PYRG - BACSU - GREMLIN Contacts

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PYRG - CTP synthase

UniProt:	P13242	Sequences: MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKERRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQMKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPISQDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSEWKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEVTENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYARNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVYQDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHPEFKSRPTRPQPLFKGFIGASVEAANQK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	535 (528)
Sequences:	2959 (1271)
Seq/√Len:	55.3

ECOLI - PYRG
BACSU - PYRG
HALSA - PYRG
SULSO - PYRG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
368_K	372_E	4.593	1.00
449_V	523_G	4.585	1.00
294_G	346_T	4.113	1.00
292_T	325_K	4.082	1.00
292_T	327_K	3.869	1.00
367_T	386_V	3.710	1.00
290_T	325_K	3.708	1.00
400_G	412_Y	3.620	1.00
374_N	499_P	3.573	1.00
166_G	169_N	3.438	1.00
293_I	348_G	3.274	1.00
327_K	346_T	3.259	1.00
24_L	261_V	3.228	1.00
446_A	492_I	3.222	1.00
435_L	456_Y	3.109	1.00
367_T	377_F	3.008	1.00
367_T	501_F	2.960	1.00
253_Q	258_D	2.801	1.00
365_V	368_K	2.797	1.00
171_M	208_I	2.795	1.00
471_Q	475_E	2.768	1.00
445_K	448_E	2.767	1.00
247_S	285_S	2.700	1.00
444_T	479_V	2.626	1.00
410_T	413_P	2.595	1.00
349_I	370_A	2.583	1.00
317_G	324_V	2.561	1.00
391_Y	395_V	2.534	1.00
322_T	529_V	2.520	1.00
386_V	389_I	2.518	1.00
327_K	345_G	2.515	1.00
398_L	472_Q	2.467	1.00
447_F	453_E	2.461	1.00
374_N	497_D	2.451	1.00
33_L	137_V	2.399	1.00
492_I	506_F	2.370	1.00
243_D	247_S	2.357	1.00
377_F	387_A	2.350	1.00
479_V	496_K	2.331	1.00
123_K	164_D	2.325	1.00
20_V	210_V	2.294	1.00
234_K	263_E	2.277	1.00
335_T	338_N	2.276	1.00
398_L	412_Y	2.266	1.00
172_Y	204_I	2.260	1.00
96_S	100_K	2.249	1.00
208_I	257_L	2.246	1.00
198_E	201_S	2.243	1.00
442_E	447_F	2.218	1.00
182_K	214_E	2.206	1.00
320_F	526_G	2.183	1.00
80_D	516_R	2.183	1.00
400_G	411_Q	2.172	1.00
446_A	481_S	2.170	1.00
219_Q	223_D	2.166	1.00
120_N	124_D	2.157	1.00
396_L	473_M	2.128	1.00
289_Q	322_T	2.121	1.00
412_Y	469_F	2.062	1.00
403_S	406_I	2.059	1.00
294_G	329_I	2.044	1.00
445_K	502_V	1.968	1.00
250_L	278_K	1.963	1.00
404_A	413_P	1.934	1.00
223_D	233_T	1.932	1.00
98_V	118_I	1.930	1.00
484_S	487_G	1.879	1.00
442_E	453_E	1.876	0.99
310_V	328_W	1.873	0.99
161_M	165_I	1.868	0.99
402_H	407_D	1.863	0.99
444_T	481_S	1.862	0.99
441_E	474_E	1.860	0.99
63_D	435_L	1.859	0.99
473_M	478_F	1.855	0.99
97_T	121_E	1.854	0.99
288_S	321_D	1.845	0.99
500_W	524_F	1.844	0.99
