GREMLIN Database
SACY - Levansucrase and sucrase synthesis operon antiterminator
UniProt: P15401 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (269)
Sequences: 3627 (3116)
Seq/√Len: 190.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_K146_H4.7701.00
83_E134_W4.3211.00
251_K257_E3.2751.00
189_Q245_S3.1131.00
233_K240_F3.0671.00
187_E193_N3.0551.00
229_I264_C3.0521.00
233_K260_E3.0091.00
105_E109_N2.9901.00
10_N13_V2.9731.00
239_A271_Q2.9251.00
181_D253_E2.6671.00
75_Q142_K2.6361.00
243_A267_A2.4951.00
186_I204_L2.4901.00
133_L152_I2.3601.00
14_V21_K2.3401.00
197_D276_R2.2761.00
185_I249_F2.2611.00
76_I135_A2.2051.00
99_H158_H2.2041.00
214_H262_E2.1301.00
79_H138_L2.1301.00
243_A263_L2.1041.00
218_G256_F2.0551.00
4_K15_K2.0461.00
7_L13_V1.9761.00
27_G31_N1.9621.00
244_L260_E1.9601.00
180_R201_Y1.9551.00
133_L149_D1.9531.00
247_G263_L1.9021.00
186_I270_I1.9011.00
239_A243_A1.8921.00
130_Q133_L1.8331.00
11_A14_V1.8221.00
80_A135_A1.7701.00
79_H134_W1.7591.00
11_A15_K1.7471.00
182_I246_I1.7321.00
207_H269_H1.7161.00
107_L147_I1.6921.00
190_L242_C1.6861.00
239_A270_I1.6841.00
186_I242_C1.6541.00
6_I33_K1.6531.00
184_E188_I1.6021.00
118_L153_G1.5971.00
241_L244_L1.5891.00
231_I235_K1.5771.00
136_R140_K1.5531.00
197_D273_F1.5521.00
212_I216_K1.5471.00
11_A16_D1.5441.00
66_P69_H1.5271.00
95_A158_H1.5261.00
248_T251_K1.5041.00
107_L148_P1.5031.00
232_I267_A1.4951.00
244_L263_L1.4781.00
247_G266_I1.4711.00
200_S276_R1.4461.00
243_A247_G1.4271.00
12_I15_K1.4121.00
132_G152_I1.4051.00
81_E88_I1.4051.00
226_A264_C1.4001.00
211_A215_I1.3851.00
200_S273_F1.3821.00
76_I80_A1.3791.00
183_I201_Y1.3731.00
229_I260_E1.3721.00
26_A29_A1.3711.00
80_A131_I1.3521.00
104_I108_S1.3431.00
225_D261_K1.3251.00
69_H73_S1.3211.00
72_I142_K1.2961.00
230_D234_E1.2941.00
227_E261_K1.2751.00
128_E156_A1.2751.00
69_H101_S1.2541.00
91_R95_A1.2531.00
32_K36_D1.2351.00
136_R152_I1.2261.00
194_I270_I1.2221.00
221_I265_Y1.2141.00
104_I147_I1.2131.00
77_I97_S1.2041.00
211_A259_P1.1851.00
10_N14_V1.1851.00
12_I16_D1.1841.00
148_P151_E1.1821.00
95_A99_H1.1811.00
186_I243_A1.1711.00
16_D19_E1.1571.00
177_T253_E1.1571.00
244_L248_T1.1481.00
194_I273_F1.1471.00
208_L211_A1.1351.00
240_F267_A1.1311.00
243_A270_I1.1271.00
132_G135_A1.1111.00
226_A261_K1.1091.00
45_K49_R1.0971.00
261_K264_C1.0931.00
181_D249_F1.0871.00
72_I143_L1.0821.00
129_F152_I1.0811.00
179_I205_V1.0761.00
132_G156_A1.0671.00
240_F260_E1.0661.00
137_A146_H1.0641.00
185_I188_I1.0641.00
240_F244_L1.0621.00
134_W138_L1.0541.00
129_F156_A1.0541.00
101_S105_E1.0441.00
13_V16_D1.0381.00
100_L155_I1.0351.00
243_A246_I1.0341.00
27_G30_F1.0321.00
100_L139_I1.0281.00
17_Q20_E1.0251.00
69_H72_I1.0231.00
93_H97_S1.0171.00
246_I249_F0.9970.99
84_L134_W0.9960.99
250_V254_Y0.9920.99
243_A266_I0.9870.99
246_I270_I0.9860.99
201_Y205_V0.9860.99
69_H104_I0.9860.99
264_C267_A0.9850.99
229_I240_F0.9830.99
