GREMLIN Database
SP2G - Sporulation sigma-E factor-processing peptidase
UniProt: P13801 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (267)
Sequences: 575 (529)
Seq/√Len: 32.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_G75_T4.6811.00
42_I74_V4.5541.00
68_S92_Y4.5201.00
256_C277_L4.4131.00
43_G71_I4.2051.00
166_S179_R3.9661.00
165_V182_I3.7851.00
170_D261_H3.3801.00
261_H272_S3.1841.00
200_I205_L2.8281.00
13_F44_S2.6611.00
169_A259_P2.5871.00
242_I256_C2.5471.00
168_Q175_T2.5221.00
202_I282_T2.5091.00
190_D240_R2.5021.00
168_Q263_T2.4831.00
198_M262_V2.3650.99
20_L36_L2.3580.99
167_V198_M2.3360.99
24_A31_V2.2810.99
199_I254_L2.2680.99
17_A40_A2.2610.99
262_V276_C2.2240.99
167_V293_A2.1920.99
181_L294_I2.1450.99
256_C279_G2.1260.98
13_F17_A2.1220.98
178_V204_K2.1040.98
191_P243_P2.0860.98
180_G293_A2.0230.98
19_L91_F1.9480.97
165_V295_I1.9350.97
246_G252_Q1.8780.97
64_K91_F1.8630.96
88_L92_Y1.8610.96
246_G249_Q1.8400.96
9_W44_S1.8220.96
170_D173_S1.7800.95
168_Q265_M1.7550.95
166_S177_H1.7140.94
190_D277_L1.7070.94
190_D256_C1.6370.93
182_I294_I1.6190.92
9_W16_D1.6110.92
254_L279_G1.5580.91
9_W48_L1.5520.91
169_A200_I1.5260.90
235_F238_K1.5150.90
198_M299_M1.4720.88
3_I8_I1.4700.88
166_S265_M1.4480.87
239_M257_V1.4360.87
96_F104_G1.4330.87
189_Y296_H1.4310.87
71_I91_F1.4220.86
257_V280_I1.4150.86
33_K37_V1.3930.85
201_Y244_Y1.3860.85
105_A142_A1.3760.84
165_V181_L1.3660.84
87_N294_I1.3640.84
168_Q177_H1.3630.84
64_K104_G1.3630.84
164_R179_R1.3600.84
188_L199_I1.3550.83
210_G293_A1.3500.83
180_G279_G1.3470.83
23_T91_F1.3420.83
167_V180_G1.3390.83
248_G252_Q1.3180.82
27_L87_N1.3010.81
253_F280_I1.2870.80
47_V63_G1.2760.80
9_W141_P1.2730.79
276_C299_M1.2720.79
7_V11_L1.2600.79
70_V263_T1.2450.78
169_A262_V1.2280.77
15_F276_C1.2260.77
201_Y284_K1.2140.76
244_Y248_G1.2090.76
21_L36_L1.2080.76
38_G79_K1.2010.75
199_I247_V1.1980.75
67_F71_I1.1940.75
238_K260_D1.1890.74
259_P278_I1.1890.74
105_A109_L1.1870.74
95_T99_G1.1840.74
83_F242_I1.1770.74
39_G74_V1.1710.73
83_F87_N1.1620.73
266_T269_E1.1570.72
17_A33_K1.1560.72
11_L19_L1.1400.71
32_K168_Q1.1320.71
193_T240_R1.1280.70
39_G71_I1.1220.70
169_A257_V1.1140.69
2_K51_F1.1140.69
11_L132_S1.1040.69
193_T210_G1.1000.68
72_V137_V1.0880.68
23_T296_H1.0830.67
165_V294_I1.0820.67
181_L297_P1.0790.67
43_G48_L1.0680.66
97_L294_I1.0610.66
66_A257_V1.0560.65
254_L291_F1.0560.65
243_P253_F1.0550.65
31_V75_T1.0530.65
80_R95_T1.0530.65
6_D243_P1.0510.65
20_L75_T1.0480.65
101_G104_G1.0460.65
200_I278_I1.0330.64
16_D92_Y1.0290.63
20_L209_F1.0260.63
178_V246_G1.0260.63
137_V261_H1.0110.62
189_Y194_K1.0080.62
33_K40_A1.0050.61
254_L278_I1.0030.61
16_D39_G1.0000.61
7_V18_L0.9920.60
198_M276_C0.9900.60
31_V34_R0.9890.60
47_V192_L0.9880.60
64_K103_I0.9850.60
24_A76_F0.9850.60
41_F69_V0.9840.60
35_R197_V0.9740.59
