SACX - BACSU - GREMLIN Contacts

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SACX - Negative regulator of SacY activity

UniProt:	P15400	Sequences: MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAIENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAAAFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLPILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQGSMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQIMTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIWSMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAAIGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATLFLGFKEETE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	459 (360)
Sequences:	4552 (2589)
Seq/√Len:	136.4

ECOLI - PTV3B PTTBC PTIBC PTYBC PTGCB PTOCB
BACSU - SACX PTSBC PTV3B PTTBC PTXBC PTWCB PTOCB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
401_Y	440_I	4.017	1.00
394_G	444_S	3.818	1.00
298_G	396_A	3.767	1.00
226_S	262_A	3.650	1.00
347_A	446_F	3.392	1.00
230_M	254_T	3.271	1.00
253_I	257_V	3.258	1.00
401_Y	433_H	2.961	1.00
164_G	178_G	2.826	1.00
397_I	444_S	2.642	1.00
341_Q	381_N	2.513	1.00
390_G	452_L	2.501	1.00
98_L	103_A	2.498	1.00
241_V	249_I	2.490	1.00
351_K	453_G	2.483	1.00
435_M	439_L	2.477	1.00
401_Y	405_V	2.381	1.00
449_T	453_G	2.369	1.00
350_L	449_T	2.359	1.00
389_I	393_I	2.355	1.00
165_F	179_A	2.341	1.00
165_F	175_P	2.292	1.00
343_G	441_A	2.266	1.00
128_L	132_I	2.246	1.00
283_Y	287_H	2.226	1.00
236_L	240_I	2.226	1.00
345_G	376_I	2.206	1.00
405_V	433_H	2.199	1.00
238_K	246_D	2.173	1.00
319_L	328_N	2.164	1.00
229_V	261_L	2.125	1.00
352_T	357_L	2.075	1.00
161_I	183_G	2.066	1.00
237_L	253_I	2.063	1.00
447_I	451_F	2.024	1.00
297_G	395_G	1.957	1.00
272_I	276_I	1.934	1.00
349_F	362_L	1.894	1.00
132_I	137_W	1.875	1.00
294_A	400_A	1.852	1.00
343_G	445_A	1.846	1.00
350_L	445_A	1.845	1.00
354_Q	357_L	1.838	1.00
232_K	235_K	1.829	1.00
390_G	394_G	1.805	1.00
107_T	171_F	1.792	1.00
433_H	436_I	1.789	1.00
126_M	153_S	1.788	1.00
402_V	437_G	1.775	1.00
245_L	249_I	1.771	1.00
342_G	368_A	1.768	1.00
390_G	448_A	1.761	1.00
275_Q	279_Q	1.745	1.00
153_S	157_I	1.732	1.00
448_A	452_L	1.730	1.00
377_V	388_F	1.718	1.00
302_T	392_A	1.693	1.00
161_I	179_A	1.692	1.00
343_G	442_A	1.691	1.00
400_A	404_A	1.688	1.00
384_L	387_P	1.686	1.00
225_L	270_A	1.685	1.00
443_V	447_I	1.682	1.00
444_S	448_A	1.679	1.00
237_L	241_V	1.645	1.00
232_K	236_L	1.639	1.00
173_S	227_V	1.632	1.00
228_F	231_S	1.623	1.00
348_V	361_A	1.616	1.00
233_I	258_T	1.614	1.00
298_G	302_T	1.613	1.00
346_L	365_S	1.608	1.00
100_P	103_A	1.565	1.00
322_N	325_V	1.562	1.00
169_R	175_P	1.561	1.00
327_V	408_V	1.539	1.00
293_G	399_G	1.528	1.00
280_S	283_Y	1.514	1.00
297_G	399_G	1.504	1.00
294_A	396_A	1.498	1.00
228_F	232_K	1.495	1.00
249_I	253_I	1.480	1.00
