GREMLIN Database
KPRS - Ribose-phosphate pyrophosphokinase
UniProt: P14193 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (306)
Sequences: 4031 (2031)
Seq/√Len: 116.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_E277_N4.5171.00
247_E271_K4.3961.00
272_E291_K4.2801.00
263_E267_N3.4501.00
277_N294_S3.3881.00
80_V127_A3.1921.00
219_T247_E3.0591.00
73_I118_F2.9961.00
13_F34_G2.7751.00
260_P264_R2.6811.00
301_E305_R2.6241.00
19_P23_K2.5311.00
171_I182_A2.5121.00
28_I300_A2.5021.00
12_I26_A2.4621.00
78_I114_T2.3951.00
219_T246_K2.3901.00
255_P275_V2.3411.00
35_K51_E2.3031.00
238_N242_E2.2261.00
66_S280_K2.2201.00
17_S64_S2.1751.00
58_D90_T2.1511.00
233_I250_A2.1231.00
133_L299_L2.1171.00
235_L238_N2.0991.00
40_R71_E2.0901.00
241_V271_K2.0761.00
133_L295_V2.0681.00
23_K27_D2.0591.00
164_K272_E2.0521.00
170_V218_K2.0431.00
227_I252_C2.0371.00
133_L278_S2.0311.00
25_I62_I2.0281.00
21_L299_L2.0121.00
131_I306_V1.9851.00
22_A33_L1.9321.00
238_N269_T1.9281.00
65_T99_G1.9161.00
120_N145_D1.8981.00
122_L127_A1.8411.00
61_I83_L1.8221.00
228_D258_S1.8151.00
172_V220_A1.7351.00
227_I273_L1.7261.00
11_K57_C1.7261.00
173_S178_G1.7151.00
169_I191_A1.7111.00
12_I62_I1.6691.00
20_E24_E1.6451.00
159_E163_G1.6371.00
37_S51_E1.6291.00
230_A234_T1.6241.00
250_A270_I1.6161.00
117_L125_A1.6131.00
134_D253_T1.6071.00
257_L273_L1.5931.00
266_N288_E1.5861.00
287_I290_F1.5581.00
56_G309_Q1.5531.00
249_Y271_K1.5531.00
217_G246_K1.5531.00
95_I130_V1.5311.00
278_S295_V1.5261.00
266_N287_I1.5231.00
36_C79_M1.5221.00
249_Y272_E1.5111.00
202_R205_V1.5091.00
178_G181_R1.5041.00
166_L169_I1.4991.00
160_Y291_K1.4991.00
16_N38_V1.4741.00
59_C83_L1.4391.00
227_I233_I1.4251.00
151_L302_A1.4241.00
161_F274_V1.4041.00
14_S22_A1.3951.00
26_A33_L1.3901.00
219_T249_Y1.3871.00
43_D97_Y1.3731.00
206_A235_L1.3721.00
241_V248_V1.3561.00
24_E296_G1.3491.00
92_N129_R1.3411.00
281_L284_E1.3371.00
260_P263_E1.3291.00
157_L293_L1.3211.00
21_L25_I1.3141.00
95_I122_L1.3021.00
252_C275_V1.2850.99
165_N168_D1.2830.99
37_S49_N1.2720.99
301_E304_I1.2690.99
29_V300_A1.2680.99
160_Y274_V1.2640.99
265_I268_S1.2580.99
283_E286_K1.2530.99
54_I83_L1.2500.99
177_G200_R1.2290.99
15_L63_Q1.2260.99
220_A240_L1.2260.99
172_V194_A1.2220.99
237_A270_I1.2190.99
265_I273_L1.2170.99
177_G198_K1.2140.99
28_I297_P1.2110.99
20_E23_K1.2070.99
39_T47_Q1.2040.99
50_I83_L1.1990.99
304_I310_Q1.1970.99
161_F221_I1.1850.99
172_V240_L1.1840.99
