GREMLIN Database
PATA - Putative N-acetyl-LL-diaminopimelate aminotransferase
UniProt: P16524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (347)
Sequences: 43411 (29777)
Seq/√Len: 1598.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_T101_A3.1141.00
51_K55_D3.0291.00
155_E192_G3.0031.00
339_A377_L2.9651.00
115_E136_K2.9051.00
291_K295_D2.7801.00
114_D163_K2.7611.00
180_E184_K2.7321.00
296_Y369_R2.7301.00
307_D320_S2.6831.00
370_E374_R2.6081.00
334_A338_D2.5741.00
73_A277_T2.5511.00
292_K365_M2.5231.00
110_L135_A2.4691.00
44_H48_A2.3721.00
245_A250_A2.3641.00
79_K85_N2.3061.00
69_E273_L2.2481.00
103_D107_R2.1801.00
300_R372_L2.1421.00
240_I272_A2.1091.00
179_S182_E2.0681.00
370_E373_D2.0681.00
184_K188_A2.0651.00
327_T330_D1.9881.00
152_R185_S1.9421.00
143_T182_E1.9251.00
48_A52_K1.9121.00
72_Q76_L1.8951.00
130_I135_A1.8821.00
194_N222_Q1.8511.00
300_R303_S1.8471.00
115_E138_V1.8411.00
76_L277_T1.8201.00
33_L371_G1.8181.00
299_D303_S1.8161.00
155_E185_S1.7761.00
153_L157_A1.7731.00
72_Q88_A1.7441.00
190_L197_V1.7371.00
298_Y302_V1.7331.00
105_A224_I1.7191.00
300_R373_D1.7161.00
295_D299_D1.7121.00
302_V308_V1.7061.00
75_Q88_A1.6931.00
115_E162_T1.6851.00
202_I228_G1.6821.00
198_L226_I1.6691.00
296_Y300_R1.6651.00
300_R376_E1.6591.00
164_C198_L1.6471.00
115_E159_T1.6341.00
298_Y310_K1.6191.00
52_K274_E1.6111.00
68_L72_Q1.6031.00
120_G139_I1.5991.00
98_A226_I1.5911.00
105_A198_L1.5891.00
297_V317_I1.5811.00
300_R304_M1.5781.00
91_E247_K1.5711.00
115_E161_N1.5541.00
150_T153_L1.5351.00
185_S188_A1.5341.00
116_V130_I1.5251.00
148_K182_E1.5231.00
47_K51_K1.5181.00
364_S367_T1.5181.00
343_L357_V1.5161.00
328_S347_S1.5111.00
334_A378_F1.5001.00
74_V242_F1.5001.00
86_Y244_F1.4881.00
153_L156_D1.4801.00
106_F130_I1.4771.00
73_A76_L1.4691.00
78_M244_F1.4671.00
127_E131_N1.4651.00
243_L253_I1.4371.00
318_F346_G1.4321.00
188_A192_G1.4261.00
69_E277_T1.4261.00
181_E184_K1.4191.00
296_Y365_M1.4171.00
190_L195_V1.4151.00
265_S268_S1.4081.00
339_A374_R1.3981.00
284_L288_E1.3971.00
330_D334_A1.3941.00
89_E247_K1.3921.00
298_Y317_I1.3841.00
158_L189_L1.3731.00
224_I245_A1.3711.00
303_S376_E1.3631.00
120_G141_D1.3581.00
155_E193_R1.3561.00
159_T162_T1.3501.00
297_V372_L1.3481.00
189_L193_R1.3471.00
151_A189_L1.3341.00
229_L272_A1.3331.00
93_I250_A1.3201.00
74_V94_I1.3061.00
151_A185_S1.3001.00
141_D153_L1.2981.00
73_A273_L1.2981.00
373_D377_L1.2831.00
48_A51_K1.2811.00
304_M376_E1.2741.00
298_Y308_V1.2581.00
289_Q292_K1.2551.00
180_E218_Y1.2531.00
180_E213_Y1.2511.00
369_R373_D1.2461.00
327_T354_E1.2441.00
288_E291_K1.2341.00
289_Q365_M1.2341.00
117_I162_T1.2321.00
47_K55_D1.2301.00
330_D333_M1.2301.00
100_Q257_H1.2291.00
76_L80_K1.2251.00
50_A271_A1.2241.00
284_L287_R1.2221.00
319_P359_L1.2211.00
