GREMLIN Database
DEGS - Signal transduction histidine-protein kinase/phosphatase DegS
UniProt: P13799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (323)
Sequences: 42272 (36720)
Seq/√Len: 2043.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_L289_Q3.3741.00
366_T378_M3.2571.00
330_K376_F3.1431.00
309_S332_N2.8801.00
331_D335_G2.8691.00
324_F380_K2.7991.00
355_K359_D2.7921.00
337_D340_E2.7131.00
370_K373_L2.6631.00
341_A367_I2.5781.00
289_Q361_L2.5501.00
328_M376_F2.5281.00
317_K328_M2.5261.00
326_I380_K2.4931.00
63_K147_N2.4871.00
278_I317_K2.4521.00
326_I378_M2.4461.00
276_Q313_E2.4351.00
276_Q315_T2.4311.00
199_V225_L2.4041.00
321_T326_I2.4001.00
328_M378_M2.3561.00
315_T330_K2.3021.00
319_E326_I2.2881.00
354_M365_M2.2571.00
250_D288_P2.1741.00
297_L358_V2.1121.00
358_V363_G2.1081.00
70_H74_R2.1051.00
367_I377_I2.0991.00
336_F340_E2.0981.00
317_K330_K2.0971.00
259_K295_F2.0831.00
274_H313_E2.0391.00
319_E328_M2.0141.00
249_D291_E1.9731.00
153_L156_V1.9591.00
58_I77_E1.9531.00
368_D376_F1.9441.00
369_S375_T1.9331.00
252_G255_P1.9181.00
278_I315_T1.9061.00
313_E332_N1.9031.00
297_L354_M1.9021.00
215_A218_G1.8631.00
66_V144_V1.8601.00
338_L341_A1.8491.00
214_G218_G1.8361.00
117_R121_L1.8281.00
312_E332_N1.8151.00
364_T380_K1.8051.00
81_N84_R1.7621.00
203_S226_R1.7621.00
358_V379_I1.7431.00
309_S312_E1.7161.00
254_I318_V1.6981.00
341_A369_S1.6931.00
186_R190_D1.6511.00
368_D378_M1.6471.00
309_S314_I1.6421.00
264_T299_Q1.6371.00
290_F293_A1.6351.00
51_K55_Y1.6081.00
327_L379_I1.5831.00
64_L85_F1.5681.00
152_D156_V1.5561.00
64_L146_L1.5431.00
177_Q181_R1.5331.00
61_G65_E1.5271.00
233_L237_R1.5261.00
297_L357_R1.5141.00
357_R361_L1.5081.00
359_D364_T1.5021.00
88_E118_R1.4941.00
298_A327_L1.4911.00
175_E179_E1.4821.00
250_D286_L1.4721.00
174_I177_Q1.4601.00
50_I53_Q1.4591.00
337_D371_I1.4431.00
127_G146_L1.4401.00
80_R84_R1.4401.00
248_L288_P1.4111.00
203_S223_K1.4101.00
265_E269_G1.4081.00
303_S307_K1.4081.00
134_R138_L1.4061.00
187_E190_D1.4051.00
289_Q294_L1.4021.00
196_L229_V1.3951.00
55_Y59_E1.3931.00
126_L147_N1.3921.00
369_S373_L1.3911.00
268_N306_L1.3911.00
279_G318_V1.3861.00
169_F172_R1.3811.00
83_H90_I1.3641.00
293_A296_R1.3641.00
96_K100_L1.3591.00
78_V82_F1.3461.00
366_T380_K1.3221.00
200_M226_R1.2951.00
186_R191_G1.2911.00
59_E80_R1.2901.00
259_K291_E1.2881.00
104_L107_I1.2811.00
252_G286_L1.2691.00
324_F364_T1.2681.00
69_R72_R1.2661.00
126_L152_D1.2651.00
285_R320_I1.2521.00
117_R123_R1.2521.00
196_L230_R1.2511.00
174_I178_E1.2331.00
197_A201_M1.2311.00
89_E92_N1.2221.00
321_T380_K1.2191.00