304_I308_E1.1750.99
68_P71_E1.1710.99
281_L290_F1.1680.99
230_A264_R1.1530.99
116_K120_N1.1480.99
169_I221_I1.1460.99
29_V304_I1.1430.99
116_K145_D1.1370.99
26_A32_Q1.1320.99
241_V269_T1.1320.99
81_D85_R1.1170.99
61_I79_M1.1110.99
16_N40_R1.1100.99
24_E294_S1.0930.98
208_V239_A1.0860.98
227_I230_A1.0840.98
104_D139_Q1.0830.98
175_D198_K1.0820.98
18_N64_S1.0810.98
281_L292_Q1.0800.98
222_L236_A1.0790.98
171_I189_L1.0790.98
68_P72_H1.0700.98
122_L130_V1.0690.98
90_T309_Q1.0650.98
166_L219_T1.0600.98
90_T128_T1.0580.98
25_I303_I1.0340.98
77_L121_L1.0310.98
107_A111_E1.0300.98
196_I236_A1.0300.98
49_N111_E1.0270.98
255_P281_L1.0210.97
216_E243_N1.0190.97
230_A260_P1.0060.97
168_D218_K1.0050.97
47_Q111_E0.9960.97
157_L251_C0.9960.97
10_L57_C0.9950.97
282_P285_K0.9930.97
156_I293_L0.9860.97
120_N123_E0.9840.97
239_A242_E0.9830.97
175_D200_R0.9810.97
170_V220_A0.9810.97
12_I31_V0.9680.96
160_Y272_E0.9670.96
158_G185_L0.9640.96
14_S17_S0.9600.96
22_A26_A0.9560.96
183_R197_D0.9560.96
10_L307_H0.9550.96
58_D92_N0.9530.96
176_H180_T0.9510.96
308_E314_Y0.9480.96
42_S228_D0.9450.96
198_K231_G0.9430.96
123_E145_D0.9420.96
16_N75_E0.9400.96
216_E244_G0.9400.96
200_R231_G0.9370.96
160_Y293_L0.9360.96
257_L275_V0.9360.96
58_D89_K0.9320.96
115_A140_I0.9300.96
234_T264_R0.9270.95
15_L79_M0.9270.95
135_L150_H0.9250.95
305_R310_Q0.9230.95
169_I219_T0.9210.95
40_R46_V0.9160.95
106_K113_I0.9150.95
237_A269_T0.9140.95
66_S279_I0.9120.95
43_D99_G0.9070.95
153_G253_T0.8970.95
160_Y164_K0.8960.95
18_N280_K0.8930.94
133_L298_L0.8910.94
42_S259_G0.8890.94
61_I80_V0.8870.94
310_Q314_Y0.8830.94
108_R111_E0.8770.94
171_I185_L0.8730.94
273_L290_F0.8700.94
13_F79_M0.8680.94
160_Y251_C0.8630.93
252_C255_P0.8620.93
14_S33_L0.8580.93
268_S289_R0.8570.93
238_N241_V0.8550.93
177_G231_G0.8520.93
50_I79_M0.8520.93
45_E103_Q0.8470.93
297_P300_A0.8430.93
168_D246_K0.8350.92
65_T68_P0.8330.92
43_D105_R0.8330.92
153_G157_L0.8290.92
20_E280_K0.8290.92
161_F249_Y0.8280.92
262_V266_N0.8270.92
174_P232_T0.8260.92
184_K187_D0.8260.92
16_N19_P0.8240.92
245_A248_V0.8230.92
198_K206_A0.8210.92
76_L122_L0.8210.92
77_L125_A0.8170.91
263_E266_N0.8160.91
234_T238_N0.8160.91
220_A248_V0.8130.91
91_I128_T0.8130.91
233_I252_C0.8070.91
28_I301_E0.8070.91
134_D181_R0.8050.91
93_I127_A0.8030.91
256_V279_I0.8000.90
23_K33_L0.7950.90
35_K52_E0.7950.90
215_I240_L0.7940.90
60_Y307_H0.7930.90
80_V93_I0.7920.90
239_A243_N0.7900.90