55_Q	110_G	1.823	0.99
387_A	501_F	1.799	0.99
351_V	377_F	1.787	0.99
360_V	386_V	1.784	0.99
63_D	82_N	1.782	0.99
85_K	93_K	1.768	0.99
127_Y	161_M	1.742	0.99
465_F	473_M	1.737	0.99
526_G	530_E	1.727	0.99
29_K	80_D	1.726	0.99
398_L	469_F	1.721	0.99
290_T	323_D	1.713	0.99
449_V	502_V	1.708	0.99
388_S	414_I	1.699	0.99
471_Q	474_E	1.675	0.99
243_D	285_S	1.666	0.99
121_E	124_D	1.654	0.99
279_E	283_K	1.642	0.99
4_Y	130_G	1.634	0.99
377_F	386_V	1.602	0.98
484_S	488_R	1.600	0.98
283_K	321_D	1.598	0.98
98_V	107_Y	1.587	0.98
361_E	364_I	1.581	0.98
470_R	483_T	1.566	0.98
374_N	498_H	1.566	0.98
382_L	406_I	1.559	0.98
472_Q	475_E	1.539	0.98
378_L	524_F	1.530	0.98
289_Q	529_V	1.524	0.98
176_T	192_T	1.523	0.98
500_W	523_G	1.522	0.98
178_V	217_I	1.520	0.98
14_S	184_A	1.518	0.98
30_N	274_M	1.507	0.98
415_I	465_F	1.495	0.97
360_V	406_I	1.495	0.97
396_L	472_Q	1.489	0.97
29_K	81_I	1.479	0.97
348_G	524_F	1.479	0.97
124_D	128_R	1.474	0.97
137_V	265_M	1.464	0.97
335_T	339_I	1.455	0.97
446_A	502_V	1.453	0.97
441_E	479_V	1.451	0.97
465_F	470_R	1.439	0.97
350_I	524_F	1.424	0.97
163_S	230_D	1.419	0.96
437_P	454_V	1.418	0.96
398_L	411_Q	1.418	0.96
388_S	493_I	1.418	0.96
449_V	500_W	1.414	0.96
155_L	202_L	1.410	0.96
235_A	260_L	1.409	0.96
174_H	195_S	1.407	0.96
438_C	506_F	1.399	0.96
360_V	382_L	1.396	0.96
3_K	169_N	1.394	0.96
101_K	106_D	1.392	0.96
511_K	518_Q	1.381	0.96
435_L	511_K	1.380	0.96
391_Y	476_Q	1.378	0.96
438_C	482_G	1.370	0.96
334_V	366_A	1.368	0.96
400_G	407_D	1.361	0.96
21_A	139_I	1.359	0.95
238_E	255_Q	1.342	0.95
97_T	125_R	1.341	0.95
239_C	252_L	1.341	0.95
440_L	446_A	1.337	0.95
209_I	225_I	1.337	0.95
437_P	456_Y	1.334	0.95
36_T	87_S	1.332	0.95
24_L	173_I	1.331	0.95
384_M	493_I	1.326	0.95
237_I	260_L	1.323	0.95
334_V	342_L	1.322	0.95
467_N	470_R	1.320	0.95
256_G	259_K	1.310	0.94
384_M	465_F	1.306	0.94
171_M	264_H	1.305	0.94
388_S	465_F	1.305	0.94
330_N	333_E	1.303	0.94
390_E	394_N	1.301	0.94
44_I	91_T	1.295	0.94
63_D	511_K	1.287	0.94
168_E	266_K	1.286	0.94
37_I	79_I	1.284	0.94
439_K	454_V	1.282	0.94
292_T	346_T	1.279	0.94
44_I	118_I	1.268	0.93
367_T	390_E	1.261	0.93
142_I	158_I	1.260	0.93
127_Y	165_I	1.257	0.93
295_L	309_V	1.254	0.93
242_A	251_E	1.249	0.93
319_A	517_P	1.247	0.93
38_Q	140_T	1.247	0.93
348_G	528_S	1.240	0.93
7_V	139_I	1.238	0.93
478_F	493_I	1.233	0.92
197_K	201_S	1.223	0.92
421_Q	424_V	1.222	0.92
416_D	421_Q	1.215	0.92
402_H	410_T	1.211	0.92
293_I	528_S	1.210	0.92
387_A	503_A	1.209	0.92
480_F	483_T	1.209	0.92
164_D	172_Y	1.207	0.92
54_Y	301_E	1.204	0.92
213_T	238_E	1.203	0.92
368_K	394_N	1.201	0.91
26_R	29_K	1.200	0.91
82_N	513_R	1.196	0.91
126_V	161_M	1.193	0.91
439_K	453_E	1.192	0.91