79_H83_E0.9830.99
140_K143_L0.9760.99
56_K59_E0.9720.99
239_A267_A0.9700.99
73_S77_I0.9630.99
81_E84_L0.9630.99
39_D42_K0.9550.99
20_E27_G0.9550.99
211_A258_F0.9540.99
211_A214_H0.9530.99
129_F153_G0.9470.99
175_I212_I0.9320.99
92_I162_A0.9290.99
82_K85_N0.9280.99
127_K130_Q0.9260.99
134_W137_A0.9250.99
273_F276_R0.9250.99
27_G33_K0.9220.99
159_I163_R0.9220.99
112_V148_P0.9200.99
118_L154_N0.9190.99
80_A159_I0.9180.99
247_G258_F0.9140.99
182_I270_I0.9140.99
126_P129_F0.9140.99
249_F253_E0.9120.99
71_Q74_E0.9080.99
78_S93_H0.9070.99
140_K147_I0.9050.99
4_K16_D0.9040.99
76_I138_L0.8990.99
12_I29_A0.8940.99
71_Q75_Q0.8900.99
227_E231_I0.8870.99
72_I138_L0.8850.99
232_I264_C0.8830.99
27_G34_K0.8830.99
133_L137_A0.8750.99
179_I182_I0.8740.99
74_E94_V0.8730.99
187_E197_D0.8720.99
72_I76_I0.8720.99
182_I249_F0.8690.99
74_E93_H0.8640.99
181_D184_E0.8600.98
156_A160_H0.8600.98
186_I190_L0.8600.98
116_P157_M0.8580.98
10_N16_D0.8570.98
187_E194_I0.8540.98
74_E78_S0.8520.98
204_L266_I0.8520.98
190_L194_I0.8500.98
265_Y269_H0.8460.98
248_T252_K0.8430.98
179_I208_L0.8430.98
242_C246_I0.8430.98
178_M182_I0.8410.98
28_I35_N0.8410.98
185_I189_Q0.8400.98
31_N34_K0.8390.98
30_F35_N0.8360.98
26_A30_F0.8360.98
20_E45_K0.8360.98
135_A138_L0.8350.98
139_I147_I0.8330.98
212_I254_Y0.8330.98
129_F133_L0.8320.98
189_Q242_C0.8290.98
203_R272_R0.8270.98
10_N15_K0.8230.98
271_Q274_Y0.8200.98
138_L141_D0.8190.98
14_V23_L0.8180.98
136_R155_I0.8120.98
14_V22_I0.8110.98
16_D21_K0.8050.98
210_F213_Q0.8030.98
99_H103_A0.7990.98
203_R276_R0.7940.97
88_I159_I0.7920.97
172_T176_T0.7900.97
269_H272_R0.7850.97
151_E265_Y0.7800.97
207_H265_Y0.7740.97
136_R139_I0.7680.97
238_D241_L0.7670.97
238_D243_A0.7640.97
20_E35_N0.7620.97
113_I151_E0.7620.97
40_P46_T0.7600.97
215_I256_F0.7590.97
17_Q21_K0.7580.97
185_I246_I0.7550.97
199_I203_R0.7510.96
20_E31_N0.7470.96
27_G106_R0.7450.96
171_Q174_D0.7440.96
73_S100_L0.7410.96
226_A263_L0.7310.96
80_A138_L0.7300.96
106_R154_N0.7300.96
180_R184_E0.7250.96
240_F243_A0.7230.96
206_T210_F0.7230.96
162_A211_A0.7220.96
178_M254_Y0.7210.96
227_E235_K0.7170.95
209_R213_Q0.7150.95
251_K254_Y0.7150.95
135_A159_I0.7140.95
253_E256_F0.7140.95
103_A107_L0.7130.95
121_I153_G0.7110.95
250_V256_F0.7100.95
203_R273_F0.7040.95
6_I34_K0.7040.95
241_L245_S0.7040.95
17_Q22_I0.7010.95
65_L101_S0.6990.95
86_I268_M0.6960.95
108_S144_G0.6940.94
11_A25_G0.6930.94
239_A274_Y0.6920.94
272_R276_R0.6920.94
80_A134_W0.6870.94
183_I270_I0.6860.94
73_S97_S0.6810.94
240_F263_L0.6790.94
86_I163_R0.6770.94
29_A32_K0.6760.94
68_D142_K0.6750.94
176_T205_V0.6730.94
227_E264_C0.6730.94
178_M208_L0.6710.93
30_F33_K0.6700.93
42_K46_T0.6700.93
73_S76_I0.6680.93
213_Q217_A0.6670.93
78_S82_K0.6630.93
179_I183_I0.6610.93
33_K37_I0.6580.93
105_E108_S0.6550.93
236_F271_Q0.6520.92
190_L193_N0.6500.92
132_G159_I0.6500.92
229_I233_K0.6490.92
89_N163_R0.6480.92
