GREMLIN Database
SECY - Protein translocase subunit SecY
UniProt: P16336 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 431 (412)
Sequences: 3187 (1692)
Seq/√Len: 83.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_V376_A5.5701.00
31_G70_F5.5501.00
354_K358_D5.2591.00
24_M166_L5.1481.00
84_I109_L4.4241.00
324_Y369_F4.1341.00
19_I23_L4.0771.00
337_A357_Q3.9421.00
299_W303_N3.8081.00
20_F24_M3.4061.00
133_N149_Y3.3231.00
95_F109_L3.3061.00
146_V150_L3.2591.00
361_T365_Y3.2391.00
103_E106_R3.1251.00
98_W112_F3.0411.00
320_I376_A2.9971.00
57_N65_Y2.9691.00
162_F166_L2.9661.00
118_I161_A2.8761.00
27_V162_F2.8141.00
84_I116_F2.6191.00
94_K97_E2.5871.00
125_A157_T2.5781.00
243_I262_L2.5491.00
338_D342_K2.5411.00
122_F157_T2.4951.00
245_Y345_G2.4881.00
316_V320_I2.4561.00
84_I95_F2.4121.00
264_L364_L2.4091.00
96_T100_K2.3831.00
12_S16_N2.2931.00
34_I69_I2.2771.00
274_V379_S2.2741.00
335_Q339_N2.2601.00
296_V300_I2.2341.00
18_I22_L2.2271.00
25_L181_I2.2001.00
161_A164_M2.1501.00
237_A266_V2.1291.00
309_P313_A2.0951.00
36_V152_I2.0611.00
25_L185_A2.0571.00
108_K111_Q2.0461.00
323_T375_L2.0441.00
147_S151_I1.9981.00
28_F186_G1.9861.00
21_T181_I1.9751.00
362_S366_R1.9061.00
241_I347_I1.9011.00
317_A321_A1.8841.00
27_V166_L1.8691.00
122_F153_A1.8491.00
323_T372_S1.8311.00
141_I144_S1.8271.00
230_G377_V1.8201.00
338_D341_K1.7781.00
200_E203_F1.7591.00
310_V313_A1.7321.00
235_Q265_K1.7271.00
17_K419_Q1.7111.00
373_I377_V1.6851.00
334_E357_Q1.6781.00
280_F318_L1.6551.00
97_E101_Q1.6401.00
247_K256_G1.6381.00
241_I363_I1.6181.00
218_A222_I1.6111.00
122_F125_A1.5881.00
114_R168_E1.5701.00
324_Y365_Y1.5681.00
94_K98_W1.5631.00
121_G157_T1.5611.00
223_A227_V1.5521.00
303_N310_V1.5481.00
202_Q217_V1.5361.00
50_M54_D1.5311.00
333_P361_T1.5271.00
235_Q374_F1.5251.00
353_G356_T1.5230.99
268_P364_L1.5190.99
40_N43_A1.5000.99
387_Q390_G1.4930.99
300_I304_F1.4870.99
288_A300_I1.4830.99
197_Q200_E1.4800.99
164_M179_I1.4800.99
291_F294_N1.4590.99
355_M358_D1.4580.99
121_G160_T1.4570.99
175_V416_L1.4540.99
117_T164_M1.4530.99
331_V336_M1.4440.99
336_M360_I1.4370.99
285_R288_A1.4350.99
298_K302_N1.4320.99
119_V123_I1.4250.99
146_V149_Y1.4200.99
84_I112_F1.4040.99
24_M162_F1.4040.99
195_I199_Y1.4030.99
320_I372_S1.3950.99
236_Q410_L1.3920.99
283_T287_I1.3550.99
312_M380_I1.3540.99
26_I30_I1.3480.99
88_Q99_S1.3390.99
360_I364_L1.3330.99
297_T300_I1.3330.99
148_T152_I1.3320.99
32_A63_A1.3210.99
23_L26_I1.3150.99
328_F361_T1.3000.98
13_D16_N1.2990.98
43_A140_L1.2850.98
88_Q109_L1.2810.98
21_T174_G1.2790.98
295_D298_K1.2760.98
