GREMLIN Database
GERD - Spore germination protein GerD
UniProt: P16450 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (175)
Sequences: 185 (149)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_L129_V5.1231.00
90_N93_E3.7430.99
124_K146_Q3.3110.97
86_E89_K2.6620.90
19_A127_M2.5270.88
141_Q145_S2.4310.86
130_M158_E2.3920.85
99_E103_K2.3600.84
38_V41_I2.3580.84
91_I143_A2.2670.81
36_K88_W2.2550.81
137_K155_V2.2330.80
128_S131_Q2.2000.79
46_D93_E2.1720.78
126_L165_Y2.0640.74
153_E159_T2.0510.74
13_L107_T2.0150.73
148_F156_I1.9980.72
135_M139_Y1.9570.70
148_F151_Y1.9510.70
17_V158_E1.9230.69
56_N161_S1.9070.68
152_L156_I1.8830.67
39_V147_E1.8670.67
169_F173_L1.8500.66
126_L135_M1.8290.65
123_Q146_Q1.8250.65
120_P153_E1.7310.60
112_V126_L1.7070.59
128_S144_K1.7040.59
109_H113_I1.6980.59
61_N64_L1.6740.58
19_A25_Q1.6720.58
55_L85_E1.6710.58
22_P148_F1.6040.54
117_M126_L1.5860.54
98_A120_P1.5800.53
145_S151_Y1.5660.53
123_Q132_D1.5620.52
26_A52_K1.5540.52
49_K143_A1.5190.50
98_A148_F1.5190.50
142_L145_S1.4710.48
46_D143_A1.4620.48
19_A46_D1.4490.47
19_A110_E1.4280.46
39_V173_L1.3960.44
77_K91_I1.3830.44
137_K172_E1.3710.43
24_D74_T1.3580.42
161_S168_Q1.3500.42
114_K122_Y1.3220.41
63_A179_D1.2740.39
123_Q128_S1.2620.38
39_V50_A1.2600.38
96_D103_K1.2540.38
48_K55_L1.2480.37
88_W104_T1.2390.37
85_E107_T1.2340.37
46_D49_K1.2320.37
132_D145_S1.2240.36
111_K126_L1.2190.36
123_Q138_K1.2110.36
57_D71_I1.2070.36
90_N164_L1.2030.35
98_A118_K1.1970.35
115_K142_L1.1840.35
10_S19_A1.1810.34
14_L51_I1.1690.34
94_D97_F1.1590.33
39_V81_S1.1420.33
53_E126_L1.1330.32
72_K123_Q1.1070.31
43_K171_D1.0960.31
89_K93_E1.0940.31
132_D136_D1.0720.30
76_E83_K1.0670.30
96_D99_E1.0540.29
175_K178_K1.0530.29
29_M165_Y1.0390.28
67_D102_A1.0330.28
46_D141_Q1.0300.28
46_D92_F1.0260.28
129_V136_D1.0230.28
111_K115_K1.0130.27
136_D158_E1.0080.27
25_Q53_E1.0050.27
28_D162_S0.9840.26
137_K164_L0.9740.26
113_I125_M0.9620.25
141_Q153_E0.9370.25
92_F109_H0.9360.25
123_Q129_V0.9360.25
48_K88_W0.9160.24
82_K131_Q0.9160.24
21_A74_T0.9140.24
68_Q74_T0.9140.24
58_D71_I0.9140.24
84_G88_W0.9120.24
121_D160_L0.9050.23
105_L112_V0.9020.23
8_L13_L0.9010.23
73_G77_K0.8970.23
67_D127_M0.8930.23
47_G159_T0.8880.23
173_L177_A0.8880.23
72_K168_Q0.8850.23
9_M16_S0.8770.22
34_T87_F0.8760.22
18_T82_K0.8720.22
127_M134_G0.8680.22
130_M142_L0.8660.22
59_A171_D0.8650.22
67_D158_E0.8580.22
49_K90_N0.8540.22
61_N164_L0.8400.21
51_I145_S0.8370.21
147_E173_L0.8370.21
36_K48_K0.8360.21
82_K85_E0.8330.21
12_F77_K0.8310.21
139_Y166_K0.8300.21
8_L93_E0.8250.21
11_C158_E0.8140.20
30_D121_D0.8070.20
9_M56_N0.8050.20
73_G129_V0.8020.20
90_N159_T0.7990.20
31_Y35_K0.7900.20
120_P149_R0.7860.20
128_S146_Q0.7790.19
12_F16_S0.7770.19
98_A146_Q0.7760.19
88_W167_K0.7760.19
101_F123_Q0.7750.19
32_D36_K0.7710.19
169_F172_E0.7690.19
78_T147_E0.7660.19
87_F91_I0.7660.19