369_S372_G1.2061.00
305_A314_I1.2061.00
66_V82_F1.1941.00
190_D194_Q1.1821.00
103_E106_M1.1651.00
226_R230_R1.1621.00
66_V75_L1.1611.00
98_H101_Q1.1471.00
98_H102_V1.1461.00
293_A360_L1.1351.00
254_I258_R1.1261.00
187_E191_G1.1051.00
234_Y292_V1.1031.00
258_R277_C1.0991.00
336_F375_T1.0961.00
191_G195_M1.0951.00
44_V48_K1.0891.00
224_N228_N1.0871.00
194_Q198_N1.0811.00
252_G284_Q1.0811.00
82_F86_S1.0781.00
254_I279_G1.0771.00
111_E114_L1.0751.00
80_R83_H1.0721.00
297_L379_I1.0691.00
124_R153_L1.0681.00
264_T302_V1.0671.00
267_Y270_K1.0631.00
156_V160_L1.0601.00
336_F341_A1.0591.00
198_N202_R1.0561.00
131_I139_V1.0461.00
301_A354_M1.0451.00
78_V83_H1.0391.00
252_G285_R1.0351.00
173_I177_Q1.0341.00
331_D374_G1.0311.00
223_K227_Q1.0291.00
198_N221_E1.0281.00
342_K345_K1.0221.00
293_A357_R1.0151.00
83_H89_E1.0111.00
220_Q224_N1.0071.00
302_V314_I1.0041.00
199_V203_S1.0021.00
186_R189_H1.0001.00
334_K344_K0.9981.00
151_Q154_R0.9941.00
246_M290_F0.9931.00
321_T324_F0.9921.00
201_M205_L0.9921.00
295_F299_Q0.9891.00
199_V229_V0.9881.00
228_N231_N0.9861.00
291_E295_F0.9811.00
296_R357_R0.9801.00
261_L265_E0.9761.00
263_T299_Q0.9681.00
260_Y295_F0.9591.00
54_V58_I0.9551.00
214_G217_D0.9521.00
157_G160_L0.9521.00
251_L256_T0.9511.00
129_Q142_I0.9501.00
300_E354_M0.9481.00
78_V93_A0.9471.00
261_L277_C0.9471.00
133_E139_V0.9441.00
248_L361_L0.9441.00
154_R158_L0.9421.00
203_S225_L0.9411.00
315_T332_N0.9381.00
48_K52_Q0.9291.00
90_I94_Y0.9251.00
48_K51_K0.9241.00
336_F367_I0.9221.00
225_L229_V0.9201.00
43_L47_L0.9171.00
280_E283_D0.9091.00
219_F223_K0.9051.00
193_A197_A0.9021.00
262_Y265_E0.8961.00
358_V365_M0.8941.00
246_M293_A0.8931.00
298_A302_V0.8901.00
256_T260_Y0.8841.00
52_Q56_E0.8831.00
203_S219_F0.8831.00
257_L318_V0.8821.00
280_E318_V0.8791.00
114_L122_E0.8771.00
186_R195_M0.8771.00
194_Q228_N0.8761.00
294_L361_L0.8731.00
103_E107_I0.8711.00
113_Q116_E0.8671.00
229_V233_L0.8611.00
112_K115_R0.8591.00
354_M358_V0.8521.00
280_E319_E0.8481.00
155_E158_L0.8461.00
242_D352_L0.8401.00
69_R129_Q0.8401.00
69_R73_N0.8371.00
43_L46_E0.8361.00
326_I366_T0.8341.00
74_R97_A0.8321.00
47_L50_I0.8261.00
238_R293_A0.8241.00
301_A377_I0.8231.00
356_E359_D0.8181.00
301_A365_M0.8161.00
338_L370_K0.8151.00
195_M229_V0.8111.00
358_V381_V0.8101.00
76_S141_Q0.8091.00
200_M230_R0.8091.00
62_D65_E0.8021.00
156_V159_L0.8001.00
88_E92_N0.7991.00
198_N201_M0.7951.00
255_P259_K0.7931.00
96_K101_Q0.7921.00
255_P291_E0.7901.00
331_D375_T0.7901.00
335_G375_T0.7891.00
216_E219_F0.7891.00
248_L289_Q0.7841.00
199_V226_R0.7841.00
179_E183_R0.7801.00