125_A153_A1.2740.98
120_L428_F1.2640.98
117_T160_T1.2630.98
241_I360_I1.2630.98
234_I237_A1.2600.98
401_S405_V1.2560.98
126_L153_A1.2510.98
57_N190_S1.2500.98
374_F403_L1.2480.98
233_F237_A1.2310.98
160_T163_L1.2270.98
75_T79_T1.2260.98
285_R289_S1.2210.98
309_P312_M1.2140.97
114_R164_M1.2020.97
43_A46_A1.1990.97
296_V299_W1.1890.97
352_P356_T1.1840.97
227_V231_V1.1810.97
20_F173_H1.1670.97
271_V398_G1.1660.97
331_V360_I1.1620.97
74_I179_I1.1620.97
80_A116_F1.1610.97
184_F409_A1.1550.97
310_V314_I1.1510.97
149_Y153_A1.1410.96
129_S152_I1.1390.96
28_F32_A1.1330.96
253_P257_G1.1330.96
252_S257_G1.1320.96
102_G105_G1.1240.96
262_L424_N1.1230.96
298_K301_Q1.1190.96
250_G255_G1.1110.96
6_S10_R1.1030.96
46_A287_I1.1030.96
70_F163_L1.1030.96
384_F388_F1.1010.96
16_N19_I1.0990.95
320_I373_I1.0810.95
411_E415_Q1.0770.95
249_T424_N1.0750.95
288_A291_F1.0730.95
42_E45_Q1.0700.95
17_K266_V1.0640.95
8_F18_I1.0630.95
251_R255_G1.0620.95
190_S193_K1.0610.95
41_A45_Q1.0610.95
15_R19_I1.0570.94
240_K261_H1.0570.94
148_T151_I1.0560.94
140_L143_K1.0530.94
7_N11_V1.0440.94
215_V219_L1.0320.94
236_Q414_K1.0310.94
417_E423_R1.0260.93
221_V225_L1.0210.93
297_T301_Q1.0210.93
332_N335_Q1.0190.93
141_I145_G1.0150.93
271_V400_T1.0130.93
57_N60_G1.0100.93
87_L91_V1.0070.93
253_P256_G1.0040.93
372_S376_A0.9980.92
180_S408_V0.9950.92
182_I286_T0.9910.92
250_G253_P0.9800.92
191_I195_I0.9800.92
262_L360_I0.9770.92
39_V43_A0.9740.92
7_N424_N0.9730.92
417_E428_F0.9710.91
122_F150_L0.9710.91
412_T416_L0.9670.91
144_S148_T0.9610.91
264_L367_L0.9610.91
185_A188_V0.9570.91
163_L182_I0.9540.91
175_V412_T0.9500.91
103_E107_R0.9490.90
167_G179_I0.9480.90
168_E247_K0.9410.90
8_F416_L0.9360.90
316_V380_I0.9340.90
203_F206_S0.9300.90
274_V399_G0.9290.90
92_V96_T0.9260.89
230_G234_I0.9250.89
194_T198_I0.9240.89
286_T290_F0.9240.89
145_G225_L0.9240.89
220_L389_A0.9210.89
183_I275_I0.9160.89
303_N314_I0.9140.89
133_N146_V0.9120.89
232_I374_F0.9090.88
42_E46_A0.9070.88
109_L280_F0.9050.88
44_L125_A0.9030.88
111_Q115_Y0.9020.88
65_Y68_S0.9010.88
234_I262_L0.9010.88
249_T254_A0.8960.88
72_M79_T0.8950.88
11_V420_L0.8930.88
51_G57_N0.8890.87
254_A258_Q0.8870.87
28_F166_L0.8850.87
234_I378_I0.8850.87
17_K289_S0.8840.87
341_K344_G0.8820.87
272_I329_V0.8820.87
411_E414_K0.8800.87
36_V129_S0.8780.87
376_A380_I0.8760.87
75_T327_A0.8740.86
157_T364_L0.8700.86
95_F112_F0.8700.86
112_F116_F0.8670.86
12_S423_R0.8660.86
293_T298_K0.8660.86
251_R257_G0.8640.86
234_I374_F0.8630.86
32_A68_S0.8610.86
306_N383_I0.8600.86
203_F213_H0.8530.85
139_M143_K0.8520.85
412_T415_Q0.8500.85
