KPRS - BACSU - GREMLIN Contacts

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KPRS - Ribose-phosphate pyrophosphokinase

UniProt:	P14193	Sequences: MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDGEVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYARQDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEYFEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGKTAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVTNSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (306)
Sequences:	4031 (2031)
Seq/√Len:	116.1

ECOLI - KPRS
BACSU - KPRS
HALSA - KPRS
SULSO - KPRS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_E	277_N	4.517	1.00
247_E	271_K	4.396	1.00
272_E	291_K	4.280	1.00
263_E	267_N	3.450	1.00
277_N	294_S	3.388	1.00
80_V	127_A	3.192	1.00
219_T	247_E	3.059	1.00
73_I	118_F	2.996	1.00
13_F	34_G	2.775	1.00
260_P	264_R	2.681	1.00
301_E	305_R	2.624	1.00
19_P	23_K	2.531	1.00
171_I	182_A	2.512	1.00
28_I	300_A	2.502	1.00
12_I	26_A	2.462	1.00
78_I	114_T	2.395	1.00
219_T	246_K	2.390	1.00
255_P	275_V	2.341	1.00
35_K	51_E	2.303	1.00
238_N	242_E	2.226	1.00
66_S	280_K	2.220	1.00
17_S	64_S	2.175	1.00
58_D	90_T	2.151	1.00
233_I	250_A	2.123	1.00
133_L	299_L	2.117	1.00
235_L	238_N	2.099	1.00
40_R	71_E	2.090	1.00
241_V	271_K	2.076	1.00
133_L	295_V	2.068	1.00
23_K	27_D	2.059	1.00
164_K	272_E	2.052	1.00
170_V	218_K	2.043	1.00
227_I	252_C	2.037	1.00
133_L	278_S	2.031	1.00
25_I	62_I	2.028	1.00
21_L	299_L	2.012	1.00
131_I	306_V	1.985	1.00
22_A	33_L	1.932	1.00
238_N	269_T	1.928	1.00
65_T	99_G	1.916	1.00
120_N	145_D	1.898	1.00
122_L	127_A	1.841	1.00
61_I	83_L	1.822	1.00
228_D	258_S	1.815	1.00
172_V	220_A	1.735	1.00
227_I	273_L	1.726	1.00
11_K	57_C	1.726	1.00
173_S	178_G	1.715	1.00
169_I	191_A	1.711	1.00
12_I	62_I	1.669	1.00
20_E	24_E	1.645	1.00
159_E	163_G	1.637	1.00
37_S	51_E	1.629	1.00
230_A	234_T	1.624	1.00
250_A	270_I	1.616	1.00
117_L	125_A	1.613	1.00
134_D	253_T	1.607	1.00
257_L	273_L	1.593	1.00
266_N	288_E	1.586	1.00
287_I	290_F	1.558	1.00
56_G	309_Q	1.553	1.00
249_Y	271_K	1.553	1.00
217_G	246_K	1.553	1.00
95_I	130_V	1.531	1.00
278_S	295_V	1.526	1.00
266_N	287_I	1.523	1.00
36_C	79_M	1.522	1.00
249_Y	272_E	1.511	1.00
202_R	205_V	1.509	1.00
178_G	181_R	1.504	1.00
166_L	169_I	1.499	1.00
160_Y	291_K	1.499	1.00
16_N	38_V	1.474	1.00
