GREMLIN Database
LDH - L-lactate dehydrogenase
UniProt: P13714 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (302)
Sequences: 4937 (2829)
Seq/√Len: 162.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A74_A4.2681.00
76_I244_T3.0041.00
216_D220_N2.9361.00
296_K300_L2.8641.00
78_C244_T2.6621.00
99_L131_A2.5171.00
121_A240_L2.4641.00
9_A71_C2.4231.00
83_A97_K2.4151.00
106_V132_T2.3741.00
27_Q245_K2.3241.00
71_C113_G2.3051.00
208_Q212_D2.2971.00
304_G308_N2.2601.00
252_N279_N2.2371.00
108_E111_A2.1971.00
217_D224_H2.1791.00
267_A299_F2.1541.00
252_N284_A2.1481.00
272_I299_F2.1401.00
279_N284_A2.1031.00
140_K262_D2.0541.00
162_Y210_E1.9891.00
213_Q217_D1.9751.00
106_V136_S1.9701.00
110_M138_L1.9501.00
7_K32_E1.9231.00
138_L142_R1.9101.00
133_W271_Y1.9061.00
276_A283_I1.8861.00
104_G108_E1.8771.00
163_F191_V1.8671.00
175_I185_V1.8421.00
272_I303_A1.8421.00
103_K107_S1.8321.00
117_I247_I1.8181.00
172_A189_A1.8171.00
297_E301_H1.8011.00
261_L274_V1.7951.00
7_K34_V1.7851.00
300_L304_G1.7821.00
277_V285_G1.7781.00
95_V309_I1.7631.00
267_A300_L1.7441.00
102_F132_T1.6861.00
107_S111_A1.6821.00
259_T276_A1.6691.00
107_S135_F1.6621.00
8_V30_T1.6561.00
260_Y271_Y1.6261.00
293_E296_K1.6191.00
43_A47_V1.6141.00
148_T273_G1.6121.00
183_L295_E1.5851.00
100_K103_K1.5681.00
293_E297_E1.5581.00
89_E97_K1.5431.00
8_V24_L1.5341.00
13_A35_V1.5281.00
10_L21_A1.5151.00
174_I184_P1.5111.00
130_Y310_L1.5111.00
118_F132_T1.5011.00
298_Q301_H1.4831.00
281_G284_A1.4801.00
129_T271_Y1.4771.00
212_D216_D1.4771.00
207_K210_E1.4711.00
68_Y112_S1.4701.00
51_N161_E1.4561.00
160_S170_V1.4521.00
130_Y134_K1.4451.00
149_T239_S1.4391.00
245_K249_H1.4331.00
103_K135_F1.4321.00
85_Q222_A1.4311.00
20_Y240_L1.4311.00
68_Y111_A1.4091.00
41_E44_M1.4061.00
51_N157_F1.3851.00
159_L170_V1.3631.00
149_T255_L1.3521.00
69_E72_K1.3481.00
301_H304_G1.3331.00
294_K298_Q1.3311.00
79_I120_V1.3221.00
250_N280_R1.3111.00
184_P215_V1.3111.00
71_C74_A1.2971.00
307_K311_K1.2951.00
90_T93_E1.2941.00
220_N223_Y1.2901.00
171_H190_N1.2831.00
120_V132_T1.2781.00
53_G238_M1.2741.00
41_E227_E1.2741.00
146_S240_L1.2721.00
22_F237_A1.2711.00
166_A169_N1.2711.00
64_S70_D1.2661.00
181_T305_V1.2631.00
109_V118_F1.2611.00
162_Y213_Q1.2531.00
297_E300_L1.2491.00
224_H227_E1.2361.00
169_N192_G1.2331.00
308_N312_P1.2281.00
267_A303_A1.2271.00
83_A86_K1.2261.00
102_F106_V1.2151.00
7_K73_D1.2091.00
