HEM3 - BACSU - GREMLIN Contacts

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HEM3 - Porphobilinogen deaminase

UniProt:	P16616	Sequences: MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKGDRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPEREDPRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLETEDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQFTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKETVTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	314 (297)
Sequences:	3530 (2292)
Seq/√Len:	133.0

ECOLI - HEM3
BACSU - HEM3
HALSA - HEM3
SULSO - HEM3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
220_T	225_K	4.337	1.00
156_Q	160_T	4.308	1.00
6_K	38_K	3.226	1.00
8_G	74_I	3.205	1.00
101_E	174_S	2.908	1.00
99_E	221_D	2.882	1.00
23_I	27_K	2.880	1.00
11_R	39_E	2.703	1.00
170_A	186_F	2.702	1.00
237_A	291_A	2.607	1.00
200_A	228_V	2.572	1.00
266_S	270_K	2.425	1.00
159_E	182_V	2.396	1.00
123_V	145_K	2.375	1.00
206_R	209_D	2.324	1.00
275_E	289_C	2.313	1.00
11_R	41_V	2.278	1.00
25_K	28_E	2.271	1.00
257_E	278_T	2.270	1.00
277_V	292_L	2.212	1.00
132_S	136_L	2.124	1.00
93_V	207_E	2.123	1.00
91_G	207_E	2.078	1.00
275_E	292_L	2.064	1.00
145_K	163_Y	2.017	1.00
114_K	117_E	1.995	1.00
47_I	50_V	1.988	1.00
4_T	34_A	1.966	1.00
151_I	176_M	1.961	1.00
123_V	143_T	1.945	1.00
7_V	23_I	1.936	1.00
13_K	152_D	1.926	1.00
221_D	224_T	1.916	1.00
4_T	36_E	1.903	1.00
147_I	166_I	1.902	1.00
259_E	278_T	1.898	1.00
93_V	213_L	1.890	1.00
95_G	205_C	1.888	1.00
261_T	276_T	1.884	1.00
279_G	285_V	1.869	1.00
264_V	298_A	1.852	1.00
67_Q	71_N	1.834	1.00
98_P	201_L	1.792	1.00
20_K	24_Q	1.790	1.00
234_F	262_G	1.769	1.00
66_E	204_E	1.767	1.00
225_K	229_L	1.762	1.00
259_E	276_T	1.744	1.00
21_W	25_K	1.734	1.00
237_A	287_K	1.708	1.00
277_V	289_C	1.695	1.00
81_M	197_G	1.695	1.00
291_A	295_D	1.679	1.00
19_T	37_I	1.657	1.00
29_I	218_Q	1.634	1.00
210_E	214_A	1.611	1.00
275_E	296_K	1.595	1.00
96_C	220_T	1.589	1.00
188_E	191_R	1.578	1.00
74_I	77_A	1.571	1.00
104_R	186_F	1.566	1.00
70_L	92_L	1.563	1.00
16_M	39_E	1.543	1.00
41_V	46_R	1.502	1.00
247_A	263_L	1.498	1.00
138_E	191_R	1.495	1.00
20_K	23_I	1.482	1.00
152_D	178_W	1.482	1.00
196_V	248_G	1.478	1.00
229_L	283_E	1.463	1.00
205_C	213_L	1.461	1.00
271_I	300_D	1.458	1.00
209_D	212_L	1.452	1.00
281_D	284_E	1.452	1.00
97_I	200_A	1.433	1.00
30_N	218_Q	1.425	1.00
136_L	144_I	1.425	1.00
9_S	37_I	1.424	1.00
25_K	29_I	1.423	1.00
27_K	34_A	1.405	1.00
227_T	252_L	1.403	1.00
113_V	117_E	1.402	1.00
68_A	73_E	1.396	1.00
95_G	213_L	1.391	1.00
104_R	170_A	1.384	1.00
6_K	36_E	1.372	1.00
277_V	288_R	1.348	1.00
222_E	226_R	1.343	1.00
23_I	35_F	1.339	1.00
288_R	292_L	1.320	1.00
185_E	191_R	1.314	1.00
124_I	165_A	1.314	1.00
116_S	191_R	1.304	1.00
284_E	288_R	1.299	1.00
102_D	170_A	1.294	1.00
81_M	202_A	1.293	1.00