182_A	254_T	1.471	1.00
106_K	170_Q	1.461	1.00
229_V	258_T	1.458	1.00
357_L	384_L	1.435	1.00
168_A	227_V	1.435	1.00
165_F	176_Y	1.418	1.00
434_Y	438_F	1.412	1.00
394_G	447_I	1.409	1.00
343_G	347_A	1.403	1.00
258_T	262_A	1.398	1.00
386_R	455_K	1.393	1.00
290_I	400_A	1.392	1.00
167_A	228_F	1.387	1.00
233_I	257_V	1.387	1.00
354_Q	358_K	1.376	1.00
276_I	280_S	1.376	1.00
446_F	450_L	1.371	1.00
346_L	350_L	1.366	1.00
318_T	322_N	1.361	1.00
348_V	352_T	1.352	1.00
100_P	104_F	1.344	1.00
384_L	454_F	1.338	1.00
282_V	286_D	1.303	1.00
124_L	252_F	1.302	1.00
397_I	440_I	1.283	1.00
300_Y	333_I	1.260	1.00
365_S	369_F	1.257	1.00
166_S	176_Y	1.253	1.00
293_G	403_V	1.248	1.00
165_F	180_V	1.239	1.00
178_G	182_A	1.239	1.00
401_Y	437_G	1.239	1.00
246_D	250_I	1.238	1.00
401_Y	436_I	1.237	1.00
301_S	338_N	1.235	1.00
125_L	152_S	1.234	1.00
394_G	445_A	1.227	1.00
398_G	440_I	1.226	1.00
335_S	434_Y	1.225	1.00
151_V	259_G	1.222	1.00
147_M	211_I	1.218	1.00
293_G	400_A	1.213	1.00
237_L	250_I	1.205	1.00
273_I	276_I	1.200	1.00
432_V	435_M	1.196	1.00
229_V	266_M	1.191	1.00
277_M	303_I	1.190	1.00
402_V	407_V	1.189	1.00
290_I	404_A	1.184	0.99
298_G	389_I	1.173	0.99
181_I	255_V	1.171	0.99
163_V	220_M	1.168	0.99
122_S	155_A	1.160	0.99
221_I	225_L	1.156	0.99
276_I	279_Q	1.155	0.99
377_V	391_A	1.152	0.99
336_M	395_G	1.150	0.99
112_F	220_M	1.148	0.99
168_A	175_P	1.143	0.99
168_A	178_G	1.130	0.99
303_I	312_F	1.130	0.99
351_K	449_T	1.123	0.99
363_P	367_T	1.113	0.99
347_A	450_L	1.113	0.99
129_I	145_I	1.108	0.99
115_I	166_S	1.097	0.99
438_F	442_A	1.094	0.99
340_A	391_A	1.085	0.99
386_R	453_G	1.082	0.99
336_M	402_V	1.077	0.99
231_S	235_K	1.074	0.99
265_V	269_A	1.067	0.99
184_L	259_G	1.060	0.99
173_S	230_M	1.059	0.99
394_G	398_G	1.057	0.99
227_V	231_S	1.048	0.99
168_A	173_S	1.048	0.99
381_N	387_P	1.042	0.99
420_I	435_M	1.034	0.99
294_A	397_I	1.033	0.99
393_I	448_A	1.031	0.99
401_Y	404_A	1.030	0.99
340_A	344_A	1.029	0.99
181_I	223_I	1.028	0.99
351_K	454_F	1.023	0.99
350_L	446_F	1.022	0.99
233_I	237_L	1.020	0.98
349_F	361_A	1.017	0.98
226_S	258_T	1.014	0.98
270_A	274_G	1.014	0.98
96_R	100_P	1.009	0.98
281_I	329_F	1.008	0.98
172_G	235_K	1.008	0.98
390_G	447_I	1.007	0.98
182_A	223_I	1.007	0.98
174_N	234_E	1.000	0.98
439_L	443_V	0.997	0.98
398_G	441_A	0.995	0.98
171_F	228_F	0.994	0.98
110_D	170_Q	0.994	0.98
154_T	183_G	0.990	0.98
158_L	188_P	0.990	0.98
139_A	142_S	0.987	0.98
438_F	441_A	0.986	0.98
298_G	392_A	0.985	0.98
167_A	224_L	0.985	0.98
123_G	412_Y	0.983	0.98
242_P	245_L	0.977	0.98
96_R	99_N	0.973	0.98
241_V	245_L	0.971	0.98
413_G	422_I	0.970	0.98
180_V	184_L	0.970	0.98
341_Q	391_A	0.970	0.98
391_A	444_S	0.968	0.98
164_G	223_I	0.967	0.98
288_A	291_A	0.966	0.98
161_I	180_V	0.962	0.98
350_L	453_G	0.957	0.98
335_S	419_M	0.951	0.98
432_V	436_I	0.950	0.98
