GREMLIN Database
LEP4 - Type 4 prepilin-like proteins leader peptide-processing enzyme
UniProt: P15378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (234)
Sequences: 2635 (2093)
Seq/√Len: 136.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E62_K5.0501.00
71_M115_H4.5551.00
33_R42_T3.6431.00
127_F178_V3.0881.00
109_V119_I2.9941.00
83_F104_S2.7421.00
20_G111_V2.7071.00
6_F80_A2.6451.00
179_I191_A2.6241.00
47_E63_S2.5441.00
105_L123_I2.4801.00
41_R47_E2.4181.00
41_R63_S2.4021.00
170_G173_I2.3791.00
12_L16_Y2.3541.00
121_N174_K2.3441.00
6_F84_A2.2781.00
5_L87_G2.2631.00
103_I229_I2.2461.00
110_A225_A2.1361.00
10_L51_I2.0861.00
200_A203_G2.0641.00
96_L100_V2.0191.00
54_F70_F2.0171.00
86_A96_L1.9921.00
98_P134_A1.9831.00
47_E57_Q1.9551.00
79_T107_I1.8851.00
143_W147_L1.8751.00
79_T83_F1.8261.00
38_F66_H1.7961.00
52_L56_F1.7521.00
86_A103_I1.7521.00
27_L35_S1.7431.00
28_S32_P1.7381.00
179_I228_S1.7311.00
5_L84_A1.6931.00
29_I32_P1.6751.00
202_Y223_A1.6741.00
44_T47_E1.6631.00
10_L80_A1.6401.00
43_L63_S1.6181.00
43_L48_L1.6101.00
131_L182_V1.6081.00
106_L225_A1.6061.00
82_L103_I1.6021.00
191_A227_G1.5991.00
70_F74_A1.5971.00
198_I230_L1.5931.00
83_F100_V1.5851.00
16_Y108_I1.5721.00
87_G96_L1.5361.00
44_T62_K1.5341.00
19_A23_I1.5331.00
227_G231_A1.5221.00
119_I221_A1.5161.00
119_I124_L1.5011.00
99_A232_Y1.4951.00
58_K65_G1.4801.00
150_A181_F1.4631.00
78_V111_V1.4491.00
101_V130_F1.4481.00
41_R44_T1.4321.00
6_F10_L1.4291.00
51_I77_L1.4161.00
212_L216_Q1.3951.00
161_A166_G1.3561.00
9_G80_A1.3561.00
161_A170_G1.3551.00
195_S224_I1.3121.00
120_P174_K1.3061.00
79_T104_S1.2741.00
187_M191_A1.2661.00
213_A216_Q1.2631.00
84_A88_I1.2571.00
14_S34_S1.2561.00
71_M111_V1.2491.00
82_L107_I1.2471.00
49_I53_S1.2401.00
149_G180_G1.2281.00
39_C64_C1.2221.00
117_M217_P1.2201.00
196_V200_A1.2141.00
44_T63_S1.2081.00
176_F191_A1.2021.00
103_I233_L1.1891.00
20_G75_A1.1891.00
111_V115_H1.1841.00
9_G83_F1.1760.99
187_M231_A1.1720.99
75_A111_V1.1690.99
153_G188_L1.1650.99
176_F224_I1.1640.99
36_C39_C1.1520.99
148_L152_A1.1510.99
120_P123_I1.1500.99
198_I223_A1.1480.99
69_S72_Y1.1430.99
35_S40_R1.1250.99
119_I175_L1.1230.99
102_F228_S1.1160.99
37_P68_I1.1140.99
142_S145_A1.0930.99
149_G153_G1.0870.99
161_A173_I1.0720.99
37_P72_Y1.0650.99
4_I8_F1.0570.99
35_S43_L1.0540.99
17_Y20_G1.0540.99
136_L148_L1.0470.99
48_L57_Q1.0410.99
36_C64_C1.0300.99
158_A162_A1.0260.99
159_V163_I1.0150.98
86_A99_A1.0110.98
159_V162_A1.0070.98
90_F99_A1.0020.98
109_V123_I1.0000.98
74_A78_V1.0000.98
