GREMLIN Database
TAGF - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase
UniProt: P13485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 746 (696)
Sequences: 516 (450)
Seq/√Len: 17.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
731_S737_K6.9371.00
12_Q49_L5.8831.00
84_T87_L5.6351.00
477_P538_Y4.7971.00
697_T700_E4.5431.00
69_K72_R4.2831.00
81_L90_K4.2201.00
520_T535_E4.1121.00
514_S520_T3.7931.00
733_R736_E3.6031.00
474_H574_T3.4971.00
30_T105_G3.4731.00
474_H653_S3.3920.99
516_N519_S3.3740.99
24_K56_H3.3720.99
386_F414_M3.3450.99
82_Q172_I3.2770.99
736_E740_N3.1970.99
43_L47_E3.1840.99
37_K87_L3.1040.99
383_T415_Y3.0190.99
539_P738_V3.0000.99
608_I631_F2.8840.98
669_V694_L2.8610.98
685_D688_K2.8570.98
434_I444_A2.8130.98
515_P538_Y2.7730.98
474_H612_H2.7470.98
26_M30_T2.7300.97
567_K605_Y2.7240.97
163_I167_R2.7130.97
570_L640_L2.6820.97
382_K449_E2.6760.97
463_K510_D2.6030.97
8_N26_M2.4960.96
600_E706_K2.4940.96
574_T612_H2.4410.95
7_T87_L2.4260.95
7_T37_K2.3730.94
13_K43_L2.3390.94
42_N45_S2.3270.93
205_N212_G2.2780.93
129_R132_A2.2190.92
404_Y407_E2.2180.92
20_E55_E2.2140.92
41_N76_E2.1960.91
50_I68_L2.1850.91
734_S737_K2.1310.90
479_K574_T2.1280.90
542_D692_G2.1160.90
383_T448_A2.0990.89
475_G657_D2.0980.89
42_N68_L2.0970.89
698_T701_T2.0880.89
398_P401_I2.0840.89
449_E468_T2.0830.89
37_K84_T2.0780.89
261_K264_V2.0650.88
658_F661_L2.0500.88
399_R690_A2.0470.88
592_L701_T2.0460.88
479_K681_G2.0350.88
159_G174_F2.0190.87
9_K39_L2.0060.87
10_R22_Q2.0010.87
596_Q699_E1.9830.86
105_G109_D1.9820.86
473_W636_D1.9620.86
396_C540_R1.9360.85
606_I629_Y1.9160.84
592_L597_L1.9150.84
684_F690_A1.9110.84
514_S535_E1.8890.83
398_P472_T1.8810.83
72_R75_T1.8700.83
386_F405_M1.8690.83
91_T104_M1.8660.83
675_Y681_G1.8610.82
405_M414_M1.8460.82
512_L538_Y1.8460.82
512_L523_F1.8440.82
401_I739_V1.8400.82
660_N727_C1.8140.81
384_V412_Y1.7970.80
127_L132_A1.7940.80
54_S68_L1.7860.80
44_G69_K1.7800.79
399_R403_E1.7800.79
541_N657_D1.7780.79
475_G575_W1.7770.79
699_E702_I1.7770.79
37_K65_F1.7740.79
665_M668_F1.7700.79
404_Y408_N1.7570.79
78_E96_H1.7560.79
453_V469_Y1.7520.78
49_L71_R1.7450.78
396_C513_I1.7380.78
536_S738_V1.7290.77
416_W610_R1.7290.77
473_W519_S1.7240.77
53_D66_L1.7220.77
77_S94_N1.7120.77
477_P519_S1.7070.76
416_W484_D1.6880.76
574_T652_S1.6760.75
397_N474_H1.6460.74
470_L738_V1.6440.74
476_T516_N1.6430.74
415_Y434_I1.6390.73
77_S96_H1.6390.73
479_K683_Y1.6360.73
99_P104_M1.6310.73
264_V267_L1.6270.73
474_H652_S1.6170.72
538_Y730_E1.6110.72
14_G45_S1.6100.72
695_V698_T1.6050.72
42_N47_E1.6010.72
686_F690_A1.5970.71
476_T519_S1.5890.71
390_N456_R1.5870.71
695_V701_T1.5860.71
398_P416_W1.5720.70
646_L705_I1.5700.70
644_S658_F1.5610.70
7_T11_K1.5600.70
388_S395_S1.5550.69
416_W472_T1.5500.69
31_V35_I1.5460.69
18_Y64_L1.5400.69
124_E129_R1.5270.68
84_T90_K1.5270.68
394_Y572_A1.5250.68
26_M93_I1.5210.68
475_G652_S1.5160.67