244_Y252_Q0.9710.59
47_V106_H0.9660.58
72_V207_P0.9650.58
99_G103_I0.9600.58
131_I246_G0.9540.57
77_G244_Y0.9510.57
111_S193_T0.9490.57
191_P256_C0.9400.56
64_K259_P0.9350.56
150_R184_S0.9290.55
181_L291_F0.9240.55
184_S201_Y0.9220.55
195_T258_K0.9150.54
64_K190_D0.9150.54
49_L63_G0.9090.54
91_F103_I0.9070.53
3_I6_D0.9050.53
144_W192_L0.9050.53
64_K107_S0.9030.53
6_D84_F0.8980.53
244_Y279_G0.8960.53
33_K242_I0.8930.52
23_T90_S0.8930.52
96_F297_P0.8910.52
169_A276_C0.8840.52
44_S131_I0.8840.52
29_R83_F0.8830.52
48_L64_K0.8810.51
40_A300_L0.8770.51
201_Y296_H0.8750.51
76_F243_P0.8700.50
38_G82_R0.8690.50
29_R87_N0.8680.50
44_S199_I0.8670.50
276_C291_F0.8640.50
291_F294_I0.8630.50
82_R205_L0.8610.50
25_F144_W0.8560.49
84_F294_I0.8520.49
64_K68_S0.8430.48
178_V280_I0.8410.48
63_G266_T0.8410.48
239_M278_I0.8400.48
97_L101_G0.8360.48
104_G108_L0.8320.47
248_G281_S0.8250.47
241_L253_F0.8210.46
165_V264_I0.8180.46
89_F267_K0.8180.46
176_L207_P0.8170.46
28_K280_I0.8150.46
259_P293_A0.8130.46
43_G67_F0.8120.46
210_G240_R0.8050.45
286_S291_F0.8030.45
15_F19_L0.8020.45
182_I252_Q0.8010.45
84_F88_L0.7980.45
16_D68_S0.7960.44
34_R66_A0.7960.44
15_F132_S0.7900.44
101_G253_F0.7900.44
201_Y292_D0.7880.44
25_F29_R0.7880.44
104_G259_P0.7870.44
25_F65_L0.7860.44
32_K289_G0.7850.43
9_W85_F0.7830.43
5_L47_V0.7820.43
62_A66_A0.7820.43
176_L267_K0.7670.42
5_L29_R0.7630.42
26_I172_G0.7620.42
73_V84_F0.7580.41
33_K144_W0.7570.41
87_N242_I0.7550.41
192_L240_R0.7440.40
199_I252_Q0.7430.40
172_G238_K0.7430.40
95_T240_R0.7420.40
13_F93_F0.7420.40
31_V38_G0.7410.40
22_L151_I0.7390.40
57_I207_P0.7380.40
236_L289_G0.7370.40
62_A205_L0.7370.40
211_T267_K0.7360.40
263_T272_S0.7280.39
26_I200_I0.7260.39
35_R239_M0.7190.38
91_F104_G0.7130.38
186_N295_I0.7120.38
147_S184_S0.7100.38
25_F246_G0.7080.37
191_P254_L0.7060.37
95_T146_F0.7050.37
203_D300_L0.7030.37
22_L99_G0.7020.37
3_I209_F0.7000.37
209_F282_T0.7000.37
206_E284_K0.6980.37
105_A241_L0.6980.37
239_M244_Y0.6960.36
40_A130_P0.6940.36
251_N269_E0.6910.36
188_L279_G0.6900.36
142_A234_R0.6900.36
54_F294_I0.6890.36
242_I278_I0.6880.36
48_L178_V0.6870.36
11_L16_D0.6840.36
190_D297_P0.6830.35
294_I298_K0.6820.35
16_D275_K0.6810.35
27_L90_S0.6790.35
85_F110_Q0.6770.35
262_V293_A0.6760.35
18_L193_T0.6730.35
67_F132_S0.6730.35
192_L241_L0.6690.34
45_S180_G0.6680.34
238_K255_L0.6640.34
199_I291_F0.6600.34
6_D27_L0.6600.34
8_I245_R0.6600.34
76_F87_N0.6590.34
173_S176_L0.6590.34
137_V151_I0.6550.33
190_D209_F0.6550.33
200_I289_G0.6540.33
257_V263_T0.6540.33
146_F150_R0.6510.33
13_F32_K0.6510.33
65_L74_V0.6510.33
198_M294_I0.6490.33
64_K258_K0.6480.33
135_F141_P0.6420.32
3_I92_Y0.6410.32
34_R60_H0.6400.32
274_D289_G0.6390.32
138_G207_P0.6390.32
199_I279_G0.6370.32
46_I291_F0.6370.32
157_K180_G0.6340.32
170_D264_I0.6340.32
64_K293_A0.6340.32