59_C	83_L	1.439	1.00
227_I	233_I	1.425	1.00
151_L	302_A	1.424	1.00
161_F	274_V	1.404	1.00
14_S	22_A	1.395	1.00
26_A	33_L	1.390	1.00
219_T	249_Y	1.387	1.00
43_D	97_Y	1.373	1.00
206_A	235_L	1.372	1.00
241_V	248_V	1.356	1.00
24_E	296_G	1.349	1.00
92_N	129_R	1.341	1.00
281_L	284_E	1.337	1.00
260_P	263_E	1.329	1.00
157_L	293_L	1.321	1.00
21_L	25_I	1.314	1.00
95_I	122_L	1.302	1.00
252_C	275_V	1.285	0.99
165_N	168_D	1.283	0.99
37_S	49_N	1.272	0.99
301_E	304_I	1.269	0.99
29_V	300_A	1.268	0.99
160_Y	274_V	1.264	0.99
265_I	268_S	1.258	0.99
283_E	286_K	1.253	0.99
54_I	83_L	1.250	0.99
177_G	200_R	1.229	0.99
15_L	63_Q	1.226	0.99
220_A	240_L	1.226	0.99
172_V	194_A	1.222	0.99
237_A	270_I	1.219	0.99
265_I	273_L	1.217	0.99
177_G	198_K	1.214	0.99
28_I	297_P	1.211	0.99
20_E	23_K	1.207	0.99
39_T	47_Q	1.204	0.99
50_I	83_L	1.199	0.99
304_I	310_Q	1.197	0.99
161_F	221_I	1.185	0.99
172_V	240_L	1.184	0.99
304_I	308_E	1.175	0.99
68_P	71_E	1.171	0.99
281_L	290_F	1.168	0.99
230_A	264_R	1.153	0.99
116_K	120_N	1.148	0.99
169_I	221_I	1.146	0.99
29_V	304_I	1.143	0.99
116_K	145_D	1.137	0.99
26_A	32_Q	1.132	0.99
241_V	269_T	1.132	0.99
81_D	85_R	1.117	0.99
61_I	79_M	1.111	0.99
16_N	40_R	1.110	0.99
24_E	294_S	1.093	0.98
208_V	239_A	1.086	0.98
227_I	230_A	1.084	0.98
104_D	139_Q	1.083	0.98
175_D	198_K	1.082	0.98
18_N	64_S	1.081	0.98
281_L	292_Q	1.080	0.98
222_L	236_A	1.079	0.98
171_I	189_L	1.079	0.98
68_P	72_H	1.070	0.98
122_L	130_V	1.069	0.98
90_T	309_Q	1.065	0.98
166_L	219_T	1.060	0.98
90_T	128_T	1.058	0.98
25_I	303_I	1.034	0.98
77_L	121_L	1.031	0.98
107_A	111_E	1.030	0.98
196_I	236_A	1.030	0.98
49_N	111_E	1.027	0.98
255_P	281_L	1.021	0.97
216_E	243_N	1.019	0.97
230_A	260_P	1.006	0.97
168_D	218_K	1.005	0.97
47_Q	111_E	0.996	0.97
157_L	251_C	0.996	0.97
10_L	57_C	0.995	0.97
282_P	285_K	0.993	0.97
156_I	293_L	0.986	0.97
120_N	123_E	0.984	0.97
239_A	242_E	0.983	0.97
175_D	200_R	0.981	0.97
170_V	220_A	0.981	0.97
12_I	31_V	0.968	0.96
160_Y	272_E	0.967	0.96
158_G	185_L	0.964	0.96
14_S	17_S	0.960	0.96
22_A	26_A	0.956	0.96
183_R	197_D	0.956	0.96
10_L	307_H	0.955	0.96
58_D	92_N	0.953	0.96
176_H	180_T	0.951	0.96
308_E	314_Y	0.948	0.96
42_S	228_D	0.945	0.96
198_K	231_G	0.943	0.96
123_E	145_D	0.942	0.96
16_N	75_E	0.940	0.96
216_E	244_G	0.940	0.96
200_R	231_G	0.937	0.96
160_Y	293_L	0.936	0.96
257_L	275_V	0.936	0.96