115_I	159_L	0.948	0.98
163_V	223_I	0.947	0.98
107_T	111_I	0.947	0.98
236_L	239_S	0.947	0.98
450_L	454_F	0.942	0.97
181_I	258_T	0.936	0.97
312_F	316_E	0.935	0.97
344_A	381_N	0.927	0.97
243_K	246_D	0.926	0.97
357_L	380_V	0.926	0.97
369_F	417_I	0.923	0.97
430_N	433_H	0.918	0.97
226_S	261_L	0.915	0.97
257_V	260_C	0.913	0.97
269_A	273_I	0.913	0.97
146_K	149_D	0.910	0.97
339_V	342_G	0.907	0.97
144_W	147_M	0.904	0.97
186_T	217_Q	0.904	0.97
344_A	391_A	0.902	0.97
173_S	178_G	0.902	0.97
296_F	331_V	0.901	0.97
329_F	332_P	0.899	0.97
126_M	156_F	0.897	0.97
302_T	388_F	0.894	0.97
240_I	249_I	0.891	0.96
129_I	152_S	0.889	0.96
266_M	270_A	0.889	0.96
440_I	443_V	0.882	0.96
216_Y	222_P	0.882	0.96
221_I	270_A	0.879	0.96
387_P	390_G	0.878	0.96
130_G	149_D	0.878	0.96
405_V	436_I	0.877	0.96
349_F	358_K	0.876	0.96
279_Q	282_V	0.871	0.96
101_A	104_F	0.871	0.96
97_K	103_A	0.869	0.96
450_L	453_G	0.863	0.96
260_C	265_V	0.863	0.96
357_L	456_E	0.862	0.96
238_K	250_I	0.860	0.96
390_G	451_F	0.856	0.96
440_I	444_S	0.855	0.96
421_S	425_P	0.854	0.95
341_Q	376_I	0.853	0.95
390_G	449_T	0.852	0.95
155_A	162_L	0.850	0.95
442_A	445_A	0.848	0.95
368_A	373_V	0.848	0.95
93_K	96_R	0.847	0.95
200_T	203_S	0.846	0.95
261_L	266_M	0.845	0.95
407_V	437_G	0.841	0.95
256_M	260_C	0.837	0.95
381_N	391_A	0.837	0.95
373_V	376_I	0.837	0.95
381_N	388_F	0.836	0.95
164_G	227_V	0.833	0.95
225_L	266_M	0.831	0.95
164_G	182_A	0.831	0.95
165_F	169_R	0.830	0.95
263_L	268_P	0.829	0.95
104_F	107_T	0.826	0.95
272_I	275_Q	0.826	0.95
162_L	180_V	0.824	0.95
229_V	233_I	0.822	0.94
325_V	329_F	0.821	0.94
96_R	103_A	0.821	0.94
106_K	110_D	0.819	0.94
223_I	227_V	0.816	0.94
387_P	449_T	0.816	0.94
111_I	224_L	0.816	0.94
151_V	184_L	0.807	0.94
171_F	231_S	0.806	0.94
107_T	228_F	0.805	0.94
162_L	183_G	0.805	0.94
241_V	250_I	0.797	0.94
191_L	195_M	0.797	0.94
441_A	445_A	0.797	0.94
337_A	341_Q	0.796	0.93
442_A	446_F	0.793	0.93
405_V	440_I	0.789	0.93
397_I	401_Y	0.788	0.93
239_S	353_K	0.785	0.93
206_I	210_H	0.785	0.93
351_K	450_L	0.784	0.93
348_V	380_V	0.783	0.93
131_M	135_F	0.780	0.93
358_K	362_L	0.779	0.93
173_S	234_E	0.778	0.93
365_S	368_A	0.777	0.93
95_S	103_A	0.775	0.93
302_T	306_S	0.775	0.93
279_Q	283_Y	0.774	0.92
229_V	232_K	0.773	0.92
167_A	171_F	0.772	0.92
117_P	120_T	0.772	0.92
261_L	265_V	0.771	0.92
144_W	206_I	0.767	0.92
451_F	455_K	0.766	0.92
142_S	146_K	0.764	0.92
360_I	364_A	0.759	0.92
135_F	138_F	0.758	0.92
122_S	154_T	0.758	0.92
195_M	198_S	0.756	0.92
132_I	138_F	0.754	0.91
352_T	456_E	0.754	0.91
299_I	302_T	0.754	0.91
290_I	294_A	0.754	0.91
348_V	387_P	0.754	0.91
341_Q	344_A	0.750	0.91
113_V	310_H	0.748	0.91
439_L	447_I	0.748	0.91
172_G	234_E	0.748	0.91
343_G	369_F	0.747	0.91
154_T	184_L	0.746	0.91
164_G	179_A	0.745	0.91
304_V	337_A	0.744	0.91
424_L	430_N	0.741	0.91