224_N227_Q0.7801.00
273_I306_L0.7791.00
363_G379_I0.7751.00
53_Q77_E0.7731.00
253_L327_L0.7731.00
97_A100_L0.7701.00
220_Q223_K0.7681.00
186_R194_Q0.7661.00
256_T289_Q0.7651.00
202_R221_E0.7651.00
50_I54_V0.7631.00
124_R150_N0.7631.00
109_Q114_L0.7631.00
168_D172_R0.7571.00
77_E90_I0.7561.00
215_A219_F0.7541.00
257_L316_V0.7501.00
45_E49_Q0.7491.00
69_R144_V0.7491.00
49_Q53_Q0.7461.00
116_E122_E0.7461.00
150_N154_R0.7451.00
205_L218_G0.7451.00
154_R157_G0.7451.00
261_L275_F0.7401.00
234_Y238_R0.7401.00
298_A329_I0.7391.00
194_Q197_A0.7391.00
198_N228_N0.7371.00
123_R148_Y0.7361.00
177_Q190_D0.7341.00
172_R176_A0.7331.00
200_M204_E0.7331.00
195_M225_L0.7321.00
273_I309_S0.7321.00
366_T379_I0.7311.00
176_A179_E0.7311.00
171_L175_E0.7301.00
113_Q127_G0.7291.00
263_T295_F0.7291.00
153_L157_G0.7271.00
192_P195_M0.7201.00
111_E115_R0.7171.00
69_R75_L0.7171.00
70_H76_S0.7151.00
118_R121_L0.7131.00
246_M360_L0.7101.00
293_A361_L0.7091.00
110_R115_R0.7091.00
64_L82_F0.7041.00
64_L81_N0.7021.00
280_E284_Q0.6991.00
187_E296_R0.6991.00
54_V57_V0.6981.00
134_R137_S0.6981.00
300_E303_S0.6981.00
202_R218_G0.6971.00
285_R325_V0.6931.00
47_L51_K0.6911.00
110_R113_Q0.6911.00
199_V202_R0.6901.00
198_N224_N0.6871.00
68_T77_E0.6861.00
260_Y302_V0.6861.00
61_G64_L0.6831.00
178_E182_K0.6821.00
195_M199_V0.6811.00
296_R299_Q0.6811.00
46_E50_I0.6811.00
227_Q259_K0.6741.00
190_D193_A0.6741.00
308_H344_K0.6681.00
240_I244_R0.6681.00
267_Y303_S0.6671.00
64_L79_S0.6641.00
308_H334_K0.6631.00
356_E360_L0.6631.00
260_Y299_Q0.6601.00
305_A329_I0.6601.00
189_H237_R0.6571.00
180_E187_E0.6561.00
95_E98_H0.6561.00
170_G173_I0.6551.00
57_V61_G0.6511.00
80_R90_I0.6511.00
184_V239_I0.6511.00
241_Y293_A0.6511.00
57_V65_E0.6481.00
125_L146_L0.6481.00
130_E143_T0.6461.00
260_Y264_T0.6461.00
258_R262_Y0.6461.00
237_R241_Y0.6461.00
45_E48_K0.6461.00
246_M361_L0.6461.00
302_V316_V0.6451.00
103_E110_R0.6451.00
155_E159_L0.6451.00
253_L325_V0.6441.00
251_L291_E0.6441.00
152_D155_E0.6431.00
192_P232_A0.6431.00
202_R222_I0.6421.00
192_P236_V0.6391.00
66_V69_R0.6371.00
92_N118_R0.6371.00
129_Q144_V0.6321.00
58_I65_E0.6311.00
106_M109_Q0.6311.00
109_Q113_Q0.6311.00
132_I141_Q0.6291.00
83_H93_A0.6281.00
181_R185_S0.6271.00
44_V47_L0.6261.00
149_L153_L0.6251.00
278_I319_E0.6241.00
169_F173_I0.6241.00
257_L298_A0.6241.00
274_H277_C0.6241.00
228_N232_A0.6211.00
336_F377_I0.6201.00
313_E330_K0.6191.00
175_E178_E0.6191.00
151_Q155_E0.6181.00
63_K66_V0.6161.00
341_A377_I0.6131.00
196_L233_L0.6121.00
180_E184_V0.6111.00
304_N350_G0.6101.00
217_D221_E0.6081.00
69_R142_I0.6081.00