116_S	185_E	1.293	1.00
230_A	260_M	1.291	1.00
292_L	296_K	1.282	1.00
187_L	192_C	1.272	1.00
234_F	289_C	1.271	1.00
287_K	291_A	1.267	1.00
174_S	179_K	1.260	1.00
24_Q	28_E	1.253	1.00
251_V	261_T	1.249	1.00
106_A	170_A	1.240	1.00
7_V	76_M	1.236	1.00
132_S	146_W	1.234	1.00
251_V	259_E	1.231	1.00
17_T	21_W	1.219	1.00
38_K	73_E	1.203	1.00
5_I	212_L	1.201	1.00
163_Y	166_I	1.190	0.99
170_A	174_S	1.185	0.99
286_G	290_A	1.183	0.99
19_T	23_I	1.179	0.99
132_S	144_I	1.176	0.99
261_T	274_K	1.168	0.99
81_M	228_V	1.162	0.99
40_I	65_I	1.151	0.99
212_L	216_F	1.151	0.99
237_A	294_A	1.144	0.99
109_S	184_T	1.141	0.99
108_I	155_L	1.138	0.99
265_A	272_I	1.128	0.99
293_M	298_A	1.127	0.99
214_A	217_S	1.126	0.99
133_A	265_A	1.118	0.99
124_I	135_L	1.117	0.99
294_A	299_K	1.117	0.99
157_K	162_D	1.115	0.99
114_K	185_E	1.104	0.99
283_E	287_K	1.102	0.99
94_I	202_A	1.100	0.99
40_I	68_A	1.099	0.99
27_K	35_F	1.093	0.99
234_F	260_M	1.091	0.99
234_F	293_M	1.089	0.99
137_I	272_I	1.081	0.99
108_I	173_L	1.080	0.99
24_Q	27_K	1.074	0.99
183_V	186_F	1.071	0.99
253_N	278_T	1.061	0.99
236_N	283_E	1.060	0.99
253_N	259_E	1.055	0.99
88_L	204_E	1.049	0.99
279_G	282_P	1.049	0.99
16_M	20_K	1.044	0.99
158_L	166_I	1.041	0.99
22_V	98_P	1.027	0.98
48_V	152_D	1.023	0.98
205_C	216_F	1.015	0.98
260_M	289_C	1.007	0.98
11_R	40_I	0.999	0.98
118_M	122_A	0.998	0.98
102_D	186_F	0.988	0.98
139_R	142_L	0.988	0.98
178_W	182_V	0.986	0.98
97_I	228_V	0.974	0.98
51_T	146_W	0.965	0.98
230_A	258_I	0.963	0.98
32_S	35_F	0.961	0.98
68_A	74_I	0.958	0.98
179_K	183_V	0.950	0.97
151_I	168_L	0.947	0.97
20_K	37_I	0.947	0.97
170_A	183_V	0.946	0.97
233_A	237_A	0.946	0.97
145_K	162_D	0.946	0.97
124_I	142_L	0.943	0.97
66_E	92_L	0.942	0.97
193_L	247_A	0.942	0.97
6_K	72_E	0.937	0.97
223_Y	227_T	0.936	0.97
135_L	142_L	0.929	0.97
7_V	19_T	0.929	0.97
113_V	184_T	0.923	0.97
284_E	287_K	0.918	0.97
103_P	249_Y	0.918	0.97
7_V	35_F	0.913	0.97
123_V	163_Y	0.902	0.96
152_D	156_Q	0.895	0.96
92_L	204_E	0.892	0.96
151_I	178_W	0.891	0.96
121_G	142_L	0.891	0.96
240_G	246_I	0.889	0.96
43_K	47_I	0.882	0.96
84_M	202_A	0.882	0.96
174_S	186_F	0.875	0.96
262_G	289_C	0.870	0.96
282_P	286_G	0.865	0.95
102_D	174_S	0.863	0.95
75_D	206_R	0.863	0.95
210_E	213_L	0.856	0.95
238_M	262_G	0.855	0.95
248_G	260_M	0.854	0.95
273_F	301_L	0.850	0.95
122_A	139_R	0.847	0.95
193_L	261_T	0.842	0.95
116_S	138_E	0.838	0.95
120_K	143_T	0.838	0.95
168_L	172_G	0.827	0.94
93_V	205_C	0.825	0.94
119_K	122_A	0.824	0.94
133_A	269_G	0.824	0.94
122_A	142_L	0.823	0.94
50_V	54_K	0.820	0.94
213_L	217_S	0.820	0.94
226_R	282_P	0.817	0.94
58_K	64_E	0.816	0.94
277_V	285_V	0.811	0.94
109_S	112_R	0.811	0.94
187_L	191_R	0.811	0.94
81_M	94_I	0.808	0.94
55_V	60_L	0.807	0.93
38_K	74_I	0.804	0.93
263_L	274_K	0.803	0.93
107_L	112_R	0.802	0.93
292_L	295_D	0.802	0.93