58_D	89_K	0.932	0.96
115_A	140_I	0.930	0.96
234_T	264_R	0.927	0.95
15_L	79_M	0.927	0.95
135_L	150_H	0.925	0.95
305_R	310_Q	0.923	0.95
169_I	219_T	0.921	0.95
40_R	46_V	0.916	0.95
106_K	113_I	0.915	0.95
237_A	269_T	0.914	0.95
66_S	279_I	0.912	0.95
43_D	99_G	0.907	0.95
153_G	253_T	0.897	0.95
160_Y	164_K	0.896	0.95
18_N	280_K	0.893	0.94
133_L	298_L	0.891	0.94
42_S	259_G	0.889	0.94
61_I	80_V	0.887	0.94
310_Q	314_Y	0.883	0.94
108_R	111_E	0.877	0.94
171_I	185_L	0.873	0.94
273_L	290_F	0.870	0.94
13_F	79_M	0.868	0.94
160_Y	251_C	0.863	0.93
252_C	255_P	0.862	0.93
14_S	33_L	0.858	0.93
268_S	289_R	0.857	0.93
238_N	241_V	0.855	0.93
177_G	231_G	0.852	0.93
50_I	79_M	0.852	0.93
45_E	103_Q	0.847	0.93
297_P	300_A	0.843	0.93
168_D	246_K	0.835	0.92
65_T	68_P	0.833	0.92
43_D	105_R	0.833	0.92
153_G	157_L	0.829	0.92
20_E	280_K	0.829	0.92
161_F	249_Y	0.828	0.92
262_V	266_N	0.827	0.92
174_P	232_T	0.826	0.92
184_K	187_D	0.826	0.92
16_N	19_P	0.824	0.92
245_A	248_V	0.823	0.92
198_K	206_A	0.821	0.92
76_L	122_L	0.821	0.92
77_L	125_A	0.817	0.91
263_E	266_N	0.816	0.91
234_T	238_N	0.816	0.91
220_A	248_V	0.813	0.91
91_I	128_T	0.813	0.91
233_I	252_C	0.807	0.91
28_I	301_E	0.807	0.91
134_D	181_R	0.805	0.91
93_I	127_A	0.803	0.91
256_V	279_I	0.800	0.90
23_K	33_L	0.795	0.90
35_K	52_E	0.795	0.90
215_I	240_L	0.794	0.90
60_Y	307_H	0.793	0.90
80_V	93_I	0.792	0.90
239_A	243_N	0.790	0.90
26_A	31_V	0.786	0.90
200_R	232_T	0.784	0.90
250_A	268_S	0.783	0.90
159_E	162_E	0.783	0.90
45_E	226_I	0.780	0.89
135_L	140_I	0.776	0.89
117_L	121_L	0.775	0.89
157_L	276_T	0.775	0.89
203_P	206_A	0.773	0.89
49_N	108_R	0.772	0.89
83_L	88_A	0.771	0.89
14_S	18_N	0.766	0.89
19_P	35_K	0.763	0.88
185_L	223_I	0.761	0.88
66_S	72_H	0.759	0.88
275_V	290_F	0.756	0.88
185_L	293_L	0.755	0.88
262_V	287_I	0.753	0.88
179_V	195_I	0.747	0.87
237_A	268_S	0.744	0.87
261_A	265_I	0.743	0.87
129_R	149_D	0.742	0.87
175_D	225_D	0.740	0.87
82_A	86_A	0.732	0.86
201_P	206_A	0.731	0.86
161_F	251_C	0.725	0.86
192_P	218_K	0.722	0.85
215_I	245_A	0.721	0.85
238_N	267_N	0.720	0.85
227_I	275_V	0.719	0.85
119_A	144_F	0.716	0.85
167_E	219_T	0.716	0.85
14_S	19_P	0.714	0.85
38_V	48_I	0.712	0.85
46_V	70_N	0.712	0.85
123_E	146_I	0.706	0.84
220_A	245_A	0.705	0.84
265_I	287_I	0.702	0.84
169_I	218_K	0.701	0.84
201_P	205_V	0.699	0.84