284_V	318_Y	1.188	0.91
292_T	345_G	1.182	0.91
91_T	118_I	1.180	0.91
158_I	172_Y	1.175	0.91
108_L	427_L	1.163	0.90
187_L	218_S	1.162	0.90
244_N	285_S	1.160	0.90
207_N	264_H	1.159	0.90
218_S	221_M	1.159	0.90
396_L	476_Q	1.152	0.90
282_N	286_N	1.146	0.89
496_K	499_P	1.146	0.89
93_K	125_R	1.142	0.89
443_G	448_E	1.141	0.89
5_I	171_M	1.139	0.89
341_E	344_S	1.136	0.89
162_K	170_V	1.136	0.89
443_G	447_F	1.134	0.89
440_L	482_G	1.134	0.89
95_Y	114_V	1.132	0.89
440_L	444_T	1.129	0.89
467_N	490_V	1.128	0.89
20_V	175_C	1.126	0.89
40_F	140_T	1.118	0.88
40_F	48_P	1.117	0.88
301_E	330_N	1.115	0.88
483_T	487_G	1.112	0.88
404_A	410_T	1.111	0.88
350_I	380_I	1.110	0.88
445_K	500_W	1.105	0.88
349_I	375_I	1.105	0.88
97_T	101_K	1.095	0.87
213_T	240_E	1.092	0.87
80_D	513_R	1.091	0.87
399_K	412_Y	1.091	0.87
495_L	498_H	1.088	0.87
472_Q	476_Q	1.085	0.87
171_M	261_V	1.083	0.87
3_K	265_M	1.082	0.87
200_R	230_D	1.080	0.86
260_L	264_H	1.078	0.86
377_F	501_F	1.074	0.86
391_Y	478_F	1.072	0.86
334_V	338_N	1.069	0.86
351_V	387_A	1.068	0.86
219_Q	233_T	1.065	0.86
313_L	324_V	1.064	0.86
137_V	267_L	1.063	0.86
480_F	490_V	1.047	0.85
387_A	493_I	1.046	0.85
26_R	30_N	1.046	0.85
250_L	281_V	1.042	0.84
19_I	248_I	1.038	0.84
259_K	263_E	1.037	0.84
287_L	321_D	1.032	0.84
20_V	239_C	1.030	0.84
419_P	488_R	1.025	0.83
162_K	172_Y	1.022	0.83
388_S	473_M	1.022	0.83
378_L	502_V	1.019	0.83
296_V	331_A	1.015	0.83
412_Y	472_Q	1.012	0.83
40_F	74_H	1.008	0.82
361_E	393_R	1.004	0.82
36_T	138_V	1.004	0.82
350_I	363_K	1.003	0.82
392_A	473_M	1.002	0.82
196_V	206_P	1.002	0.82
449_V	524_F	1.001	0.82
155_L	204_I	1.001	0.82
33_L	269_C	0.999	0.82
407_D	410_T	0.996	0.82
40_F	126_V	0.995	0.82
247_S	281_V	0.994	0.81
437_P	485_P	0.993	0.81
20_V	252_L	0.993	0.81
173_I	261_V	0.990	0.81
523_G	526_G	0.989	0.81
404_A	416_D	0.980	0.81
8_T	174_H	0.980	0.81
89_V	125_R	0.979	0.80
334_V	365_V	0.978	0.80
244_N	284_V	0.978	0.80
456_Y	511_K	0.978	0.80
446_A	504_S	0.978	0.80
200_R	205_Q	0.976	0.80
474_E	480_F	0.973	0.80
280_L	318_Y	0.970	0.80
350_I	370_A	0.969	0.80
343_T	346_T	0.966	0.80
303_P	328_W	0.962	0.79
309_V	380_I	0.959	0.79
225_I	236_V	0.957	0.79
416_D	419_P	0.956	0.79
417_L	421_Q	0.956	0.79
244_N	281_V	0.950	0.78
327_K	342_L	0.947	0.78
440_L	447_F	0.946	0.78
371_R	390_E	0.941	0.78
329_I	346_T	0.934	0.77
336_E	365_V	0.931	0.77
335_T	365_V	0.928	0.77
262_C	269_C	0.926	0.77
146_V	155_L	0.925	0.77
309_V	353_G	0.922	0.76
278_K	282_N	0.920	0.76
388_S	478_F	0.917	0.76
316_A	522_K	0.916	0.76
216_P	240_E	0.912	0.76
165_I	169_N	0.910	0.75
52_S	55_Q	0.907	0.75
162_K	167_R	0.907	0.75
253_Q	272_A	0.904	0.75
294_G	327_K	0.903	0.75
121_E	125_R	0.899	0.74
