GREMLIN Database
KBAA - KinB-signaling pathway activation protein
UniProt: P16449 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (190)
Sequences: 190 (153)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_S189_L4.8821.00
9_F195_F3.6540.98
130_F186_A3.4760.98
92_L148_V3.3290.97
9_F193_P3.3280.97
127_L131_G3.1040.96
3_S7_V2.9800.94
131_G151_L2.5680.88
18_A56_G2.4950.87
8_R12_S2.2640.81
146_T193_P2.1900.78
142_S193_P2.1240.76
149_S160_L2.0560.74
137_I141_Q1.9370.69
99_A155_V1.9050.68
2_K148_V1.8600.66
74_H77_A1.8600.66
65_M72_T1.8570.66
125_V129_I1.8490.65
79_E153_L1.8460.65
98_V160_L1.8240.64
90_L121_A1.7950.63
56_G184_C1.7610.61
142_S146_T1.7030.59
12_S116_S1.7010.59
54_G58_I1.7010.59
25_G52_F1.6640.57
24_V107_F1.6080.54
18_A177_M1.5990.54
146_T149_S1.5990.54
60_S106_R1.5670.52
51_W173_W1.5310.50
6_L99_A1.5260.50
77_A81_L1.5060.49
26_F58_I1.5040.49
133_I183_A1.4860.48
22_S49_L1.4620.47
37_F47_S1.4280.45
131_G155_V1.4200.45
18_A57_M1.4100.45
191_M195_F1.3880.44
117_L134_T1.3510.42
22_S74_H1.3480.42
13_I149_S1.3220.40
175_Y179_F1.3150.40
2_K5_G1.3070.40
143_S146_T1.3000.39
16_V133_I1.2980.39
82_R186_A1.2960.39
63_S147_F1.2910.39
79_E102_L1.2860.39
82_R151_L1.2800.38
61_V186_A1.2760.38
107_F120_Y1.2690.38
33_Y176_L1.2560.37
8_R187_F1.2530.37
52_F63_S1.2480.37
25_G173_W1.2420.37
65_M106_R1.2400.37
178_L182_M1.2370.37
77_A90_L1.2330.36
3_S58_I1.2280.36
6_L60_S1.2220.36
78_L147_F1.2050.35
18_A122_W1.2050.35
61_V64_Q1.2030.35
62_I127_L1.1830.34
111_G115_E1.1790.34
106_R120_Y1.1770.34
55_V173_W1.1740.34
3_S75_R1.1740.34
97_F160_L1.1720.34
60_S177_M1.1670.33
115_E169_N1.1670.33
143_S193_P1.1640.33
177_M184_C1.1480.33
101_D106_R1.1460.33
154_M186_A1.1360.32
140_K151_L1.1190.31
56_G177_M1.1180.31
60_S166_L1.1160.31
3_S54_G1.0960.30
43_G46_F1.0920.30
41_E45_I1.0830.30
107_F195_F1.0820.30
4_R10_F1.0700.29
90_L93_F1.0680.29
191_M194_K1.0640.29
34_R96_L1.0590.29
74_H88_N1.0590.29
73_V191_M1.0520.29
134_T181_L1.0380.28
121_A127_L1.0370.28
58_I167_R1.0320.28
77_A165_A1.0190.27
11_F72_T1.0090.27
15_A157_I1.0090.27
5_G194_K1.0040.27
107_F149_S1.0020.27
34_R117_L1.0010.27
60_S64_Q0.9990.27
164_P177_M0.9980.27
9_F191_M0.9940.26
43_G47_S0.9890.26
2_K73_V0.9800.26
62_I72_T0.9740.26
132_V151_L0.9700.26
59_F177_M0.9640.25
13_I79_E0.9640.25
56_G60_S0.9640.25
30_W41_E0.9620.25
133_I155_V0.9540.25
45_I50_F0.9530.25
89_L174_L0.9500.25
125_V131_G0.9480.25
26_F54_G0.9420.25
126_F194_K0.9340.24
15_A37_F0.9240.24
58_I180_P0.9230.24
135_A191_M0.9120.23
57_M122_W0.9100.23
102_L159_A0.9070.23
42_A151_L0.8960.23
118_A144_K0.8950.23
12_S129_I0.8950.23
59_F104_Y0.8950.23
62_I120_Y0.8950.23
43_G189_L0.8810.22
133_I139_Q0.8790.22
69_V142_S0.8790.22
141_Q194_K0.8750.22
3_S167_R0.8750.22
59_F176_L0.8740.22
5_G193_P0.8670.22
8_R195_F0.8620.22
132_V136_Y0.8620.22
161_E181_L0.8570.22
64_Q68_F0.8530.21
107_F193_P0.8520.21
23_I125_V0.8500.21
117_L131_G0.8490.21
188_Q192_L0.8470.21
20_I140_K0.8390.21
24_V179_F0.8380.21
35_G165_A0.8310.21
23_I140_K0.8200.20
12_S125_V0.8110.20
100_F162_W0.8100.20