14_L127_M0.7640.19
156_I160_L0.7620.19
132_D146_Q0.7610.19
37_M41_I0.7600.19
39_V121_D0.7540.19
45_D48_K0.7510.18
144_K147_E0.7510.18
32_D88_W0.7470.18
34_T37_M0.7460.18
24_D44_T0.7390.18
141_Q154_E0.7320.18
148_F161_S0.7280.18
155_V160_L0.7250.18
29_M150_S0.7210.18
21_A79_L0.7210.18
120_P131_Q0.7210.18
96_D164_L0.7130.17
148_F153_E0.7100.17
48_K87_F0.7070.17
127_M135_M0.7040.17
49_K133_P0.7000.17
18_T58_D0.7000.17
46_D50_A0.6990.17
25_Q63_A0.6980.17
51_I91_I0.6950.17
77_K154_E0.6920.17
37_M97_F0.6880.17
74_T146_Q0.6870.17
86_E93_E0.6860.17
39_V59_A0.6850.17
105_L113_I0.6830.17
89_K92_F0.6780.16
53_E134_G0.6740.16
25_Q134_G0.6740.16
126_L171_D0.6740.16
19_A173_L0.6660.16
92_F176_A0.6650.16
78_T125_M0.6600.16
145_S176_A0.6590.16
27_A148_F0.6580.16
91_I171_D0.6580.16
148_F179_D0.6540.16
108_E111_K0.6520.16
19_A78_T0.6500.16
21_A101_F0.6470.16
106_Q110_E0.6470.16
47_G54_L0.6430.16
9_M72_K0.6410.15
127_M139_Y0.6400.15
108_E131_Q0.6350.15
30_D58_D0.6330.15
79_L130_M0.6320.15
125_M146_Q0.6290.15
75_I179_D0.6280.15
34_T47_G0.6260.15
89_K117_M0.6250.15
15_L160_L0.6190.15
53_E85_E0.6130.15
76_E154_E0.6130.15
125_M132_D0.6120.15
151_Y159_T0.6110.15
46_D61_N0.6100.15
72_K77_K0.6070.15
112_V175_K0.6070.15
41_I103_K0.6070.15
51_I81_S0.6030.15
71_I127_M0.5980.14
68_Q96_D0.5970.14
15_L148_F0.5970.14
49_K176_A0.5930.14
21_A135_M0.5910.14
9_M12_F0.5900.14
109_H129_V0.5890.14
95_T102_A0.5880.14
57_D92_F0.5850.14
11_C14_L0.5830.14
74_T110_E0.5800.14
68_Q166_K0.5780.14
54_L70_A0.5770.14
7_L71_I0.5760.14
103_K164_L0.5730.14
69_D143_A0.5720.14
78_T110_E0.5670.14
109_H146_Q0.5670.14
123_Q135_M0.5660.14
118_K125_M0.5640.14
47_G128_S0.5620.14
80_T164_L0.5600.14
18_T170_E0.5570.13
160_L178_K0.5570.13
52_K90_N0.5550.13
169_F174_K0.5550.13
106_Q154_E0.5550.13
43_K160_L0.5540.13
137_K162_S0.5520.13
44_T51_I0.5500.13
69_D100_G0.5490.13
23_K77_K0.5460.13
118_K128_S0.5450.13
63_A143_A0.5440.13
108_E157_N0.5440.13
16_S22_P0.5390.13
124_K127_M0.5390.13
41_I175_K0.5350.13
82_K86_E0.5350.13
19_A22_P0.5340.13
148_F152_L0.5290.13
153_E157_N0.5270.13
90_N175_K0.5260.13
142_L167_K0.5260.13
123_Q160_L0.5190.13
14_L28_D0.5190.13
30_D108_E0.5170.13
96_D170_E0.5160.13
60_M178_K0.5150.13
149_R155_V0.5110.12
166_K174_K0.5110.12
46_D95_T0.5100.12
129_V181_A0.5060.12
105_L135_M0.5030.12
66_I125_M0.5030.12
33_Q65_V0.5020.12
33_Q164_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o8wA 3 0.6541 100 0.459 Contact Map
2llwA 1 0.3838 92.2 0.925 Contact Map
2lnmA 1 0.3351 88.8 0.93 Contact Map
2llvA 1 0.3784 87.5 0.932 Contact Map
4r2fA 1 0.5243 34.2 0.954 Contact Map
4mfiA 1 0.7892 27.7 0.956 Contact Map
4kysA 1 0.4108 25.9 0.957 Contact Map
3zbiC 1 0.1459 25.8 0.957 Contact Map
3ombA 1 0.7676 21.1 0.959 Contact Map
2bptA 1 0.6054 21 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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