GREMLIN Database
SP3D - Stage III sporulation protein D
UniProt: P15281 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (82)
Sequences: 333 (185)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K43_E3.6741.00
16_I41_L3.0430.99
63_H66_I2.8500.99
57_K61_D2.7890.99
12_I37_V2.7140.99
49_N55_E2.5850.98
21_K63_H2.4140.97
15_Y30_F1.8980.89
32_V61_D1.7340.84
26_I41_L1.7240.84
10_I13_G1.6860.82
15_Y26_I1.6850.82
55_E82_D1.6670.81
50_P54_N1.6330.80
8_R40_D1.6230.80
17_V55_E1.6140.79
14_K49_N1.5650.77
21_K66_I1.5650.77
7_E49_N1.5430.76
26_I63_H1.4700.72
62_Y66_I1.4670.72
5_I53_A1.4500.71
53_A56_V1.3960.68
20_K58_E1.3800.67
6_K76_K1.3760.67
19_T62_Y1.3760.67
32_V47_E1.3300.64
73_E77_L1.2780.61
2_H20_K1.2410.59
15_Y21_K1.2200.57
42_T53_A1.1980.56
4_Y53_A1.1230.51
31_G42_T1.0900.49
76_K80_K1.0840.49
13_G17_V1.0740.48
12_I25_V1.0680.48
20_K28_K1.0620.47
63_H73_E1.0600.47
40_D44_R1.0460.46
20_K46_P1.0230.45
4_Y12_I1.0190.44
63_H70_R0.9950.43
2_H6_K0.9240.38
10_I52_L0.9190.38
59_I80_K0.9180.38
55_E58_E0.9040.37
51_D65_S0.8780.36
45_L72_G0.8750.35
14_K54_N0.8680.35
64_K74_A0.8600.35
64_K70_R0.8500.34
51_D82_D0.8500.34
33_S39_K0.8340.33
1_M5_I0.8290.33
6_K73_E0.8230.32
14_K25_V0.7960.31
75_T79_Y0.7930.31
12_I30_F0.7930.31
37_V43_E0.7920.31
68_H75_T0.7910.31
20_K82_D0.7830.30
27_A70_R0.7750.30
24_R35_S0.7640.29
35_S68_H0.7600.29
24_R34_K0.7560.29
31_G59_I0.7540.29
60_L63_H0.7480.28
1_M4_Y0.7380.28
47_E55_E0.7280.27
36_T40_D0.7230.27
36_T78_K0.7210.27
2_H59_I0.7200.27
25_V51_D0.7200.27
77_L82_D0.7200.27
1_M68_H0.7190.27
14_K81_K0.7140.26
7_E58_E0.7090.26
38_H79_Y0.6850.25
18_E80_K0.6790.25
5_I13_G0.6740.24
66_I70_R0.6640.24
66_I79_Y0.6610.24
11_K19_T0.6600.24
11_K14_K0.6590.24
74_A78_K0.6540.24
77_L80_K0.6520.23
6_K49_N0.6480.23
25_V53_A0.6470.23
17_V59_I0.6460.23
8_R36_T0.6430.23
57_K69_L0.6430.23
62_Y77_L0.6320.22
47_E50_P0.6260.22
29_E32_V0.6220.22
28_K50_P0.6160.22
19_T77_L0.6100.21
42_T64_K0.6080.21
65_S74_A0.6060.21
46_P56_V0.6020.21
32_V79_Y0.6010.21
31_G74_A0.5970.21
66_I78_K0.5820.20
19_T47_E0.5700.20
17_V81_K0.5690.20
11_K29_E0.5680.20
8_R44_R0.5650.20
7_E29_E0.5610.19
29_E69_L0.5590.19
12_I65_S0.5590.19
19_T29_E0.5570.19
2_H63_H0.5560.19
1_M44_R0.5550.19
19_T55_E0.5460.19
9_T13_G0.5430.19
30_F79_Y0.5410.19
13_G51_D0.5360.18
58_E62_Y0.5360.18
10_I14_K0.5240.18
37_V45_L0.5210.18
60_L70_R0.5150.18
28_K81_K0.5090.17
14_K17_V0.5080.17
6_K17_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l0kA 1 1 99.9 0.458 Contact Map
2heoA 1 0.6129 95.4 0.846 Contact Map
2vxzA 1 0.7957 94.4 0.854 Contact Map
1oyiA 1 0.6667 94.4 0.854 Contact Map
1qpzA 2 0.7742 93.7 0.858 Contact Map
4l5jA 4 0.8065 93.4 0.86 Contact Map
4a0zA 2 0.7312 93 0.862 Contact Map
2o20A 2 0.2688 93 0.862 Contact Map
2w48A 3 0.8172 93 0.862 Contact Map
3h5oA 2 0.2043 92.9 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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