12_S137_I0.8070.20
16_V118_A0.8050.20
117_L129_I0.8010.20
63_S73_V0.8010.20
119_G126_F0.7960.20
49_L133_I0.7880.19
83_S103_M0.7850.19
90_L96_L0.7830.19
146_T195_F0.7780.19
9_F72_T0.7780.19
143_S149_S0.7750.19
143_S160_L0.7740.19
2_K179_F0.7730.19
39_T47_S0.7710.19
118_A129_I0.7700.19
5_G9_F0.7650.19
16_V55_V0.7650.19
126_F130_F0.7640.19
23_I118_A0.7490.18
6_L10_F0.7470.18
97_F104_Y0.7430.18
65_M76_F0.7380.18
144_K148_V0.7370.18
42_A145_K0.7370.18
59_F147_F0.7350.18
98_V159_A0.7350.18
11_F46_F0.7340.18
14_L82_R0.7320.18
90_L131_G0.7280.18
51_W74_H0.7260.18
92_L118_A0.7250.18
108_L121_A0.7240.18
44_Q58_I0.7210.17
2_K75_R0.7190.17
59_F174_L0.7180.17
74_H78_L0.7180.17
130_F182_M0.7180.17
24_V129_I0.7170.17
118_A121_A0.7120.17
9_F146_T0.7090.17
20_I24_V0.7040.17
73_V87_W0.7020.17
51_W72_T0.7010.17
57_M136_Y0.7010.17
135_A151_L0.6940.17
132_V165_A0.6920.17
6_L69_V0.6910.17
46_F178_L0.6910.17
122_W137_I0.6900.17
10_F64_Q0.6890.17
2_K6_L0.6860.17
26_F45_I0.6850.17
175_Y194_K0.6760.16
124_P187_F0.6750.16
20_I45_I0.6700.16
24_V118_A0.6690.16
19_L57_M0.6640.16
81_L87_W0.6610.16
29_K48_V0.6610.16
17_G70_F0.6580.16
8_R38_L0.6560.16
53_I144_K0.6530.16
26_F40_F0.6490.16
57_M61_V0.6470.16
3_S195_F0.6460.15
146_T187_F0.6450.15
9_F142_S0.6410.15
39_T125_V0.6400.15
99_A172_D0.6350.15
115_E130_F0.6280.15
10_F143_S0.6270.15
50_F72_T0.6240.15
63_S184_C0.6210.15
25_G51_W0.6160.15
17_G68_F0.6160.15
104_Y107_F0.6100.15
90_L162_W0.6090.15
100_F104_Y0.6080.15
122_W129_I0.6070.15
29_K32_E0.6040.14
61_V165_A0.6040.14
77_A131_G0.6030.14
132_V190_L0.6010.14
100_F166_L0.5990.14
142_S180_P0.5990.14
24_V157_I0.5980.14
63_S177_M0.5950.14
37_F159_A0.5940.14
21_T57_M0.5900.14
20_I183_A0.5880.14
163_F179_F0.5870.14
88_N95_I0.5860.14
102_L119_G0.5850.14
4_R162_W0.5850.14
159_A182_M0.5830.14
47_S105_V0.5830.14
47_S170_D0.5810.14
169_N174_L0.5790.14
74_H169_N0.5770.14
97_F164_P0.5740.14
78_L86_L0.5700.14
92_L151_L0.5680.14
61_V106_R0.5670.14
25_G180_P0.5650.14
127_L145_K0.5630.14
19_L99_A0.5630.14
71_L102_L0.5620.13
76_F164_P0.5590.13
55_V73_V0.5590.13
67_F142_S0.5550.13
80_I109_F0.5470.13
10_F66_G0.5450.13
86_L114_G0.5450.13
97_F193_P0.5420.13
68_F142_S0.5410.13
19_L182_M0.5370.13
75_R147_F0.5360.13
105_V153_L0.5340.13
49_L179_F0.5340.13
19_L34_R0.5330.13
174_L183_A0.5310.13
10_F188_Q0.5290.13
16_V99_A0.5260.13
11_F129_I0.5250.13
134_T154_M0.5230.13
45_I121_A0.5230.13
67_F190_L0.5200.13
105_V125_V0.5190.13
105_V189_L0.5150.12
60_S120_Y0.5140.12
4_R49_L0.5130.12
5_G61_V0.5120.12
121_A157_I0.5080.12
38_L118_A0.5050.12
64_Q106_R0.5050.12
56_G187_F0.5020.12
12_S128_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ryoA 1 0.7323 51.6 0.953 Contact Map
2zy9A 2 0.3889 36.9 0.957 Contact Map
4uc1A 3 0.7727 19.8 0.963 Contact Map
4nv5A 1 0.8485 5.7 0.971 Contact Map
3s8fA 1 0.9293 4.2 0.973 Contact Map
2gfpA 2 0.8283 3.6 0.974 Contact Map
3hd7A 1 0.1667 3.4 0.974 Contact Map
4oo9A 1 0.3737 3.2 0.974 Contact Map
2mgyA 1 0.8182 2.5 0.975 Contact Map
4he8L 1 0.4091 2.4 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.