CTC - BACSU - GREMLIN Contacts

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CTC - General stress protein CTC

UniProt:	P14194	Sequences: MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDSVELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVEVPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPAGGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	204 (192)
Sequences:	3131 (2210)
Seq/√Len:	159.5

BACSU - CTC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
108_T	141_E	4.175	1.00
5_T	63_E	3.190	1.00
102_E	126_A	2.870	1.00
106_H	139_T	2.853	1.00
130_K	165_S	2.741	1.00
25_H	41_S	2.653	1.00
61_T	68_K	2.651	1.00
20_I	41_S	2.503	1.00
43_D	46_E	2.499	1.00
109_G	145_S	2.431	1.00
107_L	122_Q	2.338	1.00
116_N	148_D	2.319	1.00
30_I	40_V	2.287	1.00
94_N	97_E	2.281	1.00
100_E	130_K	2.238	1.00
7_K	25_H	2.156	1.00
132_K	135_A	2.114	1.00
98_D	165_S	2.092	1.00
155_I	166_F	2.061	1.00
47_L	88_A	1.990	1.00
148_D	151_E	1.984	1.00
30_I	62_L	1.964	1.00
30_I	71_V	1.938	1.00
25_H	43_D	1.895	1.00
102_E	128_T	1.876	1.00
127_L	158_L	1.871	1.00
131_A	164_Y	1.866	1.00
135_A	163_D	1.817	1.00
61_T	70_S	1.810	1.00
106_H	141_E	1.782	1.00
69_H	92_V	1.768	1.00
8_E	65_S	1.755	1.00
100_E	128_T	1.751	1.00
109_G	144_I	1.723	1.00
98_D	130_K	1.709	1.00
113_G	118_G	1.705	1.00
63_E	68_K	1.688	1.00
147_L	151_E	1.624	1.00
118_G	149_V	1.615	1.00
160_A	166_F	1.608	1.00
107_L	175_A	1.595	1.00
156_A	171_D	1.539	1.00
95_M	134_K	1.536	1.00
124_L	172_E	1.534	1.00
129_V	164_Y	1.531	1.00
152_V	173_V	1.475	1.00
3_T	61_T	1.464	1.00
128_T	168_H	1.436	1.00
26_V	47_L	1.410	1.00
101_V	136_I	1.408	1.00
161_G	164_Y	1.404	1.00
29_I	39_P	1.391	1.00
13_T	17_L	1.377	1.00
3_T	63_E	1.340	1.00
156_A	170_S	1.334	1.00
44_S	48_I	1.333	1.00
107_L	144_I	1.326	1.00
109_G	143_D	1.325	1.00
114_V	120_L	1.301	1.00
182_Q	186_A	1.295	1.00
59_V	93_V	1.274	1.00
38_K	69_H	1.265	1.00
147_L	153_L	1.253	1.00
118_G	177_I	1.221	1.00
112_I	148_D	1.219	1.00
28_G	40_V	1.215	1.00
28_G	88_A	1.214	1.00
44_S	84_E	1.214	1.00
5_T	46_E	1.205	1.00
110_E	115_K	1.198	1.00
96_S	134_K	1.194	1.00
28_G	42_L	1.189	1.00
142_A	153_L	1.188	1.00
48_I	52_R	1.184	1.00
168_H	172_E	1.181	1.00
15_S	18_R	1.181	1.00
11_D	19_N	1.177	1.00
6_A	40_V	1.173	1.00
135_A	162_G	1.162	1.00
98_D	132_K	1.151	1.00
19_N	23_S	1.147	1.00
124_L	174_V	1.131	1.00
76_L	88_A	1.128	1.00
111_A	114_V	1.123	1.00
62_L	71_V	1.118	1.00
35_T	92_V	1.113	1.00
112_I	146_S	1.102	1.00
112_I	145_S	1.097	1.00
131_A	136_I	1.090	0.99
