GREMLIN Database
CTC - General stress protein CTC
UniProt: P14194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (192)
Sequences: 3131 (2210)
Seq/√Len: 159.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_T141_E4.1751.00
5_T63_E3.1901.00
102_E126_A2.8701.00
106_H139_T2.8531.00
130_K165_S2.7411.00
25_H41_S2.6531.00
61_T68_K2.6511.00
20_I41_S2.5031.00
43_D46_E2.4991.00
109_G145_S2.4311.00
107_L122_Q2.3381.00
116_N148_D2.3191.00
30_I40_V2.2871.00
94_N97_E2.2811.00
100_E130_K2.2381.00
7_K25_H2.1561.00
132_K135_A2.1141.00
98_D165_S2.0921.00
155_I166_F2.0611.00
47_L88_A1.9901.00
148_D151_E1.9841.00
30_I62_L1.9641.00
30_I71_V1.9381.00
25_H43_D1.8951.00
102_E128_T1.8761.00
127_L158_L1.8711.00
131_A164_Y1.8661.00
135_A163_D1.8171.00
61_T70_S1.8101.00
106_H141_E1.7821.00
69_H92_V1.7681.00
8_E65_S1.7551.00
100_E128_T1.7511.00
109_G144_I1.7231.00
98_D130_K1.7091.00
113_G118_G1.7051.00
63_E68_K1.6881.00
147_L151_E1.6241.00
118_G149_V1.6151.00
160_A166_F1.6081.00
107_L175_A1.5951.00
156_A171_D1.5391.00
95_M134_K1.5361.00
124_L172_E1.5341.00
129_V164_Y1.5311.00
152_V173_V1.4751.00
3_T61_T1.4641.00
128_T168_H1.4361.00
26_V47_L1.4101.00
101_V136_I1.4081.00
161_G164_Y1.4041.00
29_I39_P1.3911.00
13_T17_L1.3771.00
3_T63_E1.3401.00
156_A170_S1.3341.00
44_S48_I1.3331.00
107_L144_I1.3261.00
109_G143_D1.3251.00
114_V120_L1.3011.00
182_Q186_A1.2951.00
59_V93_V1.2741.00
38_K69_H1.2651.00
147_L153_L1.2531.00
118_G177_I1.2211.00
112_I148_D1.2191.00
28_G40_V1.2151.00
28_G88_A1.2141.00
44_S84_E1.2141.00
5_T46_E1.2051.00
110_E115_K1.1981.00
96_S134_K1.1941.00
28_G42_L1.1891.00
142_A153_L1.1881.00
48_I52_R1.1841.00
168_H172_E1.1811.00
15_S18_R1.1811.00
11_D19_N1.1771.00
6_A40_V1.1731.00
135_A162_G1.1621.00
98_D132_K1.1511.00
19_N23_S1.1471.00
124_L174_V1.1311.00
76_L88_A1.1281.00
111_A114_V1.1231.00
62_L71_V1.1181.00
35_T92_V1.1131.00
112_I146_S1.1021.00
112_I145_S1.0971.00
131_A136_I1.0900.99
72_M99_I1.0830.99
31_Y89_D1.0710.99
70_S95_M1.0610.99
120_L177_I1.0440.99
121_Q178_L1.0440.99
120_L175_A1.0320.99
124_L168_H1.0310.99
3_T68_K1.0090.99
192_E195_D1.0010.99
6_A64_V1.0000.99
112_I116_N0.9920.99
17_L20_I0.9890.99
185_A188_V0.9800.99
184_E187_E0.9710.99
183_Q186_A0.9680.99
42_L90_F0.9670.99
186_A189_D0.9650.99
45_V49_K0.9640.99
7_K41_S0.9630.99
33_K97_E0.9620.99
70_S134_K0.9590.99
123_P176_S0.9570.99
147_L152_V0.9570.99
123_P173_V0.9480.99
96_S132_K0.9450.99
7_K65_S0.9390.98
62_L90_F0.9380.98
149_V179_P0.9360.98
130_K167_N0.9300.98
40_V71_V0.9200.98
173_V176_S0.9150.98
63_E66_G0.9030.98
144_I147_L0.8990.98
79_D82_K0.8980.98
140_I160_A0.8890.98
79_D86_T0.8850.98
12_F39_P0.8820.98
142_A158_L0.8740.98
13_T16_S0.8710.97
51_L85_I0.8670.97
124_L155_I0.8660.97
127_L155_I0.8630.97
119_V180_P0.8590.97
113_G117_G0.8540.97
114_V118_G0.8510.97
49_K52_R0.8320.97
111_A118_G0.8300.97
108_T143_D0.8220.96
155_I168_H0.8210.96
182_Q185_A0.8110.96
78_T83_N0.8080.96
111_A144_I0.8010.96
16_S22_T0.7990.96
28_G90_F0.7950.96
191_E194_A0.7900.96
29_I37_N0.7850.95
146_S159_P0.7840.95
121_Q176_S0.7790.95
30_I69_H0.7770.95
33_K92_V0.7750.95
72_M101_V0.7740.95
28_G47_L0.7650.95
74_T91_Q0.7630.95
