GREMLIN Database
KINA - Sporulation kinase A
UniProt: P16497 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 606 (471)
Sequences: 7925 (6930)
Seq/√Len: 319.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_D375_R4.3251.00
418_L435_V4.2751.00
154_S250_I3.9671.00
391_E394_S3.3311.00
588_H600_K3.3251.00
592_H595_K2.9791.00
281_A372_V2.9461.00
266_R270_Q2.8111.00
554_L589_V2.7621.00
543_K598_A2.7461.00
550_P553_V2.7461.00
577_F581_E2.6681.00
464_L501_G2.6071.00
589_V599_F2.5781.00
294_S297_S2.5761.00
342_K381_K2.5621.00
217_E256_K2.5031.00
576_T587_I2.4721.00
521_M545_E2.4561.00
142_T146_E2.4391.00
255_R259_Q2.4291.00
239_Y243_Q2.3481.00
509_V580_I2.3301.00
320_D344_S2.3231.00
347_T351_R2.3071.00
540_V601_I2.3061.00
415_K439_L2.2961.00
177_A223_L2.2891.00
462_E503_Q2.2851.00
155_P249_L2.2751.00
539_H600_K2.2721.00
149_V166_Y2.2611.00
549_I553_V2.2381.00
222_R226_T2.2361.00
256_K259_Q2.2351.00
501_G583_H2.2321.00
381_K384_E2.2201.00
380_R384_E2.2161.00
347_T353_I2.1931.00
279_T298_L2.1931.00
279_T374_L2.1821.00
170_A173_S2.1751.00
364_F367_E2.1661.00
273_I290_F2.1511.00
356_E380_R2.1141.00
361_P368_A2.1131.00
155_P174_M2.1071.00
130_I134_S2.0911.00
231_E250_I2.0841.00
422_K433_D2.0531.00
169_S173_S2.0481.00
463_Y500_N2.0441.00
491_S530_I1.9921.00
152_L156_L1.9781.00
530_I541_T1.9591.00
146_E150_E1.9591.00
541_T598_A1.9501.00
356_E375_R1.9461.00
302_A348_F1.9341.00
539_H602_S1.9331.00
422_K436_F1.9241.00
530_I543_K1.9031.00
270_Q274_Q1.8791.00
215_M231_E1.8691.00
537_S602_S1.8641.00
532_T539_H1.8551.00
344_S352_V1.8341.00
465_N468_K1.8131.00
520_S563_T1.8051.00
282_V369_A1.7901.00
219_T229_H1.7431.00
159_S163_K1.7401.00
239_Y242_Q1.7241.00
379_E382_Q1.7111.00
489_R526_T1.6961.00
528_D543_K1.6941.00
222_R228_V1.6911.00
544_D548_G1.6821.00
550_P593_P1.6801.00
293_E297_S1.6721.00
196_Y219_T1.6691.00
357_M374_L1.6661.00
384_E388_L1.6561.00
509_V576_T1.6401.00
580_I601_I1.6371.00
317_H320_D1.6341.00
491_S528_D1.6291.00
182_A223_L1.6151.00
467_K531_I1.6121.00
344_S354_Y1.6121.00
343_Q357_M1.6081.00
167_V171_M1.6021.00
284_H287_K1.5931.00
265_S268_R1.5921.00
178_K182_A1.5851.00
281_A288_W1.5851.00
276_S280_I1.5841.00
306_D348_F1.5801.00
580_I585_G1.5791.00
363_T368_A1.5781.00
509_V579_I1.5731.00
186_K190_E1.5551.00
489_R528_D1.5521.00
541_T600_K1.5461.00
130_I133_A1.5421.00
532_T541_T1.5381.00
421_M432_F1.5351.00
346_F352_V1.5241.00
172_L180_K1.5211.00
521_M527_V1.5201.00
551_E554_L1.5151.00
167_V172_L1.5141.00
219_T227_P1.5101.00
