GREMLIN Database
KAD - Adenylate kinase
UniProt: P16304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (207)
Sequences: 4140 (2444)
Seq/√Len: 169.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_K176_M3.5451.00
50_K54_D2.9261.00
71_R76_D2.8231.00
122_E140_V2.7431.00
35_F64_T2.7151.00
52_Y60_P2.6421.00
97_E189_K2.6301.00
199_Q207_D2.5841.00
23_D209_K2.4341.00
48_E51_S2.4061.00
128_R139_L2.3761.00
161_A164_N2.3491.00
199_Q203_D2.2951.00
38_A70_E2.2841.00
37_A41_E2.2421.00
113_I197_G2.2261.00
173_E177_K2.2231.00
130_C133_C2.2191.00
19_R205_Y2.2111.00
112_N194_N2.2081.00
65_I86_F2.2021.00
114_E194_N2.1871.00
126_G138_H2.1641.00
131_S158_Y2.0751.00
187_S194_N2.0631.00
131_S155_G1.9581.00
44_P48_E1.8271.00
24_Y209_K1.7981.00
65_I95_A1.7751.00
150_C153_D1.7491.00
42_E47_L1.7391.00
165_E169_S1.6801.00
109_Y193_A1.6441.00
124_L168_V1.6301.00
97_E185_F1.6291.00
193_A211_L1.6261.00
170_K173_E1.6011.00
44_P47_L1.5981.00
130_C153_D1.5941.00
23_D205_Y1.5821.00
48_E66_G1.5721.00
149_I156_E1.5681.00
75_D78_E1.5471.00
39_M53_I1.5251.00
133_C153_D1.5101.00
180_Q184_D1.4871.00
71_R74_K1.4851.00
16_Q208_V1.4161.00
116_D198_Q1.4001.00
130_C150_C1.4001.00
119_V198_Q1.3901.00
119_V122_E1.3891.00
51_S55_K1.3861.00
131_S156_E1.3731.00
200_D203_D1.3631.00
132_V153_D1.3551.00
146_T149_I1.3521.00
19_R202_Q1.3501.00
174_V178_Q1.3501.00
11_A115_V1.3291.00
115_V197_G1.3161.00
205_Y209_K1.3091.00
126_G139_L1.3061.00
133_C150_C1.2951.00
206_A210_D1.2721.00
38_A43_T1.2511.00
164_N167_T1.2381.00
27_P71_R1.2331.00
121_M169_S1.2301.00
38_A67_I1.2201.00
203_D207_D1.2091.00
10_G124_L1.1931.00
38_A41_E1.1831.00
91_A94_E1.1821.00
60_P63_V1.1681.00
2_N105_K1.1661.00
128_R159_Q1.1641.00
125_T165_E1.1601.00
129_I136_T1.1521.00
184_D188_E1.1411.00
135_T152_K1.1411.00
63_V66_G1.1371.00
111_I208_V1.1321.00
117_K169_S1.1311.00
117_K173_E1.1291.00
176_M180_Q1.1251.00
43_T46_G1.1231.00
199_Q204_V1.1121.00
138_H141_F1.1041.00
32_G36_R1.1031.00
4_V107_I1.1021.00
170_K174_V1.0961.00
196_N199_Q1.0841.00
69_K103_Y1.0841.00
121_M125_T1.0821.00
52_Y57_E1.0761.00
18_E22_E1.0721.00
112_N183_L1.0661.00
48_E62_E1.0530.99
6_M183_L1.0510.99
34_M38_A1.0510.99
5_L20_I1.0470.99
150_C155_G1.0450.99
25_G79_R1.0410.99
37_A71_R1.0250.99
195_V204_V1.0180.99
71_R77_C1.0160.99
94_E97_E1.0110.99
81_F107_I1.0100.99
117_K172_L1.0010.99
35_F39_M0.9990.99
130_C155_G0.9980.99
8_L175_N0.9970.99
69_K73_G0.9940.99
26_I81_F0.9820.99
145_K151_D0.9810.99
169_S173_E0.9770.99
97_E186_Y0.9710.99
5_L113_I0.9700.99
160_R163_D0.9520.99
95_A98_E0.9510.99
196_N204_V0.9470.99
16_Q205_Y0.9450.99
49_A66_G0.9450.99
172_L176_M0.9390.99
110_V192_L0.9320.99
20_I208_V0.9310.99
144_P151_D0.9280.99
128_R157_L0.9250.99
49_A52_Y0.9250.99
19_R22_E0.9240.99
5_L17_G0.9240.99
21_V28_H0.9240.99
94_E98_E0.9230.99
57_E170_K0.9190.99
153_D156_E0.9190.99
27_P77_C0.8970.98
135_T142_N0.8970.98
61_D92_Q0.8890.98
66_G69_K0.8860.98
14_G84_D0.8850.98
203_D206_A0.8740.98
5_L82_L0.8690.98
26_I80_G0.8680.98
184_D187_S0.8670.98
49_A53_I0.8660.98
38_A49_A0.8620.98
121_M168_V0.8620.98
94_E185_F0.8460.98
195_V208_V0.8430.97
195_V211_L0.8420.97
2_N107_I0.8400.97
20_I82_L0.8370.97
135_T153_D0.8360.97
107_I191_Y0.8320.97
41_E74_K0.8280.97
90_V94_E0.8270.97
175_N179_T0.8240.97
167_T170_K0.8180.97
182_L192_L0.8130.97
146_T151_D0.8130.97