141_E159_P0.7610.95
32_G92_V0.7550.94
107_L174_V0.7440.94
129_V140_I0.7400.94
190_E195_D0.7390.94
120_L144_I0.7380.94
54_E58_A0.7380.94
189_D193_S0.7360.94
158_L174_V0.7350.93
113_G177_I0.7290.93
114_V177_I0.7240.93
103_V137_P0.7230.93
154_T157_D0.7220.93
87_H109_G0.7190.93
186_A190_E0.7190.93
46_E49_K0.7170.93
45_V48_I0.7100.92
113_G147_L0.7100.92
50_T61_T0.7050.92
12_F17_L0.7040.92
13_T18_R0.6970.92
150_N179_P0.6960.92
40_V62_L0.6930.91
8_E38_K0.6920.91
151_E157_D0.6910.91
64_V69_H0.6890.91
127_L166_F0.6870.91
34_D92_V0.6840.91
11_D16_S0.6820.91
73_V88_A0.6820.91
31_Y87_H0.6790.90
98_D133_P0.6780.90
42_L47_L0.6710.90
49_K53_D0.6690.90
152_V176_S0.6680.90
179_P183_Q0.6650.90
79_D84_E0.6580.89
50_T58_A0.6530.89
156_A169_E0.6530.89
100_E167_N0.6510.89
24_G44_S0.6500.89
154_T173_V0.6480.88
8_E67_E0.6470.88
97_E133_P0.6470.88
187_E192_E0.6420.88
26_V44_S0.6410.88
152_V178_L0.6400.88
76_L85_I0.6380.88
17_L22_T0.6320.87
103_V129_V0.6310.87
188_V191_E0.6260.87
20_I44_S0.6220.86
157_D171_D0.6210.86
59_V70_S0.6200.86
99_I131_A0.6190.86
11_D41_S0.6190.86
16_S19_N0.6180.86
20_I25_H0.6130.85
60_I71_V0.6080.85
132_K136_I0.6080.85
147_L177_I0.6070.85
142_A147_L0.6070.85
59_V134_K0.6070.85
113_G144_I0.6060.85
117_G180_P0.6060.85
50_T73_V0.6060.85
13_T37_N0.6030.85
31_Y37_N0.6000.84
111_A120_L0.5990.84
155_I174_V0.5990.84
65_S68_K0.5980.84
182_Q188_V0.5960.84
101_V133_P0.5900.83
160_A164_Y0.5890.83
184_E188_V0.5870.83
101_V129_V0.5810.82
111_A177_I0.5790.82
113_G148_D0.5790.82
60_I69_H0.5780.82
44_S79_D0.5770.82
63_E67_E0.5760.82
52_R72_M0.5750.82
187_E190_E0.5750.82
77_Q87_H0.5670.81
101_V104_P0.5620.80
190_E193_S0.5620.80
143_D146_S0.5610.80
51_L76_L0.5610.80
179_P182_Q0.5610.80
51_L73_V0.5600.80
182_Q195_D0.5600.80
181_Q184_E0.5600.80
48_I84_E0.5570.80
179_P185_A0.5560.79
155_I170_S0.5520.79
113_G149_V0.5490.79
57_N131_A0.5450.78
127_L168_H0.5450.78
109_G147_L0.5450.78
45_V51_L0.5440.78
95_M133_P0.5420.78
49_K60_I0.5370.77
34_D97_E0.5320.76
4_L60_I0.5320.76
28_G39_P0.5310.76
57_N136_I0.5310.76
145_S148_D0.5290.76
128_T167_N0.5290.76
52_R78_T0.5270.76
93_V131_A0.5260.76
18_R21_R0.5250.76
56_K75_D0.5220.75
47_L53_D0.5210.75
79_D83_N0.5200.75
6_A62_L0.5190.75
149_V180_P0.5190.75
57_N71_V0.5140.74
35_T69_H0.5140.74
118_G147_L0.5130.74
24_G84_E0.5120.74
123_P172_E0.5120.74
140_I166_F0.5110.74
77_Q89_D0.5100.73
189_D195_D0.5090.73
142_A156_A0.5060.73
185_A191_E0.5050.73
104_P139_T0.5050.73
3_T50_T0.5040.73
127_L142_A0.5040.73
114_V144_I0.5030.72
15_S19_N0.5030.72
19_N74_T0.5030.72
18_R31_Y0.5010.72
159_P162_G0.5000.72
107_L153_L0.5000.72
143_D159_P0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1feuA 1 0.8971 100 0.099 Contact Map
2zjrS 1 0.848 100 0.105 Contact Map
1b75A 1 0.4559 100 0.53 Contact Map
2l3uA 1 0.451 78.1 0.927 Contact Map
3lywA 1 0.402 75.4 0.928 Contact Map
2kq1A 1 0.5147 51.8 0.939 Contact Map
4qdyA 2 0.5588 42 0.942 Contact Map
4j2nA 4 0.2451 15.4 0.953 Contact Map
1y6uA 1 0.2402 13 0.955 Contact Map
1q7lB 2 0.3578 10.6 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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