472_E507_K1.5041.00
274_Q293_E1.4891.00
510_F540_V1.4851.00
581_E586_V1.4631.00
413_A438_E1.4621.00
169_S172_L1.4611.00
229_H256_K1.4601.00
150_E169_S1.4581.00
591_S597_T1.4381.00
281_A295_G1.4371.00
157_C247_L1.4321.00
521_M525_G1.4201.00
141_I144_D1.4171.00
269_Y273_I1.4151.00
193_E196_Y1.4091.00
586_V602_S1.4021.00
558_G587_I1.3931.00
167_V183_I1.3901.00
579_I583_H1.3811.00
417_F431_Y1.3771.00
232_V249_L1.3671.00
422_K429_E1.3581.00
131_E134_S1.3451.00
505_Q508_Q1.3441.00
487_F526_T1.3431.00
175_L220_W1.3391.00
590_D598_A1.3351.00
310_K314_D1.3341.00
231_E255_R1.3271.00
525_G545_E1.3271.00
549_I557_I1.3241.00
386_L389_K1.3231.00
282_V371_Q1.3091.00
218_Q232_V1.3071.00
553_V556_R1.2971.00
382_Q386_L1.2961.00
385_E388_L1.2871.00
291_M296_I1.2781.00
492_Y531_I1.2771.00
467_K492_Y1.2711.00
260_T264_K1.2691.00
221_K227_P1.2621.00
477_L514_I1.2601.00
501_G506_L1.2491.00
295_G299_F1.2461.00
559_E562_L1.2441.00
329_Q333_E1.2381.00
419_Q436_F1.2371.00
236_P244_A1.2331.00
317_H344_S1.2321.00
590_D600_K1.2321.00
481_A518_V1.2301.00
269_Y272_L1.2251.00
145_Y149_V1.2181.00
497_I533_E1.2151.00
477_L511_I1.2141.00
259_Q263_Q1.2121.00
138_T141_I1.2081.00
591_S594_E1.2001.00
421_M428_N1.1971.00
303_T306_D1.1941.00
260_T263_Q1.1881.00
296_I304_Y1.1811.00
556_R562_L1.1801.00
171_M175_L1.1761.00
383_T387_M1.1741.00
177_A182_A1.1741.00
169_S180_K1.1711.00
424_T428_N1.1621.00
443_E447_S1.1601.00
502_D505_Q1.1591.00
317_H352_V1.1481.00
508_Q579_I1.1451.00
234_A245_E1.1391.00
425_M428_N1.1311.00
403_I449_L1.1311.00
283_I328_I1.1281.00
418_L422_K1.1251.00
206_R210_G1.1241.00
291_M295_G1.1211.00
268_R282_V1.1181.00
401_A406_E1.1011.00
330_N335_K1.0971.00
187_S190_E1.0901.00
417_F434_I1.0871.00
145_Y148_L1.0851.00
354_Y378_S1.0841.00
142_T145_Y1.0821.00
551_E592_H1.0811.00
265_S269_Y1.0791.00
254_S257_K1.0741.00
342_K356_E1.0701.00
193_E219_T1.0671.00
252_I256_K1.0651.00
406_E409_N1.0611.00
478_E482_N1.0601.00
472_E503_Q1.0591.00
299_F345_W1.0591.00
591_S595_K1.0581.00
382_Q385_E1.0571.00
526_T545_E1.0551.00
262_L265_S1.0451.00
157_C164_I1.0401.00
261_I264_K1.0391.00
282_V289_V1.0381.00
385_E389_K1.0361.00
480_Q483_L1.0331.00
283_I359_C1.0321.00
193_E227_P1.0301.00
509_V601_I1.0181.00
138_T142_T1.0151.00
387_M391_E1.0131.00
229_H253_S1.0101.00
158_I188_S1.0081.00
215_M233_K1.0081.00
414_I439_L1.0071.00
165_V244_A1.0051.00
180_K184_I1.0051.00
519_E563_T1.0031.00
406_E410_P1.0021.00
166_Y180_K1.0021.00
292_N295_G1.0011.00
155_P168_N1.0001.00