269_A	272_I	0.740	0.91
177_L	230_M	0.738	0.91
407_V	433_H	0.737	0.91
299_I	312_F	0.733	0.90
306_S	378_F	0.731	0.90
301_S	377_V	0.731	0.90
293_G	333_I	0.729	0.90
289_G	292_A	0.729	0.90
318_T	321_A	0.728	0.90
445_A	453_G	0.726	0.90
283_Y	289_G	0.725	0.90
172_G	178_G	0.723	0.90
339_V	438_F	0.722	0.90
192_D	195_M	0.721	0.90
245_L	370_L	0.711	0.89
386_R	454_F	0.703	0.88
205_D	209_L	0.702	0.88
131_M	137_W	0.698	0.88
153_S	187_H	0.696	0.88
355_S	358_K	0.696	0.88
335_S	402_V	0.695	0.88
344_A	387_P	0.695	0.88
274_G	308_L	0.694	0.88
389_I	392_A	0.694	0.88
146_K	150_L	0.691	0.88
417_I	421_S	0.690	0.87
254_T	258_T	0.688	0.87
294_A	298_G	0.684	0.87
296_F	312_F	0.684	0.87
341_Q	368_A	0.683	0.87
221_I	305_L	0.683	0.87
193_P	204_L	0.681	0.87
362_L	365_S	0.680	0.87
133_K	145_I	0.679	0.87
340_A	394_G	0.679	0.87
293_G	297_G	0.677	0.86
406_Q	429_A	0.677	0.86
295_L	299_I	0.676	0.86
425_P	430_N	0.676	0.86
182_A	230_M	0.676	0.86
234_E	250_I	0.675	0.86
344_A	449_T	0.675	0.86
337_A	340_A	0.675	0.86
161_I	182_A	0.675	0.86
452_L	456_E	0.675	0.86
190_L	194_S	0.672	0.86
354_Q	456_E	0.672	0.86
364_A	367_T	0.671	0.86
131_M	134_V	0.670	0.86
336_M	398_G	0.669	0.86
394_G	448_A	0.668	0.86
301_S	337_A	0.668	0.86
159_L	220_M	0.668	0.86
321_A	325_V	0.666	0.86
295_L	298_G	0.665	0.85
297_G	396_A	0.665	0.85
99_N	102_A	0.663	0.85
393_I	396_A	0.663	0.85
95_S	98_L	0.662	0.85
299_I	392_A	0.660	0.85
339_V	437_G	0.660	0.85
345_G	365_S	0.660	0.85
397_I	400_A	0.658	0.85
241_V	253_I	0.657	0.85
407_V	415_T	0.656	0.85
415_T	419_M	0.655	0.85
149_D	153_S	0.653	0.84
411_S	422_I	0.645	0.84
122_S	159_L	0.644	0.84
345_G	349_F	0.643	0.84
383_K	387_P	0.641	0.83
311_S	314_A	0.641	0.83
380_V	384_L	0.636	0.83
233_I	254_T	0.633	0.83
296_F	303_I	0.632	0.82
342_G	345_G	0.630	0.82
133_K	149_D	0.629	0.82
348_V	357_L	0.628	0.82
339_V	416_G	0.628	0.82
271_S	275_Q	0.625	0.82
336_M	340_A	0.625	0.82
247_V	250_I	0.625	0.82
257_V	261_L	0.625	0.82
407_V	431_F	0.621	0.81
434_Y	439_L	0.621	0.81
399_G	403_V	0.617	0.81
227_V	230_M	0.617	0.81
388_F	391_A	0.617	0.81
429_A	432_V	0.616	0.81
338_N	373_V	0.616	0.81
394_G	397_I	0.615	0.81
344_A	348_V	0.612	0.80
317_A	321_A	0.612	0.80
386_R	390_G	0.608	0.80
370_L	418_P	0.607	0.80
104_F	110_D	0.606	0.80
135_F	139_A	0.605	0.80
278_T	312_F	0.605	0.80
162_L	179_A	0.603	0.79
283_Y	286_D	0.602	0.79
361_A	365_S	0.600	0.79
346_L	446_F	0.599	0.79
287_H	291_A	0.598	0.79
111_I	167_A	0.597	0.79
124_L	127_G	0.595	0.79
288_A	292_A	0.594	0.78
133_K	137_W	0.594	0.78
126_M	157_I	0.593	0.78
345_G	361_A	0.592	0.78
243_K	356_S	0.592	0.78
348_V	351_K	0.591	0.78
346_L	349_F	0.590	0.78
356_S	360_I	0.588	0.78
108_L	306_S	0.587	0.78
299_I	303_I	0.587	0.78
347_A	449_T	0.587	0.78
351_K	386_R	0.587	0.78
178_G	227_V	0.587	0.78
237_L	240_I	0.585	0.77
119_I	310_H	0.583	0.77
