GREMLIN Database
GLMU - Bifunctional protein GlmU
UniProt: P14192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (429)
Sequences: 4181 (2708)
Seq/√Len: 130.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_I302_S3.7221.00
371_E394_L3.5761.00
143_I166_V3.5581.00
156_H164_R3.4031.00
301_N317_H3.3991.00
375_D400_G3.1461.00
152_K163_E3.1021.00
398_E417_E2.9121.00
340_N357_D2.7921.00
132_V167_T2.7731.00
187_Q209_E2.7701.00
290_D307_R2.5811.00
119_H127_T2.4861.00
20_K290_D2.4261.00
336_S350_I2.3751.00
350_I353_T2.3311.00
31_K39_D2.2781.00
302_S315_V2.2761.00
145_S149_A2.2701.00
361_A367_V2.2541.00
21_L27_P2.2481.00
132_V217_Q2.2381.00
355_F361_A2.1971.00
396_K414_T2.1811.00
357_D374_T2.1511.00
97_T178_N2.1501.00
315_V318_S2.1161.00
359_S399_D2.1111.00
137_T156_H2.1001.00
183_R209_E2.0281.00
295_P312_Q2.0211.00
307_R323_D1.9921.00
268_V286_Q1.9771.00
400_G418_G1.9701.00
304_I310_I1.9581.00
48_K69_E1.9581.00
289_E306_S1.9481.00
273_T291_T1.9351.00
246_K250_Q1.9141.00
414_T430_D1.8781.00
432_P435_A1.8741.00
150_V215_A1.8671.00
270_G289_E1.8621.00
160_S163_E1.8491.00
278_G296_H1.8471.00
374_T399_D1.8431.00
288_G306_S1.8391.00
248_H269_I1.8361.00
161_E164_R1.8191.00
87_Q186_D1.8061.00
6_A46_L1.7751.00
338_I342_V1.7491.00
407_S421_V1.7441.00
385_V408_N1.7381.00
306_S322_N1.7311.00
117_K121_Q1.7311.00
80_A188_V1.7171.00
248_H251_N1.7151.00
267_A281_I1.7151.00
271_S289_E1.7121.00
308_T324_V1.7071.00
371_E396_K1.6651.00
339_G357_D1.6571.00
319_K337_V1.6571.00
431_V437_A1.6541.00
337_V354_Q1.6421.00
50_V71_R1.6401.00
6_A41_A1.6361.00
227_V230_R1.6321.00
352_K394_L1.6131.00
417_E433_G1.6081.00
408_N426_T1.6051.00
305_G322_N1.6041.00
399_D417_E1.5911.00
322_N340_N1.5901.00
226_G230_R1.5831.00
281_I285_V1.5751.00
418_G434_K1.5701.00
308_T340_N1.5701.00
99_V176_F1.5691.00
226_G229_D1.5661.00
57_A72_V1.5561.00
353_T367_V1.5451.00
376_V399_D1.5211.00
180_A211_E1.5141.00
416_G433_G1.5031.00
403_I409_L1.4981.00
124_A214_A1.4931.00
323_D341_E1.4851.00
335_D352_K1.4851.00
138_G156_H1.4831.00
270_G306_S1.4821.00
321_G340_N1.4761.00
96_V120_T1.4671.00
315_V320_V1.4631.00
229_D250_Q1.4591.00
77_L81_H1.4571.00
143_I152_K1.4571.00
318_S336_S1.4511.00
135_D156_H1.4511.00
35_E63_Q1.4471.00
413_V427_V1.4441.00
224_T228_N1.4411.00
282_K300_M1.4391.00
300_M316_N1.4271.00
427_V437_A1.4251.00
38_V49_L1.4221.00
245_N255_L1.4151.00
416_G430_D1.4081.00
96_V175_C1.4081.00
230_R233_L1.4071.00
264_S267_A1.4061.00
42_L67_K1.4021.00
224_T227_V1.3971.00
273_T306_S1.3951.00
376_V417_E1.3951.00
407_S415_V1.3921.00
87_Q182_F1.3891.00
303_A319_K1.3811.00
184_A205_I1.3691.00
126_R206_L1.3691.00
286_Q303_A1.3601.00
227_V250_Q1.3581.00
274_V292_I1.3551.00
145_S151_Q1.3531.00