110_M137_G1.2011.00
259_T283_I1.1961.00
187_S295_E1.1951.00
76_I119_L1.1891.00
262_D268_D1.1891.00
75_D114_F1.1841.00
138_L143_V1.1771.00
20_Y244_T1.1671.00
133_W260_Y1.1651.00
24_L33_L1.1641.00
40_K67_T1.1601.00
77_V109_V1.1551.00
125_V145_G1.1501.00
41_E228_K1.1491.00
254_I277_V1.1431.00
216_D219_K1.1421.00
20_Y78_C1.1371.00
277_V284_A1.1321.00
131_A135_F1.1261.00
261_L264_Q1.1261.00
187_S292_N1.1211.00
52_H221_A1.1171.00
109_V138_L1.1171.00
113_G116_G1.1171.00
22_F26_N1.1161.00
91_R123_N1.1121.00
300_L303_A1.1091.00
123_N178_H1.1051.00
94_L98_N1.1051.00
24_L29_I1.1041.00
242_R253_S1.1021.00
144_I247_I1.0871.00
97_K100_K1.0841.00
224_H228_K1.0831.00
34_V70_D1.0790.99
91_R178_H1.0780.99
257_V276_A1.0770.99
104_G107_S1.0760.99
79_I132_T1.0760.99
20_Y237_A1.0640.99
115_D139_P1.0540.99
301_H305_V1.0480.99
39_N42_K1.0440.99
125_V129_T1.0430.99
77_V116_G1.0410.99
198_E290_N1.0340.99
141_E281_G1.0240.99
96_E100_K1.0220.99
45_G228_K1.0220.99
139_P142_R1.0210.99
210_E213_Q1.0200.99
32_E62_K1.0190.99
117_I142_R1.0180.99
194_V198_E1.0140.99
65_Y70_D1.0140.99
67_T70_D1.0120.99
85_Q226_I1.0070.99
93_E96_E1.0020.99
277_V287_T1.0000.99
190_N193_G0.9990.99
119_L243_I0.9930.99
15_F233_Y0.9930.99
156_R171_H0.9880.99
181_T302_S0.9870.99
145_G258_S0.9840.99
294_K297_E0.9750.99
102_F128_L0.9740.99
264_Q287_T0.9720.99
133_W143_V0.9710.99
106_V118_F0.9670.99
34_V74_A0.9620.99
308_N311_K0.9610.99
299_F303_A0.9600.99
18_S46_D0.9600.99
29_I249_H0.9450.99
36_I68_Y0.9440.99
89_E93_E0.9380.99
160_S167_P0.9340.99
42_K46_D0.9340.99
18_S237_A0.9310.98
83_A101_I0.9300.98
168_Q251_E0.9290.98
21_A35_V0.9280.98
75_D115_D0.9240.98
185_V291_L0.9240.98
77_V113_G0.9220.98
78_C119_L0.9210.98
157_F161_E0.9130.98
43_A66_G0.9100.98
181_T301_H0.9060.98
220_N227_E0.9020.98
74_A77_V0.9020.98
27_Q241_A0.9000.98
66_G70_D0.8990.98
263_G266_G0.8920.98
237_A241_A0.8910.98
127_I309_I0.8890.98
73_D114_F0.8880.98
72_K112_S0.8870.98
129_T145_G0.8860.98
304_G311_K0.8830.98
291_L299_F0.8810.98
76_I248_L0.8810.98
106_V135_F0.8790.98
155_F172_A0.8780.98
222_A226_I0.8770.98
158_M217_D0.8750.98
79_I102_F0.8710.98
29_I241_A0.8710.98
194_V199_L0.8710.98
140_K260_Y0.8660.98
85_Q223_Y0.8540.97
240_L244_T0.8520.97
245_K251_E0.8510.97
279_N282_G0.8420.97
6_N248_L0.8360.97
102_F120_V0.8270.97
152_S156_R0.8260.97
13_A46_D0.8250.97
175_I183_L0.8240.97
256_T273_G0.8240.97
155_F184_P0.8230.97
69_E112_S0.8210.97
