GREMLIN Database
COMA2 - Putative esterase ComA2
UniProt: P14205 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (118)
Sequences: 1912 (1189)
Seq/√Len: 109.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_V85_T3.1661.00
25_A52_A2.6741.00
52_A88_A2.6611.00
14_E26_V2.5761.00
108_D112_R2.4771.00
79_K112_R2.3981.00
71_L99_T2.2941.00
17_E24_V2.2881.00
53_A119_C2.2821.00
49_A117_S2.2771.00
17_E22_R2.1551.00
19_T22_R2.0901.00
89_I107_Y2.0891.00
94_H99_T1.9381.00
57_A100_I1.9241.00
57_A121_L1.8761.00
7_L47_A1.8651.00
46_V73_I1.8571.00
75_A115_C1.8421.00
92_P95_I1.7811.00
26_V87_K1.7701.00
105_H113_L1.7201.00
45_S114_I1.5991.00
16_V26_V1.5951.00
46_V75_A1.5821.00
22_R91_E1.5731.00
7_L44_A1.5191.00
22_R89_I1.4881.00
56_G102_Y1.4621.00
27_M44_A1.4321.00
24_V89_I1.4201.00
13_I25_A1.3921.00
105_H116_I1.3811.00
45_S106_I1.3731.00
15_I25_A1.3301.00
53_A104_I1.3110.99
37_F58_Q1.3060.99
39_Y80_S1.2790.99
31_H34_V1.2660.99
39_Y69_V1.2490.99
24_V87_K1.1570.99
50_E70_G1.1540.99
68_C123_V1.1520.99
40_L45_S1.1440.99
8_L51_T1.1340.98
81_V114_I1.0950.98
72_E76_N1.0780.98
107_Y111_E1.0700.98
56_G90_A1.0560.97
16_V24_V1.0510.97
75_A117_S1.0490.97
30_D33_T1.0400.97
104_I119_C1.0250.97
78_L113_L1.0030.97
15_I55_A1.0020.97
78_L101_V0.9950.96
69_V124_I0.9920.96
100_I123_V0.9830.96
74_N118_R0.9720.96
76_N101_V0.9690.96
72_E118_R0.9680.96
61_I68_C0.9650.96
103_H116_I0.9560.95
87_K107_Y0.9460.95
12_G32_R0.9410.95
34_V83_E0.9370.95
48_L88_A0.9340.95
45_S115_C0.9340.95
67_A124_I0.9310.95
87_K109_E0.9210.94
11_L47_A0.9190.94
81_V108_D0.9040.94
21_E92_P0.9020.94
93_V116_I0.9010.94
98_T122_A0.8930.94
88_A104_I0.8890.93
58_Q68_C0.8880.93
13_I47_A0.8870.93
100_I121_L0.8780.93
18_N59_N0.8640.92
46_V117_S0.8590.92
50_E54_S0.8550.92
78_L94_H0.8510.92
23_C59_N0.8480.92
8_L15_I0.8390.91
91_E103_H0.8300.91
35_Q54_S0.8280.91
10_A32_R0.8270.91
63_H66_Q0.8210.90
54_S70_G0.8120.90
60_L95_I0.8070.90
57_A68_C0.8010.89
29_V40_L0.7990.89
73_I117_S0.7990.89
6_T9_E0.7900.89
39_Y82_K0.7890.88
79_K108_D0.7850.88
25_A88_A0.7750.88
15_I18_N0.7680.87
18_N55_A0.7640.87
58_Q67_A0.7630.87
71_L76_N0.7590.86
49_A104_I0.7520.86
13_I27_M0.7520.86
21_E95_I0.7490.86
71_L122_A0.7390.85
23_C56_G0.7360.85
7_L10_A0.7350.85
6_T34_V0.7220.84
68_C121_L0.7190.83
99_T122_A0.7170.83
61_I65_T0.7130.83
20_A59_N0.7080.82
46_V119_C0.7030.82
14_E85_T0.7020.82
6_T10_A0.7020.82
102_Y121_L0.7000.82
13_I48_L0.6960.81
73_I77_H0.6940.81
91_E105_H0.6850.80
61_I66_Q0.6780.80
7_L11_L0.6750.79
27_M48_L0.6730.79
81_V109_E0.6710.79
92_P102_Y0.6710.79
56_G95_I0.6680.79
16_V25_A0.6670.79
43_G47_A0.6640.78
45_S77_H0.6610.78
76_N120_T0.6580.78
97_R110_Q0.6350.75
86_V106_I0.6350.75
103_H118_R0.6330.75
101_V118_R0.6310.75
33_T44_A0.6260.74
20_A95_I0.6160.73
77_H115_C0.6150.73
60_L100_I0.6110.72
28_P85_T0.6020.71
8_L55_A0.5980.71
12_G30_D0.5900.70
35_Q70_G0.5890.69
15_I52_A0.5880.69
37_F67_A0.5850.69
12_G85_T0.5830.69
27_M40_L0.5790.68
91_E107_Y0.5750.68
36_P54_S0.5740.68
44_A86_V0.5630.66
6_T33_T0.5630.66
73_I120_T0.5610.66
85_T109_E0.5600.66
98_T124_I0.5600.66
89_I111_E0.5590.65
61_I64_T0.5590.65
35_Q50_E0.5580.65
78_L116_I0.5550.65
50_E77_H0.5550.65
34_V38_G0.5540.65
40_L86_V0.5540.65
20_A60_L0.5520.65
61_I121_L0.5500.64
52_A90_A0.5490.64
72_E119_C0.5470.64
13_I77_H0.5460.64
57_A103_H0.5410.63
87_K108_D0.5390.63
45_S50_E0.5310.62
40_L44_A0.5310.62
83_E109_E0.5300.61
33_T86_V0.5300.61
61_I123_V0.5260.61
56_G100_I0.5250.61
97_R111_E0.5120.59
46_V74_N0.5110.59
16_V95_I0.5050.58
10_A33_T0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yocA 4 0.9841 99.9 0.417 Contact Map
1t82A 2 0.9762 99.9 0.417 Contact Map
3lmbA 2 0.9841 99.9 0.427 Contact Map
1sh8A 2 0.9841 99.9 0.429 Contact Map
4rmmA 2 0.9444 99.9 0.434 Contact Map
3gekA 3 0.9603 99.9 0.434 Contact Map
4m20A 3 0.9683 99.9 0.452 Contact Map
3e8pA 3 0.9841 99.9 0.453 Contact Map
4qd8A 3 0.9921 99.9 0.453 Contact Map
2q78A 4 0.9206 99.9 0.453 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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