103_Q	226_I	0.696	0.83
237_A	250_A	0.696	0.83
302_A	315_L	0.695	0.83
81_D	116_K	0.695	0.83
55_R	87_S	0.695	0.83
24_E	27_D	0.692	0.83
136_H	225_D	0.690	0.83
104_D	200_R	0.689	0.83
24_E	28_I	0.689	0.83
10_L	31_V	0.689	0.83
77_L	117_L	0.686	0.82
277_N	295_V	0.685	0.82
11_K	34_G	0.684	0.82
73_I	77_L	0.680	0.82
127_A	146_I	0.678	0.82
78_I	117_L	0.675	0.81
154_V	185_L	0.669	0.81
81_D	117_L	0.668	0.81
165_N	219_T	0.668	0.81
90_T	307_H	0.667	0.81
13_F	36_C	0.666	0.80
168_D	219_T	0.665	0.80
11_K	52_E	0.661	0.80
152_M	184_K	0.661	0.80
12_I	29_V	0.660	0.80
28_I	296_G	0.660	0.80
95_I	99_G	0.659	0.80
21_L	62_I	0.659	0.80
49_N	227_I	0.658	0.80
204_N	228_D	0.654	0.79
269_T	289_R	0.653	0.79
16_N	36_C	0.653	0.79
295_V	299_L	0.652	0.79
65_T	76_L	0.652	0.79
13_F	54_I	0.649	0.79
153_G	276_T	0.648	0.79
261_A	268_S	0.648	0.79
135_L	148_I	0.647	0.79
44_G	229_T	0.646	0.78
273_L	287_I	0.646	0.78
275_V	292_Q	0.644	0.78
201_P	207_E	0.644	0.78
201_P	208_V	0.642	0.78
227_I	257_L	0.642	0.78
42_S	204_N	0.638	0.78
266_N	289_R	0.637	0.77
112_P	117_L	0.637	0.77
234_T	237_A	0.637	0.77
34_G	52_E	0.637	0.77
302_A	312_V	0.632	0.77
80_V	88_A	0.630	0.77
161_F	185_L	0.629	0.77
173_S	177_G	0.627	0.76
50_I	54_I	0.624	0.76
288_E	291_K	0.621	0.76
261_A	264_R	0.620	0.76
204_N	258_S	0.620	0.76
197_D	210_N	0.618	0.75
195_I	212_V	0.617	0.75
241_V	247_E	0.616	0.75
274_V	293_L	0.614	0.75
81_D	120_N	0.613	0.75
222_L	270_I	0.612	0.75
131_I	302_A	0.612	0.75
14_S	36_C	0.612	0.75
102_R	175_D	0.611	0.75
94_V	303_I	0.611	0.75
200_R	206_A	0.610	0.74
15_L	176_H	0.609	0.74
198_K	232_T	0.609	0.74
17_S	63_Q	0.606	0.74
138_P	180_T	0.599	0.73
80_V	125_A	0.597	0.73
139_Q	142_G	0.597	0.73
177_G	232_T	0.596	0.73
25_I	299_L	0.596	0.73
55_R	60_Y	0.596	0.73
55_R	149_D	0.591	0.72
252_C	273_L	0.589	0.72
106_K	110_R	0.588	0.72
204_N	229_T	0.588	0.72
182_A	193_I	0.586	0.71
98_Y	101_A	0.585	0.71
312_V	315_L	0.583	0.71
86_A	106_K	0.582	0.71
170_V	215_I	0.582	0.71
88_A	91_I	0.582	0.71
136_H	175_D	0.580	0.71
102_R	228_D	0.579	0.71
117_L	120_N	0.577	0.70
231_G	260_P	0.577	0.70
185_L	251_C	0.576	0.70
104_D	136_H	0.575	0.70
296_G	300_A	0.574	0.70
104_D	137_A	0.574	0.70
152_M	158_G	0.571	0.69
186_A	191_A	0.571	0.69
130_V	144_F	0.570	0.69
127_A	130_V	0.570	0.69
53_S	57_C	0.570	0.69
132_A	135_L	0.569	0.69
203_P	231_G	0.568	0.69
251_C	274_V	0.567	0.69