214_S217_T1.2201.00
189_L195_V1.2181.00
182_E185_S1.2131.00
50_A54_I1.2121.00
49_A274_E1.2111.00
65_A254_L1.2091.00
320_S356_Y1.2071.00
67_Y270_K1.2021.00
117_I140_V1.1951.00
118_M137_P1.1941.00
78_M242_F1.1911.00
188_A191_K1.1861.00
302_V310_K1.1821.00
28_E340_G1.1691.00
294_L298_Y1.1631.00
74_V92_I1.1621.00
106_F110_L1.1611.00
65_A71_R1.1571.00
127_E139_I1.1561.00
106_F166_V1.1521.00
110_L116_V1.1421.00
227_N242_F1.1371.00
332_S343_L1.1361.00
71_R75_Q1.1361.00
320_S355_G1.1351.00
155_E159_T1.1341.00
96_T100_Q1.1301.00
257_H261_V1.1281.00
252_H255_K1.1271.00
187_A219_L1.1241.00
52_K56_E1.1151.00
156_D160_P1.1061.00
69_E270_K1.1021.00
289_Q293_R1.1011.00
288_E292_K1.1001.00
181_E185_S1.0971.00
108_T256_V1.0951.00
365_M369_R1.0931.00
221_D246_P1.0911.00
273_L277_T1.0901.00
300_R369_R1.0851.00
224_I243_L1.0811.00
107_R133_C1.0791.00
87_D91_E1.0741.00
130_I137_P1.0731.00
274_E277_T1.0661.00
251_K255_K1.0631.00
335_L375_L1.0581.00
44_H47_K1.0561.00
322_K355_G1.0551.00
87_D247_K1.0521.00
68_L88_A1.0511.00
112_P134_G1.0461.00
180_E217_T1.0451.00
359_L371_G1.0371.00
109_I164_C1.0361.00
329_F347_S1.0351.00
45_H278_N1.0331.00
69_E72_Q1.0321.00
47_K54_I1.0311.00
75_Q87_D1.0251.00
111_S114_D1.0201.00
209_D312_S1.0181.00
184_K218_Y1.0161.00
101_A243_L1.0141.00
104_A257_H1.0131.00
75_Q92_I1.0121.00
328_S355_G1.0111.00
155_E189_L1.0081.00
196_F224_I1.0071.00
143_T150_T1.0051.00
101_A226_I1.0031.00
294_L361_F0.9991.00
68_L71_R0.9991.00
122_I168_P0.9891.00
49_A52_K0.9871.00
335_L343_L0.9851.00
187_A223_T0.9851.00
187_A197_V0.9841.00
331_F357_V0.9841.00
70_L94_I0.9801.00
367_T370_E0.9801.00
91_E250_A0.9801.00
165_V195_V0.9771.00
293_R296_Y0.9761.00
191_K221_D0.9721.00
295_D310_K0.9641.00
109_I196_F0.9611.00
304_M373_D0.9591.00
191_K220_R0.9571.00
184_K219_L0.9471.00
108_T253_I0.9431.00
203_Y316_Y0.9401.00
196_F222_Q0.9401.00
96_T265_S0.9311.00
38_P290_Y0.9171.00
80_K280_F0.9171.00
299_D369_R0.9171.00
93_I253_I0.9131.00
92_I244_F0.9111.00
29_D340_G0.9011.00
274_E278_N0.8941.00
226_I243_L0.8921.00
116_V164_C0.8921.00
140_V157_A0.8911.00
98_A202_I0.8911.00
296_Y299_D0.8901.00
33_L368_L0.8881.00
158_L195_V0.8851.00
91_E220_R0.8831.00
77_Y205_E0.8831.00
306_L321_I0.8821.00
196_F249_I0.8801.00
216_A225_V0.8781.00
299_D302_V0.8781.00
40_F289_Q0.8781.00
197_V215_I0.8751.00
152_R156_D0.8711.00
247_K251_K0.8711.00
297_V300_R0.8681.00
105_A253_I0.8651.00
52_K55_D0.8641.00
297_V368_L0.8641.00
334_A339_A0.8621.00
215_I218_Y0.8611.00
341_V375_L0.8601.00
131_N137_P0.8601.00
158_L162_T0.8591.00
152_R155_E0.8541.00
207_T210_R0.8541.00
149_L182_E0.8491.00
99_S125_G0.8451.00
215_I223_T0.8441.00
285_I288_E0.8431.00
98_A228_G0.8431.00
285_I289_Q0.8401.00
296_Y372_L0.8391.00
159_T193_R0.8351.00
117_I165_V0.8301.00
201_E225_V0.8261.00