26_A31_V0.7860.90
200_R232_T0.7840.90
250_A268_S0.7830.90
159_E162_E0.7830.90
45_E226_I0.7800.89
135_L140_I0.7760.89
117_L121_L0.7750.89
157_L276_T0.7750.89
203_P206_A0.7730.89
49_N108_R0.7720.89
83_L88_A0.7710.89
14_S18_N0.7660.89
19_P35_K0.7630.88
185_L223_I0.7610.88
66_S72_H0.7590.88
275_V290_F0.7560.88
185_L293_L0.7550.88
262_V287_I0.7530.88
179_V195_I0.7470.87
237_A268_S0.7440.87
261_A265_I0.7430.87
129_R149_D0.7420.87
175_D225_D0.7400.87
82_A86_A0.7320.86
201_P206_A0.7310.86
161_F251_C0.7250.86
192_P218_K0.7220.85
215_I245_A0.7210.85
238_N267_N0.7200.85
227_I275_V0.7190.85
119_A144_F0.7160.85
167_E219_T0.7160.85
14_S19_P0.7140.85
38_V48_I0.7120.85
46_V70_N0.7120.85
123_E146_I0.7060.84
220_A245_A0.7050.84
265_I287_I0.7020.84
169_I218_K0.7010.84
201_P205_V0.6990.84
103_Q226_I0.6960.83
237_A250_A0.6960.83
302_A315_L0.6950.83
81_D116_K0.6950.83
55_R87_S0.6950.83
24_E27_D0.6920.83
136_H225_D0.6900.83
104_D200_R0.6890.83
24_E28_I0.6890.83
10_L31_V0.6890.83
77_L117_L0.6860.82
277_N295_V0.6850.82
11_K34_G0.6840.82
73_I77_L0.6800.82
127_A146_I0.6780.82
78_I117_L0.6750.81
154_V185_L0.6690.81
81_D117_L0.6680.81
165_N219_T0.6680.81
90_T307_H0.6670.81
13_F36_C0.6660.80
168_D219_T0.6650.80
11_K52_E0.6610.80
152_M184_K0.6610.80
12_I29_V0.6600.80
28_I296_G0.6600.80
95_I99_G0.6590.80
21_L62_I0.6590.80
49_N227_I0.6580.80
204_N228_D0.6540.79
269_T289_R0.6530.79
16_N36_C0.6530.79
295_V299_L0.6520.79
65_T76_L0.6520.79
13_F54_I0.6490.79
153_G276_T0.6480.79
261_A268_S0.6480.79
135_L148_I0.6470.79
44_G229_T0.6460.78
273_L287_I0.6460.78
275_V292_Q0.6440.78
201_P207_E0.6440.78
201_P208_V0.6420.78
227_I257_L0.6420.78
42_S204_N0.6380.78
266_N289_R0.6370.77
112_P117_L0.6370.77
234_T237_A0.6370.77
34_G52_E0.6370.77
302_A312_V0.6320.77
80_V88_A0.6300.77
161_F185_L0.6290.77
173_S177_G0.6270.76
50_I54_I0.6240.76
288_E291_K0.6210.76
261_A264_R0.6200.76
204_N258_S0.6200.76
197_D210_N0.6180.75
195_I212_V0.6170.75
241_V247_E0.6160.75
274_V293_L0.6140.75
81_D120_N0.6130.75
222_L270_I0.6120.75
131_I302_A0.6120.75
14_S36_C0.6120.75
102_R175_D0.6110.75
94_V303_I0.6110.75
200_R206_A0.6100.74
15_L176_H0.6090.74
198_K232_T0.6090.74
17_S63_Q0.6060.74
138_P180_T0.5990.73
80_V125_A0.5970.73
139_Q142_G0.5970.73
177_G232_T0.5960.73
25_I299_L0.5960.73
55_R60_Y0.5960.73
55_R149_D0.5910.72
252_C273_L0.5890.72
106_K110_R0.5880.72
204_N229_T0.5880.72
182_A193_I0.5860.71
98_Y101_A0.5850.71
312_V315_L0.5830.71