67_D	72_H	0.565	0.69
237_A	241_V	0.564	0.69
201_P	204_N	0.561	0.68
76_L	95_I	0.561	0.68
241_V	245_A	0.560	0.68
59_C	88_A	0.560	0.68
98_Y	144_F	0.558	0.68
176_H	193_I	0.558	0.68
281_L	285_K	0.558	0.68
26_A	29_V	0.558	0.68
234_T	268_S	0.558	0.68
48_I	79_M	0.558	0.68
183_R	199_R	0.556	0.67
34_G	54_I	0.555	0.67
15_L	18_N	0.555	0.67
305_R	314_Y	0.555	0.67
104_D	175_D	0.555	0.67
298_L	315_L	0.553	0.67
179_V	193_I	0.553	0.67
156_I	277_N	0.552	0.67
197_D	212_V	0.551	0.67
47_Q	108_R	0.550	0.67
202_R	206_A	0.546	0.66
207_E	235_L	0.544	0.66
183_R	187_D	0.544	0.66
311_S	314_Y	0.544	0.66
173_S	181_R	0.544	0.66
211_I	243_N	0.542	0.66
306_V	312_V	0.541	0.65
137_A	140_I	0.541	0.65
158_G	188_R	0.539	0.65
44_G	226_I	0.539	0.65
156_I	298_L	0.536	0.65
285_K	290_F	0.536	0.65
46_V	75_E	0.536	0.65
98_Y	115_A	0.536	0.65
14_S	62_I	0.535	0.65
175_D	231_G	0.535	0.65
21_L	296_G	0.534	0.64
262_V	290_F	0.533	0.64
30_G	162_E	0.531	0.64
106_K	138_P	0.531	0.64
234_T	265_I	0.531	0.64
64_S	99_G	0.530	0.64
273_L	289_R	0.529	0.64
230_A	262_V	0.529	0.64
85_R	106_K	0.529	0.64
138_P	303_I	0.527	0.63
37_S	47_Q	0.526	0.63
230_A	250_A	0.524	0.63
247_E	288_E	0.523	0.63
199_R	208_V	0.523	0.63
89_K	128_T	0.523	0.63
284_E	287_I	0.522	0.63
275_V	281_L	0.520	0.62
55_R	110_R	0.519	0.62
84_K	91_I	0.519	0.62
28_I	304_I	0.517	0.62
12_I	34_G	0.516	0.62
281_L	286_K	0.515	0.62
92_N	131_I	0.515	0.62
98_Y	119_A	0.514	0.61
103_Q	114_T	0.513	0.61
150_H	180_T	0.512	0.61
176_H	197_D	0.511	0.61
107_A	138_P	0.511	0.61
87_S	149_D	0.508	0.61
66_S	69_V	0.508	0.61
170_V	194_A	0.508	0.61
237_A	248_V	0.508	0.61
264_R	267_N	0.508	0.61
65_T	73_I	0.507	0.60
220_A	251_C	0.506	0.60
182_A	223_I	0.505	0.60
69_V	72_H	0.503	0.60
90_T	131_I	0.501	0.60
297_P	301_E	0.501	0.60
196_I	239_A	0.501	0.60
174_P	198_K	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1dkuA	5	0.9306	100	0.143	Contact Map
2ji4A	5	0.918	100	0.154	Contact Map
3s5jB	2	0.9527	100	0.158	Contact Map
3dahA	5	0.9527	100	0.179	Contact Map
4twbA	2	0.877	100	0.208	Contact Map
1u9yA	3	0.8644	100	0.239	Contact Map
3lrtA	2	0.9022	100	0.241	Contact Map
3dezA	2	0.6088	100	0.708	Contact Map
1o57A	2	0.7823	99.9	0.733	Contact Map
3m3hA	2	0.5836	99.9	0.758	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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