49_A53_A0.8251.00
304_M372_L0.8221.00
250_A254_L0.8191.00
67_Y273_L0.8141.00
329_F333_M0.8141.00
294_L311_P0.8121.00
207_T212_H0.8111.00
117_I157_A0.8091.00
180_E211_P0.8071.00
29_D370_E0.8041.00
143_T153_L0.8031.00
306_L319_P0.8021.00
281_D285_I0.8011.00
77_Y233_H0.7981.00
48_A55_D0.7981.00
307_D322_K0.7941.00
100_Q261_V0.7891.00
343_L359_L0.7881.00
162_T195_V0.7881.00
45_H48_A0.7861.00
333_M338_D0.7851.00
119_P140_V0.7831.00
208_Y291_K0.7821.00
229_L242_F0.7811.00
95_T243_L0.7801.00
77_Y82_A0.7791.00
270_K273_L0.7781.00
162_T165_V0.7781.00
99_S123_Y0.7751.00
97_G239_R0.7701.00
341_V374_R0.7681.00
151_A186_I0.7671.00
321_I357_V0.7661.00
116_V135_A0.7651.00
257_H264_A0.7651.00
205_E232_S0.7641.00
292_K295_D0.7611.00
138_V159_T0.7591.00
219_L223_T0.7591.00
328_S354_E0.7571.00
119_P149_L0.7561.00
191_K222_Q0.7561.00
45_H274_E0.7541.00
329_F345_P0.7541.00
297_V361_F0.7531.00
224_I249_I0.7531.00
76_L79_K0.7501.00
70_L74_V0.7501.00
245_A253_I0.7491.00
240_I264_A0.7471.00
110_L164_C0.7471.00
282_D286_M0.7381.00
191_K219_L0.7341.00
106_F164_C0.7331.00
67_Y269_Q0.7321.00
142_T171_S0.7311.00
331_F378_F0.7311.00
145_H182_E0.7301.00
339_A378_F0.7291.00
151_A182_E0.7261.00
201_E214_S0.7261.00
281_D284_L0.7261.00
50_A267_I0.7261.00
213_Y217_T0.7251.00
66_G71_R0.7241.00
332_S345_P0.7221.00
240_I268_S0.7211.00
118_M130_I0.7211.00
93_I243_L0.7211.00
341_V371_G0.7211.00
110_L114_D0.7211.00
119_P171_S0.7211.00
151_A155_E0.7191.00
366_D369_R0.7171.00
32_S37_Q0.7151.00
53_A271_A0.7141.00
27_H340_G0.7141.00
43_P46_V0.7111.00
209_D294_L0.7081.00
117_I154_I0.7021.00
328_S345_P0.6981.00
219_L222_Q0.6971.00
172_N203_Y0.6961.00
100_Q104_A0.6941.00
41_F47_K0.6931.00
126_Y130_I0.6901.00
295_D298_Y0.6861.00
293_R364_S0.6781.00
29_D367_T0.6761.00
27_H30_V0.6761.00
221_D248_D0.6761.00
84_F216_A0.6721.00
220_R223_T0.6721.00
171_S174_T0.6711.00
113_G136_K0.6701.00
286_M290_Y0.6671.00
75_Q86_Y0.6651.00
120_G350_S0.6651.00
138_V162_T0.6641.00
128_P131_N0.6621.00
58_V270_K0.6621.00
71_R88_A0.6601.00
346_G356_Y0.6591.00
143_T146_G0.6581.00
115_E163_K0.6561.00
158_L193_R0.6531.00
292_K296_Y0.6511.00
282_D285_I0.6511.00
167_L183_L0.6471.00
36_G203_Y0.6441.00
42_T45_H0.6421.00
296_Y368_L0.6421.00
73_A276_V0.6421.00
232_S283_A0.6411.00
165_V190_L0.6401.00
94_I240_I0.6401.00
104_A253_I0.6401.00
105_A226_I0.6361.00
213_Y218_Y0.6351.00
102_I129_I0.6331.00
319_P356_Y0.6301.00
166_V198_L0.6301.00
154_I189_L0.6301.00
42_T282_D0.6301.00
140_V153_L0.6281.00
46_V275_A0.6281.00
305_G322_K0.6261.00
332_S357_V0.6251.00
39_D293_R0.6251.00
106_F135_A0.6251.00
283_A287_R0.6241.00
245_A249_I0.6231.00
326_M331_F0.6231.00
177_T313_G0.6221.00
82_A204_S0.6211.00
154_I165_V0.6201.00
199_S225_V0.6201.00
318_F356_Y0.6171.00
209_D291_K0.6151.00