72_M	99_I	1.083	0.99
31_Y	89_D	1.071	0.99
70_S	95_M	1.061	0.99
120_L	177_I	1.044	0.99
121_Q	178_L	1.044	0.99
120_L	175_A	1.032	0.99
124_L	168_H	1.031	0.99
3_T	68_K	1.009	0.99
192_E	195_D	1.001	0.99
6_A	64_V	1.000	0.99
112_I	116_N	0.992	0.99
17_L	20_I	0.989	0.99
185_A	188_V	0.980	0.99
184_E	187_E	0.971	0.99
183_Q	186_A	0.968	0.99
42_L	90_F	0.967	0.99
186_A	189_D	0.965	0.99
45_V	49_K	0.964	0.99
7_K	41_S	0.963	0.99
33_K	97_E	0.962	0.99
70_S	134_K	0.959	0.99
123_P	176_S	0.957	0.99
147_L	152_V	0.957	0.99
123_P	173_V	0.948	0.99
96_S	132_K	0.945	0.99
7_K	65_S	0.939	0.98
62_L	90_F	0.938	0.98
149_V	179_P	0.936	0.98
130_K	167_N	0.930	0.98
40_V	71_V	0.920	0.98
173_V	176_S	0.915	0.98
63_E	66_G	0.903	0.98
144_I	147_L	0.899	0.98
79_D	82_K	0.898	0.98
140_I	160_A	0.889	0.98
79_D	86_T	0.885	0.98
12_F	39_P	0.882	0.98
142_A	158_L	0.874	0.98
13_T	16_S	0.871	0.97
51_L	85_I	0.867	0.97
124_L	155_I	0.866	0.97
127_L	155_I	0.863	0.97
119_V	180_P	0.859	0.97
113_G	117_G	0.854	0.97
114_V	118_G	0.851	0.97
49_K	52_R	0.832	0.97
111_A	118_G	0.830	0.97
108_T	143_D	0.822	0.96
155_I	168_H	0.821	0.96
182_Q	185_A	0.811	0.96
78_T	83_N	0.808	0.96
111_A	144_I	0.801	0.96
16_S	22_T	0.799	0.96
28_G	90_F	0.795	0.96
191_E	194_A	0.790	0.96
29_I	37_N	0.785	0.95
146_S	159_P	0.784	0.95
121_Q	176_S	0.779	0.95
30_I	69_H	0.777	0.95
33_K	92_V	0.775	0.95
72_M	101_V	0.774	0.95
28_G	47_L	0.765	0.95
74_T	91_Q	0.763	0.95
141_E	159_P	0.761	0.95
32_G	92_V	0.755	0.94
107_L	174_V	0.744	0.94
129_V	140_I	0.740	0.94
190_E	195_D	0.739	0.94
120_L	144_I	0.738	0.94
54_E	58_A	0.738	0.94
189_D	193_S	0.736	0.94
158_L	174_V	0.735	0.93
113_G	177_I	0.729	0.93
114_V	177_I	0.724	0.93
103_V	137_P	0.723	0.93
154_T	157_D	0.722	0.93
87_H	109_G	0.719	0.93
186_A	190_E	0.719	0.93
46_E	49_K	0.717	0.93
45_V	48_I	0.710	0.92
113_G	147_L	0.710	0.92
50_T	61_T	0.705	0.92
12_F	17_L	0.704	0.92
13_T	18_R	0.697	0.92
150_N	179_P	0.696	0.92
40_V	62_L	0.693	0.91
8_E	38_K	0.692	0.91
151_E	157_D	0.691	0.91
64_V	69_H	0.689	0.91
127_L	166_F	0.687	0.91
34_D	92_V	0.684	0.91
11_D	16_S	0.682	0.91
73_V	88_A	0.682	0.91
31_Y	87_H	0.679	0.90
98_D	133_P	0.678	0.90
42_L	47_L	0.671	0.90
49_K	53_D	0.669	0.90
152_V	176_S	0.668	0.90
179_P	183_Q	0.665	0.90
79_D	84_E	0.658	0.89
50_T	58_A	0.653	0.89
156_A	169_E	0.653	0.89
100_E	167_N	0.651	0.89
24_G	44_S	0.650	0.89
154_T	173_V	0.648	0.88
8_E	67_E	0.647	0.88
97_E	133_P	0.647	0.88
187_E	192_E	0.642	0.88
26_V	44_S	0.641	0.88
152_V	178_L	0.640	0.88
76_L	85_I	0.638	0.88