200_A	224_T	0.802	0.93
26_L	33_F	0.796	0.93
43_K	55_V	0.793	0.93
5_I	35_F	0.793	0.93
266_S	271_I	0.792	0.93
135_L	144_I	0.789	0.93
120_K	141_D	0.781	0.92
23_I	37_I	0.780	0.92
256_D	280_N	0.778	0.92
110_K	159_E	0.773	0.92
52_L	57_G	0.773	0.92
90_E	207_E	0.773	0.92
9_S	15_A	0.772	0.92
288_R	291_A	0.772	0.92
5_I	76_M	0.772	0.92
224_T	228_V	0.772	0.92
89_P	92_L	0.771	0.92
223_Y	252_L	0.771	0.92
62_V	92_L	0.768	0.92
238_M	246_I	0.766	0.92
14_L	151_I	0.764	0.91
104_R	188_E	0.764	0.91
189_P	249_Y	0.764	0.91
137_I	274_K	0.758	0.91
271_I	296_K	0.757	0.91
107_L	165_A	0.756	0.91
265_A	274_K	0.750	0.91
25_K	99_E	0.749	0.91
21_W	201_L	0.749	0.91
227_T	250_S	0.746	0.91
273_F	293_M	0.744	0.90
52_L	60_L	0.744	0.90
263_L	272_I	0.739	0.90
136_L	143_T	0.739	0.90
13_K	17_T	0.738	0.90
104_R	189_P	0.737	0.90
11_R	16_M	0.736	0.90
147_I	163_Y	0.734	0.90
62_V	86_A	0.733	0.90
52_L	56_G	0.732	0.90
43_K	46_R	0.725	0.89
125_G	163_Y	0.725	0.89
81_M	97_I	0.725	0.89
106_A	173_L	0.724	0.89
107_L	110_K	0.722	0.89
234_F	290_A	0.718	0.89
56_G	60_L	0.716	0.89
134_Q	193_L	0.715	0.89
97_I	225_K	0.714	0.89
115_L	185_E	0.712	0.88
43_K	64_E	0.712	0.88
134_Q	192_C	0.707	0.88
16_M	37_I	0.706	0.88
122_A	141_D	0.705	0.88
21_W	98_P	0.705	0.88
233_A	283_E	0.702	0.88
8_G	38_K	0.702	0.88
190_E	261_T	0.692	0.87
107_L	184_T	0.689	0.87
107_L	115_L	0.688	0.87
215_L	218_Q	0.686	0.86
233_A	286_G	0.684	0.86
26_L	35_F	0.683	0.86
193_L	249_Y	0.683	0.86
194_P	249_Y	0.683	0.86
17_T	201_L	0.682	0.86
217_S	220_T	0.682	0.86
66_E	88_L	0.681	0.86
226_R	252_L	0.679	0.86
234_F	248_G	0.676	0.86
106_A	183_V	0.676	0.86
66_E	84_M	0.672	0.85
69_L	72_E	0.671	0.85
227_T	251_V	0.669	0.85
14_L	101_E	0.668	0.85
158_L	163_Y	0.667	0.85
208_S	213_L	0.667	0.85
96_C	216_F	0.663	0.85
20_K	39_E	0.662	0.84
17_T	20_K	0.661	0.84
86_A	133_A	0.661	0.84
253_N	257_E	0.659	0.84
26_L	215_L	0.658	0.84
196_V	235_L	0.657	0.84
30_N	215_L	0.656	0.84
266_S	269_G	0.655	0.84
100_R	227_T	0.655	0.84
21_W	24_Q	0.652	0.84
119_K	139_R	0.652	0.84
63_K	66_E	0.652	0.84
151_I	172_G	0.651	0.83
138_E	187_L	0.651	0.83
230_A	282_P	0.650	0.83
96_C	205_C	0.650	0.83
156_Q	159_E	0.650	0.83
9_S	39_E	0.649	0.83
66_E	69_L	0.648	0.83
86_A	241_G	0.646	0.83
115_L	118_M	0.645	0.83
282_P	285_V	0.645	0.83
233_A	287_K	0.644	0.83
193_L	263_L	0.644	0.83
275_E	293_M	0.643	0.83
6_K	75_D	0.640	0.82
70_L	91_G	0.640	0.82
72_E	208_S	0.634	0.82
22_V	96_C	0.634	0.82
76_M	216_F	0.633	0.82
86_A	235_L	0.632	0.82
60_L	240_G	0.629	0.81
22_V	203_I	0.628	0.81
19_T	35_F	0.627	0.81
223_Y	226_R	0.625	0.81
241_G	244_V	0.624	0.81
283_E	286_G	0.622	0.81
33_F	215_L	0.622	0.81
92_L	206_R	0.619	0.80
55_V	62_V	0.619	0.80
19_T	76_M	0.617	0.80
121_G	139_R	0.617	0.80
211_E	214_A	0.617	0.80
63_K	70_L	0.617	0.80
22_V	219_F	0.613	0.80
155_L	159_E	0.609	0.79
42_T	64_E	0.603	0.79
239_E	299_K	0.600	0.78
