GREMLIN Database
COTE - Spore coat protein E
UniProt: P14016 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (175)
Sequences: 208 (145)
Seq/√Len: 11.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_V152_E3.7850.99
108_L134_L3.2720.97
159_W163_L2.8380.92
13_V88_K2.6680.90
116_V129_A2.5500.88
40_I175_L2.3550.83
85_D134_L2.3290.82
68_Y75_E2.2790.81
13_V52_K2.2050.78
61_D67_S2.1150.75
10_K140_E2.1010.75
85_D131_R2.0710.74
46_D57_E2.0380.72
64_V161_D2.0090.71
11_A141_T1.9650.70
20_T85_D1.8980.67
56_I84_V1.8760.66
31_K114_L1.8430.64
39_W42_N1.8400.64
38_G106_K1.8310.64
14_A52_K1.8260.64
34_S47_A1.8040.63
77_V125_I1.7910.62
10_K36_L1.7770.61
56_I104_I1.7650.61
105_A133_F1.7210.59
24_N60_Y1.6940.58
95_N145_V1.6800.57
13_V91_Y1.6310.55
125_I153_E1.6020.53
33_S163_L1.5820.52
4_Y148_N1.5580.51
4_Y77_V1.5380.50
60_Y105_A1.5130.49
36_L41_I1.5110.49
146_E168_E1.5040.49
145_V165_E1.5020.48
35_I174_F1.4530.46
54_V64_V1.4380.45
59_Y135_A1.4280.45
109_Q112_N1.4260.45
14_A23_T1.4260.45
99_D127_V1.4240.45
14_A101_H1.4220.45
56_I167_L1.4210.45
52_K88_K1.4000.44
24_N133_F1.3840.43
62_I77_V1.3780.43
38_G129_A1.3650.42
125_I170_I1.3570.42
51_G55_E1.3560.42
150_D163_L1.3540.41
39_W43_H1.3470.41
41_I73_K1.3450.41
115_E140_E1.3440.41
94_N116_V1.3160.40
15_K73_K1.3140.40
72_T139_G1.3130.40
63_N74_T1.3090.39
45_Y133_F1.2860.38
102_E155_D1.2820.38
24_N105_A1.2790.38
44_K128_Q1.2760.38
105_A108_L1.2530.37
18_K103_V1.2110.35
35_I137_V1.2020.35
127_V140_E1.1910.34
34_S131_R1.1890.34
136_E142_K1.1850.34
62_I170_I1.1820.34
77_V159_W1.1820.34
148_N168_E1.1750.33
88_K134_L1.1710.33
44_K116_V1.1680.33
8_I19_F1.1640.33
89_L93_D1.1540.33
119_S126_V1.1430.32
70_D80_R1.1240.31
30_K160_E1.1010.30
158_D164_D1.0980.30
62_I102_E1.0960.30
52_K133_F1.0880.30
75_E120_P1.0810.30
149_P172_P1.0770.29
40_I117_T1.0680.29
49_K73_K1.0660.29
153_E175_L1.0590.29
26_I110_Q1.0520.28
69_A157_E1.0410.28
120_P126_V1.0340.28
24_N67_S1.0330.28
13_V56_I1.0320.28
31_K94_N1.0130.27
3_E80_R1.0130.27
79_E137_V1.0110.27
7_I18_K1.0020.26
44_K96_Y0.9960.26
80_R147_V0.9940.26
15_K42_N0.9940.26
14_A98_D0.9890.26
28_P55_E0.9870.26
167_L173_E0.9860.26
99_D121_N0.9790.26
40_I90_R0.9770.26
155_D162_E0.9720.25
78_T85_D0.9710.25
25_T32_P0.9650.25
171_N176_V0.9610.25
17_R172_P0.9560.25
16_G42_N0.9490.25
54_V85_D0.9460.24
9_T15_K0.9350.24
10_K41_I0.9280.24
63_N76_V0.9260.24
14_A88_K0.9230.24
171_N177_G0.9230.24
169_D173_E0.9210.24
56_I117_T0.9210.24
27_S147_V0.9110.23
24_N170_I0.9100.23
99_D122_G0.9010.23
83_Y131_R0.8990.23
150_D160_E0.8970.23
43_H83_Y0.8890.22
154_D173_E0.8860.22
15_K39_W0.8810.22
106_K145_V0.8780.22
27_S155_D0.8660.22
101_H116_V0.8650.22
42_N83_Y0.8630.22
72_T75_E0.8490.21
35_I56_I0.8310.21
13_V120_P0.8270.20
53_T171_N0.8170.20
23_T114_L0.8070.20
144_V148_N0.8060.20
36_L140_E0.7860.19
93_D135_A0.7840.19
62_I164_D0.7840.19
