GREMLIN Database
ODO2 - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
UniProt: P16263 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (404)
Sequences: 7897 (5090)
Seq/√Len: 253.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_E316_K3.7871.00
25_P57_E3.6451.00
301_L309_E3.3841.00
364_L371_E3.3691.00
56_Q76_S3.2461.00
259_K402_T3.2451.00
315_K319_N3.1861.00
23_K33_E3.1751.00
188_E276_K3.0381.00
61_D64_D2.9021.00
189_V271_E2.8981.00
368_A374_F2.8701.00
23_K55_L2.7661.00
309_E312_E2.6891.00
135_K160_E2.6501.00
316_K326_E2.6371.00
250_T280_I2.5941.00
266_E275_K2.5921.00
218_E365_R2.5561.00
138_D141_Q2.5411.00
198_T201_K2.5271.00
22_L34_Y2.5151.00
253_V332_F2.5041.00
260_Y402_T2.4781.00
30_E52_S2.4701.00
57_E74_T2.4671.00
368_A376_N2.3861.00
219_V382_I2.2481.00
364_L378_P2.2471.00
20_Q62_S2.2141.00
3_E74_T2.2061.00
212_M385_S2.1761.00
220_D377_R2.1691.00
190_Q274_V2.1651.00
277_F297_D2.1461.00
60_K70_E2.1211.00
301_L305_G2.1051.00
59_L74_T2.0851.00
281_G292_V2.0541.00
330_G353_Q1.9931.00
28_Y54_V1.9701.00
258_K299_D1.9651.00
20_Q37_E1.9591.00
257_L332_F1.9551.00
55_L73_G1.9401.00
59_L71_I1.9381.00
369_I373_R1.9321.00
369_I375_E1.9281.00
254_V278_Y1.9211.00
192_M267_I1.8971.00
250_T298_A1.8901.00
3_E71_I1.8861.00
141_Q159_Y1.8731.00
18_I36_L1.8601.00
131_L157_E1.8371.00
24_Q27_D1.8361.00
253_V403_I1.8171.00
233_D237_E1.8141.00
153_K157_E1.8051.00
15_E65_T1.7951.00
186_P276_K1.7911.00
31_Q52_S1.7751.00
189_V273_I1.7651.00
130_K134_E1.7521.00
198_T202_R1.7481.00
30_E33_E1.7281.00
55_L58_V1.7241.00
279_D296_R1.7231.00
288_E320_N1.7121.00
254_V298_A1.6941.00
250_T282_I1.6651.00
402_T405_N1.6441.00
250_T310_I1.6431.00
317_A322_L1.6431.00
205_E209_T1.6391.00
249_F359_M1.6271.00
132_A139_L1.6211.00
195_R199_I1.6171.00
67_Q70_E1.6141.00
265_A274_V1.6071.00
202_R205_E1.6011.00
282_I310_I1.6001.00
137_I142_V1.5911.00
236_F242_K1.5801.00
223_A226_N1.5731.00
36_L72_I1.5631.00
262_L274_V1.5611.00
188_E274_V1.5591.00
22_L37_E1.5491.00
225_M245_F1.5431.00
255_A406_L1.5381.00
157_E161_K1.5281.00
297_D300_R1.5221.00
124_A139_L1.5191.00
207_Q212_M1.5091.00
131_L156_V1.5001.00
60_K66_V1.4921.00
347_P358_G1.4901.00
265_A390_I1.4851.00
295_V309_E1.4791.00
210_S349_L1.4601.00
230_R411_E1.4341.00
222_T377_R1.4291.00
302_T305_G1.4261.00
310_I314_A1.3931.00
354_V390_I1.3881.00
250_T334_I1.3841.00
366_P374_F1.3801.00
37_E46_E1.3761.00
256_A403_I1.3711.00
196_R199_I1.3591.00
332_F355_G1.3461.00
260_Y398_G1.3321.00
268_Q271_E1.3321.00
262_L395_E1.3251.00
216_F344_M1.3251.00