246_F251_P1.5150.67
475_G612_H1.5060.67
31_V36_L1.5000.66
389_F512_L1.4980.66
271_Y274_N1.4950.66
398_P454_N1.4950.66
567_K604_E1.4860.66
243_L247_E1.4770.65
612_H653_S1.4770.65
126_L132_A1.4760.65
394_Y399_R1.4630.64
475_G574_T1.4610.64
484_D525_R1.4550.64
386_F398_P1.4430.63
456_R505_E1.4380.63
50_I66_L1.4330.63
538_Y613_Y1.4320.63
454_N509_W1.4280.63
127_L130_L1.4280.63
448_A546_N1.4270.62
389_F454_N1.4200.62
52_I56_H1.4180.62
410_P430_G1.4160.62
110_F198_Q1.4150.62
240_V244_Y1.4110.62
380_K701_T1.4080.61
574_T653_S1.4050.61
12_Q71_R1.4040.61
698_T702_I1.4000.61
479_K675_Y1.4000.61
538_Y571_Y1.3940.61
457_L469_Y1.3910.60
11_K73_S1.3850.60
474_H538_Y1.3840.60
15_K210_K1.3780.60
389_F636_D1.3760.60
438_S475_G1.3760.60
691_P722_F1.3750.59
385_I448_A1.3740.59
400_A638_R1.3730.59
476_T538_Y1.3600.59
612_H652_S1.3520.58
387_E436_R1.3390.57
125_P128_K1.3390.57
12_Q95_A1.3370.57
397_N616_A1.3300.57
522_I683_Y1.3260.57
11_K76_E1.3250.57
671_D675_Y1.3200.56
240_V246_F1.3160.56
242_E250_V1.3150.56
244_Y247_E1.3140.56
477_P515_P1.3130.56
125_P129_R1.3110.56
78_E94_N1.3040.55
477_P509_W1.3030.55
21_E26_M1.2950.55
416_W519_S1.2940.55
390_N613_Y1.2900.55
315_V318_K1.2880.54
696_K700_E1.2880.54
675_Y683_Y1.2860.54
388_S399_R1.2810.54
484_D610_R1.2700.53
219_K222_I1.2700.53
67_K83_N1.2680.53
648_I653_S1.2670.53
645_D734_S1.2670.53
23_K35_I1.2650.53
538_Y541_N1.2650.53
48_L55_E1.2640.53
102_V106_Q1.2580.53
440_K443_F1.2550.52
592_L661_L1.2520.52
478_L484_D1.2500.52
11_K22_Q1.2500.52
45_S71_R1.2430.52
225_E228_T1.2400.52
456_R509_W1.2390.51
36_L70_E1.2350.51
453_V613_Y1.2310.51
248_V252_L1.2310.51
456_R485_M1.2310.51
381_R449_E1.2300.51
387_E391_G1.2280.51
397_N540_R1.2260.51
13_K71_R1.2260.51
50_I54_S1.2240.51
516_N522_I1.2220.50
695_V704_A1.2210.50
394_Y422_Y1.2200.50
594_L727_C1.2200.50
394_Y403_E1.2160.50
610_R613_Y1.2150.50
398_P402_Y1.2110.50
471_Q482_A1.2090.50
463_K478_L1.2030.49
473_W682_F1.2000.49
641_Y654_V1.1940.49
386_F416_W1.1910.49
383_T444_A1.1900.49
26_M36_L1.1890.48
14_G46_L1.1870.48
222_I225_E1.1850.48
69_K75_T1.1820.48
477_P523_F1.1810.48
398_P484_D1.1810.48
379_V466_H1.1760.48
484_D509_W1.1720.47
396_C670_P1.1670.47
542_D732_G1.1650.47
9_K112_V1.1590.47
13_K47_E1.1520.46
278_G281_I1.1500.46
540_R544_L1.1430.46
395_S538_Y1.1430.46
463_K541_N1.1380.45
481_L615_V1.1350.45
163_I166_K1.1340.45
479_K653_S1.1330.45
47_E96_H1.1310.45
607_V625_E1.1300.45
394_Y538_Y1.1270.45
46_L56_H1.1260.45
475_G481_L1.1220.44
454_N472_T1.1180.44
399_R686_F1.1180.44
148_E151_I1.1140.44
471_Q538_Y1.1130.44
571_Y601_L1.1120.44
416_W454_N1.1110.44
399_R425_P1.1080.44
469_Y614_L1.1050.43
15_K95_A1.1030.43
119_E123_Q1.1010.43
477_P571_Y1.1010.43
514_S633_A1.1000.43
659_A665_M1.1000.43
666_L703_E1.1000.43
87_L163_I1.0990.43
519_S538_Y1.0990.43
141_F144_D1.0960.43
45_S49_L1.0950.43
183_E187_T1.0940.43
541_N722_F1.0940.43
591_D670_P1.0900.43