158_M161_E0.8180.97
15_F18_S0.8150.96
243_I257_V0.8090.96
40_K44_M0.8090.96
119_L244_T0.8050.96
60_P166_A0.8040.96
44_M228_K0.8010.96
87_P227_E0.7990.96
274_V286_I0.7960.96
265_Y269_D0.7950.96
209_E213_Q0.7930.96
23_A237_A0.7900.96
119_L247_I0.7890.96
195_P198_E0.7880.96
309_I312_P0.7850.96
20_Y24_L0.7830.96
149_T243_I0.7830.96
304_G307_K0.7820.96
101_I122_T0.7820.96
68_Y105_I0.7810.96
252_N277_V0.7780.95
130_Y133_W0.7760.95
85_Q94_L0.7700.95
165_A170_V0.7700.95
106_V110_M0.7650.95
85_Q89_E0.7650.95
11_I105_I0.7640.95
215_V219_K0.7630.95
159_L163_F0.7610.95
125_V147_G0.7600.95
34_V66_G0.7580.95
20_Y80_C0.7550.95
73_D115_D0.7540.95
262_D287_T0.7530.95
305_V309_I0.7520.95
40_K66_G0.7510.94
186_W218_V0.7500.94
165_A191_V0.7480.94
10_L20_Y0.7450.94
180_D223_Y0.7450.94
139_P143_V0.7450.94
90_T180_D0.7440.94
163_F170_V0.7430.94
36_I71_C0.7420.94
68_Y72_K0.7420.94
79_I105_I0.7370.94
110_M136_S0.7370.94
78_C240_L0.7340.94
94_L226_I0.7310.94
15_F231_A0.7310.94
225_I235_G0.7290.94
274_V285_G0.7270.93
92_L127_I0.7260.93
116_G138_L0.7250.93
143_V271_Y0.7190.93
24_L241_A0.7170.93
102_F135_F0.7170.93
223_Y227_E0.7160.93
21_A50_L0.7160.93
117_I144_I0.7110.93
213_Q216_D0.7100.93
133_W136_S0.7090.93
81_A101_I0.7090.93
212_D294_K0.7070.93
132_T136_S0.7060.92
197_S211_L0.7050.92
23_A26_N0.7030.92
44_M66_G0.7030.92
155_F189_A0.7030.92
134_K137_G0.7030.92
263_G288_E0.7000.92
19_S234_Y0.6980.92
91_R94_L0.6970.92
6_N31_D0.6950.92
110_M116_G0.6940.92
46_D237_A0.6930.92
250_N279_N0.6900.92
133_W140_K0.6870.91
74_A113_G0.6840.91
243_I255_L0.6830.91
19_S233_Y0.6800.91
206_Y210_E0.6780.91
24_L244_T0.6750.91
270_V307_K0.6740.91
257_V278_V0.6740.91
130_Y269_D0.6720.91
96_E312_P0.6700.90
174_I215_V0.6670.90
134_K260_Y0.6650.90
6_N75_D0.6640.90
267_A296_K0.6640.90
19_S23_A0.6610.90
156_R242_R0.6600.90
100_K104_G0.6590.90
148_T181_T0.6590.90
235_G238_M0.6590.90
136_S143_V0.6590.90
110_M118_F0.6580.90
9_A34_V0.6570.90
270_V303_A0.6560.89
188_H289_L0.6540.89
206_Y209_E0.6530.89
24_L30_T0.6480.89
141_E284_A0.6470.89
91_R151_D0.6450.89
92_L309_I0.6450.89
222_A231_A0.6430.88
175_I289_L0.6410.88
9_A113_G0.6410.88
246_A255_L0.6410.88
222_A232_T0.6390.88
68_Y108_E0.6340.88
183_L302_S0.6320.88
303_A307_K0.6320.88
291_L300_L0.6320.88
140_K271_Y0.6290.87
163_F206_Y0.6260.87
52_H157_F0.6250.87
47_V51_N0.6240.87
39_N43_A0.6230.87
226_I231_A0.6220.87
99_L135_F0.6210.87