316_V373_I0.8480.85
130_Y133_N0.8480.85
313_A317_A0.8470.85
222_I226_A0.8460.85
187_I271_V0.8420.84
130_Y149_Y0.8390.84
81_S400_T0.8360.84
234_I370_V0.8360.84
73_G116_F0.8360.84
299_W302_N0.8350.84
194_T396_Q0.8330.84
36_V67_F0.8330.84
116_F179_I0.8270.83
195_I198_I0.8270.83
244_Q418_S0.8260.83
274_V375_L0.8250.83
17_K28_F0.8240.83
280_F321_A0.8230.83
143_K146_V0.8210.83
293_T296_V0.8170.83
417_E427_G0.8160.82
250_G257_G0.8130.82
166_L308_H0.8130.82
126_L156_L0.8100.82
153_A157_T0.8060.82
95_F98_W0.8060.82
150_L154_L0.8040.82
27_V299_W0.7990.81
346_Y352_P0.7990.81
54_D57_N0.7980.81
339_N343_Q0.7960.81
350_V359_R0.7930.81
201_T206_S0.7920.81
214_I218_A0.7870.80
271_V399_G0.7850.80
290_F340_L0.7810.80
110_A168_E0.7790.79
79_T83_I0.7780.79
385_F389_A0.7770.79
72_M336_M0.7770.79
281_L380_I0.7740.79
33_F57_N0.7690.79
6_S385_F0.7680.78
8_F11_V0.7680.78
250_G256_G0.7660.78
278_V315_Y0.7650.78
270_G403_L0.7640.78
227_V381_L0.7640.78
243_I429_M0.7630.78
301_Q305_D0.7620.78
78_I404_I0.7620.78
193_K197_Q0.7600.78
190_S283_T0.7590.78
5_I9_M0.7580.78
239_R284_P0.7550.77
306_N311_G0.7530.77
225_L229_V0.7510.77
336_M374_F0.7480.77
220_L224_I0.7480.77
291_F297_T0.7480.77
120_L279_A0.7470.77
17_K142_E0.7460.76
94_K163_L0.7450.76
404_I408_V0.7420.76
217_V221_V0.7420.76
271_V275_I0.7410.76
333_P337_A0.7400.76
226_A229_V0.7390.76
157_T161_A0.7370.76
20_F169_Q0.7360.75
67_F156_L0.7340.75
292_G297_T0.7320.75
145_G148_T0.7310.75
28_F185_A0.7310.75
129_S153_A0.7300.75
83_I120_L0.7300.75
367_L372_S0.7290.75
305_D314_I0.7250.74
99_S235_Q0.7230.74
196_G199_Y0.7220.74
250_G254_A0.7210.74
96_T99_S0.7200.74
282_I286_T0.7180.74
21_T24_M0.7170.74
74_I163_L0.7170.74
328_F372_S0.7160.73
74_I238_V0.7120.73
72_M160_T0.7120.73
295_D373_I0.7110.73
198_I201_T0.7100.73
294_N299_W0.7100.73
123_I162_F0.7100.73
340_L345_G0.7090.73
249_T422_K0.7060.72
38_Y148_T0.7060.72
74_I161_A0.7040.72
13_D419_Q0.7040.72
69_I389_A0.7010.72
196_G200_E0.6990.72
312_M383_I0.6970.71
123_I316_V0.6940.71
28_F68_S0.6930.71
325_F329_V0.6920.71
403_L406_V0.6920.71
84_I317_A0.6900.71
69_I219_L0.6860.70
25_L191_I0.6840.70
418_S422_K0.6820.70
63_A265_K0.6800.70
359_R363_I0.6800.70
28_F63_A0.6790.69
241_I350_V0.6790.69
275_I399_G0.6760.69
191_I402_L0.6760.69
199_Y203_F0.6750.69
277_A315_Y0.6740.69
71_A109_L0.6740.69
67_F272_I0.6710.69
35_P191_I0.6710.69
420_L423_R0.6710.69
227_V397_I0.6700.68
185_A226_A0.6700.68
89_M329_V0.6690.68
68_S118_I0.6690.68
294_N313_A0.6690.68
107_R247_K0.6670.68
315_Y342_K0.6650.68
78_I322_F0.6630.68
46_A150_L0.6630.68
125_A129_S0.6630.68
311_G328_F0.6620.68
