GREMLIN Database
THIO - Thioredoxin
UniProt: P14949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 104 (99)
Sequences: 9291 (6193)
Seq/√Len: 622.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V64_A2.9681.00
41_E93_K2.3541.00
6_A53_V2.3171.00
12_S66_K2.2761.00
45_E93_K2.0991.00
92_P95_A2.0811.00
8_D62_E1.9481.00
76_L86_T1.9271.00
45_E97_Q1.8951.00
20_V51_K1.8611.00
56_D59_E1.7661.00
8_D63_T1.7421.00
29_C32_C1.7371.00
18_G51_K1.7351.00
23_D54_K1.7131.00
67_Y78_L1.6571.00
83_V86_T1.6561.00
19_V77_V1.6401.00
38_V41_E1.6331.00
46_M97_Q1.6321.00
76_L83_V1.6261.00
21_L39_L1.5941.00
97_Q101_N1.5481.00
8_D60_N1.5261.00
90_F95_A1.5151.00
95_A98_E1.5101.00
42_L52_I1.5101.00
39_L52_I1.5001.00
38_V93_K1.4941.00
27_P56_D1.4431.00
21_L75_L1.4331.00
14_E51_K1.4321.00
4_V14_E1.4031.00
57_V72_I1.4021.00
10_S14_E1.4011.00
7_T10_S1.3871.00
6_A14_E1.3351.00
87_S91_K1.3341.00
20_V53_V1.3141.00
42_L97_Q1.2541.00
46_M101_N1.2351.00
85_E99_L1.2181.00
87_S99_L1.2171.00
55_I63_T1.2031.00
36_A40_E1.1491.00
42_L93_K1.1371.00
35_I75_L1.1041.00
93_K97_Q1.0981.00
7_T60_N1.0671.00
77_V99_L1.0631.00
61_Q65_G1.0601.00
91_K95_A1.0481.00
23_D36_A1.0481.00
5_K54_K1.0231.00
35_I38_V1.0051.00
22_A78_L0.9981.00
55_I64_A0.9921.00
14_E20_V0.9821.00
79_K84_V0.9771.00
75_L96_L0.9481.00
42_L46_M0.9451.00
36_A54_K0.9301.00
4_V51_K0.9271.00
77_V100_V0.9231.00
35_I96_L0.9191.00
42_L96_L0.9121.00
40_E54_K0.8931.00
25_W54_K0.8881.00
39_L75_L0.8841.00
19_V79_K0.8641.00
49_K101_N0.8621.00
82_E85_E0.8331.00
34_M90_F0.8081.00
38_V92_P0.8021.00
17_E20_V0.7831.00
5_K59_E0.7811.00
11_F67_Y0.7781.00
44_Q47_G0.7701.00
98_E101_N0.7671.00
15_T20_V0.7661.00
50_L100_V0.7571.00
91_K99_L0.7501.00
11_F15_T0.7461.00
38_V42_L0.7451.00
63_T66_K0.7451.00
11_F24_F0.7431.00
21_L52_I0.7421.00
24_F67_Y0.7391.00
62_E66_K0.7351.00
35_I91_K0.7291.00
43_D52_I0.7151.00
23_D35_I0.7051.00
30_G33_K0.6991.00
94_E98_E0.6841.00
17_E80_D0.6831.00
27_P58_D0.6801.00
19_V80_D0.6671.00
60_N63_T0.6551.00
21_L96_L0.6531.00
99_L102_K0.6531.00
46_M50_L0.6471.00
46_M49_K0.6461.00
24_F57_V0.6441.00
5_K53_V0.6411.00
21_L100_V0.6411.00
28_W33_K0.6301.00
24_F69_V0.6291.00
25_W56_D0.6281.00
11_F22_A0.6241.00
41_E44_Q0.6191.00
22_A53_V0.6151.00
18_G80_D0.6111.00
61_Q64_A0.6111.00
25_W72_I0.6091.00
10_S53_V0.6071.00
69_V74_T0.5981.00
6_A22_A0.5961.00
23_D31_P0.5911.00
78_L83_V0.5911.00
31_P34_M0.5871.00
31_P71_S0.5871.00
34_M38_V0.5861.00
11_F63_T0.5841.00
21_L77_V0.5761.00
27_P33_K0.5751.00
13_A16_S0.5751.00
62_E65_G0.5661.00
26_A29_C0.5651.00
5_K27_P0.5651.00
81_G85_E0.5621.00
10_S13_A0.5591.00
35_I39_L0.5591.00
18_G49_K0.5561.00
4_V20_V0.5561.00
30_G34_M0.5551.00
55_I60_N0.5420.99
24_F76_L0.5350.99
41_E45_E0.5290.99
79_K82_E0.5200.99
14_E53_V0.5130.99
6_A10_S0.5100.99
70_M86_T0.5100.99
14_E17_E0.5060.99
18_G48_D0.5050.99
45_E101_N0.5050.99
39_L96_L0.5010.99
5_K25_W0.5000.99
25_W29_C0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f8uA 2 1 99.8 0.149 Contact Map
2r2jA 2 0.9712 99.8 0.166 Contact Map
2b5eA 1 1 99.8 0.174 Contact Map
3apoA 1 0.9231 99.8 0.175 Contact Map
3ed3A 1 1 99.8 0.198 Contact Map
4ekzA 1 1 99.8 0.201 Contact Map
1sjiA 2 0.9904 99.8 0.213 Contact Map
3us3A 2 0.9904 99.8 0.214 Contact Map
4tveA 1 1 99.8 0.214 Contact Map
4i6xA 1 0.9904 99.8 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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