17_L	22_T	0.632	0.87
103_V	129_V	0.631	0.87
188_V	191_E	0.626	0.87
20_I	44_S	0.622	0.86
157_D	171_D	0.621	0.86
59_V	70_S	0.620	0.86
99_I	131_A	0.619	0.86
11_D	41_S	0.619	0.86
16_S	19_N	0.618	0.86
20_I	25_H	0.613	0.85
60_I	71_V	0.608	0.85
132_K	136_I	0.608	0.85
147_L	177_I	0.607	0.85
142_A	147_L	0.607	0.85
59_V	134_K	0.607	0.85
113_G	144_I	0.606	0.85
117_G	180_P	0.606	0.85
50_T	73_V	0.606	0.85
13_T	37_N	0.603	0.85
31_Y	37_N	0.600	0.84
111_A	120_L	0.599	0.84
155_I	174_V	0.599	0.84
65_S	68_K	0.598	0.84
182_Q	188_V	0.596	0.84
101_V	133_P	0.590	0.83
160_A	164_Y	0.589	0.83
184_E	188_V	0.587	0.83
101_V	129_V	0.581	0.82
111_A	177_I	0.579	0.82
113_G	148_D	0.579	0.82
60_I	69_H	0.578	0.82
44_S	79_D	0.577	0.82
63_E	67_E	0.576	0.82
52_R	72_M	0.575	0.82
187_E	190_E	0.575	0.82
77_Q	87_H	0.567	0.81
101_V	104_P	0.562	0.80
190_E	193_S	0.562	0.80
143_D	146_S	0.561	0.80
51_L	76_L	0.561	0.80
179_P	182_Q	0.561	0.80
51_L	73_V	0.560	0.80
182_Q	195_D	0.560	0.80
181_Q	184_E	0.560	0.80
48_I	84_E	0.557	0.80
179_P	185_A	0.556	0.79
155_I	170_S	0.552	0.79
113_G	149_V	0.549	0.79
57_N	131_A	0.545	0.78
127_L	168_H	0.545	0.78
109_G	147_L	0.545	0.78
45_V	51_L	0.544	0.78
95_M	133_P	0.542	0.78
49_K	60_I	0.537	0.77
34_D	97_E	0.532	0.76
4_L	60_I	0.532	0.76
28_G	39_P	0.531	0.76
57_N	136_I	0.531	0.76
145_S	148_D	0.529	0.76
128_T	167_N	0.529	0.76
52_R	78_T	0.527	0.76
93_V	131_A	0.526	0.76
18_R	21_R	0.525	0.76
56_K	75_D	0.522	0.75
47_L	53_D	0.521	0.75
79_D	83_N	0.520	0.75
6_A	62_L	0.519	0.75
149_V	180_P	0.519	0.75
57_N	71_V	0.514	0.74
35_T	69_H	0.514	0.74
118_G	147_L	0.513	0.74
24_G	84_E	0.512	0.74
123_P	172_E	0.512	0.74
140_I	166_F	0.511	0.74
77_Q	89_D	0.510	0.73
189_D	195_D	0.509	0.73
142_A	156_A	0.506	0.73
185_A	191_E	0.505	0.73
104_P	139_T	0.505	0.73
3_T	50_T	0.504	0.73
127_L	142_A	0.504	0.73
114_V	144_I	0.503	0.72
15_S	19_N	0.503	0.72
19_N	74_T	0.503	0.72
18_R	31_Y	0.501	0.72
159_P	162_G	0.500	0.72
107_L	153_L	0.500	0.72
143_D	159_P	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1feuA	1	0.8971	100	0.099	Contact Map
2zjrS	1	0.848	100	0.105	Contact Map
1b75A	1	0.4559	100	0.53	Contact Map
2l3uA	1	0.451	78.1	0.927	Contact Map
3lywA	1	0.402	75.4	0.928	Contact Map
2kq1A	1	0.5147	51.8	0.939	Contact Map
4qdyA	2	0.5588	42	0.942	Contact Map
4j2nA	4	0.2451	15.4	0.953	Contact Map
1y6uA	1	0.2402	13	0.955	Contact Map
1q7lB	2	0.3578	10.6	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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