19_A108_I0.9970.98
33_R44_T0.9950.98
154_F158_A0.9910.98
16_Y104_S0.9830.98
200_A204_A0.9490.98
194_F227_G0.9390.97
24_P112_T0.9360.97
7_I11_I0.9360.97
102_F179_I0.9330.97
46_A56_F0.9330.97
175_L221_A0.9310.97
90_F93_S0.9300.97
61_C64_C0.9180.97
20_G112_T0.9100.97
204_A208_L0.9070.97
117_M219_P0.9060.97
229_I233_L0.8970.97
69_S73_P0.8940.97
105_L127_F0.8920.97
36_C61_C0.8920.97
157_L192_F0.8770.96
170_G174_K0.8760.96
90_F96_L0.8720.96
192_F196_V0.8680.96
109_V124_L0.8650.96
200_A207_V0.8630.96
39_C61_C0.8620.96
199_G203_G0.8620.96
135_R146_G0.8590.96
5_L100_V0.8580.96
145_A186_K0.8540.96
13_G79_T0.8500.95
82_L229_I0.8440.95
51_I73_P0.8390.95
47_E53_S0.8360.95
206_A210_G0.8350.95
80_A84_A0.8330.95
131_L178_V0.8320.95
10_L73_P0.8280.95
108_I123_I0.8280.95
124_L178_V0.8260.95
191_A195_S0.8250.95
195_S220_F0.8240.95
193_F196_V0.8180.94
107_I111_V0.8160.94
183_L187_M0.8140.94
157_L161_A0.8140.94
183_L231_A0.8130.94
169_G172_D0.8120.94
198_I226_A0.8110.94
207_V210_G0.8070.94
230_L234_Y0.8060.94
45_P48_L0.8060.94
118_L174_K0.8030.94
150_A177_A0.8020.94
71_M75_A0.7980.94
93_S96_L0.7980.94
199_G223_A0.7860.93
102_F182_V0.7820.93
18_T24_P0.7780.93
46_A62_K0.7770.93
153_G180_G0.7770.93
157_L173_I0.7770.93
43_L47_E0.7770.93
121_N124_L0.7770.93
190_A231_A0.7710.92
151_A154_F0.7660.92
191_A228_S0.7590.92
85_A233_L0.7580.92
17_Y75_A0.7540.92
168_V196_V0.7540.92
158_A173_I0.7530.91
14_S76_E0.7520.91
135_R140_L0.7500.91
21_C25_L0.7500.91
20_G108_I0.7440.91
106_L175_L0.7380.91
17_Y72_Y0.7370.91
103_I232_Y0.7350.90
121_N125_I0.7240.90
24_P116_F0.7220.90
205_A208_L0.7210.90
191_A231_A0.7140.89
53_S57_Q0.7130.89
195_S227_G0.7130.89
41_R62_K0.7120.89
176_F196_V0.7110.89
157_L167_G0.7100.89
149_G184_G0.7100.89
9_G13_G0.7080.89
34_S76_E0.7080.89
207_V212_L0.7070.89
152_A155_L0.7060.89
42_T47_E0.7050.89
135_R181_F0.7040.89
210_G213_A0.7030.88
34_S39_C0.6980.88
125_I129_P0.6930.88
54_F59_G0.6910.88
64_C76_E0.6880.87
12_L104_S0.6870.87
49_I56_F0.6840.87
98_P182_V0.6810.87
16_Y107_I0.6800.87
15_F34_S0.6790.87
135_R142_S0.6750.86
183_L191_A0.6740.86
73_P77_L0.6650.86
43_L52_L0.6610.85
154_F173_I0.6590.85
156_F160_I0.6570.85
133_A151_A0.6560.85
113_D171_G0.6560.85
82_L86_A0.6520.84
113_D172_D0.6510.84
16_Y79_T0.6510.84
78_V107_I0.6500.84
89_R92_I0.6480.84
211_R214_K0.6470.84
21_C37_P0.6470.84
134_A138_S0.6440.84
83_F86_A0.6430.84
157_L224_I0.6430.84
146_G181_F0.6400.83
145_A185_V0.6400.83
162_A170_G0.6400.83
150_A154_F0.6390.83
50_P76_E0.6380.83
168_V220_F0.6360.83
