GREMLIN Database
YUXH - Uncharacterized protein YuxH
UniProt: P14203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (391)
Sequences: 1095 (908)
Seq/√Len: 45.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_E96_T5.2591.00
107_K137_D5.0071.00
357_H369_K4.1371.00
12_N16_Q3.8031.00
290_S334_H3.6621.00
138_I166_L3.5811.00
41_T44_L3.3071.00
86_V114_A3.1541.00
356_G359_N3.1061.00
131_K134_S3.0591.00
128_L131_K2.9361.00
144_L175_E2.9041.00
67_F87_I2.8971.00
58_T63_C2.8781.00
172_T175_E2.8621.00
130_E134_S2.8071.00
164_I186_L2.7721.00
228_T232_E2.7301.00
320_Y361_Y2.7291.00
129_L134_S2.7181.00
143_F179_A2.7031.00
294_I331_T2.6821.00
216_E226_R2.6611.00
321_M401_W2.5921.00
40_A44_L2.4941.00
165_F184_F2.4551.00
88_E140_K2.4291.00
91_E168_E2.4251.00
91_E117_D2.4091.00
90_L168_E2.3561.00
359_N362_Y2.3031.00
62_R112_M2.2981.00
13_R180_V2.2551.00
89_I93_I2.2511.00
356_G362_Y2.2181.00
311_K390_E2.1191.00
90_L117_D2.1111.00
330_D337_I2.0861.00
112_M138_I2.0711.00
88_E168_E2.0640.99
303_K401_W2.0420.99
128_L134_S2.0390.99
80_F85_L2.0170.99
375_N378_T2.0070.99
11_F293_E2.0020.99
90_L166_L2.0000.99
64_F138_I1.9880.99
25_R171_E1.9710.99
320_Y364_M1.9520.99
212_E233_R1.9410.99
301_R372_E1.9030.99
291_K334_H1.8660.99
141_I184_F1.8450.99
247_S250_S1.8400.99
216_E230_Y1.8190.99
89_I113_L1.8180.99
293_E296_K1.8140.99
30_N33_S1.7980.99
90_L169_K1.7850.99
352_Q358_Q1.7820.98
309_A320_Y1.7650.98
261_Q264_M1.7640.98
164_I185_Q1.7530.98
348_D352_Q1.7260.98
25_R66_N1.7240.98
371_I395_Y1.7190.98
117_D168_E1.7160.98
228_T260_Q1.7150.98
171_E190_Y1.7130.98
18_V64_F1.7030.98
169_K190_Y1.6680.98
41_T46_I1.6680.98
303_K306_E1.6670.98
337_I354_L1.6640.98
155_L165_F1.6560.98
357_H362_Y1.6520.98
176_Y191_F1.6460.97
303_K307_L1.6390.97
353_A359_N1.6330.97
88_E91_E1.6170.97
103_C113_L1.6170.97
326_F329_I1.6170.97
64_F86_V1.6150.97
139_L163_L1.5780.97
301_R327_S1.5720.97
140_K188_Q1.5680.97
13_R185_Q1.5660.97
66_N88_E1.5620.96
93_I99_L1.5500.96
89_I103_C1.5450.96
66_N168_E1.5250.96
41_T49_F1.5060.96
238_S259_I1.4970.96
254_Q261_Q1.4930.95
224_I263_I1.4770.95
27_S30_N1.4680.95
159_G185_Q1.4560.95
91_E116_D1.4520.95
41_T45_V1.4210.94
18_V186_L1.4150.94
21_E66_N1.4130.94
216_E219_K1.3960.93
147_T150_E1.3960.93
25_R190_Y1.3860.93
75_N105_E1.3860.93
66_N116_D1.3570.92
66_N91_E1.3520.92
395_Y399_L1.3490.92
305_C323_I1.3390.92
15_E176_Y1.3270.92
387_D390_E1.3120.91
323_I350_V1.3110.91
226_R229_E1.3100.91
