GREMLIN Database
GRPE - Protein GrpE
UniProt: P15874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (170)
Sequences: 4804 (3738)
Seq/√Len: 286.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_L52_K3.3611.00
134_A169_K2.9151.00
41_Q46_Q2.8321.00
88_D130_E2.5221.00
133_E172_K2.4171.00
136_E140_Q2.3761.00
42_I45_L2.3701.00
54_N58_R2.1481.00
95_S122_Q2.1221.00
168_Q182_M2.1021.00
95_S98_R2.0851.00
45_L49_L2.0581.00
128_K133_E2.0371.00
148_Q182_M2.0141.00
66_Y70_S1.9861.00
48_L53_E1.9621.00
155_D158_Y1.9581.00
125_E128_K1.8851.00
88_D129_K1.8831.00
151_M184_K1.8251.00
165_E184_K1.8061.00
86_V132_V1.7831.00
146_L172_K1.7801.00
63_F66_Y1.7671.00
44_E48_L1.7641.00
53_E57_L1.7421.00
153_A164_V1.6831.00
125_E129_K1.6461.00
46_Q50_E1.6131.00
97_E169_K1.6041.00
137_A166_E1.5931.00
47_G51_E1.5691.00
64_E67_K1.5601.00
97_E120_H1.5541.00
159_G162_I1.5371.00
117_E121_R1.5361.00
143_D146_L1.5121.00
43_N46_Q1.5061.00
41_Q44_E1.5041.00
72_L76_A1.4991.00
83_Q176_R1.4531.00
98_R101_Q1.4481.00
42_I46_Q1.4441.00
86_V178_I1.4051.00
164_V186_N1.3931.00
172_K175_D1.3781.00
68_R72_L1.3761.00
82_S85_I1.3681.00
141_E162_I1.3481.00
56_L59_V1.3291.00
111_S114_Q1.3221.00
153_A184_K1.3171.00
64_E68_R1.3151.00
155_D186_N1.2751.00
61_A65_N1.2631.00
153_A165_E1.2601.00
99_A116_M1.2571.00
40_N44_E1.2511.00
38_L42_I1.2501.00
135_I177_V1.2431.00
35_S38_L1.2401.00
133_E175_D1.2351.00
114_Q117_E1.2221.00
59_V63_F1.2131.00
167_M184_K1.2051.00
71_R75_E1.2041.00
158_Y186_N1.2031.00
51_E55_K1.1941.00
121_R125_E1.1941.00
75_E79_K1.1921.00
158_Y164_V1.1821.00
74_M78_Q1.1451.00
50_E54_N1.1431.00
120_H124_V1.1381.00
49_L53_E1.1301.00
56_L60_Q1.1231.00
138_V166_E1.1141.00
107_E110_K1.1071.00
40_N43_N1.1061.00
85_I130_E1.1031.00
137_A140_Q1.0941.00
152_Q161_N1.0791.00
94_D179_R1.0741.00
55_K60_Q1.0551.00
138_V165_E1.0491.00
127_L132_V1.0441.00
80_Y174_K1.0391.00
28_Q31_E1.0291.00
60_Q64_E1.0251.00
70_S74_M1.0241.00
158_Y162_I1.0211.00
34_E39_Q1.0131.00
47_G50_E0.9981.00
162_I186_N0.9901.00
110_K114_Q0.9891.00
48_L52_K0.9891.00
74_M77_S0.9881.00
80_Y176_R0.9841.00
36_E39_Q0.9811.00
36_E40_N0.9771.00
48_L51_E0.9641.00
93_L127_L0.9621.00
92_A126_A0.9571.00
150_V182_M0.9561.00
79_K174_K0.9521.00
96_F120_H0.9511.00
93_L171_Y0.9501.00
97_E101_Q0.9471.00
96_F119_V0.9351.00
132_V173_L0.9321.00
52_K56_L0.9241.00
58_R61_A0.9211.00
151_M167_M0.9201.00
137_A181_S0.9151.00
35_S39_Q0.8991.00
59_V66_Y0.8991.00
63_F70_S0.8971.00
124_V134_A0.8911.00
142_F149_A0.8841.00
92_A123_L0.8801.00
177_V180_P0.8781.00
52_K55_K0.8671.00
39_Q43_N0.8641.00
44_E47_G0.8591.00
122_Q125_E0.8561.00
134_A166_E0.8541.00
54_N62_D0.8521.00
166_E181_S0.8481.00
34_E37_L0.8401.00
98_R168_Q0.8321.00
31_E35_S0.8251.00
65_N68_R0.8181.00
103_E106_N0.8171.00
140_Q166_E0.8121.00
148_Q168_Q0.8100.99