187_V273_I1.3211.00
364_L376_N1.3191.00
25_P61_D1.3171.00
144_T151_V1.3121.00
4_I73_G1.3021.00
365_R379_M1.3001.00
215_T396_A1.2981.00
232_K242_K1.2911.00
253_V399_F1.2911.00
350_N353_Q1.2881.00
201_K205_E1.2831.00
204_V208_Q1.2791.00
401_V405_N1.2771.00
189_V268_Q1.2691.00
382_I403_I1.2671.00
54_V76_S1.2561.00
187_V276_K1.2461.00
357_L403_I1.2411.00
154_Q158_A1.2411.00
196_R392_D1.2341.00
281_G353_Q1.2171.00
5_K71_I1.2071.00
229_K233_D1.2031.00
19_A44_N1.2001.00
366_P376_N1.1911.00
144_T150_R1.1871.00
137_I160_E1.1811.00
131_L135_K1.1801.00
224_V248_F1.1801.00
191_K271_E1.1771.00
215_T386_Y1.1741.00
272_L390_I1.1671.00
220_D369_I1.1591.00
214_T385_S1.1591.00
404_K408_E1.1571.00
267_I390_I1.1571.00
24_Q58_V1.1501.00
323_T326_E1.1401.00
154_Q157_E1.1291.00
277_F299_D1.1261.00
314_A318_R1.1251.00
226_N230_R1.1101.00
221_M224_V1.1061.00
218_E343_L1.1031.00
210_S351_S1.0961.00
54_V79_A1.0951.00
222_T378_P1.0891.00
402_T406_L1.0871.00
250_T295_V1.0861.00
214_T346_T1.0851.00
278_Y299_D1.0851.00
263_L355_G1.0821.00
146_D155_D1.0811.00
279_D297_D1.0781.00
234_Q412_Q1.0731.00
122_T151_V1.0711.00
253_V355_G1.0701.00
213_L386_Y1.0691.00
251_K255_A1.0661.00
229_K232_K1.0661.00
135_K157_E1.0611.00
215_T342_S1.0571.00
222_T226_N1.0551.00
34_Y46_E1.0521.00
285_A398_G1.0461.00
226_N229_K1.0441.00
143_P159_Y1.0431.00
217_N404_K1.0391.00
357_L384_L1.0331.00
285_A340_F1.0321.00
343_L363_Q1.0321.00
279_D294_V1.0291.00
362_I378_P1.0251.00
250_T306_I1.0241.00
268_Q273_I1.0221.00
139_L151_V1.0201.00
6_V16_G1.0161.00
359_M380_M1.0141.00
25_P56_Q1.0111.00
297_D301_L1.0101.00
187_V277_F1.0091.00
137_I156_V1.0081.00
316_K323_T1.0071.00
204_V210_S1.0041.00
291_V322_L1.0031.00
332_F399_F1.0011.00
221_M362_I0.9991.00
263_L391_V0.9981.00
221_M380_M0.9941.00
132_A137_I0.9921.00
369_I377_R0.9911.00
367_V379_M0.9901.00
25_P58_V0.9881.00
13_I16_G0.9841.00
388_H393_G0.9811.00
384_L400_L0.9761.00
197_Q270_D0.9681.00
367_V377_R0.9671.00
337_G345_S0.9621.00
332_F357_L0.9621.00
51_E75_I0.9611.00
312_E315_K0.9601.00
4_I75_I0.9591.00
124_A132_A0.9581.00
212_M349_L0.9571.00
29_V55_L0.9571.00
364_L370_D0.9511.00
394_K398_G0.9511.00
66_V70_E0.9511.00
255_A413_L0.9501.00
9_L16_G0.9471.00
24_Q62_S0.9471.00
18_I60_K0.9451.00
216_F346_T0.9441.00
239_N308_K0.9431.00
139_L142_V0.9401.00
21_W58_V0.9391.00
332_F384_L0.9391.00
285_A394_K0.9371.00
231_R243_L0.9371.00
132_A151_V0.9341.00
197_Q201_K0.9311.00
295_V301_L0.9221.00
35_L49_A0.9181.00
219_V404_K0.9171.00
295_V310_I0.9121.00
29_V49_A0.9111.00
18_I72_I0.9091.00