140_K168_E1.3060.91
32_Y35_K1.3030.91
167_A184_F1.3000.91
32_Y36_D1.2920.91
177_K180_V1.2920.91
393_E397_E1.2910.90
255_K348_D1.2850.90
370_L375_N1.2780.90
66_N140_K1.2780.90
239_Y329_I1.2760.90
248_S251_R1.2510.89
40_A46_I1.2510.89
270_E273_R1.2420.89
25_R169_K1.2410.89
170_V192_F1.2330.88
148_R178_Q1.2240.88
15_E191_F1.2060.87
6_A25_R1.2010.87
88_E188_Q1.2000.87
222_P268_F1.1930.87
305_C368_V1.1860.86
302_A325_M1.1850.86
67_F77_P1.1840.86
234_D240_Q1.1840.86
5_V57_L1.1840.86
11_F192_F1.1760.86
66_N188_Q1.1750.86
19_A61_K1.1700.86
23_L169_K1.1690.85
228_T263_I1.1650.85
304_L368_V1.1640.85
391_A394_C1.1520.85
116_D168_E1.1490.84
143_F184_F1.1450.84
298_S326_F1.1420.84
66_N190_Y1.1400.84
7_R20_Y1.1390.84
15_E173_R1.1380.84
66_N171_E1.1320.84
319_S350_V1.1320.84
73_F102_R1.1230.83
227_V263_I1.1180.83
129_L132_L1.1150.83
142_D169_K1.1130.83
265_L274_W1.1060.82
252_L256_I1.1050.82
19_A48_S1.0990.82
293_E325_M1.0990.82
42_T45_V1.0980.82
66_N169_K1.0970.82
91_E166_L1.0960.82
167_A170_V1.0960.82
176_Y192_F1.0940.81
143_F175_E1.0790.81
331_T334_H1.0750.80
298_S328_L1.0720.80
268_F272_K1.0630.79
41_T48_S1.0610.79
37_G68_T1.0600.79
303_K321_M1.0560.79
353_A365_L1.0510.79
173_R177_K1.0430.78
151_R184_F1.0370.78
114_A168_E1.0370.78
49_F80_F1.0230.77
308_L336_E1.0180.76
176_Y187_F1.0140.76
190_Y195_P1.0100.76
45_V49_F1.0100.76
242_L326_F1.0090.76
12_N333_L1.0080.76
90_L140_K0.9940.75
72_M342_Q0.9900.74
139_L164_I0.9870.74
263_I275_I0.9870.74
65_V85_L0.9780.74
91_E118_F0.9780.74
304_L371_I0.9740.73
305_C364_M0.9740.73
240_Q282_D0.9730.73
177_K181_Q0.9580.72
341_V344_L0.9570.72
345_P351_G0.9540.72
310_R317_P0.9450.71
245_L256_I0.9440.71
319_S322_L0.9390.70
44_L48_S0.9390.70
328_L331_T0.9380.70
144_L169_K0.9370.70
300_I402_C0.9370.70
23_L171_E0.9340.70
73_F77_P0.9320.70
302_A321_M0.9270.69
308_L364_M0.9270.69
166_L169_K0.9240.69
341_V354_L0.9220.69
370_L378_T0.9210.69
272_K305_C0.9180.69
337_I355_L0.9160.69
142_D168_E0.9150.68
25_R168_E0.9130.68
97_P131_K0.9130.68
6_A197_I0.9100.68
169_K195_P0.9090.68
44_L274_W0.8990.67
23_L168_E0.8990.67
214_L355_L0.8980.67
232_E306_E0.8980.67
347_K350_V0.8920.66
171_E195_P0.8850.66
91_E169_K0.8850.66
41_T195_P0.8790.65
170_V375_N0.8760.65
11_F17_V0.8750.65
81_N166_L0.8740.65
114_A117_D0.8730.65
352_Q357_H0.8710.65
33_S38_D0.8690.64
337_I341_V0.8670.64
235_L326_F0.8670.64
191_F294_I0.8660.64
268_F274_W0.8640.64
4_F27_S0.8610.64
210_Y236_S0.8590.63
96_T190_Y0.8580.63