275_I322_F0.6610.67
5_I50_M0.6610.67
251_R256_G0.6610.67
184_F188_V0.6600.67
304_F311_G0.6580.67
328_F365_Y0.6580.67
186_G189_S0.6570.67
110_A386_I0.6560.67
336_M425_Y0.6550.67
334_E354_K0.6550.67
69_I162_F0.6550.67
242_A246_A0.6540.67
112_F269_A0.6540.67
231_V241_I0.6520.66
410_L414_K0.6520.66
407_G411_E0.6510.66
271_V276_F0.6490.66
14_I175_V0.6490.66
129_S149_Y0.6480.66
20_F267_N0.6480.66
47_Q50_M0.6470.66
86_L325_F0.6460.66
14_I126_L0.6440.65
385_F391_L0.6440.65
354_K357_Q0.6440.65
85_Q182_I0.6440.65
98_W102_G0.6430.65
28_F97_E0.6410.65
34_I377_V0.6400.65
84_I272_I0.6390.65
295_D299_W0.6390.65
69_I103_E0.6390.65
57_N63_A0.6380.65
365_Y369_F0.6380.65
265_K270_G0.6370.65
281_L285_R0.6350.64
315_Y379_S0.6340.64
11_V15_R0.6330.64
216_K220_L0.6320.64
77_Y276_F0.6320.64
122_F126_L0.6310.64
79_T274_V0.6310.64
43_A68_S0.6300.64
181_I378_I0.6300.64
89_M243_I0.6300.64
14_I315_Y0.6290.64
24_M163_L0.6290.64
243_I340_L0.6280.63
28_F34_I0.6280.63
241_I262_L0.6280.63
346_Y407_G0.6260.63
274_V278_V0.6250.63
317_A320_I0.6250.63
265_K330_Q0.6240.63
215_V292_G0.6230.63
79_T316_V0.6230.63
266_V269_A0.6230.63
222_I294_N0.6230.63
274_V407_G0.6220.63
6_S336_M0.6210.63
268_P368_T0.6210.63
126_L130_Y0.6200.62
94_K241_I0.6190.62
219_L222_I0.6190.62
346_Y418_S0.6170.62
333_P360_I0.6150.62
247_K261_H0.6140.62
188_V240_K0.6130.62
248_G251_R0.6120.61
319_I373_I0.6100.61
68_S428_F0.6070.61
88_Q91_V0.6050.61
23_L27_V0.6040.60
56_L360_I0.6040.60
143_K226_A0.6020.60
235_Q238_V0.6010.60
39_V42_E0.6010.60
183_I186_G0.6000.60
321_A324_Y0.5990.60
99_S395_A0.5980.60
173_H398_G0.5980.60
20_F265_K0.5960.59
341_K363_I0.5950.59
360_I367_L0.5950.59
28_F73_G0.5950.59
228_I390_G0.5940.59
254_A257_G0.5930.59
114_R271_V0.5930.59
118_I290_F0.5930.59
11_V417_E0.5920.59
220_L332_N0.5920.59
355_M377_V0.5910.59
53_F372_S0.5910.59
251_R254_A0.5910.59
94_K112_F0.5900.59
45_Q48_S0.5900.59
81_S275_I0.5900.59
43_A150_L0.5890.59
16_N23_L0.5880.58
151_I154_L0.5880.58
308_H312_M0.5870.58
239_R363_I0.5860.58
46_A298_K0.5850.58
74_I164_M0.5850.58
103_E225_L0.5840.58
14_I416_L0.5830.58
181_I412_T0.5820.58
58_T229_V0.5810.58
175_V181_I0.5810.58
11_V14_I0.5800.57
181_I185_A0.5800.57
78_I377_V0.5800.57
141_I148_T0.5800.57
51_G306_N0.5790.57
54_D160_T0.5770.57
315_Y380_I0.5770.57
126_L228_I0.5770.57
58_T79_T0.5760.57
269_A381_L0.5750.57
386_I395_A0.5740.57
369_F384_F0.5740.57
91_V112_F0.5730.56
93_P96_T0.5730.56
99_S106_R0.5710.56
377_V381_L0.5710.56
274_V340_L0.5700.56
12_S15_R0.5700.56
11_V422_K0.5690.56
215_V388_F0.5690.56
85_Q325_F0.5680.56
272_I323_T0.5670.56
141_I152_I0.5670.56