247_S306_I0.9051.00
199_I203_L0.9051.00
255_A258_K0.9051.00
128_A153_K0.9041.00
158_A161_K0.9001.00
15_E67_Q0.8991.00
291_V327_L0.8951.00
144_T149_G0.8921.00
127_S153_K0.8921.00
93_S96_S0.8911.00
22_L46_E0.8881.00
225_M378_P0.8851.00
132_A142_V0.8841.00
215_T360_H0.8841.00
247_S303_F0.8781.00
259_K406_L0.8771.00
4_I35_L0.8771.00
322_L327_L0.8751.00
60_K64_D0.8731.00
158_A162_P0.8691.00
253_V357_L0.8671.00
215_T400_L0.8651.00
145_G152_R0.8640.99
207_Q211_A0.8630.99
258_K278_Y0.8590.99
17_T63_G0.8570.99
145_G155_D0.8570.99
88_T91_T0.8560.99
6_V38_L0.8560.99
305_G308_K0.8550.99
38_L47_L0.8520.99
207_Q210_S0.8480.99
17_T65_T0.8480.99
279_D330_G0.8390.99
187_V275_K0.8380.99
128_A156_V0.8370.99
230_R409_D0.8350.99
249_F380_M0.8310.99
343_L381_Y0.8200.99
281_G330_G0.8140.99
156_V159_Y0.8130.99
227_L248_F0.8090.99
32_G48_T0.8080.99
145_G149_G0.8050.99
128_A132_A0.8050.99
386_Y396_A0.8040.99
219_V407_L0.8040.99
192_M272_L0.8030.99
58_V61_D0.8020.99
359_M382_I0.8010.99
94_K97_V0.8010.99
305_G309_E0.7980.99
146_D149_G0.7980.99
195_R286_A0.7960.99
355_G384_L0.7940.99
355_G391_V0.7940.99
89_E93_S0.7930.99
304_A308_K0.7920.99
8_E11_E0.7910.99
58_V64_D0.7900.99
214_T383_A0.7890.99
144_T155_D0.7880.99
243_L247_S0.7870.99
9_L38_L0.7850.99
207_Q348_I0.7770.99
160_E163_A0.7740.99
202_R350_N0.7730.99
243_L248_F0.7700.99
194_R197_Q0.7670.99
343_L361_K0.7650.99
207_Q385_S0.7630.99
279_D326_E0.7600.99
124_A128_A0.7600.99
192_M269_G0.7600.99
218_E363_Q0.7600.99
132_A138_D0.7550.99
215_T337_G0.7480.99
410_P413_L0.7460.99
103_A106_A0.7450.99
23_K27_D0.7440.98
284_V318_R0.7430.98
245_F362_I0.7420.98
122_T140_S0.7400.98
337_G358_G0.7400.98
260_Y395_E0.7400.98
195_R288_E0.7370.98
249_F407_L0.7350.98
142_V159_Y0.7350.98
163_A166_P0.7330.98
301_L312_E0.7300.98
206_V212_M0.7290.98
207_Q214_T0.7290.98
31_Q49_A0.7290.98
221_M407_L0.7290.98
135_K161_K0.7260.98
124_A151_V0.7250.98
92_E95_E0.7250.98
161_K164_S0.7240.98
56_Q74_T0.7220.98
364_L368_A0.7220.98
35_L73_G0.7200.98
370_D373_R0.7200.98
132_A156_V0.7180.98
203_L292_V0.7180.98
263_L354_V0.7180.98
56_Q78_G0.7170.98
87_P90_K0.7140.98
294_V329_G0.7130.98
104_E108_Q0.7130.98
8_E12_S0.7120.98
14_S67_Q0.7120.98
131_L153_K0.7110.98
384_L396_A0.7100.98
176_A179_A0.7080.98
102_Q106_A0.7070.98
241_V308_K0.7040.98
232_K236_F0.7020.98
164_S167_A0.7020.98
9_L12_S0.7020.98
217_N342_S0.7010.98
279_D353_Q0.7010.98
403_I407_L0.7000.98
29_V75_I0.6990.98
255_A259_K0.6990.98
312_E326_E0.6980.98
296_R325_S0.6970.98
330_G350_N0.6970.98
399_F403_I0.6970.98
264_N331_S0.6940.98