45_L48_L0.7960.99
160_S186_N0.7910.99
17_E20_E0.7870.99
73_E76_A0.7860.99
110_K113_L0.7800.99
124_V128_K0.7800.99
50_E53_E0.7750.99
167_M182_M0.7700.99
24_A28_Q0.7490.99
84_N87_T0.7450.99
58_R65_N0.7420.99
31_E34_E0.7410.99
77_S81_R0.7380.99
70_S73_E0.7380.99
137_A163_V0.7370.99
81_R85_I0.7350.99
19_I22_Q0.7340.99
43_N47_G0.7330.99
140_Q146_L0.7310.99
115_G118_M0.7290.99
68_R71_R0.7260.99
164_V184_K0.7250.99
100_L117_E0.7230.99
25_A28_Q0.7210.99
75_E78_Q0.7190.99
83_Q173_L0.7190.99
18_I21_E0.7030.99
38_L41_Q0.7030.99
33_N36_E0.6980.98
151_M165_E0.6970.98
21_E24_A0.6930.98
135_I172_K0.6920.98
77_S80_Y0.6850.98
82_S130_E0.6820.98
91_P122_Q0.6800.98
26_D29_Q0.6790.98
93_L124_V0.6770.98
88_D91_P0.6760.98
16_Q19_I0.6760.98
91_P168_Q0.6720.98
46_Q49_L0.6710.98
22_Q25_A0.6680.98
82_S174_K0.6660.98
79_K83_Q0.6650.98
154_E186_N0.6630.98
84_N88_D0.6630.98
123_L127_L0.6630.98
141_E161_N0.6610.98
90_L179_R0.6520.98
173_L178_I0.6520.98
93_L120_H0.6430.97
32_T35_S0.6410.97
141_E159_G0.6390.97
106_N110_K0.6390.97
112_L116_M0.6370.97
56_L63_F0.6360.97
83_Q87_T0.6320.97
147_H163_V0.6310.97
114_Q121_R0.6290.97
80_Y83_Q0.6280.97
83_Q178_I0.6280.97
106_N109_T0.6270.97
98_R102_V0.6260.97
63_F67_K0.6240.97
166_E169_K0.6230.97
100_L115_G0.6200.97
23_A26_D0.6200.97
96_F116_M0.6190.97
104_A113_L0.6170.97
150_V167_M0.6150.97
78_Q84_N0.6130.97
34_E38_L0.6120.97
62_D66_Y0.6070.96
49_L56_L0.6020.96
54_N57_L0.6010.96
20_E23_A0.6000.96
57_L64_E0.5980.96
71_R74_M0.5960.96
142_F163_V0.5950.96
76_A79_K0.5930.96
100_L120_H0.5920.96
79_K175_D0.5870.96
106_N113_L0.5870.96
135_I181_S0.5810.95
69_R73_E0.5750.95
126_A130_E0.5730.95
122_Q126_A0.5720.95
86_V173_L0.5700.95
131_G174_K0.5690.95
82_S86_V0.5680.95
16_Q27_E0.5660.95
20_E24_A0.5570.94
140_Q163_V0.5560.94
32_T36_E0.5550.94
118_M121_R0.5520.94
24_A27_E0.5520.94
155_D159_G0.5440.94
61_A68_R0.5440.94
103_E113_L0.5430.93
92_A122_Q0.5420.93
101_Q165_E0.5400.93
16_Q20_E0.5370.93
37_L40_N0.5300.93
55_K59_V0.5280.93
116_M119_V0.5270.92
21_E28_Q0.5260.92
16_Q21_E0.5240.92
159_G186_N0.5210.92
89_L123_L0.5160.92
52_K59_V0.5160.92
73_E77_S0.5140.91
141_E163_V0.5130.91
63_F74_M0.5120.91
39_Q42_I0.5070.91
153_A186_N0.5050.91
137_A147_H0.5040.91
20_E28_Q0.5020.91
100_L116_M0.5010.90
19_I32_T0.5010.90
148_Q180_P0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aniA 2 0.8342 100 0.086 Contact Map
1dkgA 2 0.8075 100 0.086 Contact Map
3a6mA 2 0.8824 100 0.121 Contact Map
4rsiB 1 0.9305 62.2 0.919 Contact Map
3swyA 3 0.246 45.9 0.927 Contact Map
3he5A 1 0.2513 44.2 0.928 Contact Map
4etpB 1 0.7112 43.6 0.928 Contact Map
1i84S 2 0 38.1 0.93 Contact Map
3swfA 3 0.3155 35.5 0.931 Contact Map
3ojaB 1 0.3797 34.5 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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