200_A206_A0.6340.83
112_T116_F0.6310.82
157_L176_F0.6260.82
22_R32_P0.6240.82
17_Y21_C0.6220.82
164_T167_G0.6220.82
34_S50_P0.6210.81
148_L185_V0.6210.81
68_I76_E0.6200.81
109_V120_P0.6200.81
49_I52_L0.6120.81
113_D169_G0.6080.80
122_R126_F0.6040.80
210_G216_Q0.5990.79
25_L115_H0.5980.79
225_A228_S0.5970.79
158_A170_G0.5950.79
118_L121_N0.5950.79
33_R45_P0.5940.79
175_L225_A0.5940.79
109_V221_A0.5910.78
135_R143_W0.5900.78
86_A233_L0.5890.78
127_F154_F0.5880.78
124_L181_F0.5860.78
208_L211_R0.5840.77
126_F130_F0.5830.77
103_I107_I0.5810.77
70_F73_P0.5800.77
57_Q62_K0.5780.77
133_A137_I0.5760.76
34_S68_I0.5740.76
117_M218_L0.5730.76
106_L179_I0.5720.76
149_G185_V0.5710.76
205_A209_T0.5680.75
85_A229_I0.5670.75
6_F77_L0.5660.75
81_C85_A0.5640.75
191_A224_I0.5620.75
14_S18_T0.5620.75
67_R70_F0.5590.74
102_F224_I0.5580.74
180_G184_G0.5550.74
98_P102_F0.5540.74
200_A223_A0.5540.74
112_T115_H0.5540.74
85_A234_Y0.5530.73
50_P64_C0.5530.73
99_A140_L0.5500.73
174_K222_P0.5500.73
206_A212_L0.5490.73
183_L232_Y0.5480.73
5_L83_F0.5470.73
91_G96_L0.5440.72
112_T131_L0.5430.72
11_I53_S0.5420.72
112_T120_P0.5400.72
112_T222_P0.5370.71
119_I171_G0.5360.71
194_F198_I0.5360.71
166_G215_R0.5340.71
128_L177_A0.5340.71
141_D145_A0.5330.71
10_L77_L0.5320.71
50_P53_S0.5310.70
14_S68_I0.5310.70
211_R216_Q0.5300.70
101_V205_A0.5300.70
21_C71_M0.5290.70
147_L151_A0.5280.70
207_V214_K0.5270.70
161_A168_V0.5230.69
102_F131_L0.5210.69
105_L126_F0.5190.69
92_I96_L0.5190.69
22_R34_S0.5170.68
14_S39_C0.5160.68
179_I183_L0.5150.68
153_G157_L0.5150.68
171_G221_A0.5140.68
18_T48_L0.5140.68
209_T212_L0.5140.68
17_Y37_P0.5130.68
100_V104_S0.5120.68
14_S48_L0.5120.68
165_H215_R0.5110.68
198_I227_G0.5090.67
123_I178_V0.5080.67
126_F181_F0.5080.67
43_L46_A0.5080.67
202_Y206_A0.5070.67
127_F131_L0.5070.67
98_P130_F0.5070.67
198_I202_Y0.5070.67
207_V213_A0.5060.67
15_F48_L0.5050.67
75_A107_I0.5050.67
203_G218_L0.5040.67
5_L96_L0.5030.66
112_T123_I0.5030.66
102_F127_F0.5010.66
5_L9_G0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s0xA 1 0.5968 99.5 0.745 Contact Map
3py7A 1 0.2702 41.9 0.943 Contact Map
4xlgA 1 0.2218 39.5 0.944 Contact Map
2ct0A 1 0.2621 36.9 0.945 Contact Map
1iymA 1 0.1694 27.7 0.948 Contact Map
3u6pA 1 0.1653 23.6 0.95 Contact Map
1ee8A 2 0.2379 21.3 0.951 Contact Map
3j20Y 1 0.2016 20.2 0.952 Contact Map
4pd2A 1 0.2419 18.7 0.952 Contact Map
4v3lC 1 0.2298 18.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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