107_L151_E0.6470.92
203_R269_H0.6440.92
91_R162_A0.6430.92
226_A230_D0.6390.92
108_S137_A0.6380.92
190_L246_I0.6380.92
197_D275_Q0.6380.92
54_D57_Q0.6350.91
139_I143_L0.6340.91
231_I236_F0.6330.91
242_C270_I0.6320.91
115_N153_G0.6280.91
67_E71_Q0.6260.91
169_M172_T0.6250.91
161_T210_F0.6230.91
88_I92_I0.6210.91
200_S204_L0.6200.90
16_D20_E0.6190.90
120_E153_G0.6160.90
120_E149_D0.6160.90
231_I234_E0.6140.90
155_I158_H0.6120.90
84_L128_E0.6100.90
233_K264_C0.6090.90
227_E232_I0.6080.90
129_F149_D0.6080.90
137_A141_D0.6080.90
78_S81_E0.6070.90
183_I200_S0.6040.89
80_A84_L0.6040.89
176_T201_Y0.5970.89
184_E195_V0.5960.89
99_H151_E0.5950.89
132_G155_I0.5930.88
99_H203_R0.5920.88
250_V258_F0.5910.88
165_N266_I0.5890.88
119_N123_V0.5880.88
232_I268_M0.5870.88
115_N121_I0.5850.88
214_H221_I0.5850.88
150_D153_G0.5850.88
35_N38_V0.5850.88
115_N120_E0.5830.88
107_L112_V0.5820.88
204_L273_F0.5810.87
84_L88_I0.5800.87
115_N150_D0.5790.87
69_H108_S0.5790.87
106_R151_E0.5780.87
228_M231_I0.5760.87
31_N35_N0.5740.87
84_L131_I0.5730.87
10_N29_A0.5730.87
92_I211_A0.5730.87
104_I139_I0.5720.87
185_I245_S0.5690.86
15_K24_L0.5690.86
86_I127_K0.5690.86
175_I205_V0.5680.86
229_I261_K0.5650.86
158_H210_F0.5650.86
20_E34_K0.5630.86
126_P156_A0.5620.86
212_I256_F0.5600.85
199_I204_L0.5570.85
183_I186_I0.5540.85
75_Q79_H0.5530.85
19_E264_C0.5530.85
133_L146_H0.5510.85
182_I204_L0.5510.85
244_L247_G0.5500.84
232_I263_L0.5500.84
103_A148_P0.5480.84
25_G31_N0.5470.84
215_I259_P0.5470.84
129_F160_H0.5420.84
240_F271_Q0.5420.84
80_A132_G0.5410.83
77_I135_A0.5400.83
158_H161_T0.5380.83
76_I139_I0.5370.83
22_I27_G0.5360.83
50_K90_E0.5340.83
76_I79_H0.5320.82
11_A29_A0.5310.82
33_K36_D0.5310.82
19_E70_I0.5310.82
271_Q275_Q0.5310.82
183_I187_E0.5290.82
79_H131_I0.5290.82
152_I156_A0.5290.82
117_L120_E0.5280.82
15_K40_P0.5280.82
36_D40_P0.5280.82
221_I261_K0.5270.82
114_K150_D0.5270.82
137_A140_K0.5260.82
199_I210_F0.5260.82
131_I159_I0.5240.82
104_I145_I0.5230.81
73_S139_I0.5190.81
179_I201_Y0.5170.81
88_I163_R0.5170.81
20_E33_K0.5160.81
210_F217_A0.5150.80
92_I97_S0.5150.80
233_K236_F0.5140.80
77_I92_I0.5130.80
187_E192_I0.5120.80
138_L142_K0.5110.80
182_I243_A0.5100.80
229_I275_Q0.5100.80
209_R271_Q0.5090.80
236_F265_Y0.5070.79
187_E195_V0.5060.79
269_H276_R0.5050.79
241_L248_T0.5050.79
215_I262_E0.5040.79
186_I189_Q0.5020.79
25_G30_F0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6iA 2 0.9107 100 0.333 Contact Map
1h99A 2 0.7821 100 0.335 Contact Map
3sqnA 2 0.8893 100 0.442 Contact Map
3rioA 1 0.5893 99.9 0.595 Contact Map
3ufeA 2 0.3821 99.7 0.656 Contact Map
3nufA 2 0.4214 89.5 0.904 Contact Map
1auuA 2 0.1964 84.6 0.911 Contact Map
1l1cA 2 0.1929 84.1 0.912 Contact Map
1wwpA 2 0.2607 5 0.958 Contact Map
1wtyA 4 0.2643 4.9 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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