263_L395_E0.6930.98
186_P277_F0.6920.98
216_F383_A0.6910.98
200_A267_I0.6890.98
223_A377_R0.6880.98
16_G43_V0.6880.98
344_M381_Y0.6860.97
128_A151_V0.6860.97
9_L47_L0.6840.97
6_V66_V0.6840.97
221_M378_P0.6840.97
89_E92_E0.6830.97
257_L263_L0.6820.97
100_E103_A0.6810.97
349_L355_G0.6810.97
286_A291_V0.6810.97
253_V256_A0.6800.97
256_A402_T0.6790.97
54_V78_G0.6780.97
19_A63_G0.6780.97
246_M249_F0.6780.97
345_S360_H0.6730.97
316_K322_L0.6720.97
131_L137_I0.6700.97
16_G38_L0.6700.97
257_L278_Y0.6700.97
220_D367_V0.6640.97
206_V351_S0.6640.97
25_P74_T0.6630.97
294_V330_G0.6620.97
86_A91_T0.6610.97
18_I58_V0.6610.97
122_T139_L0.6600.97
246_M339_T0.6600.97
28_Y78_G0.6590.97
218_E381_Y0.6580.97
28_Y52_S0.6580.97
234_Q238_Q0.6570.97
223_A411_E0.6560.97
249_F334_I0.6550.97
409_D412_Q0.6550.97
218_E379_M0.6540.97
337_G342_S0.6540.97
49_A52_S0.6520.97
316_K321_K0.6520.97
382_I400_L0.6510.97
296_R309_E0.6510.97
358_G385_S0.6510.97
214_T358_G0.6480.96
156_V160_E0.6480.96
95_E98_K0.6470.96
340_F397_V0.6470.96
234_Q237_E0.6460.96
137_I141_Q0.6440.96
204_V207_Q0.6440.96
91_T94_K0.6430.96
333_T353_Q0.6420.96
34_Y37_E0.6410.96
280_I332_F0.6410.96
85_P89_E0.6380.96
294_V353_Q0.6370.96
99_E103_A0.6360.96
181_Q184_D0.6360.96
324_L328_Q0.6360.96
236_F239_N0.6360.96
185_K277_F0.6350.96
22_L25_P0.6350.96
257_L399_F0.6350.96
108_Q112_E0.6330.96
32_G52_S0.6320.96
360_H397_V0.6310.96
146_D152_R0.6310.96
263_L399_F0.6290.96
330_G351_S0.6290.96
99_E102_Q0.6280.96
369_I374_F0.6270.96
49_A75_I0.6270.96
190_Q262_L0.6240.96
246_M336_N0.6240.96
369_I376_N0.6220.96
19_A22_L0.6220.96
262_L265_A0.6210.95
16_G40_T0.6210.95
246_M334_I0.6200.95
85_P88_T0.6190.95
59_L70_E0.6160.95
237_E240_E0.6130.95
285_A395_E0.6110.95
217_N400_L0.6090.95
344_M383_A0.6080.95
183_F186_P0.6080.95
300_R305_G0.6080.95
3_E59_L0.6080.95
77_E80_G0.6070.95
159_Y163_A0.6060.95
224_V407_L0.6060.95
368_A371_E0.6050.95
93_S97_V0.6040.95
337_G360_H0.6030.95
282_I334_I0.6030.95
192_M268_Q0.6030.95
370_D376_N0.6030.95
4_I50_E0.6020.95
106_A109_E0.6010.95
254_V258_K0.6000.95
228_R232_K0.6000.95
246_M282_I0.5990.95
364_L374_F0.5980.94
325_S328_Q0.5980.94
309_E313_L0.5980.94
185_K276_K0.5940.94
311_G315_K0.5930.94
225_M362_I0.5910.94
102_Q105_P0.5910.94
149_G155_D0.5910.94
23_K73_G0.5910.94
231_R234_Q0.5880.94
192_M271_E0.5850.94
127_S131_L0.5850.94
142_V155_D0.5850.94
209_T351_S0.5830.94
185_K279_D0.5820.94
87_P91_T0.5820.94
5_K69_G0.5810.94
227_L411_E0.5810.94
252_A407_L0.5800.94
323_T328_Q0.5800.94
232_K240_E0.5790.93
309_E316_K0.5770.93