6_M182_L0.8040.97
2_N108_D0.8010.97
106_P191_Y0.8000.97
73_G103_Y0.7990.97
201_I205_Y0.7940.96
130_C135_T0.7910.96
27_P76_D0.7900.96
126_G141_F0.7870.96
118_D169_S0.7790.96
93_A186_Y0.7730.96
39_M46_G0.7730.96
65_I68_V0.7540.95
114_E183_L0.7520.95
185_F189_K0.7520.95
133_C155_G0.7500.95
206_A209_K0.7430.95
143_P147_P0.7400.95
32_G88_R0.7320.94
207_D210_D0.7280.94
133_C152_K0.7250.94
179_T182_L0.7190.94
37_A74_K0.7160.94
71_R75_D0.7140.94
15_T123_R0.7140.94
118_D122_E0.7070.93
16_Q195_V0.7020.93
153_D157_L0.7020.93
135_T150_C0.6990.93
110_V191_Y0.6980.93
120_L168_V0.6940.93
116_D119_V0.6910.92
159_Q164_N0.6880.92
38_A46_G0.6870.92
137_Y144_P0.6860.92
163_D167_T0.6840.92
70_E74_K0.6830.92
126_G140_V0.6800.92
45_L66_G0.6750.92
71_R80_G0.6740.92
34_M67_I0.6740.92
6_M175_N0.6730.91
36_R88_R0.6730.91
35_F68_V0.6720.91
28_H33_D0.6700.91
18_E28_H0.6700.91
89_T92_Q0.6690.91
207_D211_L0.6680.91
125_T164_N0.6660.91
30_S33_D0.6640.91
115_V120_L0.6630.91
198_Q204_V0.6620.91
3_L109_Y0.6620.91
196_N207_D0.6610.91
155_G158_Y0.6580.91
7_G10_G0.6580.91
12_G15_T0.6520.90
22_E152_K0.6520.90
47_L51_S0.6520.90
38_A66_G0.6440.90
77_C80_G0.6440.90
208_V211_L0.6390.89
112_N192_L0.6380.89
14_G36_R0.6330.89
87_P92_Q0.6330.89
138_H144_P0.6330.89
6_M110_V0.6320.89
64_T68_V0.6320.89
150_C154_G0.6320.89
47_L50_K0.6270.88
10_G168_V0.6260.88
70_E73_G0.6260.88
58_L88_R0.6230.88
48_E52_Y0.6210.88
42_E50_K0.6180.88
129_I158_Y0.6160.87
51_S54_D0.6160.87
27_P80_G0.6160.87
18_E21_V0.6160.87
16_Q204_V0.6120.87
2_N6_M0.6110.87
8_L11_A0.6090.87
149_I154_G0.6040.86
121_M165_E0.5970.86
120_L172_L0.5950.86
52_Y55_K0.5910.85
35_F53_I0.5910.85
130_C156_E0.5830.84
109_Y211_L0.5830.84
151_D154_G0.5810.84
148_G151_D0.5800.84
132_V155_G0.5780.84
61_D89_T0.5780.84
22_E25_G0.5770.84
109_Y191_Y0.5750.84
9_P167_T0.5740.84
52_Y63_V0.5740.84
85_G88_R0.5710.83
12_G123_R0.5710.83
24_Y205_Y0.5710.83
144_P148_G0.5700.83
76_D80_G0.5690.83
62_E66_G0.5680.83
51_S63_V0.5670.83
41_E49_A0.5660.83
160_R171_R0.5640.82
6_M28_H0.5630.82
3_L107_I0.5580.82
49_A55_K0.5550.81
20_I212_L0.5520.81
49_A60_P0.5490.81
2_N81_F0.5420.80
20_I205_Y0.5420.80
198_Q207_D0.5420.80
138_H143_P0.5420.80
127_R163_D0.5410.80
7_G12_G0.5400.80
72_L77_C0.5380.79
149_I155_G0.5370.79
14_G58_L0.5300.78
90_V185_F0.5290.78
109_Y212_L0.5280.78
182_L186_Y0.5270.78
45_L67_I0.5270.78
31_T68_V0.5270.78
162_D171_R0.5260.78
130_C152_K0.5230.78
11_A17_G0.5230.78
9_P120_L0.5210.77
29_I34_M0.5200.77
88_R127_R0.5180.77
6_M168_V0.5170.77
32_G58_L0.5170.77
72_L81_F0.5160.77
32_G163_D0.5150.76
35_F49_A0.5150.76
56_G61_D0.5150.76
49_A67_I0.5150.76
166_E170_K0.5120.76
86_F92_Q0.5120.76
134_G137_Y0.5090.76
111_I195_V0.5080.76
188_E191_Y0.5080.76
49_A59_V0.5050.75
29_I81_F0.5040.75
113_I208_V0.5040.75
151_D155_G0.5040.75
117_K121_M0.5000.74
54_D161_A0.5000.74
197_G204_V0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 1 100 0.309 Contact Map
4jzkA 1 0.9631 100 0.34 Contact Map
3be4A 1 0.9677 100 0.345 Contact Map
3tlxA 1 0.9862 100 0.347 Contact Map
3gmtA 1 0.8848 100 0.347 Contact Map
2xb4A 4 0.977 100 0.351 Contact Map
4pzlA 2 0.9724 100 0.352 Contact Map
1ak2A 1 1 100 0.355 Contact Map
1akyA 1 0.9908 100 0.366 Contact Map
4nu0A 1 0.9724 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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