23_T156_E0.7770.19
100_E124_K0.7770.19
20_T145_V0.7750.19
110_Q118_I0.7690.19
150_D158_D0.7620.18
88_K171_N0.7540.18
84_V163_L0.7510.18
5_R174_F0.7480.18
99_D162_E0.7470.18
91_Y113_C0.7470.18
60_Y106_K0.7450.18
28_P35_I0.7440.18
68_Y102_E0.7440.18
22_C173_E0.7420.18
38_G104_I0.7400.18
166_E171_N0.7390.18
6_E175_L0.7370.18
135_A175_L0.7360.18
90_R105_A0.7320.18
156_E162_E0.7300.18
83_Y118_I0.7260.17
123_N163_L0.7220.17
16_G113_C0.7160.17
8_I17_R0.7140.17
40_I82_K0.7060.17
35_I118_I0.7040.17
53_T177_G0.7020.17
121_N143_V0.7000.17
170_I177_G0.6980.17
4_Y87_I0.6980.17
119_S164_D0.6890.16
30_K175_L0.6890.16
5_R127_V0.6870.16
169_D177_G0.6790.16
105_A166_E0.6750.16
101_H169_D0.6740.16
160_E173_E0.6690.16
17_R25_T0.6680.16
78_T128_Q0.6660.16
40_I59_Y0.6660.16
69_A135_A0.6660.16
48_E124_K0.6650.16
61_D102_E0.6650.16
117_T177_G0.6630.16
162_E165_E0.6620.16
50_I114_L0.6600.16
71_N127_V0.6590.16
56_I103_V0.6550.16
25_T120_P0.6550.16
11_A67_S0.6530.16
169_D176_V0.6450.15
29_E44_K0.6440.15
59_Y80_R0.6430.15
16_G127_V0.6390.15
28_P51_G0.6370.15
35_I45_Y0.6360.15
31_K150_D0.6360.15
48_E154_D0.6320.15
26_I97_L0.6280.15
121_N126_V0.6230.15
57_E120_P0.6230.15
79_E169_D0.6180.15
110_Q139_G0.6180.15
16_G87_I0.6160.15
59_Y82_K0.6120.15
135_A161_D0.6120.15
28_P93_D0.6110.15
168_E172_P0.6100.14
59_Y157_E0.6070.14
24_N34_S0.6060.14
59_Y97_L0.6050.14
17_R40_I0.5970.14
97_L175_L0.5940.14
8_I145_V0.5920.14
85_D112_N0.5920.14
40_I165_E0.5920.14
44_K150_D0.5840.14
16_G39_W0.5840.14
13_V101_H0.5810.14
5_R47_A0.5800.14
131_R164_D0.5780.14
33_S122_G0.5770.14
57_E173_E0.5760.14
54_V122_G0.5760.14
117_T121_N0.5760.14
78_T110_Q0.5760.14
67_S126_V0.5710.14
61_D83_Y0.5710.14
81_V117_T0.5690.14
39_W83_Y0.5690.14
12_V139_G0.5620.13
150_D162_E0.5610.13
44_K82_K0.5610.13
117_T128_Q0.5610.13
170_I174_F0.5530.13
113_C175_L0.5460.13
10_K73_K0.5460.13
50_I70_D0.5460.13
13_V22_C0.5460.13
20_T48_E0.5440.13
120_P144_V0.5400.13
21_Q89_L0.5390.13
30_K69_A0.5380.13
3_E143_V0.5290.13
22_C91_Y0.5250.13
8_I151_W0.5240.13
51_G167_L0.5240.13
70_D160_E0.5230.13
21_Q54_V0.5220.13
127_V154_D0.5180.12
17_R149_P0.5180.12
50_I128_Q0.5160.12
15_K43_H0.5140.12
110_Q127_V0.5140.12
87_I90_R0.5110.12
24_N131_R0.5090.12
85_D109_Q0.5080.12
39_W132_E0.5060.12
94_N129_A0.5040.12
26_I64_V0.5020.12
40_I129_A0.5020.12
26_I141_T0.5010.12
38_G42_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vu9A 1 0.4144 7.1 0.968 Contact Map
4ewcA 2 0.6188 5 0.97 Contact Map
2ww5A 1 0.3315 4.4 0.971 Contact Map
3wa1A 4 0.3978 4.2 0.971 Contact Map
4exkA 2 0.5856 4 0.972 Contact Map
3n91A 1 0.4972 3.5 0.972 Contact Map
1nh2C 1 0.0221 3 0.973 Contact Map
2jssB 1 0.1989 2.8 0.974 Contact Map
3tndB 3 0.3204 2.7 0.974 Contact Map
4u7aA 1 0 2.7 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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