226_G233_L1.3481.00
320_V324_V1.3431.00
384_T397_I1.3391.00
266_D284_E1.3351.00
228_N232_A1.3281.00
34_V64_L1.3231.00
183_R187_Q1.3181.00
157_K193_A1.3161.00
321_G337_V1.3161.00
308_T321_G1.3091.00
115_M127_T1.3091.00
415_V419_A1.3061.00
229_D233_L1.3021.00
228_N233_L1.2901.00
225_L228_N1.2841.00
410_V428_T1.2751.00
81_H84_K1.2681.00
225_L234_S1.2651.00
247_R251_N1.2611.00
263_I267_A1.2591.00
344_I350_I1.2581.00
343_K362_S1.2571.00
355_F359_S1.2561.00
331_H346_N1.2531.00
81_H85_Q1.2481.00
227_V233_L1.2431.00
398_E414_T1.2401.00
224_T230_R1.2391.00
291_T308_T1.2381.00
304_I308_T1.2381.00
287_I293_I1.2361.00
290_D306_S1.2311.00
176_F202_V1.2301.00
350_I367_V1.2301.00
359_S376_V1.2281.00
287_I291_T1.2251.00
292_I309_V1.2231.00
54_G76_Q1.2231.00
41_A100_I1.2171.00
76_Q81_H1.2131.00
226_G231_V1.1980.99
227_V231_V1.1970.99
330_A346_N1.1960.99
270_G288_G1.1940.99
299_I304_I1.1940.99
35_E39_D1.1930.99
144_R168_E1.1910.99
225_L230_R1.1860.99
376_V401_A1.1860.99
244_I248_H1.1840.99
226_G232_A1.1720.99
227_V232_A1.1710.99
125_K177_D1.1680.99
134_E167_T1.1660.99
113_E117_K1.1640.99
308_T322_N1.1630.99
53_V57_A1.1600.99
355_F367_V1.1540.99
339_G354_Q1.1540.99
27_P32_P1.1540.99
228_N231_V1.1500.99
130_T215_A1.1490.99
222_Q226_G1.1480.99
242_E259_M1.1420.99
382_S407_S1.1390.99
57_A61_K1.1360.99
43_K109_A1.1320.99
403_I421_V1.1260.99
115_M129_L1.1260.99
372_V378_L1.1260.99
401_A419_A1.1240.99
98_I112_M1.1230.99
204_E208_N1.1210.99
226_G234_S1.1190.99
111_T221_F1.1130.99
40_E109_A1.1070.99
95_G178_N1.1030.99
92_D182_F1.0980.99
270_G273_T1.0970.99
101_C104_T1.0840.99
224_T229_D1.0830.99
401_A415_V1.0820.99
256_I274_V1.0800.99
376_V398_E1.0790.99
224_T231_V1.0760.99
395_T409_L1.0690.99
401_A417_E1.0660.99
311_K325_N1.0640.99
279_T295_P1.0600.99
224_T232_A1.0570.99
77_L197_Y1.0540.99
314_V329_F1.0500.99
22_Y59_E1.0470.99
361_A365_S1.0460.99
65_G70_Y1.0450.99
273_T288_G1.0430.98
32_P63_Q1.0420.98
190_N197_Y1.0390.98
61_K72_V1.0360.98
83_V99_V1.0300.98
177_D180_A1.0300.98
269_I273_T1.0280.98
149_A212_T1.0260.98
229_D232_A1.0260.98
25_L63_Q1.0210.98
320_V332_I1.0200.98
353_T370_A1.0200.98
53_V70_Y1.0190.98
320_V326_I1.0190.98
356_G359_S1.0140.98
269_I287_I1.0130.98
188_V205_I1.0130.98
221_F226_G1.0120.98
59_E62_K1.0120.98
115_M175_C1.0100.98
324_V342_V1.0020.98
108_T221_F1.0000.98
184_A209_E0.9970.98
90_L95_G0.9940.98
341_E358_R0.9940.98
24_V102_G0.9880.98
131_A169_I0.9850.98
118_E216_Y0.9850.98
178_N182_F0.9770.98
276_Y292_I0.9760.98
162_E165_L0.9750.98
225_L232_A0.9740.98
341_E357_D0.9710.98
356_G399_D0.9670.98
187_Q205_I0.9670.98
221_F228_N0.9660.98
180_A183_R0.9650.97
244_I247_R0.9630.97
20_K271_S0.9620.97
354_Q371_E0.9590.97