221_E225_L0.6071.00
198_N205_L0.6071.00
363_G381_V0.6061.00
231_N295_F0.6051.00
70_H141_Q0.6031.00
254_I285_R0.6001.00
114_L124_R0.5981.00
271_V306_L0.5971.00
336_F369_S0.5961.00
256_T294_L0.5931.00
297_L361_L0.5911.00
63_K81_N0.5881.00
110_R126_L0.5871.00
367_I375_T0.5851.00
202_R225_L0.5841.00
301_A379_I0.5821.00
134_R140_S0.5811.00
251_L288_P0.5801.00
196_L200_M0.5801.00
248_L362_E0.5801.00
307_K343_E0.5791.00
264_T303_S0.5781.00
283_D320_I0.5761.00
272_K311_S0.5761.00
316_V329_I0.5741.00
180_E186_R0.5741.00
124_R149_L0.5741.00
310_E334_K0.5731.00
180_E191_G0.5721.00
363_G382_P0.5721.00
51_K54_V0.5721.00
197_A202_R0.5701.00
66_V146_L0.5681.00
264_T306_L0.5671.00
341_A368_D0.5661.00
294_L298_A0.5661.00
201_M221_E0.5641.00
56_E60_L0.5621.00
190_D197_A0.5611.00
126_L129_Q0.5601.00
254_I284_Q0.5581.00
336_F351_L0.5581.00
71_A140_S0.5571.00
230_R234_Y0.5571.00
79_S82_F0.5551.00
213_R218_G0.5541.00
365_M377_I0.5541.00
190_D195_M0.5511.00
307_K345_K0.5501.00
168_D171_L0.5501.00
268_N273_I0.5501.00
328_M368_D0.5491.00
258_R261_L0.5491.00
93_A97_A0.5481.00
94_Y97_A0.5441.00
61_G145_V0.5431.00
93_A96_K0.5431.00
318_V327_L0.5421.00
71_A139_V0.5411.00
320_I325_V0.5391.00
334_K375_T0.5391.00
220_Q262_Y0.5391.00
266_E269_G0.5361.00
221_E224_N0.5361.00
177_Q182_K0.5351.00
203_S222_I0.5331.00
230_R233_L0.5331.00
105_T108_Q0.5331.00
127_G144_V0.5321.00
349_F353_G0.5311.00
280_E320_I0.5301.00
183_R190_D0.5291.00
97_A101_Q0.5291.00
78_V90_I0.5281.00
95_E101_Q0.5271.00
128_L147_N0.5261.00
88_E93_A0.5251.00
244_R347_K0.5251.00
109_Q112_K0.5251.00
46_E49_Q0.5231.00
255_P258_R0.5231.00
189_H233_L0.5211.00
117_R120_D0.5211.00
223_K226_R0.5201.00
268_N275_F0.5191.00
245_P248_L0.5191.00
99_K102_V0.5191.00
78_V86_S0.5181.00
280_E285_R0.5181.00
352_L356_E0.5151.00
83_H88_E0.5141.00
81_N85_F0.5141.00
353_G357_R0.5141.00
69_R98_H0.5141.00
127_G131_I0.5141.00
149_L152_D0.5131.00
57_V143_T0.5101.00
202_R224_N0.5091.00
103_E109_Q0.5091.00
180_E189_H0.5071.00
112_K153_L0.5041.00
273_I332_N0.5031.00
256_T295_F0.5031.00
193_A200_M0.5021.00
133_E140_S0.5011.00
90_I93_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8623 100 0.295 Contact Map
4gczA 2 0.8805 100 0.311 Contact Map
3a0rA 2 0.8026 100 0.313 Contact Map
4r3aA 1 0.761 100 0.379 Contact Map
4q20A 2 0.5584 100 0.457 Contact Map
4r39A 1 0.5247 100 0.465 Contact Map
2c2aA 2 0.574 100 0.47 Contact Map
3jz3A 2 0.4026 100 0.47 Contact Map
4bixA 2 0.5558 100 0.477 Contact Map
3d36A 2 0.5403 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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