GREMLIN Database
RL16 - 50S ribosomal protein L16
UniProt: P14577 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (135)
Sequences: 1925 (759)
Seq/√Len: 65.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_E115_R3.6801.00
27_V33_G3.5121.00
118_L131_F3.2431.00
36_A127_I2.8401.00
116_E119_R2.8331.00
31_E107_S2.7211.00
42_I68_I2.5471.00
74_Y92_G2.5141.00
35_Q130_K2.4421.00
41_W96_V2.3761.00
111_E133_K2.3001.00
72_K96_V2.2251.00
110_S113_V2.1251.00
58_M106_I2.0501.00
22_K25_T2.0111.00
115_R131_F1.9821.00
38_E128_K1.9231.00
122_S129_T1.9011.00
54_M64_V1.8671.00
54_M106_I1.8161.00
50_A104_F1.7751.00
17_M39_A1.7421.00
48_E51_R1.7281.00
15_G72_K1.6940.99
77_K81_V1.6870.99
64_V106_I1.6230.99
34_I122_S1.6200.99
55_T64_V1.6160.99
29_F67_K1.6010.99
35_Q132_V1.5730.99
42_I127_I1.5680.99
43_T46_Q1.5670.99
50_A125_L1.5600.99
32_F131_F1.5570.99
76_A91_E1.5360.99
42_I103_L1.5320.99
14_R41_W1.5270.99
12_E73_P1.4810.98
58_M113_V1.4610.98
78_P81_V1.4040.98
71_S101_K1.3910.98
46_Q126_P1.3750.97
21_A101_K1.3460.97
82_R93_W1.3210.97
102_V132_V1.2800.96
75_T88_G1.2490.96
119_R123_H1.2470.95
57_Y113_V1.2400.95
58_M61_G1.1600.93
24_G28_H1.1430.93
109_V114_A1.1370.93
17_M96_V1.1360.93
35_Q102_V1.1250.92
27_V132_V1.1130.92
17_M72_K1.0990.91
3_L7_V1.0840.91
14_R74_Y1.0710.90
33_G132_V1.0460.89
7_V93_W1.0320.89
24_G101_K1.0310.89
14_R77_K1.0140.88
40_S104_F1.0140.88
34_I129_T1.0100.87
50_A53_A1.0100.87
85_S93_W0.9820.86
27_V102_V0.9800.86
76_A92_G0.9770.86
78_P82_R0.9730.85
19_G98_K0.9720.85
7_V12_E0.9640.85
40_S127_I0.9450.84
41_W72_K0.9380.83
16_K39_A0.9340.83
54_M121_A0.9290.83
52_I85_S0.9290.83
114_A131_F0.9220.82
31_E134_R0.9180.82
74_Y96_V0.8990.81
37_L127_I0.8820.79
117_A121_A0.8800.79
28_H67_K0.8730.79
3_L14_R0.8730.79
18_R39_A0.8650.78
53_A121_A0.8570.77
29_F65_W0.8410.76
75_T90_P0.8290.75
21_A24_G0.8290.75
25_T35_Q0.8250.75
71_S93_W0.8190.74
42_I126_P0.8070.73
11_R15_G0.8040.73
39_A99_P0.8030.73
68_I127_I0.7910.71
12_E72_K0.7830.71
107_S134_R0.7830.71
57_Y120_L0.7790.70
36_A101_K0.7740.70
60_R120_L0.7620.69
53_A120_L0.7590.68
52_I64_V0.7500.67
68_I103_L0.7480.67
58_M64_V0.7480.67
47_I68_I0.7470.67
103_L129_T0.7450.67
14_R17_M0.7440.67
54_M61_G0.7420.67
3_L44_N0.7370.66
27_V134_R0.7300.65
35_Q135_E0.7270.65
9_Y12_E0.7230.64
61_G85_S0.7210.64
15_G96_V0.7190.64
57_Y85_S0.7150.64
106_I118_L0.7100.63
53_A123_H0.7080.63
47_I69_F0.7070.63
51_R56_R0.7060.63
44_N52_I0.7030.62
109_V113_V0.7030.62
54_M58_M0.6980.62
33_G102_V0.6970.62
68_I101_K0.6960.62
15_G74_Y0.6940.61
29_F45_R0.6820.60
27_V31_E0.6810.60
12_E71_S0.6810.60
41_W74_Y0.6740.59
50_A103_L0.6660.58
3_L79_L0.6660.58
20_R25_T0.6650.58
121_A125_L0.6620.58
64_V118_L0.6590.57
7_V90_P0.6590.57
67_K108_G0.6560.57
57_Y83_M0.6540.57
115_R119_R0.6510.56
5_K93_W0.6500.56
98_K101_K0.6480.56
73_P93_W0.6470.56
1_M5_K0.6470.56
2_L70_P0.6410.55
90_P93_W0.6390.55
15_G41_W0.6360.55
21_A25_T0.6350.55
106_I114_A0.6340.54
12_E93_W0.6320.54
73_P90_P0.6290.54
73_P101_K0.6190.53
20_R99_P0.6180.53
58_M104_F0.6150.52
33_G105_E0.6050.51
111_E131_F0.6030.51
45_R80_E0.6020.51
26_E128_K0.6010.51
56_R117_A0.5980.50
23_G26_E0.5920.50
121_A129_T0.5920.50
18_R72_K0.5860.49
9_Y13_H0.5850.49
72_K94_V0.5810.48
44_N92_G0.5800.48
6_R9_Y0.5790.48
68_I97_V0.5770.48
15_G19_G0.5760.48
41_W94_V0.5660.47
61_G121_A0.5590.46
17_M41_W0.5580.46
55_T120_L0.5580.46
57_Y116_E0.5550.45
47_I66_I0.5530.45
14_R81_V0.5490.45
14_R85_S0.5450.44
12_E90_P0.5410.44
19_G122_S0.5390.43
48_E124_K0.5350.43
1_M33_G0.5290.42
113_V119_R0.5290.42
19_G94_V0.5290.42
37_L40_S0.5280.42
57_Y119_R0.5260.42
38_E42_I0.5260.42
30_G65_W0.5240.42
63_K107_S0.5230.42
55_T106_I0.5210.41
41_W90_P0.5190.41
95_A103_L0.5160.41
31_E133_K0.5160.41
15_G39_A0.5150.41
98_K130_K0.5140.41
72_K99_P0.5130.40
22_K42_I0.5120.40
29_F35_Q0.5110.40
116_E123_H0.5090.40
40_S68_I0.5090.40
52_I78_P0.5080.40
13_H52_I0.5080.40
15_G99_P0.5070.40
78_P89_A0.5050.40
18_R31_E0.5050.40
24_G134_R0.5000.39
58_M107_S0.5000.39
30_G67_K0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb6Q 1 0.9792 100 0.12 Contact Map
3bboO 1 0.9375 100 0.131 Contact Map
4tp9M 1 0.9444 100 0.141 Contact Map
1vw4K 1 1 100 0.167 Contact Map
3j7yN 1 0.9931 100 0.191 Contact Map
1ffkF 1 0.9514 100 0.357 Contact Map
1vq8H 1 0.9514 100 0.372 Contact Map
3j21N 1 0.9514 100 0.379 Contact Map
1vx7Q 1 0.9514 100 0.381 Contact Map
3zf7K 1 1 100 0.381 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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