102_Q108_Q0.5770.93
78_G81_E0.5770.93
244_G307_E0.5750.93
324_L327_L0.5740.93
165_K168_P0.5730.93
186_P297_D0.5720.93
103_A109_E0.5720.93
365_R381_Y0.5720.93
88_T92_E0.5700.93
347_P385_S0.5700.93
233_D236_F0.5690.93
163_A167_A0.5690.93
349_L385_S0.5680.93
204_V211_A0.5670.93
90_K94_K0.5660.93
279_D292_V0.5660.93
405_N412_Q0.5650.93
37_E44_N0.5650.93
293_P330_G0.5640.93
116_S120_S0.5630.93
18_I50_E0.5620.92
21_W60_K0.5620.92
105_P109_E0.5610.92
211_A389_R0.5600.92
10_A45_V0.5600.92
86_A90_K0.5600.92
142_V156_V0.5590.92
275_K331_S0.5590.92
282_I335_T0.5570.92
366_P377_R0.5570.92
28_Y55_L0.5540.92
131_L160_E0.5530.92
347_P383_A0.5510.92
13_I68_V0.5500.92
344_M347_P0.5490.92
280_I306_I0.5490.92
206_V349_L0.5490.92
40_T43_V0.5490.92
13_I360_H0.5460.91
95_E104_E0.5460.91
34_Y48_T0.5460.91
256_A406_L0.5450.91
39_E194_R0.5420.91
163_A168_P0.5420.91
278_Y331_S0.5420.91
137_I159_Y0.5410.91
398_G401_V0.5410.91
292_V353_Q0.5400.91
99_E104_E0.5400.91
284_V313_L0.5390.91
266_E277_F0.5370.91
191_K194_R0.5370.91
36_L47_L0.5360.91
97_V100_E0.5350.91
92_E96_S0.5340.90
59_L72_I0.5340.90
220_D223_A0.5330.90
216_F381_Y0.5320.90
222_T367_V0.5320.90
195_R198_T0.5320.90
82_S85_P0.5310.90
296_R326_E0.5310.90
142_V151_V0.5310.90
196_R200_A0.5310.90
38_L44_N0.5290.90
9_L72_I0.5260.90
354_V391_V0.5260.90
298_A306_I0.5250.90
308_K312_E0.5240.90
82_S86_A0.5240.90
168_P174_P0.5240.90
287_D319_N0.5240.90
202_R352_P0.5230.90
364_L369_I0.5230.90
385_S397_V0.5220.89
6_V45_V0.5220.89
262_L390_I0.5220.89
160_E164_S0.5210.89
395_E398_G0.5210.89
114_A117_E0.5200.89
206_V210_S0.5200.89
21_W36_L0.5190.89
169_Q176_A0.5180.89
349_L352_P0.5170.89
275_K354_V0.5120.89
262_L272_L0.5120.89
306_I313_L0.5110.88
76_S79_A0.5100.88
214_T347_P0.5100.88
104_E107_A0.5090.88
357_L382_I0.5080.88
6_V73_G0.5080.88
373_R376_N0.5070.88
100_E104_E0.5050.88
12_S50_E0.5050.88
157_E160_E0.5040.88
101_K104_E0.5040.88
25_P28_Y0.5030.88
5_K70_E0.5030.88
202_R351_S0.5020.88
94_K98_K0.5020.88
92_E98_K0.5000.87
150_R155_D0.5000.87
190_Q272_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0.1007 100 0.147 Contact Map
2ii3A 4 0.554 100 0.456 Contact Map
1sczA 4 0.5588 100 0.457 Contact Map
4n72A 3 0.5851 100 0.462 Contact Map
1dpbA 4 0.5779 100 0.462 Contact Map
3maeA 3 0.5683 100 0.464 Contact Map
3b8kA 1 0.5707 100 0.466 Contact Map
3l60A 3 0.5372 100 0.476 Contact Map
3rqcA 4 0.5228 100 0.489 Contact Map
2xt6A 2 0.458 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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