25_I33_L0.6200.87
108_E112_S0.6190.87
220_N224_H0.6180.86
267_A307_K0.6170.86
146_S258_S0.6160.86
109_V112_S0.6160.86
92_L305_V0.6150.86
30_T33_L0.6140.86
143_V146_S0.6130.86
178_H222_A0.6120.86
121_A146_S0.6090.86
80_C121_A0.6080.86
215_V298_Q0.6050.85
86_K97_K0.6050.85
160_S165_A0.6030.85
82_G122_T0.6020.85
253_S277_V0.6020.85
151_D154_R0.6000.85
18_S234_Y0.5970.85
185_V188_H0.5930.84
267_A272_I0.5890.84
71_C110_M0.5870.84
23_A241_A0.5860.83
22_F234_Y0.5830.83
10_L33_L0.5830.83
79_I106_V0.5830.83
262_D269_D0.5790.83
36_I105_I0.5760.82
307_K310_L0.5740.82
92_L312_P0.5730.82
261_L266_G0.5730.82
25_I50_L0.5730.82
183_L298_Q0.5730.82
183_L215_V0.5730.82
171_H253_S0.5720.82
161_E217_D0.5720.82
183_L291_L0.5660.81
98_N128_L0.5650.81
89_E94_L0.5650.81
16_V121_A0.5620.81
125_V146_S0.5620.81
133_W138_L0.5610.81
290_N296_K0.5580.80
246_A253_S0.5570.80
208_Q294_K0.5550.80
159_L172_A0.5540.80
263_G268_D0.5540.80
162_Y206_Y0.5490.79
8_V33_L0.5490.79
45_G94_L0.5480.79
123_N232_T0.5480.79
54_K59_Q0.5480.79
259_T262_D0.5470.79
156_R172_A0.5450.79
242_R251_E0.5440.79
82_G85_Q0.5430.79
19_S22_F0.5400.78
82_G88_G0.5380.78
264_Q285_G0.5340.77
207_K211_L0.5340.77
105_I109_V0.5330.77
124_P154_R0.5320.77
123_N154_R0.5310.77
246_A251_E0.5300.77
194_V197_S0.5290.77
72_K111_A0.5290.77
155_F183_L0.5290.77
267_A270_V0.5280.77
265_Y289_L0.5270.77
17_G21_A0.5270.77
32_E60_P0.5260.76
142_R281_G0.5250.76
259_T273_G0.5250.76
91_R222_A0.5230.76
253_S256_T0.5220.76
46_D234_Y0.5210.76
279_N283_I0.5210.76
13_A33_L0.5210.76
21_A33_L0.5200.76
103_K131_A0.5190.75
103_K134_K0.5170.75
115_D142_R0.5160.75
29_I245_K0.5160.75
247_I250_N0.5140.75
159_L189_A0.5120.74
173_H256_T0.5090.74
11_I71_C0.5070.74
261_L267_A0.5040.73
48_M228_K0.5040.73
57_A238_M0.5030.73
14_G151_D0.5020.73
175_I291_L0.5010.73
39_N65_Y0.5010.73
292_N296_K0.5000.73
48_M224_H0.5000.73
246_A256_T0.5000.73
20_Y121_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nepX 4 0.9437 100 0.232 Contact Map
2d4aB 4 0.9531 100 0.232 Contact Map
4plzA 4 0.9406 100 0.241 Contact Map
1a5zA 3 0.975 100 0.241 Contact Map
1lldA 3 0.9719 100 0.243 Contact Map
1guzA 4 0.9437 100 0.245 Contact Map
4cl3A 4 0.9563 100 0.246 Contact Map
2hjrA 4 0.9688 100 0.26 Contact Map
4bgvA 4 0.9688 100 0.261 Contact Map
4rorA 4 0.9812 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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