142_I150_V0.9580.97
34_V51_T0.9580.97
125_K211_E0.9560.97
206_L211_E0.9550.97
384_T395_T0.9510.97
419_A431_V0.9470.97
22_Y56_G0.9430.97
114_Q117_K0.9410.97
221_F224_T0.9370.97
224_T233_L0.9360.97
225_L229_D0.9350.97
96_V177_D0.9280.97
7_V83_V0.9230.97
350_I361_A0.9210.97
372_V376_V0.9200.97
75_K81_H0.9190.97
284_E301_N0.9170.97
327_G346_N0.9120.96
118_E122_R0.9050.96
323_D340_N0.9040.96
270_G291_T0.9040.96
188_V202_V0.8990.96
325_N343_K0.8950.96
240_M244_I0.8950.96
29_C240_M0.8940.96
33_M225_L0.8930.96
154_V163_E0.8930.96
170_N174_Y0.8880.96
176_F181_L0.8870.96
350_I355_F0.8850.96
114_Q219_G0.8750.96
7_V97_T0.8750.96
20_K289_E0.8750.96
228_N254_T0.8750.96
297_T313_S0.8750.96
130_T168_E0.8740.96
291_T306_S0.8740.96
342_V356_G0.8740.96
143_I154_V0.8710.95
128_I142_I0.8710.95
188_V200_P0.8700.95
133_A169_I0.8640.95
304_I315_V0.8640.95
54_G81_H0.8580.95
294_G312_Q0.8570.95
276_Y282_K0.8570.95
330_A344_I0.8560.95
5_F93_E0.8550.95
38_V68_S0.8510.95
222_Q234_S0.8510.95
324_V339_G0.8470.95
308_T326_I0.8430.95
42_L49_L0.8410.94
157_K194_Q0.8400.94
149_A207_K0.8390.94
153_I200_P0.8360.94
133_A167_T0.8350.94
13_Q76_Q0.8340.94
84_K87_Q0.8330.94
338_I350_I0.8310.94
356_G371_E0.8280.94
50_V89_F0.8270.94
401_A421_V0.8250.94
421_V427_V0.8250.94
21_L59_E0.8240.94
128_I150_V0.8230.94
158_D194_Q0.8220.94
304_I320_V0.8220.94
307_R322_N0.8140.93
422_A429_E0.8140.93
106_L111_T0.8140.93
309_V325_N0.8130.93
263_I275_I0.8130.93
223_E233_L0.8130.93
299_I315_V0.8120.93
242_E246_K0.8120.93
58_E62_K0.8090.93
29_C244_I0.8060.93
385_V405_C0.8030.93
168_E215_A0.7980.93
282_K298_E0.7960.93
324_V357_D0.7960.93
207_K213_V0.7960.93
298_E314_V0.7950.93
385_V402_F0.7910.92
5_F48_K0.7890.92
408_N421_V0.7870.92
130_T150_V0.7870.92
276_Y279_T0.7870.92
151_Q207_K0.7860.92
264_S282_K0.7850.92
353_T394_L0.7850.92
294_G297_T0.7850.92
58_E61_K0.7840.92
288_G291_T0.7840.92
367_V384_T0.7830.92
225_L231_V0.7800.92
415_V421_V0.7780.92
36_H240_M0.7760.92
225_L233_L0.7750.92
255_L261_T0.7740.92
222_Q225_L0.7720.92
51_T68_S0.7700.91
419_A433_G0.7690.91
56_G59_E0.7690.91
98_I116_L0.7680.91
14_G23_K0.7640.91
159_A164_R0.7630.91
71_R86_A0.7620.91
230_R234_S0.7610.91
429_E438_I0.7590.91
183_R186_D0.7560.91
73_Q76_Q0.7540.91
109_A113_E0.7510.90
382_S409_L0.7500.90
275_I281_I0.7500.90
296_H312_Q0.7490.90
297_T312_Q0.7460.90
53_V61_K0.7440.90
398_E433_G0.7430.90
128_I171_T0.7430.90
365_S382_S0.7430.90
27_P274_V0.7400.90
221_F230_R0.7380.90
8_V38_V0.7370.90
126_R176_F0.7370.90
401_A433_G0.7360.90
91_A182_F0.7340.89
244_I263_I0.7340.89
408_N438_I0.7330.89
276_Y294_G0.7320.89
400_G417_E0.7310.89
130_T142_I0.7300.89
324_V340_N0.7280.89
294_G309_V0.7280.89
316_N331_H0.7280.89
245_N249_M0.7270.89