116_D140_K0.8560.63
71_L274_W0.8500.63
91_E142_D0.8490.63
342_Q351_G0.8430.62
114_A140_K0.8400.62
141_I165_F0.8380.62
210_Y277_I0.8370.61
336_E339_E0.8360.61
244_F273_R0.8350.61
307_L401_W0.8340.61
294_I337_I0.8330.61
8_Q190_Y0.8310.61
23_L195_P0.8290.61
17_V293_E0.8260.60
376_W379_C0.8250.60
45_V80_F0.8250.60
184_F281_K0.8220.60
140_K190_Y0.8220.60
8_Q25_R0.8200.60
190_Y193_S0.8180.60
90_L93_I0.8160.59
90_L114_A0.8150.59
305_C325_M0.8130.59
117_D140_K0.8060.59
44_L47_N0.8040.58
93_I168_E0.8030.58
161_R256_I0.8030.58
231_I259_I0.8020.58
88_E169_K0.8010.58
18_V61_K0.7990.58
211_Y215_N0.7970.58
90_L116_D0.7960.58
23_L91_E0.7950.57
73_F99_L0.7950.57
273_R306_E0.7940.57
168_E190_Y0.7930.57
30_N197_I0.7920.57
143_F172_T0.7900.57
102_R105_E0.7900.57
21_E188_Q0.7890.57
235_L298_S0.7880.57
158_Y184_F0.7880.57
252_L265_L0.7860.57
120_A139_L0.7850.57
6_A23_L0.7840.56
390_E397_E0.7800.56
81_N106_L0.7780.56
234_D326_F0.7770.56
178_Q181_Q0.7720.55
23_L66_N0.7710.55
17_V20_Y0.7690.55
292_H299_L0.7680.55
270_E318_A0.7660.55
58_T204_S0.7640.54
220_E245_L0.7630.54
277_I303_K0.7620.54
97_P182_D0.7620.54
33_S274_W0.7610.54
214_L304_L0.7610.54
156_Q159_G0.7600.54
141_I146_T0.7580.54
306_E401_W0.7560.54
42_T49_F0.7560.54
91_E140_K0.7550.54
140_K169_K0.7530.53
10_I19_A0.7530.53
340_I343_E0.7520.53
235_L247_S0.7510.53
353_A362_Y0.7500.53
83_K109_M0.7490.53
225_K260_Q0.7470.53
56_K343_E0.7470.53
242_L345_P0.7460.53
82_P139_L0.7440.53
89_I198_I0.7420.52
102_R106_L0.7380.52
245_L252_L0.7380.52
6_A190_Y0.7360.52
21_E116_D0.7350.52
49_F71_L0.7340.52
117_D190_Y0.7310.51
23_L116_D0.7280.51
88_E116_D0.7270.51
67_F71_L0.7250.51
371_I376_W0.7190.50
9_P259_I0.7180.50
241_I245_L0.7160.50
248_S299_L0.7160.50
72_M102_R0.7140.50
40_A45_V0.7140.50
23_L190_Y0.7130.49
87_I102_R0.7120.49
90_L138_I0.7080.49
49_F78_T0.7080.49
168_E195_P0.7060.49
319_S349_E0.7030.49
367_L382_L0.7030.49
213_L329_I0.7010.48
238_S244_F0.7000.48
263_I271_I0.6980.48
151_R165_F0.6950.48
6_A95_I0.6950.48
66_N90_L0.6940.48
143_F170_V0.6930.48
367_L379_C0.6920.47
106_L113_L0.6910.47
21_E140_K0.6900.47
200_G278_L0.6890.47
24_Y191_F0.6890.47
256_I265_L0.6880.47
24_Y192_F0.6870.47
242_L258_S0.6860.47
40_A48_S0.6850.47
198_I203_L0.6850.47
43_D281_K0.6810.46
157_T162_G0.6790.46
263_I357_H0.6790.46
222_P298_S0.6770.46
65_V346_L0.6770.46
165_F235_L0.6760.46
221_Q268_F0.6730.46
115_L188_Q0.6720.45
165_F278_L0.6710.45
174_K314_R0.6700.45