167_R	207_N	0.896	0.74
211_V	225_I	0.890	0.74
367_T	389_I	0.890	0.74
156_E	159_R	0.890	0.74
416_D	422_K	0.889	0.74
29_K	79_I	0.887	0.73
258_D	272_A	0.886	0.73
100_K	426_D	0.880	0.73
114_V	118_I	0.877	0.73
33_L	262_C	0.877	0.73
81_I	513_R	0.876	0.73
382_L	403_S	0.875	0.72
95_Y	153_P	0.874	0.72
38_Q	48_P	0.874	0.72
495_L	501_F	0.874	0.72
455_V	518_Q	0.872	0.72
263_E	266_K	0.869	0.72
104_R	426_D	0.867	0.72
130_G	138_V	0.865	0.72
418_L	421_Q	0.865	0.72
295_L	310_V	0.862	0.71
48_P	74_H	0.861	0.71
137_V	262_C	0.860	0.71
83_L	87_S	0.857	0.71
317_G	525_I	0.855	0.71
37_I	87_S	0.855	0.71
340_A	373_N	0.855	0.71
26_R	515_T	0.854	0.71
108_L	431_L	0.853	0.71
304_D	309_V	0.852	0.70
312_S	316_A	0.852	0.70
254_K	278_K	0.852	0.70
391_Y	495_L	0.851	0.70
192_T	225_I	0.848	0.70
86_F	128_R	0.847	0.70
447_F	451_Q	0.845	0.70
234_K	260_L	0.845	0.70
316_A	320_F	0.843	0.70
251_E	254_K	0.842	0.70
257_L	261_V	0.841	0.69
320_F	525_I	0.841	0.69
98_V	155_L	0.841	0.69
339_I	365_V	0.840	0.69
417_L	422_K	0.831	0.69
339_I	342_L	0.829	0.68
492_I	504_S	0.827	0.68
31_R	258_D	0.826	0.68
307_I	314_R	0.824	0.68
182_K	215_M	0.824	0.68
44_I	98_V	0.823	0.68
210_V	239_C	0.819	0.67
89_V	304_D	0.818	0.67
179_P	192_T	0.818	0.67
216_P	238_E	0.817	0.67
180_Y	184_A	0.817	0.67
316_A	525_I	0.815	0.67
213_T	217_I	0.814	0.67
242_A	248_I	0.813	0.67
384_M	504_S	0.813	0.67
437_P	484_S	0.812	0.67
289_Q	321_D	0.808	0.66
480_F	493_I	0.808	0.66
208_I	260_L	0.807	0.66
15_L	20_V	0.805	0.66
130_G	135_A	0.805	0.66
127_Y	164_D	0.802	0.66
30_N	272_A	0.801	0.66
34_N	134_N	0.797	0.65
344_S	369_Y	0.797	0.65
33_L	136_D	0.796	0.65
338_N	341_E	0.791	0.65
396_L	478_F	0.791	0.65
374_N	496_K	0.788	0.64
445_K	449_V	0.787	0.64
158_I	170_V	0.786	0.64
399_K	411_Q	0.783	0.64
459_H	491_E	0.778	0.63
162_K	230_D	0.776	0.63
40_F	89_V	0.776	0.63
187_L	221_M	0.776	0.63
316_A	324_V	0.774	0.63
439_K	487_G	0.774	0.63
445_K	497_D	0.772	0.63
176_T	179_P	0.771	0.63
469_F	472_Q	0.768	0.62
439_K	485_P	0.767	0.62
457_E	518_Q	0.765	0.62
291_I	528_S	0.765	0.62
412_Y	468_E	0.764	0.62
369_Y	373_N	0.761	0.62
389_I	402_H	0.761	0.62
292_T	347_D	0.759	0.61
94_I	125_R	0.759	0.61
63_D	456_Y	0.758	0.61
222_K	255_Q	0.756	0.61
294_G	347_D	0.756	0.61
444_T	482_G	0.755	0.61
222_K	238_E	0.755	0.61
329_I	334_V	0.752	0.61
367_T	387_A	0.752	0.61
344_S	373_N	0.750	0.61
364_I	386_V	0.749	0.60
446_A	503_A	0.745	0.60
38_Q	87_S	0.744	0.60
483_T	490_V	0.743	0.60
97_T	100_K	0.743	0.60
88_N	108_L	0.741	0.60
60_F	82_N	0.741	0.60
183_A	226_A	0.740	0.59
499_P	531_A	0.739	0.59
66_A	85_K	0.738	0.59
60_F	513_R	0.736	0.59
129_A	138_V	0.734	0.59
349_I	524_F	0.734	0.59
517_P	522_K	0.733	0.59
239_C	255_Q	0.732	0.59