48_V	59_G	0.600	0.78
297_G	301_L	0.598	0.78
51_T	54_K	0.597	0.78
88_L	92_L	0.597	0.78
197_G	200_A	0.596	0.78
40_I	152_D	0.596	0.78
135_L	167_I	0.593	0.77
76_M	205_C	0.590	0.77
49_D	55_V	0.589	0.77
11_R	42_T	0.589	0.77
65_I	98_P	0.588	0.77
13_K	176_M	0.586	0.77
244_V	297_G	0.586	0.77
47_I	55_V	0.585	0.76
158_L	165_A	0.584	0.76
112_R	184_T	0.583	0.76
50_V	53_S	0.582	0.76
253_N	256_D	0.581	0.76
101_E	171_A	0.580	0.76
273_F	297_G	0.576	0.75
289_C	292_L	0.575	0.75
238_M	264_V	0.574	0.75
258_I	285_V	0.574	0.75
155_L	158_L	0.572	0.75
273_F	296_K	0.570	0.75
101_E	169_A	0.570	0.75
63_K	68_A	0.570	0.75
58_K	244_V	0.569	0.74
155_L	173_L	0.568	0.74
254_G	257_E	0.565	0.74
110_K	113_V	0.563	0.74
152_D	176_M	0.561	0.73
53_S	243_Q	0.560	0.73
126_T	132_S	0.560	0.73
226_R	258_I	0.556	0.73
239_E	246_I	0.556	0.73
171_A	201_L	0.556	0.73
167_I	192_C	0.555	0.73
138_E	141_D	0.555	0.73
58_K	66_E	0.555	0.73
194_P	250_S	0.554	0.73
106_A	186_F	0.553	0.72
56_G	59_G	0.553	0.72
54_K	243_Q	0.551	0.72
111_N	164_D	0.551	0.72
233_A	289_C	0.551	0.72
264_V	293_M	0.550	0.72
46_R	50_V	0.550	0.72
239_E	262_G	0.549	0.72
230_A	286_G	0.548	0.72
10_R	14_L	0.547	0.72
127_S	146_W	0.545	0.71
35_F	76_M	0.543	0.71
212_L	215_L	0.542	0.71
250_S	260_M	0.541	0.71
250_S	258_I	0.540	0.71
178_W	183_V	0.540	0.71
279_G	289_C	0.539	0.70
118_M	121_G	0.539	0.70
125_G	161_E	0.538	0.70
48_V	129_L	0.538	0.70
77_A	194_P	0.537	0.70
40_I	74_I	0.537	0.70
294_A	298_A	0.534	0.70
50_V	55_V	0.534	0.70
69_L	206_R	0.533	0.70
17_T	173_L	0.533	0.70
63_K	67_Q	0.532	0.70
109_S	113_V	0.532	0.70
47_I	60_L	0.531	0.69
10_R	15_A	0.530	0.69
118_M	165_A	0.526	0.69
120_K	139_R	0.525	0.69
207_E	213_L	0.525	0.69
8_G	40_I	0.523	0.68
262_G	286_G	0.523	0.68
249_Y	261_T	0.522	0.68
63_K	89_P	0.522	0.68
87_V	236_N	0.522	0.68
80_S	202_A	0.517	0.67
248_G	286_G	0.516	0.67
252_L	258_I	0.514	0.67
262_G	290_A	0.514	0.67
57_G	62_V	0.513	0.67
134_Q	238_M	0.513	0.67
243_Q	246_I	0.511	0.66
80_S	203_I	0.510	0.66
214_A	218_Q	0.509	0.66
229_L	282_P	0.509	0.66
134_Q	263_L	0.506	0.66
158_L	161_E	0.506	0.66
115_L	187_L	0.505	0.66
108_I	184_T	0.504	0.65
264_V	297_G	0.503	0.65
157_K	163_Y	0.503	0.65
226_R	279_G	0.502	0.65
226_R	280_N	0.502	0.65
97_I	202_A	0.502	0.65
144_I	192_C	0.502	0.65
43_K	63_K	0.500	0.65
13_K	20_K	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mlvA	1	0.9108	100	0.024	Contact Map
1gtkA	1	0.9299	100	0.026	Contact Map
3ecrA	1	0.9204	100	0.033	Contact Map
4htgA	2	0.9331	100	0.042	Contact Map
4qhqA	1	0.6497	97	0.933	Contact Map
4gotA	1	0.6783	97	0.934	Contact Map
3ir1A	3	0.672	96.8	0.935	Contact Map
4ntlA	1	0.6656	96.8	0.936	Contact Map
3un6A	1	0.8248	96.8	0.936	Contact Map
3up9A	1	0.672	96.7	0.936	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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