362_L	366_L	0.581	0.77
386_R	389_I	0.581	0.77
450_L	455_K	0.581	0.77
116_I	416_G	0.580	0.77
234_E	238_K	0.580	0.77
351_K	456_E	0.579	0.77
105_A	382_L	0.579	0.77
168_A	230_M	0.578	0.77
233_I	253_I	0.577	0.76
129_I	149_D	0.575	0.76
225_L	228_F	0.575	0.76
325_V	330_L	0.574	0.76
341_Q	373_V	0.572	0.76
433_H	440_I	0.572	0.76
326_G	330_L	0.572	0.76
337_A	415_T	0.571	0.76
359_K	363_P	0.571	0.76
446_F	449_T	0.568	0.75
181_I	226_S	0.568	0.75
301_S	388_F	0.568	0.75
410_N	424_L	0.567	0.75
348_V	384_L	0.567	0.75
317_A	412_Y	0.567	0.75
294_A	297_G	0.565	0.75
424_L	431_F	0.565	0.75
196_L	199_K	0.563	0.75
415_T	422_I	0.563	0.75
127_G	293_G	0.562	0.75
156_F	159_L	0.558	0.74
326_G	329_F	0.557	0.74
338_N	365_S	0.557	0.74
427_G	430_N	0.555	0.74
336_M	441_A	0.555	0.74
118_A	177_L	0.555	0.74
121_A	255_V	0.555	0.74
313_Y	316_E	0.554	0.74
150_L	187_H	0.553	0.73
252_F	255_V	0.552	0.73
418_P	421_S	0.552	0.73
345_G	381_N	0.552	0.73
357_L	454_F	0.552	0.73
301_S	373_V	0.551	0.73
435_M	438_F	0.551	0.73
420_I	424_L	0.551	0.73
190_L	263_L	0.550	0.73
205_D	208_G	0.550	0.73
298_G	306_S	0.546	0.72
123_G	314_A	0.546	0.72
157_I	188_P	0.544	0.72
203_S	212_P	0.544	0.72
212_P	271_S	0.542	0.72
118_A	180_V	0.541	0.72
112_F	314_A	0.540	0.72
127_G	416_G	0.538	0.71
157_I	217_Q	0.537	0.71
296_F	333_I	0.537	0.71
173_S	254_T	0.537	0.71
367_T	376_I	0.537	0.71
395_G	399_G	0.536	0.71
387_P	391_A	0.535	0.71
154_T	187_H	0.535	0.71
104_F	108_L	0.534	0.71
201_P	204_L	0.533	0.71
416_G	419_M	0.530	0.70
297_G	333_I	0.527	0.70
342_G	365_S	0.526	0.70
206_I	209_L	0.526	0.70
128_L	131_M	0.525	0.70
116_I	371_G	0.525	0.70
123_G	367_T	0.523	0.69
172_G	175_P	0.523	0.69
338_N	391_A	0.522	0.69
109_S	310_H	0.519	0.69
125_L	252_F	0.518	0.68
337_A	391_A	0.518	0.68
308_L	315_I	0.516	0.68
94_A	103_A	0.513	0.68
337_A	398_G	0.513	0.68
133_K	138_F	0.513	0.68
175_P	227_V	0.512	0.68
206_I	211_I	0.511	0.67
133_K	140_A	0.510	0.67
216_Y	274_G	0.510	0.67
281_I	315_I	0.509	0.67
141_G	146_K	0.508	0.67
229_V	257_V	0.508	0.67
212_P	215_G	0.507	0.67
127_G	388_F	0.507	0.67
108_L	119_I	0.505	0.67
337_A	373_V	0.505	0.67
202_S	205_D	0.504	0.66
301_S	341_Q	0.504	0.66
123_G	127_G	0.504	0.66
119_I	455_K	0.504	0.66
304_V	341_Q	0.502	0.66
357_L	361_A	0.502	0.66
226_S	230_M	0.502	0.66
221_I	277_M	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qnqA	2	0.8061	100	0.648	Contact Map
3ipjA	1	0.1983	100	0.789	Contact Map
1ibaA	1	0.1678	100	0.794	Contact Map
3bp3A	1	0.1743	100	0.794	Contact Map
4bxoA	1	0.1176	53	0.971	Contact Map
1kftA	1	0.1024	39.1	0.973	Contact Map
4n8nA	1	0.1046	33.4	0.974	Contact Map
2a1jB	2	0.1133	31.7	0.975	Contact Map
3noyA	2	0.183	30.1	0.975	Contact Map
1x2iA	2	0.1111	27.5	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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