43_L96_H1.0890.43
121_A124_E1.0880.42
451_W610_R1.0870.42
387_E469_Y1.0870.42
388_S391_G1.0850.42
227_K230_G1.0850.42
731_S734_S1.0840.42
456_R481_L1.0840.42
621_L628_A1.0830.42
509_W641_Y1.0810.42
472_T538_Y1.0800.42
386_F451_W1.0790.42
602_G606_I1.0790.42
523_F723_Y1.0780.42
453_V456_R1.0760.42
394_Y473_W1.0760.42
27_I56_H1.0710.41
12_Q53_D1.0700.41
478_L681_G1.0670.41
193_L705_I1.0670.41
396_C454_N1.0650.41
10_R19_T1.0640.41
16_S62_Y1.0630.41
454_N538_Y1.0610.41
415_Y444_A1.0600.41
389_F456_R1.0570.41
125_P130_L1.0540.41
239_F242_E1.0510.40
478_L683_Y1.0510.40
577_D727_C1.0470.40
88_E112_V1.0460.40
386_F401_I1.0440.40
472_T541_N1.0430.40
641_Y661_L1.0390.40
599_Q628_A1.0390.40
389_F473_W1.0380.40
394_Y519_S1.0380.40
463_K477_P1.0320.39
31_V108_Y1.0320.39
597_L667_F1.0300.39
25_V29_N1.0290.39
474_H575_W1.0280.39
20_E24_K1.0270.39
19_T49_L1.0250.39
473_W670_P1.0240.39
598_R627_F1.0240.39
399_R636_D1.0200.39
544_L641_Y1.0180.38
385_I658_F1.0170.38
15_K18_Y1.0170.38
472_T727_C1.0160.38
475_G653_S1.0110.38
43_L77_S1.0090.38
457_L482_A1.0060.38
288_L291_G1.0040.38
676_R679_L1.0030.38
401_I405_M0.9970.37
413_K440_K0.9950.37
80_P97_V0.9940.37
544_L661_L0.9910.37
440_K444_A0.9910.37
478_L519_S0.9890.37
119_E124_E0.9880.37
453_V457_L0.9870.37
460_W463_K0.9870.37
471_Q526_A0.9850.37
519_S523_F0.9810.36
266_R272_I0.9810.36
448_A719_F0.9800.36
662_K719_F0.9770.36
474_H540_R0.9770.36
48_L51_S0.9760.36
396_C575_W0.9740.36
47_E71_R0.9730.36
221_P224_L0.9730.36
29_N78_E0.9730.36
397_N513_I0.9730.36
472_T476_T0.9730.36
10_R26_M0.9720.36
454_N691_P0.9680.36
212_G668_F0.9680.36
44_G76_E0.9680.36
578_D679_L0.9670.36
515_P655_F0.9660.36
675_Y722_F0.9650.35
451_W614_L0.9650.35
69_K79_F0.9650.35
19_T25_V0.9640.35
120_D124_E0.9640.35
656_F661_L0.9630.35
390_N455_S0.9610.35
309_A320_K0.9590.35
61_D64_L0.9580.35
13_K45_S0.9540.35
396_C638_R0.9540.35
120_D123_Q0.9500.35
485_M523_F0.9490.35
395_S454_N0.9480.35
476_T727_C0.9480.35
667_F690_A0.9480.35
24_K28_E0.9460.34
387_E398_P0.9430.34
60_E63_Q0.9410.34
27_I61_D0.9400.34
413_K432_P0.9380.34
80_P96_H0.9350.34
174_F177_I0.9330.34
659_A722_F0.9330.34
511_Y742_V0.9320.34
94_N97_V0.9320.34
605_Y713_Y0.9320.34
161_F174_F0.9310.34
659_A684_F0.9270.33
647_L658_F0.9260.33
267_L270_E0.9260.33
572_A680_R0.9260.33
607_V613_Y0.9230.33
509_W512_L0.9200.33
58_F82_Q0.9190.33
477_P512_L0.9180.33
454_N519_S0.9170.33
426_F429_K0.9170.33
651_Y671_D0.9160.33
152_L155_T0.9160.33
19_T40_K0.9150.33
477_P514_S0.9140.33
389_F396_C0.9120.33
475_G506_A0.9100.33
402_Y429_K0.9090.32
111_Y160_N0.9070.32
479_K516_N0.9070.32
665_M695_V0.9050.32
453_V686_F0.9040.32
14_G47_E0.9020.32
479_K571_Y0.9010.32
200_R208_L0.8990.32
388_S637_I0.8970.32
67_K79_F0.8970.32
396_C544_L0.8960.32
41_N72_R0.8960.32
571_Y691_P0.8960.32
455_S638_R0.8960.32
132_A135_N0.8950.32
88_E107_T0.8940.32
377_M380_K0.8910.32
156_T161_F0.8890.31
518_Y522_I0.8870.31
416_W675_Y0.8860.31