280_I292_N0.9991.00
139_T142_T0.9991.00
293_E296_I0.9981.00
172_L178_K0.9981.00
513_L542_V0.9931.00
158_I247_L0.9871.00
481_A527_V0.9851.00
477_L518_V0.9811.00
266_R269_Y0.9781.00
514_I529_I0.9761.00
408_R443_E0.9741.00
418_L436_F0.9731.00
414_I435_V0.9701.00
283_I312_I0.9691.00
168_N171_M0.9651.00
155_P171_M0.9651.00
267_E271_L0.9561.00
361_P369_A0.9551.00
553_V564_T0.9541.00
204_I234_A0.9531.00
434_I438_E0.9521.00
289_V369_A0.9491.00
549_I555_N0.9461.00
359_C370_V0.9451.00
554_L591_S0.9441.00
558_G599_F0.9411.00
416_G420_L0.9411.00
272_L371_Q0.9391.00
531_I540_V0.9391.00
263_Q266_R0.9391.00
396_A400_A0.9371.00
273_I292_N0.9361.00
279_T295_G0.9341.00
255_R258_F0.9331.00
510_F514_I0.9311.00
580_I587_I0.9311.00
330_N334_Q0.9291.00
283_I372_V0.9281.00
407_I445_I0.9281.00
537_S586_V0.9251.00
229_H252_I0.9141.00
406_E508_Q0.9131.00
505_Q579_I0.9121.00
278_D294_S0.9101.00
149_V156_L0.9091.00
514_I527_V0.9081.00
296_I303_T0.9071.00
311_N314_D0.9071.00
413_A417_F0.9061.00
201_K205_I0.9001.00
178_K181_D0.8961.00
463_Y498_Y0.8951.00
158_I234_A0.8951.00
558_G589_V0.8921.00
157_C246_L0.8891.00
163_K187_S0.8881.00
272_L276_S0.8821.00
273_I280_I0.8811.00
557_I599_F0.8801.00
362_T369_A0.8791.00
205_I209_K0.8791.00
207_M236_P0.8781.00
291_M307_L0.8761.00
175_L249_L0.8731.00
326_E330_N0.8721.00
415_K440_S0.8721.00
430_H434_I0.8701.00
143_D147_R0.8661.00
354_Y377_I0.8631.00
466_L538_V0.8621.00
202_N206_R0.8591.00
557_I589_V0.8571.00
331_I370_V0.8561.00
220_W228_V0.8561.00
359_C372_V0.8561.00
137_S140_Y0.8551.00
283_I286_G0.8541.00
417_F435_V0.8531.00
464_L469_L0.8491.00
134_S139_T0.8461.00
354_Y381_K0.8461.00
588_H602_S0.8451.00
296_I307_L0.8441.00
448_E505_Q0.8441.00
549_I554_L0.8431.00
436_F440_S0.8421.00
353_I376_D0.8421.00
235_S246_L0.8381.00
293_E304_Y0.8351.00
486_I490_T0.8351.00
539_H588_H0.8341.00
412_T416_G0.8341.00
417_F438_E0.8331.00
292_N376_D0.8331.00
230_L249_L0.8321.00
263_Q267_E0.8321.00
283_I288_W0.8271.00
167_V175_L0.8221.00
435_V439_L0.8211.00
390_S394_S0.8171.00
470_I510_F0.8161.00
157_C244_A0.8161.00
149_V168_N0.8091.00
282_V292_N0.8091.00
194_E197_H0.8071.00
151_N246_L0.8071.00
237_T244_A0.8061.00
413_A434_I0.8061.00
451_M505_Q0.8041.00
156_L168_N0.8041.00
513_L601_I0.8031.00
521_M524_G0.8021.00
164_I168_N0.8001.00
156_L246_L0.7921.00
287_K311_N0.7901.00
465_N498_Y0.7891.00
359_C374_L0.7891.00
513_L587_I0.7881.00
158_I162_G0.7841.00
290_F304_Y0.7841.00
526_T543_K0.7831.00
588_H601_I0.7821.00
324_V343_Q0.7811.00
239_Y244_A0.7791.00