107_R114_R0.5660.56
81_S163_L0.5660.56
181_I228_I0.5650.55
121_G161_A0.5630.55
333_P364_L0.5630.55
57_N62_G0.5630.55
28_F182_I0.5630.55
30_I34_I0.5610.55
122_F395_A0.5600.55
65_Y347_I0.5600.55
326_Y345_G0.5600.55
29_R189_S0.5600.55
202_Q212_I0.5590.55
200_E204_V0.5580.55
158_G162_F0.5570.54
110_A161_A0.5560.54
224_I227_V0.5540.54
118_I378_I0.5530.54
78_I400_T0.5500.53
32_A421_V0.5500.53
36_V73_G0.5480.53
64_L71_A0.5480.53
168_E329_V0.5480.53
8_F14_I0.5480.53
44_L51_G0.5470.53
296_V317_A0.5470.53
197_Q289_S0.5470.53
271_V322_F0.5460.53
315_Y378_I0.5460.53
64_L89_M0.5450.53
117_T227_V0.5430.53
286_T336_M0.5430.53
101_Q104_V0.5420.52
190_S194_T0.5410.52
78_I271_V0.5400.52
188_V191_I0.5400.52
74_I81_S0.5370.52
340_L343_Q0.5360.52
33_F68_S0.5360.52
30_I285_R0.5360.52
73_G91_V0.5350.51
167_G327_A0.5350.51
190_S381_L0.5340.51
117_T270_G0.5340.51
17_K173_H0.5330.51
206_S212_I0.5330.51
224_I395_A0.5320.51
278_V307_T0.5320.51
134_N139_M0.5320.51
224_I385_F0.5320.51
32_A332_N0.5310.51
154_L384_F0.5310.51
185_A329_V0.5310.51
10_R258_Q0.5310.51
19_I92_V0.5300.51
233_F300_I0.5300.51
229_V233_F0.5290.51
199_Y313_A0.5290.51
68_S190_S0.5290.51
51_G67_F0.5280.51
320_I369_F0.5280.51
304_F307_T0.5270.50
192_P239_R0.5270.50
140_L314_I0.5270.50
80_A236_Q0.5270.50
424_N429_M0.5270.50
273_P375_L0.5260.50
66_Q70_F0.5260.50
247_K252_S0.5260.50
241_I348_P0.5240.50
275_I411_E0.5230.50
243_I339_N0.5220.50
166_L182_I0.5220.50
266_V413_M0.5210.50
181_I387_Q0.5210.50
235_Q274_V0.5200.50
272_I319_I0.5200.50
49_Q196_G0.5190.49
224_I228_I0.5190.49
239_R348_P0.5180.49
217_V405_V0.5170.49
184_F326_Y0.5160.49
245_Y322_F0.5140.49
249_T255_G0.5130.49
346_Y422_K0.5110.48
166_L347_I0.5110.48
180_S322_F0.5100.48
234_I266_V0.5100.48
288_A429_M0.5090.48
59_F148_T0.5090.48
191_I224_I0.5080.48
294_N338_D0.5080.48
369_F373_I0.5080.48
65_Y225_L0.5070.48
132_F231_V0.5060.48
19_I212_I0.5060.48
156_L397_I0.5060.48
133_N144_S0.5050.48
95_F360_I0.5030.47
124_Q366_R0.5020.47
12_S36_V0.5020.47
268_P374_F0.5010.47
8_F367_L0.5010.47
163_L269_A0.5000.47
61_G276_F0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zjsY 2 0.9466 100 0.046 Contact Map
3dinC 1 0.9165 100 0.051 Contact Map
3dl8G 1 0.9327 100 0.053 Contact Map
3j01A 1 0.9768 100 0.073 Contact Map
1rh5A 1 0.8608 100 0.118 Contact Map
3mp7A 1 0.7633 100 0.123 Contact Map
2ww9A 1 0.9281 100 0.151 Contact Map
4w251 1 0.8074 100 0.201 Contact Map
3giaA 1 0.5128 8.2 0.977 Contact Map
3ar4A 1 0.2807 4.5 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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