238_S242_L0.6690.45
65_V333_L0.6660.45
335_R340_I0.6650.45
316_Q361_Y0.6640.45
99_L350_V0.6600.44
271_I275_I0.6600.44
6_A66_N0.6580.44
400_E404_N0.6570.44
87_I111_Y0.6570.44
90_L115_L0.6560.44
363_Q398_A0.6550.44
85_L341_V0.6490.43
171_E188_Q0.6480.43
115_L183_G0.6480.43
297_I372_E0.6480.43
77_P111_Y0.6470.43
6_A171_E0.6470.43
244_F250_S0.6460.43
66_N117_D0.6450.43
57_L87_I0.6440.43
357_H389_E0.6430.43
338_E342_Q0.6420.43
224_I268_F0.6420.43
371_I399_L0.6410.42
230_Y233_R0.6390.42
23_L40_A0.6350.42
159_G162_G0.6350.42
40_A171_E0.6340.42
158_Y326_F0.6340.42
33_S36_D0.6330.42
151_R179_A0.6330.42
69_E73_F0.6310.42
301_R328_L0.6300.41
269_N272_K0.6280.41
228_T369_K0.6280.41
306_E321_M0.6270.41
66_N195_P0.6260.41
72_M113_L0.6250.41
90_L171_E0.6250.41
95_I165_F0.6250.41
25_R88_E0.6240.41
8_Q88_E0.6230.41
318_A397_E0.6230.41
299_L397_E0.6220.41
245_L265_L0.6170.40
88_E190_Y0.6160.40
223_N226_R0.6160.40
18_V138_I0.6160.40
202_D213_L0.6160.40
8_Q116_D0.6150.40
168_E171_E0.6150.40
5_V245_L0.6140.40
100_I373_S0.6140.40
8_Q140_K0.6140.40
41_T47_N0.6140.40
320_Y323_I0.6120.40
305_C345_P0.6120.40
139_L322_L0.6120.40
143_F146_T0.6110.40
147_T153_T0.6100.40
44_L49_F0.6100.40
200_G274_W0.6100.40
69_E93_I0.6070.39
8_Q171_E0.6060.39
26_E274_W0.6060.39
304_L308_L0.6030.39
235_L239_Y0.6030.39
33_S141_I0.6020.39
25_R116_D0.6020.39
118_F168_E0.6010.39
46_I49_F0.6010.39
352_Q356_G0.5980.38
48_S53_G0.5940.38
305_C371_I0.5940.38
364_M369_K0.5940.38
172_T242_L0.5930.38
19_A347_K0.5920.38
100_I156_Q0.5920.38
297_I300_I0.5910.38
67_F329_I0.5910.38
235_L332_L0.5910.38
100_I132_L0.5890.38
8_Q23_L0.5890.38
88_E171_E0.5880.37
160_C166_L0.5850.37
78_T273_R0.5840.37
168_E188_Q0.5830.37
139_L224_I0.5820.37
69_E99_L0.5810.37
66_N166_L0.5800.37
155_L201_H0.5790.37
35_K38_D0.5790.37
52_I63_C0.5790.37
69_E94_P0.5790.37
294_I334_H0.5780.37
298_S304_L0.5780.37
114_A171_E0.5770.36
319_S344_L0.5770.36
9_P218_S0.5770.36
248_S252_L0.5760.36
173_R191_F0.5760.36
307_L311_K0.5760.36
10_I194_E0.5750.36
13_R162_G0.5750.36
312_T348_D0.5740.36
6_A24_Y0.5730.36
90_L144_L0.5720.36
398_A401_W0.5720.36
72_M99_L0.5710.36
17_V374_N0.5710.36
142_D170_V0.5700.36
141_I187_F0.5690.36
251_R274_W0.5670.36
226_R269_N0.5660.35
148_R182_D0.5660.35
130_E303_K0.5650.35
53_G57_L0.5650.35
15_E321_M0.5650.35
362_Y366_E0.5640.35
90_L118_F0.5610.35
91_E144_L0.5600.35
303_K318_A0.5590.35
292_H346_L0.5580.35
30_N36_D0.5570.35
269_N336_E0.5570.35