29_C265_P0.7260.89
421_V426_T0.7250.89
140_G155_E0.7230.89
12_G23_K0.7220.89
41_A46_L0.7220.89
222_Q227_V0.7200.88
422_A438_I0.7200.88
275_I279_T0.7190.88
311_K328_P0.7160.88
418_G433_G0.7160.88
146_E151_Q0.7140.88
64_L70_Y0.7130.88
229_D246_K0.7080.88
143_I163_E0.7070.88
101_C171_T0.7070.88
416_G419_A0.7060.87
419_A435_A0.7050.87
184_A202_V0.7030.87
128_I203_I0.7000.87
152_K204_E0.7000.87
299_I310_I0.6990.87
84_K197_Y0.6990.87
223_E226_G0.6980.87
99_V199_L0.6960.87
305_G308_T0.6940.87
308_T320_V0.6930.87
222_Q228_N0.6930.87
223_E227_V0.6920.86
432_P437_A0.6900.86
9_L101_C0.6900.86
421_V425_S0.6870.86
291_T322_N0.6860.86
324_V338_I0.6860.86
138_G230_R0.6860.86
223_E230_R0.6850.86
28_V33_M0.6810.86
9_L52_I0.6800.85
403_I415_V0.6800.85
101_C174_Y0.6770.85
273_T289_E0.6740.85
403_I407_S0.6730.85
228_N234_S0.6720.85
180_A206_L0.6710.85
223_E239_F0.6700.85
372_V397_I0.6680.84
407_S420_Y0.6670.84
281_I287_I0.6670.84
29_C36_H0.6670.84
220_N243_R0.6670.84
66_D70_Y0.6660.84
36_H265_P0.6640.84
40_E43_K0.6620.84
355_F362_S0.6560.83
425_S428_T0.6550.83
310_I313_S0.6540.83
370_A384_T0.6530.83
255_L263_I0.6530.83
107_L173_T0.6520.83
34_V60_V0.6510.83
100_I112_M0.6500.83
81_H197_Y0.6490.83
291_T305_G0.6490.83
69_E89_F0.6480.83
328_P346_N0.6460.82
87_Q91_A0.6450.82
312_Q328_P0.6450.82
61_K70_Y0.6440.82
122_R212_T0.6440.82
32_P35_E0.6440.82
108_T111_T0.6440.82
255_L275_I0.6430.82
355_F372_V0.6420.82
44_L112_M0.6390.82
313_S330_A0.6370.82
257_D260_N0.6360.81
221_F227_V0.6350.81
326_I338_I0.6340.81
408_N425_S0.6340.81
359_S374_T0.6340.81
302_S318_S0.6340.81
313_S328_P0.6330.81
5_F90_L0.6330.81
280_V295_P0.6330.81
313_S326_I0.6320.81
268_V284_E0.6320.81
270_G290_D0.6320.81
288_G322_N0.6310.81
221_F225_L0.6290.81
269_I275_I0.6290.81
226_G235_Q0.6280.81
361_A378_L0.6250.80
382_S385_V0.6250.80
73_Q81_H0.6250.80
356_G374_T0.6230.80
358_R375_D0.6220.80
410_V426_T0.6220.80
8_V41_A0.6220.80
332_I336_S0.6200.80
88_P91_A0.6180.80
422_A426_T0.6170.80
40_E44_L0.6150.79
221_F232_A0.6150.79
106_L240_M0.6150.79
84_K186_D0.6150.79
221_F231_V0.6110.79
248_H263_I0.6110.79
6_A44_L0.6110.79
97_T181_L0.6110.79
12_G16_R0.6110.79
222_Q230_R0.6080.79
415_V427_V0.6070.78
422_A428_T0.6040.78
367_V378_L0.6000.78
50_V86_A0.5990.77
305_G340_N0.5970.77
381_G402_F0.5960.77
196_E201_D0.5950.77
365_S381_G0.5950.77
359_S362_S0.5940.77
344_I355_F0.5940.77
305_G319_K0.5930.77
16_R23_K0.5920.77
257_D262_Y0.5920.77
179_E183_R0.5890.76
248_H253_V0.5880.76
62_K66_D0.5870.76
241_K245_N0.5870.76
283_G301_N0.5860.76
403_I416_G0.5850.76
257_D261_T0.5840.76
421_V438_I0.5840.76
239_F242_E0.5820.75
229_D234_S0.5820.75
409_L415_V0.5820.75
168_E217_Q0.5820.75
224_T234_S0.5810.75