104_A256_V0.6151.00
45_H282_D0.6131.00
197_V219_L0.6091.00
51_K54_I0.6091.00
328_S332_S0.6071.00
211_P217_T0.6071.00
208_Y313_G0.6051.00
212_H217_T0.6051.00
118_M127_E0.6041.00
297_V359_L0.6021.00
294_L310_K0.6011.00
363_C367_T0.6011.00
206_L287_R0.5991.00
331_F335_L0.5991.00
31_I370_E0.5981.00
373_D376_E0.5981.00
49_A271_A0.5951.00
99_S262_S0.5951.00
374_R377_L0.5941.00
303_S369_R0.5921.00
183_L215_I0.5921.00
56_E274_E0.5911.00
103_D133_C0.5901.00
169_Y201_E0.5901.00
45_H280_F0.5901.00
208_Y361_F0.5901.00
138_V157_A0.5871.00
77_Y204_S0.5851.00
214_S225_V0.5851.00
103_D129_I0.5851.00
106_F133_C0.5821.00
78_M225_V0.5821.00
346_G349_F0.5811.00
42_T46_V0.5781.00
107_R256_V0.5781.00
145_H153_L0.5771.00
301_L319_P0.5771.00
347_S354_E0.5761.00
94_I269_Q0.5761.00
208_Y294_L0.5751.00
93_I245_A0.5751.00
114_D161_N0.5731.00
145_H179_S0.5731.00
336_L342_A0.5721.00
327_T331_F0.5711.00
320_S323_S0.5661.00
93_I254_L0.5651.00
46_V235_M0.5651.00
178_L182_E0.5651.00
42_T47_K0.5641.00
34_T342_A0.5611.00
335_L378_F0.5601.00
148_K179_S0.5591.00
287_R291_K0.5581.00
45_H281_D0.5571.00
118_M139_I0.5561.00
211_P214_S0.5541.00
248_D251_K0.5501.00
190_L194_N0.5501.00
308_V317_I0.5491.00
178_L183_L0.5471.00
170_P313_G0.5451.00
307_D323_S0.5431.00
40_F43_P0.5431.00
291_K294_L0.5431.00
332_S336_L0.5431.00
176_V312_S0.5421.00
293_R365_M0.5381.00
302_V307_D0.5371.00
306_L379_V0.5361.00
318_F358_R0.5351.00
183_L199_S0.5351.00
169_Y177_T0.5351.00
293_R367_T0.5331.00
190_L193_R0.5321.00
106_F129_I0.5321.00
271_A274_E0.5311.00
62_T67_Y0.5291.00
270_K274_E0.5281.00
230_S239_R0.5281.00
105_A164_C0.5271.00
72_Q277_T0.5271.00
326_M334_A0.5271.00
96_T264_A0.5261.00
328_S331_F0.5261.00
31_I374_R0.5261.00
254_L257_H0.5251.00
204_S227_N0.5251.00
364_S369_R0.5241.00
199_S215_I0.5231.00
266_S270_K0.5221.00
370_E377_L0.5221.00
229_L276_V0.5211.00
214_S218_Y0.5211.00
36_G316_Y0.5211.00
156_D159_T0.5211.00
187_A220_R0.5201.00
143_T148_K0.5191.00
70_L272_A0.5181.00
141_D157_A0.5151.00
269_Q273_L0.5151.00
71_R254_L0.5131.00
328_S357_V0.5111.00
79_K83_D0.5091.00
172_N358_R0.5091.00
80_K277_T0.5061.00
103_D260_N0.5061.00
251_K254_L0.5021.00
91_E245_A0.5021.00
300_R368_L0.5011.00
149_L154_I0.5001.00
164_C196_F0.5001.00
67_Y266_S0.5001.00
246_P249_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4my5A 2 0.972 100 0.291 Contact Map
1gd9A 2 0.972 100 0.307 Contact Map
2o1bA 2 0.9389 100 0.309 Contact Map
1u08A 2 0.9542 100 0.31 Contact Map
3h14A 2 0.9237 100 0.313 Contact Map
3dydA 2 0.9338 100 0.314 Contact Map
1vp4A 2 0.9695 100 0.315 Contact Map
1xi9A 4 0.9593 100 0.315 Contact Map
1b5pA 2 0.9517 100 0.316 Contact Map
1yizA 2 0.9644 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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