79_K97_L0.6330.32
131_I300_L0.6330.32
39_G239_M0.6320.32
14_C18_L0.6300.32
5_L14_C0.6260.31
84_F297_P0.6240.31
64_K76_F0.6230.31
20_L43_G0.6230.31
22_L111_S0.6230.31
7_V276_C0.6220.31
158_N184_S0.6220.31
102_I106_H0.6220.31
180_G243_P0.6190.31
6_D16_D0.6170.31
17_A260_D0.6150.30
188_L254_L0.6120.30
18_L140_F0.6070.30
86_Q298_K0.6060.30
4_Y75_T0.6060.30
56_P261_H0.6020.30
272_S300_L0.6010.30
8_I99_G0.6010.30
20_L134_L0.5990.29
200_I279_G0.5980.29
29_R141_P0.5980.29
64_K92_Y0.5970.29
169_A293_A0.5970.29
97_L164_R0.5960.29
34_R167_V0.5960.29
188_L244_Y0.5960.29
41_F56_P0.5950.29
19_L159_I0.5950.29
2_K280_I0.5940.29
46_I293_A0.5910.29
93_F138_G0.5910.29
242_I277_L0.5850.28
2_K253_F0.5850.28
137_V270_M0.5830.28
69_V267_K0.5810.28
49_L260_D0.5810.28
54_F74_V0.5800.28
182_I259_P0.5780.28
40_A135_F0.5770.28
10_L98_M0.5770.28
43_G210_G0.5770.28
197_V280_I0.5740.28
7_V49_L0.5730.28
90_S154_I0.5700.27
187_Q297_P0.5700.27
177_H278_I0.5690.27
186_N196_P0.5690.27
96_F139_G0.5680.27
4_Y12_N0.5670.27
201_Y245_R0.5660.27
40_A138_G0.5660.27
248_G251_N0.5650.27
278_I290_E0.5650.27
266_T300_L0.5640.27
284_K289_G0.5630.27
62_A195_T0.5610.27
39_G153_D0.5600.27
129_D248_G0.5600.27
146_F152_E0.5570.27
32_K37_V0.5560.27
169_A264_I0.5550.26
259_P276_C0.5510.26
49_L196_P0.5500.26
68_S141_P0.5500.26
147_S159_I0.5500.26
47_V246_G0.5460.26
212_A253_F0.5450.26
9_W293_A0.5440.26
8_I249_Q0.5430.26
142_A175_T0.5420.26
206_E211_T0.5390.25
23_T92_Y0.5380.25
133_W140_F0.5370.25
5_L44_S0.5370.25
68_S88_L0.5370.25
270_M300_L0.5360.25
195_T257_V0.5360.25
178_V200_I0.5360.25
9_W281_S0.5350.25
102_I141_P0.5350.25
58_V278_I0.5320.25
39_G159_I0.5300.25
100_G183_D0.5290.25
189_Y201_Y0.5290.25
138_G206_E0.5280.25
244_Y285_L0.5270.25
3_I242_I0.5240.25
181_L286_S0.5230.24
175_T274_D0.5230.24
68_S91_F0.5210.24
40_A250_Q0.5210.24
279_G291_F0.5200.24
81_F248_G0.5200.24
142_A196_P0.5190.24
159_I242_I0.5160.24
134_L138_G0.5160.24
156_T194_K0.5160.24
67_F102_I0.5150.24
162_E172_G0.5150.24
74_V236_L0.5150.24
20_L72_V0.5140.24
246_G288_D0.5130.24
25_F54_F0.5120.24
56_P268_E0.5110.24
137_V140_F0.5110.24
199_I208_I0.5100.24
115_V211_T0.5090.24
169_A199_I0.5080.24
7_V154_I0.5080.24
193_T200_I0.5080.24
156_T193_T0.5060.23
249_Q259_P0.5050.23
77_G167_V0.5030.23
139_G144_W0.5030.23
26_I282_T0.5030.23
16_D71_I0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xnjA 1 0.4272 16.7 0.964 Contact Map
2hahA 2 0.3528 10.5 0.967 Contact Map
3s8iA 2 0.3366 10.4 0.967 Contact Map
3ec0A 2 0.3204 10 0.967 Contact Map
2i1aA 2 0.3139 9.2 0.968 Contact Map
2nr9A 2 0.4304 8.6 0.968 Contact Map
4njnA 4 0.4013 7.6 0.969 Contact Map
3ar4A 1 0.4854 7 0.969 Contact Map
2hs1A 2 0.3204 6.6 0.97 Contact Map
1fmbA 2 0.3269 6.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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