GREMLIN Database
PHOP - Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
UniProt: P13792 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (205)
Sequences: 76471 (54188)
Seq/√Len: 3784.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_V31_T3.7311.00
15_V33_S3.2201.00
19_Q31_T3.1201.00
8_V38_A2.7501.00
39_L67_Q2.6111.00
36_E58_K2.5851.00
30_I47_P2.4851.00
35_G59_L2.4691.00
34_D58_K2.3881.00
43_E71_Q2.3721.00
59_L67_Q2.3321.00
4_K30_I2.2001.00
4_K28_D2.0911.00
19_Q23_E2.0361.00
21_N107_P2.0341.00
25_S111_N2.0171.00
32_A41_K1.9511.00
89_K109_E1.8921.00
33_S37_E1.8891.00
200_R203_D1.8601.00
55_M83_K1.8541.00
52_L64_V1.8361.00
165_K168_E1.7901.00
34_D37_E1.7711.00
30_I41_K1.7281.00
6_L32_A1.7261.00
79_M92_G1.7251.00
65_C77_I1.7151.00
183_R203_D1.7081.00
86_E106_S1.7051.00
69_R98_D1.6621.00
67_Q71_Q1.6571.00
41_K45_E1.6481.00
79_M97_A1.6221.00
143_D156_K1.5921.00
30_I45_E1.5711.00
171_L175_R1.5661.00
59_L63_E1.5621.00
35_G64_V1.5551.00
60_D63_E1.5531.00
22_L114_V1.5261.00
205_H208_H1.5111.00
99_D113_R1.5071.00
66_K95_L1.4931.00
83_K88_D1.4691.00
67_Q70_Q1.4591.00
172_Y189_A1.4551.00
41_K44_T1.4381.00
42_A68_L1.4171.00
65_C79_M1.3891.00
50_I75_F1.3781.00
166_E212_K1.3761.00
182_T185_L1.3691.00
78_L117_I1.3601.00
39_L64_V1.3601.00
181_L189_A1.3551.00
49_L114_V1.3541.00
63_E66_K1.3491.00
140_V145_K1.3461.00
36_E59_L1.3421.00
12_E33_S1.3221.00
98_D120_R1.3001.00
176_H179_R1.2901.00
4_K45_E1.2881.00
52_L65_C1.2781.00
9_D15_V1.2681.00
41_K47_P1.2581.00
27_Y115_K1.2571.00
10_D53_D1.2481.00
8_V56_L1.2461.00
54_V62_I1.2281.00
54_V79_M1.2251.00
98_D117_I1.2241.00
39_L59_L1.2151.00
172_Y176_H1.2031.00
32_A38_A1.2011.00
40_K44_T1.2011.00
167_F171_L1.1811.00
85_E88_D1.1681.00
145_K154_Y1.1651.00
37_E40_K1.1601.00
6_L47_P1.1551.00
37_E41_K1.1501.00
62_I92_G1.1461.00
36_E40_K1.1351.00
6_L38_A1.1301.00
62_I91_L1.1261.00
72_K75_F1.1221.00
49_L118_L1.1211.00
147_L150_H1.1181.00
94_E115_K1.1161.00
26_G115_K1.1091.00
184_D199_T1.1051.00
111_N115_K1.0931.00
185_L189_A1.0891.00
152_E159_Q1.0871.00
86_E90_V1.0831.00
25_S115_K1.0831.00
200_R204_V1.0781.00
146_I174_G1.0591.00
91_L95_L1.0561.00
204_V207_S1.0471.00
172_Y181_L1.0451.00
5_I27_Y1.0361.00
66_K91_L1.0261.00
168_E171_L1.0221.00
201_I205_H1.0221.00
6_L41_K1.0081.00
112_A116_A1.0011.00
109_E112_A0.9921.00
32_A37_E0.9811.00
38_A42_A0.9791.00
38_A64_V0.9761.00
52_L77_I0.9721.00
87_F91_L0.9651.00
62_I95_L0.9601.00
8_V50_I0.9521.00
39_L43_E0.9521.00
50_I68_L0.9491.00
181_L185_L0.9491.00
18_L80_L0.9451.00
90_V94_E0.9391.00
148_P171_L0.9371.00
12_E16_T0.9371.00
7_V18_L0.9361.00
19_Q29_V0.9331.00
54_V60_D0.9321.00
89_K102_T0.9321.00
42_A72_K0.9311.00
16_T31_T0.9281.00
164_P168_E0.9271.00
6_L42_A0.9261.00
8_V32_A0.9251.00
215_N225_T0.9131.00
217_T220_P0.9091.00
52_L79_M0.8971.00
172_Y186_L0.8961.00
12_E15_V0.8831.00
7_V29_V0.8781.00
117_I120_R0.8771.00
13_S17_L0.8771.00
63_E67_Q0.8751.00
78_L113_R0.8701.00
65_C95_L0.8701.00
65_C97_A0.8691.00
40_K43_E0.8671.00
51_V110_V0.8631.00
146_I167_F0.8601.00
169_L173_L0.8591.00
27_Y111_N0.8571.00
149_D179_R0.8511.00
91_L94_E0.8471.00
154_Y159_Q0.8451.00
199_T203_D0.8411.00
54_V88_D0.8401.00
18_L110_V0.8381.00
86_E89_K0.8321.00
215_N221_I0.8311.00
64_V68_L0.8301.00
206_I210_R0.8231.00
84_D102_T0.8221.00
50_I77_I0.8191.00