276_Y295_P0.5800.75
23_K103_D0.5780.75
83_V181_L0.5780.75
56_G76_Q0.5780.75
64_L68_S0.5760.75
125_K180_A0.5750.75
80_A189_S0.5750.75
5_F97_T0.5730.74
401_A416_G0.5730.74
135_D138_G0.5720.74
343_K361_A0.5710.74
376_V400_G0.5710.74
431_V435_A0.5700.74
50_V69_E0.5700.74
245_N263_I0.5680.74
402_F421_V0.5670.74
184_A206_L0.5630.73
419_A437_A0.5620.73
144_R215_A0.5610.73
352_K369_D0.5610.73
73_Q82_A0.5590.73
293_I297_T0.5580.72
378_L405_C0.5570.72
403_I408_N0.5570.72
365_S383_I0.5560.72
15_T18_K0.5560.72
342_V350_I0.5560.72
288_G293_I0.5560.72
395_T411_A0.5560.72
32_P39_D0.5550.72
298_E312_Q0.5550.72
425_S437_A0.5510.71
125_K212_T0.5510.71
402_F407_S0.5510.71
38_V64_L0.5500.71
221_F229_D0.5500.71
149_A214_A0.5500.71
406_N437_A0.5480.71
108_T243_R0.5480.71
362_S380_C0.5460.71
262_Y278_G0.5450.71
277_P280_V0.5450.71
398_E416_G0.5450.71
225_L235_Q0.5440.71
279_T294_G0.5430.70
309_V313_S0.5430.70
291_T304_I0.5420.70
378_L403_I0.5420.70
150_V213_V0.5420.70
326_I342_V0.5420.70
258_P264_S0.5420.70
156_H159_A0.5410.70
71_R85_Q0.5400.70
284_E303_A0.5380.70
367_V372_V0.5360.69
421_V437_A0.5360.69
428_T438_I0.5350.69
264_S285_V0.5330.69
260_N265_P0.5330.69
77_L190_N0.5320.69
223_E228_N0.5320.69
5_F95_G0.5310.69
142_I168_E0.5300.69
84_K185_I0.5290.68
359_S375_D0.5280.68
101_C172_G0.5280.68
376_V426_T0.5280.68
397_I409_L0.5280.68
383_I408_N0.5280.68
53_V60_V0.5260.68
416_G432_P0.5260.68
294_G311_K0.5250.68
400_G434_K0.5240.68
380_C408_N0.5240.68
343_K406_N0.5230.68
381_G385_V0.5230.68
332_I338_I0.5230.68
380_C405_C0.5220.67
384_T411_A0.5200.67
388_D393_Y0.5200.67
305_G321_G0.5200.67
199_L202_V0.5200.67
308_T323_D0.5200.67
124_A211_E0.5180.67
314_V331_H0.5180.67
338_I344_I0.5170.67
111_T129_L0.5170.67
410_V435_A0.5160.67
354_Q394_L0.5160.67
401_A408_N0.5140.66
31_K36_H0.5130.66
218_T222_Q0.5130.66
390_K393_Y0.5120.66
200_P203_I0.5120.66
52_I82_A0.5100.66
84_K189_S0.5100.66
362_S375_D0.5080.65
396_K433_G0.5080.65
414_T417_E0.5070.65
40_E112_M0.5070.65
131_A222_Q0.5070.65
316_N346_N0.5050.65
313_S346_N0.5050.65
231_V235_Q0.5040.65
273_T287_I0.5040.65
417_E434_K0.5030.65
25_L57_A0.5020.64
376_V408_N0.5010.64
116_L120_T0.5000.64
62_K65_G0.5000.64
55_H76_Q0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hm9A 3 0.9912 100 0.367 Contact Map
4g3qA 3 0.9912 100 0.371 Contact Map
4fceA 3 0.9561 100 0.397 Contact Map
2v0hA 3 0.9737 100 0.398 Contact Map
2ggoA 3 0.8268 100 0.523 Contact Map
1yp2A 4 0.8399 100 0.562 Contact Map
3brkX 2 0.7829 100 0.575 Contact Map
2icyA 1 0.6842 100 0.625 Contact Map
2i5kA 5 0.6798 100 0.629 Contact Map
4r7pA 4 0.6557 100 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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