86_A106_K0.5820.71
170_V215_I0.5820.71
88_A91_I0.5820.71
136_H175_D0.5800.71
102_R228_D0.5790.71
117_L120_N0.5770.70
231_G260_P0.5770.70
185_L251_C0.5760.70
104_D136_H0.5750.70
296_G300_A0.5740.70
104_D137_A0.5740.70
152_M158_G0.5710.69
186_A191_A0.5710.69
130_V144_F0.5700.69
127_A130_V0.5700.69
53_S57_C0.5700.69
132_A135_L0.5690.69
203_P231_G0.5680.69
251_C274_V0.5670.69
67_D72_H0.5650.69
237_A241_V0.5640.69
201_P204_N0.5610.68
76_L95_I0.5610.68
241_V245_A0.5600.68
59_C88_A0.5600.68
98_Y144_F0.5580.68
176_H193_I0.5580.68
281_L285_K0.5580.68
26_A29_V0.5580.68
234_T268_S0.5580.68
48_I79_M0.5580.68
183_R199_R0.5560.67
34_G54_I0.5550.67
15_L18_N0.5550.67
305_R314_Y0.5550.67
104_D175_D0.5550.67
298_L315_L0.5530.67
179_V193_I0.5530.67
156_I277_N0.5520.67
197_D212_V0.5510.67
47_Q108_R0.5500.67
202_R206_A0.5460.66
207_E235_L0.5440.66
183_R187_D0.5440.66
311_S314_Y0.5440.66
173_S181_R0.5440.66
211_I243_N0.5420.66
306_V312_V0.5410.65
137_A140_I0.5410.65
158_G188_R0.5390.65
44_G226_I0.5390.65
156_I298_L0.5360.65
285_K290_F0.5360.65
46_V75_E0.5360.65
98_Y115_A0.5360.65
14_S62_I0.5350.65
175_D231_G0.5350.65
21_L296_G0.5340.64
262_V290_F0.5330.64
30_G162_E0.5310.64
106_K138_P0.5310.64
234_T265_I0.5310.64
64_S99_G0.5300.64
273_L289_R0.5290.64
230_A262_V0.5290.64
85_R106_K0.5290.64
138_P303_I0.5270.63
37_S47_Q0.5260.63
230_A250_A0.5240.63
247_E288_E0.5230.63
199_R208_V0.5230.63
89_K128_T0.5230.63
284_E287_I0.5220.63
275_V281_L0.5200.62
55_R110_R0.5190.62
84_K91_I0.5190.62
28_I304_I0.5170.62
12_I34_G0.5160.62
281_L286_K0.5150.62
92_N131_I0.5150.62
98_Y119_A0.5140.61
103_Q114_T0.5130.61
150_H180_T0.5120.61
176_H197_D0.5110.61
107_A138_P0.5110.61
87_S149_D0.5080.61
66_S69_V0.5080.61
170_V194_A0.5080.61
237_A248_V0.5080.61
264_R267_N0.5080.61
65_T73_I0.5070.60
220_A251_C0.5060.60
182_A223_I0.5050.60
69_V72_H0.5030.60
90_T131_I0.5010.60
297_P301_E0.5010.60
196_I239_A0.5010.60
174_P198_K0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dkuA 5 0.9306 100 0.143 Contact Map
2ji4A 5 0.918 100 0.154 Contact Map
3s5jB 2 0.9527 100 0.158 Contact Map
3dahA 5 0.9527 100 0.179 Contact Map
4twbA 2 0.877 100 0.208 Contact Map
1u9yA 3 0.8644 100 0.239 Contact Map
3lrtA 2 0.9022 100 0.241 Contact Map
3dezA 2 0.6088 100 0.708 Contact Map
1o57A 2 0.7823 99.9 0.733 Contact Map
3m3hA 2 0.5836 99.9 0.758 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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