560_P578_N0.7791.00
228_V251_D0.7741.00
281_A374_L0.7711.00
345_W353_I0.7711.00
168_N251_D0.7701.00
418_L439_L0.7701.00
158_I204_I0.7701.00
471_G490_T0.7691.00
411_L446_L0.7670.99
360_I371_Q0.7650.99
199_I202_N0.7650.99
517_A527_V0.7650.99
362_T371_Q0.7650.99
282_V290_F0.7630.99
493_E532_T0.7610.99
258_F261_I0.7570.99
431_Y435_V0.7560.99
304_Y308_I0.7550.99
148_L246_L0.7550.99
421_M435_V0.7510.99
175_L228_V0.7490.99
192_I200_V0.7480.99
470_I529_I0.7480.99
157_C168_N0.7440.99
290_F293_E0.7420.99
507_K511_I0.7410.99
316_L343_Q0.7390.99
454_K569_T0.7390.99
406_E445_I0.7380.99
389_K392_K0.7380.99
325_K329_Q0.7380.99
192_I196_Y0.7340.99
256_K260_T0.7340.99
464_L506_L0.7320.99
298_L355_T0.7320.99
377_I381_K0.7320.99
276_S373_I0.7310.99
238_V242_Q0.7310.99
154_S170_A0.7290.99
460_V505_Q0.7280.99
322_E326_E0.7280.99
384_E387_M0.7270.99
433_D437_S0.7250.99
154_S248_L0.7240.99
302_A306_D0.7240.99
203_R207_M0.7240.99
515_K519_E0.7230.99
200_V207_M0.7210.99
407_I442_I0.7210.99
283_I370_V0.7200.99
363_T369_A0.7190.99
473_V514_I0.7190.99
144_D166_Y0.7190.99
556_R559_E0.7180.99
418_L432_F0.7170.99
155_P170_A0.7170.99
549_I597_T0.7170.99
261_I265_S0.7160.99
141_I146_E0.7150.99
257_K261_I0.7140.99
469_L473_V0.7140.99
218_Q234_A0.7140.99
406_E438_E0.7140.99
364_F369_A0.7130.99
313_Y321_H0.7120.99
284_H289_V0.7120.99
217_E231_E0.7090.99
549_I589_V0.7080.99
513_L599_F0.7080.99
408_R442_I0.7060.99
207_M245_E0.7050.99
383_T386_L0.7040.99
167_V180_K0.7010.99
476_L511_I0.7010.99
279_T299_F0.7010.99
450_L569_T0.7010.99
268_R290_F0.7010.99
328_I359_C0.6990.99
404_A409_N0.6970.99
549_I573_L0.6970.99
571_L575_V0.6970.99
318_P321_H0.6970.99
148_L152_L0.6960.99
409_N416_G0.6950.99
364_F368_A0.6920.99
148_L157_C0.6920.99
296_I302_A0.6920.99
420_L431_Y0.6880.99
403_I438_E0.6880.99
355_T374_L0.6880.99
198_D202_N0.6880.99
147_R246_L0.6860.99
467_K471_G0.6860.99
312_I328_I0.6830.99
232_V247_L0.6820.99
192_I197_H0.6800.99
561_F574_M0.6790.99
299_F374_L0.6770.99
408_R450_L0.6760.99
279_T292_N0.6760.99
470_I531_I0.6750.99
403_I409_N0.6750.99
279_T357_M0.6730.99
466_L540_V0.6720.99
279_T296_I0.6720.99
192_I218_Q0.6720.99
334_Q337_E0.6710.99
206_R211_M0.6710.99
547_E591_S0.6690.99
313_Y325_K0.6670.99
272_L282_V0.6660.99
563_T567_K0.6630.99
272_L277_I0.6610.99
331_I361_P0.6590.98
509_V583_H0.6590.98
528_D545_E0.6570.98
281_A359_C0.6560.98
264_K268_R0.6540.98
220_W230_L0.6540.98
519_E565_K0.6530.98
284_H369_A0.6530.98
438_E441_R0.6510.98
278_D373_I0.6510.98
