379_N382_T0.6420.64
104_A145_A0.6410.64
276_M289_L0.6400.64
140_E146_V0.6400.64
129_Q143_K0.6400.64
240_L257_V0.6400.64
45_I121_V0.6390.63
197_A215_T0.6390.63
136_T139_N0.6370.63
119_G347_A0.6360.63
370_L378_L0.6350.63
9_D89_T0.6350.63
23_F46_I0.6350.63
187_I212_I0.6350.63
275_F296_F0.6340.63
19_E300_I0.6300.62
313_E316_E0.6290.62
222_L225_R0.6280.62
148_V321_V0.6270.62
352_A386_I0.6270.62
44_N57_A0.6240.62
122_R146_V0.6210.61
25_P123_D0.6210.61
200_N321_V0.6200.61
125_F143_K0.6190.61
101_F110_M0.6190.61
107_L322_E0.6170.61
110_M114_E0.6110.60
3_I58_V0.6070.59
397_V413_F0.6060.59
247_I277_V0.6050.59
267_K270_K0.6040.59
173_A245_I0.6030.59
2_H5_V0.6030.59
7_G12_S0.6020.59
118_L146_V0.6010.59
404_A408_E0.6000.59
122_R277_V0.5990.58
351_K354_A0.5980.58
156_T173_A0.5980.58
173_A180_L0.5960.58
116_Q283_R0.5950.58
172_L175_K0.5940.58
214_R250_T0.5940.58
206_I245_I0.5930.58
400_L409_K0.5920.58
350_E354_A0.5910.57
393_P419_I0.5910.57
383_K398_K0.5910.57
111_V140_E0.5910.57
354_A358_E0.5890.57
325_I329_I0.5890.57
101_F343_P0.5890.57
373_R376_K0.5890.57
101_F348_L0.5870.57
168_A307_V0.5860.57
349_R393_P0.5850.57
22_S48_S0.5850.57
178_G398_K0.5830.56
202_H226_F0.5830.56
166_S279_I0.5830.56
45_I100_L0.5830.56
261_M288_A0.5820.56
164_S297_L0.5810.56
172_L303_L0.5800.56
124_S128_A0.5800.56
5_V89_T0.5800.56
95_A326_E0.5790.56
110_M304_E0.5790.56
193_M303_L0.5780.56
149_G321_V0.5760.56
358_E361_D0.5750.55
182_S185_I0.5750.55
2_H6_V0.5740.55
223_A230_A0.5740.55
53_T342_V0.5730.55
176_I267_K0.5730.55
166_S170_V0.5720.55
32_M36_K0.5720.55
411_A418_D0.5720.55
407_E411_A0.5720.55
409_K413_F0.5700.55
198_A251_G0.5700.55
51_N301_D0.5690.55
178_G251_G0.5690.55
27_E30_E0.5690.55
128_A367_L0.5690.55
108_D139_N0.5670.54
153_H397_V0.5660.54
314_R317_T0.5650.54
23_F53_T0.5650.54
94_D389_M0.5640.54
223_A228_G0.5640.54
247_I355_I0.5620.54
364_E378_L0.5620.54
104_A134_I0.5600.53
315_R319_E0.5590.53
40_S69_I0.5580.53
243_A274_L0.5580.53
2_H93_S0.5570.53
34_Q47_V0.5570.53
203_G306_I0.5560.53
250_T253_S0.5550.53
253_S284_D0.5550.53
240_L262_M0.5550.53
149_G152_T0.5550.53
156_T317_T0.5530.53
349_R389_M0.5520.52
27_E34_Q0.5500.52
329_I332_F0.5500.52
155_E328_T0.5490.52
100_L201_L0.5490.52
386_I390_L0.5480.52
74_A80_S0.5470.52
53_T142_F0.5470.52
153_H381_H0.5470.52
361_D364_E0.5470.52
190_A218_K0.5460.52
195_E249_S0.5460.52
233_L236_L0.5460.52
7_G13_A0.5460.52
34_Q71_K0.5450.52
20_K79_L0.5450.52
74_A77_F0.5440.51
259_K292_L0.5440.51
8_V13_A0.5430.51
363_I370_L0.5430.51
412_L416_I0.5420.51
5_V96_A0.5420.51
307_V310_N0.5420.51
220_K232_S0.5410.51
257_V262_M0.5400.51
309_A313_E0.5390.51
371_S376_K0.5380.51
327_E331_E0.5370.50
154_A246_L0.5370.50
201_L211_V0.5370.50
29_A33_V0.5360.50
236_L243_A0.5360.50
382_T388_Q0.5350.50
13_A86_P0.5330.50
7_G196_L0.5330.50
396_K416_I0.5320.50
188_L256_V0.5310.50
267_K293_E0.5300.50
403_D406_S0.5300.50
55_I129_Q0.5300.50
219_A230_A0.5290.49
74_A81_K0.5270.49
125_F146_V0.5260.49
233_L254_E0.5260.49
247_I284_D0.5260.49
29_A127_T0.5250.49
215_T398_K0.5250.49
315_R322_E0.5250.49
213_N233_L0.5240.49
396_K409_K0.5230.49
195_E199_E0.5230.49
6_V90_F0.5220.49
82_E85_S0.5210.48
66_R90_F0.5200.48
18_R335_W0.5200.48
172_L306_I0.5200.48
373_R378_L0.5200.48
183_K294_G0.5200.48
166_S171_E0.5190.48
246_L323_L0.5180.48
45_I56_Y0.5180.48
3_I352_A0.5170.48
164_S201_L0.5170.48
356_Q363_I0.5170.48
269_R296_F0.5160.48
179_N315_R0.5160.48
171_E174_K0.5160.48
235_Q239_A0.5160.48
55_I69_I0.5150.48
410_L413_F0.5150.48
200_N300_I0.5140.47
399_E402_A0.5130.47
213_N222_L0.5130.47
378_L388_Q0.5130.47
209_V252_A0.5120.47
25_P29_A0.5120.47
176_I275_F0.5120.47
23_F28_L0.5120.47
220_K229_E0.5110.47
46_I76_W0.5090.47
67_Y364_E0.5090.47
168_A306_I0.5090.47
220_K230_A0.5080.47
30_E76_W0.5080.47
14_P121_V0.5080.47
392_D396_K0.5080.47
139_N409_K0.5080.47
299_D388_Q0.5070.47
132_K316_E0.5060.46
378_L382_T0.5050.46
373_R377_L0.5050.46
173_A230_A0.5050.46
121_V126_K0.5050.46
28_L32_M0.5050.46
384_S417_F0.5040.46
271_G293_E0.5040.46
110_M165_V0.5040.46
299_D374_E0.5030.46
165_V201_L0.5030.46
215_T230_A0.5020.46
283_R297_L0.5020.46
381_H384_S0.5020.46
192_K314_R0.5020.46
362_S388_Q0.5010.46
26_N29_A0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7rA 2 0.8747 100 0.328 Contact Map
1gpjA 2 0.8659 100 0.445 Contact Map
4ppmA 2 0.1429 99.9 0.807 Contact Map
1edzA 2 0.6374 99.9 0.819 Contact Map
1p77A 1 0.5582 99.9 0.827 Contact Map
3u62A 1 0.5121 99.9 0.828 Contact Map
1nytA 6 0.567 99.9 0.84 Contact Map
3fbtA 2 0.5736 99.8 0.844 Contact Map
4b4uA 2 0.5648 99.8 0.847 Contact Map
2eggA 5 0.5758 99.8 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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