368_V395_Y0.5550.34
116_D171_E0.5550.34
327_S372_E0.5540.34
24_Y92_D0.5540.34
307_L394_C0.5540.34
231_I306_E0.5530.34
51_N322_L0.5530.34
41_T169_K0.5530.34
5_V197_I0.5510.34
45_V65_V0.5510.34
60_G205_T0.5480.34
79_S213_L0.5470.34
97_P128_L0.5470.34
297_I328_L0.5460.34
256_I261_Q0.5450.34
67_F283_L0.5440.34
81_N266_L0.5430.33
356_G366_E0.5430.33
87_I260_Q0.5420.33
156_Q161_R0.5410.33
128_L229_E0.5410.33
11_F340_I0.5400.33
229_E338_E0.5390.33
88_E167_A0.5390.33
106_L243_K0.5390.33
24_Y399_L0.5380.33
4_F30_N0.5380.33
210_Y275_I0.5370.33
75_N102_R0.5350.33
391_A402_C0.5350.33
218_S299_L0.5340.33
182_D349_E0.5340.33
23_L41_T0.5340.33
207_F214_L0.5330.33
114_A169_K0.5330.33
108_K162_G0.5320.32
77_P87_I0.5320.32
78_T109_M0.5320.32
307_L387_D0.5320.32
214_L365_L0.5310.32
183_G187_F0.5300.32
129_L271_I0.5300.32
58_T263_I0.5300.32
197_I331_T0.5300.32
103_C204_S0.5290.32
247_S340_I0.5290.32
184_F187_F0.5280.32
24_Y41_T0.5280.32
246_N262_A0.5280.32
13_R186_L0.5260.32
37_G132_L0.5260.32
342_Q384_N0.5250.32
155_L264_M0.5240.32
118_F134_S0.5230.32
72_M204_S0.5220.32
144_L171_E0.5220.32
333_L340_I0.5210.32
57_L63_C0.5210.32
78_T270_E0.5170.31
6_A169_K0.5170.31
54_I391_A0.5140.31
14_K178_Q0.5140.31
13_R112_M0.5140.31
22_L190_Y0.5130.31
116_D188_Q0.5110.31
265_L268_F0.5110.31
360_D386_L0.5110.31
43_D46_I0.5110.31
216_E371_I0.5100.31
84_Q201_H0.5100.31
131_K377_D0.5090.31
95_I100_I0.5070.30
49_F54_I0.5070.30
51_N59_E0.5070.30
305_C320_Y0.5070.30
8_Q66_N0.5060.30
52_I57_L0.5060.30
77_P102_R0.5060.30
175_E179_A0.5060.30
140_K171_E0.5050.30
169_K197_I0.5050.30
210_Y323_I0.5050.30
140_K193_S0.5050.30
171_E194_E0.5040.30
179_A184_F0.5040.30
245_L249_H0.5040.30
183_G195_P0.5040.30
156_Q339_E0.5030.30
300_I395_Y0.5030.30
319_S347_K0.5030.30
19_A192_F0.5020.30
141_I151_R0.5020.30
311_K394_C0.5020.30
322_L337_I0.5010.30
227_V232_E0.5010.30
90_L119_Y0.5010.30
103_C264_M0.5000.30
17_V399_L0.5000.30
85_L120_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j40A 2 0.4914 100 0.736 Contact Map
3pjxA 1 0.4694 100 0.738 Contact Map
4fojA 1 0.4841 100 0.739 Contact Map
3hv8A 1 0.4792 100 0.742 Contact Map
3kzpA 2 0.4719 100 0.746 Contact Map
2r6oA 2 0.5086 100 0.747 Contact Map
4q6jA 4 0.4866 100 0.748 Contact Map
4hjfA 1 0.511 100 0.749 Contact Map
3s83A 1 0.5037 100 0.75 Contact Map
3gfzA 2 0.4988 100 0.75 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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