217_E255_R0.6510.98
407_I410_P0.6500.98
234_A247_L0.6500.98
399_L404_A0.6500.98
148_L153_P0.6470.98
448_E508_Q0.6470.98
406_E442_I0.6470.98
140_Y144_D0.6460.98
468_K472_E0.6450.98
415_K443_E0.6430.98
139_T143_D0.6410.98
402_G409_N0.6410.98
450_L453_A0.6410.98
473_V511_I0.6400.98
529_I540_V0.6390.98
189_Y197_H0.6380.98
172_L175_L0.6380.98
207_M210_G0.6370.98
407_I411_L0.6360.98
406_E561_F0.6350.98
134_S138_T0.6350.98
426_E429_E0.6350.98
547_E597_T0.6350.98
155_P232_V0.6340.98
282_V362_T0.6340.98
380_R383_T0.6340.98
473_V477_L0.6330.98
560_P574_M0.6330.98
470_I490_T0.6320.98
450_L454_K0.6310.98
279_T355_T0.6310.98
589_V597_T0.6300.98
387_M390_S0.6290.98
322_E325_K0.6280.98
281_A357_M0.6270.98
279_T294_S0.6270.98
409_N443_E0.6260.98
280_I290_F0.6260.98
143_D146_E0.6260.98
136_E140_Y0.6240.98
486_I518_V0.6240.98
163_K184_I0.6230.98
397_G452_L0.6220.98
258_F262_L0.6210.98
188_S234_A0.6210.98
269_Y371_Q0.6200.98
164_I167_V0.6190.98
300_E347_T0.6170.98
419_Q422_K0.6170.98
414_I418_L0.6160.98
534_D539_H0.6140.98
451_M455_P0.6140.98
177_A191_F0.6130.98
422_K432_F0.6120.98
390_S393_L0.6120.98
358_V375_R0.6110.98
553_V562_L0.6110.98
269_Y290_F0.6110.98
286_G292_N0.6100.97
298_L353_I0.6090.97
352_V378_S0.6070.97
312_I374_L0.6060.97
378_S382_Q0.6060.97
469_L501_G0.6030.97
159_S165_V0.6030.97
357_M372_V0.6020.97
158_I245_E0.6010.97
137_S141_I0.6010.97
334_Q338_S0.6010.97
510_F542_V0.6000.97
506_L583_H0.6000.97
295_G374_L0.5990.97
415_K418_L0.5990.97
411_L417_F0.5980.97
406_E576_T0.5970.97
152_L155_P0.5960.97
200_V203_R0.5950.97
484_N521_M0.5950.97
505_Q583_H0.5950.97
164_I247_L0.5950.97
205_I208_Q0.5940.97
324_V327_R0.5940.97
323_D326_E0.5930.97
200_V218_Q0.5920.97
361_P370_V0.5920.97
400_A563_T0.5910.97
281_A291_M0.5910.97
424_T431_Y0.5910.97
300_E349_Q0.5900.97
172_L177_A0.5900.97
331_I338_S0.5890.97
292_N296_I0.5880.97
585_G604_P0.5880.97
409_N450_L0.5880.97
345_W355_T0.5880.97
156_L248_L0.5880.97
493_E531_I0.5880.97
203_R206_R0.5870.97
229_H235_S0.5860.97
473_V507_K0.5840.97
396_A409_N0.5840.97
503_Q507_K0.5830.97
409_N413_A0.5830.97
338_S341_V0.5810.97
171_M249_L0.5770.96
274_Q290_F0.5770.96
564_T567_K0.5770.96
316_L324_V0.5770.96
238_V244_A0.5750.96
152_L248_L0.5750.96
271_L275_N0.5730.96
421_M431_Y0.5730.96
505_Q582_N0.5710.96
237_T246_L0.5710.96
534_D537_S0.5710.96
155_P230_L0.5700.96
439_L443_E0.5690.96
158_I164_I0.5680.96
288_W292_N0.5660.96
172_L183_I0.5660.96
437_S472_E0.5660.96
291_M304_Y0.5660.96
484_N518_V0.5660.96
519_E567_K0.5660.96