184_D188_S0.8161.00
4_K47_P0.8151.00
220_P223_I0.8121.00
107_P111_N0.8091.00
16_T19_Q0.8091.00
163_T212_K0.8091.00
46_K72_K0.8071.00
200_R207_S0.8051.00
56_L64_V0.8051.00
4_K48_D0.7951.00
179_R185_L0.7951.00
68_L73_L0.7931.00
151_Y168_E0.7921.00
14_I105_F0.7851.00
90_V108_R0.7811.00
109_E113_R0.7791.00
20_Y24_R0.7781.00
208_H211_D0.7771.00
216_N220_P0.7771.00
185_L188_S0.7701.00
51_V80_L0.7701.00
59_L64_V0.7651.00
66_K70_Q0.7641.00
35_G39_L0.7601.00
116_A119_R0.7581.00
54_V83_K0.7581.00
88_D91_L0.7551.00
207_S211_D0.7551.00
42_A75_F0.7541.00
183_R199_T0.7531.00
172_Y175_R0.7501.00
76_P98_D0.7481.00
78_L99_D0.7431.00
87_F108_R0.7421.00
204_V208_H0.7391.00
51_V114_V0.7371.00
55_M82_A0.7371.00
42_A47_P0.7331.00
116_A121_S0.7241.00
106_S109_E0.7221.00
35_G58_K0.7151.00
80_L105_F0.7121.00
21_N111_N0.7091.00
93_L113_R0.7061.00
16_T20_Y0.7051.00
8_V64_V0.7051.00
168_E172_Y0.7041.00
7_V19_Q0.6891.00
203_D206_I0.6871.00
39_L42_A0.6841.00
214_E217_T0.6841.00
7_V31_T0.6821.00
154_Y157_E0.6821.00
175_R189_A0.6811.00
105_F110_V0.6781.00
140_V143_D0.6771.00
197_G202_V0.6771.00
210_R215_N0.6721.00
43_E67_Q0.6681.00
118_L121_S0.6621.00
92_G97_A0.6611.00
121_S125_A0.6561.00
76_P118_L0.6561.00
9_D56_L0.6551.00
146_I153_A0.6541.00
143_D155_F0.6511.00
35_G56_L0.6471.00
5_I22_L0.6461.00
144_L155_F0.6451.00
94_E112_A0.6421.00
17_L21_N0.6411.00
42_A50_I0.6401.00
214_E221_I0.6371.00
15_V19_Q0.6371.00
86_E108_R0.6371.00
22_L27_Y0.6351.00
216_N221_I0.6301.00
68_L77_I0.6281.00
108_R112_A0.6261.00
23_E29_V0.6231.00
155_F158_S0.6231.00
151_Y167_F0.6221.00
43_E72_K0.6211.00
53_D103_K0.6151.00
173_L206_I0.6141.00
81_T89_K0.6101.00
5_I49_L0.6071.00
74_M124_A0.6051.00
74_M123_I0.6001.00
69_R76_P0.5961.00
99_D116_A0.5941.00
221_I224_K0.5931.00
139_I148_P0.5921.00
89_K106_S0.5881.00
69_R75_F0.5881.00
39_L71_Q0.5871.00
214_E220_P0.5851.00
198_D201_I0.5831.00
23_E28_D0.5791.00
144_L153_A0.5771.00
165_K205_H0.5771.00
11_E82_A0.5761.00
113_R117_I0.5751.00
62_I88_D0.5731.00
112_A115_K0.5731.00
147_L152_E0.5701.00
51_V78_L0.5681.00
148_P175_R0.5671.00
105_F109_E0.5641.00
115_K119_R0.5641.00
139_I174_G0.5631.00
146_I171_L0.5631.00
54_V92_G0.5581.00
52_L56_L0.5521.00
155_F216_N0.5471.00
10_D81_T0.5461.00
176_H189_A0.5451.00
175_R181_L0.5431.00
179_R189_A0.5391.00
87_F90_V0.5391.00
65_C69_R0.5371.00
76_P120_R0.5361.00
145_K157_E0.5351.00
68_L75_F0.5341.00
220_P224_K0.5331.00
27_Y118_L0.5311.00
84_D104_P0.5301.00
90_V93_L0.5281.00
155_F215_N0.5251.00
11_E14_I0.5251.00
49_L117_I0.5231.00
42_A64_V0.5231.00
217_T221_I0.5201.00
163_T166_E0.5191.00
21_N25_S0.5181.00
17_L20_Y0.5141.00
52_L68_L0.5131.00
141_I174_G0.5121.00
14_I17_L0.5111.00
201_I204_V0.5091.00
92_G100_Y0.5091.00
155_F214_E0.5061.00
143_D147_L0.5051.00
183_R206_I0.5041.00
5_I114_V0.5001.00
8_V35_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r0jA 2 0.9208 100 0.249 Contact Map
1ys7A 2 0.9417 100 0.25 Contact Map
2gwrA 1 0.9292 100 0.252 Contact Map
1kgsA 1 0.9125 100 0.252 Contact Map
2oqrA 2 0.9417 100 0.259 Contact Map
4b09A 2 0.8958 100 0.265 Contact Map
4kfcA 2 0.9333 100 0.278 Contact Map
1p2fA 1 0.9042 100 0.287 Contact Map
2hqrA 2 0.9167 100 0.297 Contact Map
3q9sA 1 0.8708 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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