122_E125_P0.8860.31
17_F38_S0.8850.31
42_N50_I0.8830.31
126_L130_L0.8830.31
405_M522_I0.8810.31
473_W512_L0.8800.31
145_Q148_E0.8780.31
55_E60_E0.8780.31
25_V45_S0.8780.31
403_E667_F0.8780.31
389_F477_P0.8760.31
388_S398_P0.8760.31
13_K42_N0.8750.31
519_S727_C0.8730.31
388_S394_Y0.8710.31
567_K645_D0.8710.31
572_A610_R0.8710.31
472_T610_R0.8690.30
205_N208_L0.8680.30
477_P484_D0.8680.30
185_S189_Y0.8680.30
17_F39_L0.8660.30
43_L94_N0.8640.30
477_P516_N0.8630.30
463_K722_F0.8600.30
597_L647_L0.8600.30
662_K723_Y0.8590.30
109_D348_L0.8590.30
580_F586_Y0.8580.30
160_N700_E0.8570.30
434_I648_I0.8570.30
64_L70_E0.8550.30
438_S657_D0.8550.30
540_R652_S0.8500.29
571_Y610_R0.8490.29
517_G728_Y0.8480.29
269_M272_I0.8460.29
59_L64_L0.8440.29
474_H576_R0.8430.29
399_R402_Y0.8410.29
77_S80_P0.8400.29
572_A676_R0.8390.29
484_D655_F0.8380.29
388_S454_N0.8370.29
282_Q285_S0.8350.29
107_T160_N0.8350.29
35_I66_L0.8330.29
39_L44_G0.8320.29
389_F392_K0.8320.29
426_F665_M0.8300.28
389_F682_F0.8290.28
43_L97_V0.8280.28
214_T217_E0.8270.28
576_R652_S0.8260.28
415_Y436_R0.8250.28
9_K84_T0.8240.28
691_P727_C0.8230.28
455_S482_A0.8230.28
327_R331_Y0.8220.28
666_L697_T0.8220.28
613_Y637_I0.8200.28
389_F393_Q0.8200.28
538_Y743_F0.8190.28
455_S512_L0.8180.28
485_M507_S0.8170.28
416_W538_Y0.8150.28
580_F670_P0.8140.28
388_S472_T0.8140.28
66_L69_K0.8140.28
125_P132_A0.8140.28
479_K655_F0.8120.28
517_G532_T0.8100.28
279_T328_V0.8100.28
268_F271_Y0.8030.27
47_E78_E0.8030.27
20_E56_H0.8020.27
448_A705_I0.8020.27
667_F726_F0.7990.27
665_M686_F0.7980.27
127_L131_S0.7970.27
471_Q682_F0.7970.27
182_E185_S0.7960.27
141_F145_Q0.7950.27
570_L642_M0.7940.27
451_W469_Y0.7910.27
478_L675_Y0.7900.27
473_W538_Y0.7900.27
80_P94_N0.7900.27
153_P158_K0.7900.27
26_M59_L0.7890.27
402_Y433_Y0.7880.26
388_S527_F0.7870.26
207_I211_G0.7870.26
459_L505_E0.7860.26
450_Y468_T0.7860.26
178_E182_E0.7850.26
455_S614_L0.7850.26
667_F722_F0.7840.26
265_Y271_Y0.7840.26
602_G727_C0.7830.26
473_W541_N0.7820.26
523_F655_F0.7800.26
455_S538_Y0.7800.26
224_L227_K0.7790.26
675_Y685_D0.7790.26
577_D610_R0.7790.26
679_L682_F0.7790.26
516_N538_Y0.7780.26
366_T731_S0.7770.26
416_W634_Y0.7750.26
76_E156_T0.7750.26
84_T101_P0.7720.26
571_Y722_F0.7720.26
222_I227_K0.7710.26
240_V243_L0.7710.26
28_E55_E0.7690.26
469_Y613_Y0.7690.26
55_E109_D0.7680.26
203_N208_L0.7680.26
594_L698_T0.7680.26
588_F609_L0.7670.26
7_T39_L0.7660.25
23_K31_V0.7650.25
397_N670_P0.7640.25
396_C580_F0.7630.25
479_K484_D0.7630.25
41_N52_I0.7620.25
43_L71_R0.7620.25
512_L539_P0.7620.25
11_K15_K0.7580.25
394_Y484_D0.7570.25
516_N727_C0.7570.25
388_S541_N0.7560.25
546_N638_R0.7550.25
25_V97_V0.7550.25
387_E454_N0.7540.25
116_K644_S0.7540.25
420_K467_T0.7530.25
107_T111_Y0.7510.25
145_Q149_L0.7490.25
471_Q514_S0.7470.25
481_L613_Y0.7470.25
24_K46_L0.7470.25
476_T670_P0.7470.25
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323_T329_N0.6360.20