330_N336_T0.5650.96
343_Q359_C0.5650.96
316_L321_H0.5640.96
444_L504_N0.5630.96
133_A138_T0.5630.96
474_S478_E0.5630.96
465_N496_S0.5620.96
549_I591_S0.5610.96
159_S244_A0.5600.96
481_A486_I0.5600.96
153_P168_N0.5600.96
491_S532_T0.5580.96
295_G375_R0.5580.96
578_N581_E0.5580.96
549_I599_F0.5570.96
512_N576_T0.5570.96
513_L576_T0.5570.96
405_H512_N0.5560.96
587_I601_I0.5560.96
295_G298_L0.5550.96
288_W372_V0.5540.96
402_G560_P0.5530.96
272_L280_I0.5530.96
265_S270_Q0.5520.96
342_K380_R0.5520.96
550_P564_T0.5500.95
134_S137_S0.5490.95
469_L507_K0.5490.95
287_K309_G0.5490.95
401_A409_N0.5490.95
278_D371_Q0.5490.95
136_E139_T0.5480.95
149_V152_L0.5470.95
216_I232_V0.5470.95
282_V286_G0.5460.95
452_L574_M0.5460.95
397_G456_Q0.5450.95
277_I360_I0.5430.95
477_L515_K0.5420.95
290_F354_Y0.5410.95
192_I220_W0.5410.95
520_S547_E0.5390.95
164_I171_M0.5330.95
575_V579_I0.5330.95
144_D148_L0.5320.95
168_N253_S0.5300.94
257_K260_T0.5300.94
292_N343_Q0.5300.94
509_V540_V0.5290.94
415_K436_F0.5280.94
408_R447_S0.5280.94
164_I185_G0.5270.94
171_M247_L0.5260.94
496_S531_I0.5260.94
275_N358_V0.5250.94
163_K185_G0.5230.94
277_I375_R0.5220.94
228_V234_A0.5220.94
172_L176_G0.5210.94
153_P246_L0.5210.94
562_L565_K0.5210.94
275_N282_V0.5200.94
174_M228_V0.5200.94
236_P245_E0.5200.94
240_K243_Q0.5200.94
400_A579_I0.5190.94
176_G182_A0.5190.94
145_Y166_Y0.5180.94
220_W232_V0.5180.94
447_S451_M0.5180.94
345_W357_M0.5180.94
220_W229_H0.5170.94
274_Q292_N0.5170.94
401_A407_I0.5160.94
195_E227_P0.5160.94
141_I145_Y0.5160.94
164_I204_I0.5150.94
207_M211_M0.5150.94
323_D327_R0.5140.93
417_F424_T0.5140.93
158_I175_L0.5140.93
469_L472_E0.5140.93
295_G307_L0.5120.93
410_P575_V0.5120.93
188_S191_F0.5110.93
343_Q374_L0.5090.93
345_W374_L0.5080.93
521_M563_T0.5060.93
218_Q229_H0.5060.93
441_R507_K0.5040.93
188_S200_V0.5030.93
439_L442_I0.5030.93
511_I576_T0.5030.93
279_T370_V0.5030.93
288_W309_G0.5020.93
338_S359_C0.5020.93
493_E496_S0.5020.93
254_S258_F0.5010.93
177_A222_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.5759 100 0.479 Contact Map
3a0rA 2 0.5314 100 0.509 Contact Map
4i5sA 2 0.6287 100 0.536 Contact Map
4r3aA 1 0.505 100 0.583 Contact Map
4q20A 2 0.363 100 0.641 Contact Map
3d36A 2 0.3564 100 0.645 Contact Map
2c2aA 2 0.3746 100 0.647 Contact Map
4mpcA 2 0.4769 100 0.648 Contact Map
3jz3A 2 0.2574 100 0.649 Contact Map
2q8gA 2 0.4835 100 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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