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162_S181_S0.5810.18
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509_W535_E0.5660.17
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386_F402_Y0.5650.17
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318_K329_N0.5630.17
93_I103_E0.5630.17
122_E132_A0.5620.17
597_L690_A0.5620.17
26_M244_Y0.5620.17
29_N76_E0.5620.17
388_S538_Y0.5620.17
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506_A666_L0.5610.17
8_N104_M0.5610.17
29_N94_N0.5610.17
397_N653_S0.5590.17
27_I63_Q0.5590.17
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478_L516_N0.5530.17
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509_W541_N0.5530.17
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31_V111_Y0.5400.17
38_S707_Q0.5400.17
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654_V670_P0.5380.17
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170_K448_A0.5300.16
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207_I210_K0.5290.16
368_K461_I0.5290.16
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398_P463_K0.5280.16
456_R469_Y0.5260.16
601_L675_Y0.5260.16
388_S416_W0.5260.16
293_R305_K0.5260.16
456_R484_D0.5260.16
723_Y727_C0.5250.16
90_K166_K0.5250.16
65_F82_Q0.5250.16
26_M85_G0.5250.16
389_F515_P0.5240.16
574_T681_G0.5240.16
715_L718_S0.5240.16
203_N210_K0.5220.16
294_K297_L0.5220.16
693_P708_I0.5210.16
509_W526_A0.5200.16
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588_F661_L0.5190.16
267_L316_F0.5170.16
476_T655_F0.5170.16
608_I634_Y0.5160.16
454_N476_T0.5160.16
590_L670_P0.5140.16
505_E611_M0.5140.16
509_W681_G0.5120.16
396_C538_Y0.5120.16
74_G631_F0.5120.16
475_G541_N0.5110.16
473_W594_L0.5110.16
481_L679_L0.5100.16
453_V519_S0.5100.16
286_T289_V0.5100.16
17_F54_S0.5100.16
476_T613_Y0.5100.16
388_S418_V0.5080.16
610_R640_L0.5070.16
48_L82_Q0.5070.16
591_D660_N0.5070.16
243_L246_F0.5070.16
394_Y535_E0.5070.16
468_T511_Y0.5070.16
572_A732_G0.5060.15
77_S97_V0.5060.15
579_Q648_I0.5060.15
21_E210_K0.5050.15
649_T656_F0.5050.15
122_E126_L0.5050.15
438_S540_R0.5050.15
620_D624_F0.5050.15
485_M614_L0.5040.15
451_W467_T0.5030.15
11_K95_A0.5030.15
473_W585_R0.5030.15
482_A691_P0.5030.15
178_E181_S0.5020.15
299_G303_I0.5020.15
235_R242_E0.5020.15
353_K357_K0.5020.15
82_Q109_D0.5020.15
240_V252_L0.5020.15
383_T447_R0.5020.15
394_Y512_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0.5416 100 0.392 Contact Map
3bcvA 2 0.2413 100 0.816 Contact Map
1qg8A 1 0.2936 100 0.83 Contact Map
2z86A 2 0.3338 100 0.842 Contact Map
1fo8A 1 0.4062 99.9 0.863 Contact Map
3ckjA 2 0.3418 99.9 0.87 Contact Map
2nxvA 4 0.3003 99.9 0.873 Contact Map
2d7iA 1 0.5442 99.9 0.873 Contact Map
2bo4A 4 0.4638 99.9 0.875 Contact Map
4fixA 3 0.5697 99.9 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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