15_L	175_C	0.729	0.58
523_G	527_A	0.726	0.58
276_E	515_T	0.722	0.58
350_I	387_A	0.718	0.57
201_S	484_S	0.717	0.57
333_E	342_L	0.716	0.57
62_T	66_A	0.716	0.57
209_I	231_I	0.715	0.57
38_Q	139_I	0.713	0.57
123_K	160_Q	0.712	0.57
168_E	264_H	0.711	0.56
380_I	504_S	0.711	0.56
363_K	386_V	0.710	0.56
348_G	378_L	0.710	0.56
119_T	160_Q	0.709	0.56
184_A	241_D	0.709	0.56
437_P	486_D	0.709	0.56
115_I	119_T	0.707	0.56
265_M	270_K	0.705	0.56
62_T	68_T	0.705	0.56
370_A	377_F	0.704	0.56
368_K	373_N	0.702	0.55
187_L	215_M	0.701	0.55
94_I	121_E	0.699	0.55
493_I	503_A	0.695	0.55
441_E	483_T	0.695	0.55
31_R	262_C	0.695	0.55
51_M	59_V	0.694	0.55
235_A	264_H	0.692	0.54
309_V	352_P	0.692	0.54
420_E	431_L	0.691	0.54
253_Q	271_E	0.690	0.54
438_C	446_A	0.689	0.54
82_N	435_L	0.688	0.54
165_I	170_V	0.688	0.54
178_V	238_E	0.686	0.54
281_V	285_S	0.685	0.54
334_V	339_I	0.685	0.54
287_L	323_D	0.685	0.54
8_T	195_S	0.684	0.54
217_I	221_M	0.684	0.54
114_V	149_I	0.684	0.54
197_K	200_R	0.683	0.53
181_I	184_A	0.683	0.53
38_Q	89_V	0.682	0.53
276_E	279_E	0.679	0.53
113_Q	150_E	0.679	0.53
296_V	351_V	0.679	0.53
303_P	310_V	0.677	0.53
162_K	207_N	0.675	0.53
441_E	444_T	0.675	0.53
522_K	526_G	0.674	0.52
361_E	402_H	0.673	0.52
378_L	523_G	0.672	0.52
406_I	410_T	0.670	0.52
208_I	255_Q	0.670	0.52
15_L	177_L	0.669	0.52
232_D	264_H	0.669	0.52
336_E	339_I	0.669	0.52
54_Y	60_F	0.667	0.52
470_R	480_F	0.666	0.52
120_N	223_D	0.665	0.52
482_G	492_I	0.664	0.51
443_G	479_V	0.664	0.51
259_K	269_C	0.664	0.51
398_L	410_T	0.661	0.51
332_E	358_R	0.660	0.51
339_I	343_T	0.659	0.51
470_R	490_V	0.659	0.51
391_Y	473_M	0.659	0.51
345_G	375_I	0.659	0.51
4_Y	127_Y	0.656	0.51
247_S	250_L	0.655	0.50
316_A	319_A	0.655	0.50
93_K	97_T	0.654	0.50
48_P	180_Y	0.653	0.50
104_R	427_L	0.653	0.50
142_I	155_L	0.652	0.50
366_A	370_A	0.651	0.50
447_F	452_D	0.650	0.50
36_T	135_A	0.648	0.50
46_V	51_M	0.646	0.49
211_V	431_L	0.646	0.49
258_D	262_C	0.646	0.49
208_I	235_A	0.645	0.49
14_S	239_C	0.645	0.49
452_D	530_E	0.644	0.49
394_N	399_K	0.644	0.49
33_L	268_A	0.644	0.49
373_N	442_E	0.643	0.49
513_R	516_R	0.643	0.49
320_F	529_V	0.643	0.49
360_V	389_I	0.642	0.49
100_K	104_R	0.642	0.49
309_V	421_Q	0.642	0.49
396_L	474_E	0.641	0.49
493_I	501_F	0.641	0.49
502_V	520_L	0.640	0.49
84_N	87_S	0.640	0.49
382_L	386_V	0.640	0.49
302_L	305_A	0.638	0.49
280_L	515_T	0.637	0.49
388_S	391_Y	0.637	0.49
170_V	204_I	0.636	0.48
66_A	93_K	0.635	0.48
153_P	194_H	0.634	0.48
364_I	394_N	0.630	0.48
60_F	79_I	0.630	0.48
25_G	139_I	0.629	0.48
427_L	431_L	0.629	0.48
313_L	350_I	0.628	0.48
36_T	79_I	0.627	0.47
275_S	278_K	0.627	0.47
63_D	510_F	0.626	0.47
248_I	255_Q	0.626	0.47
481_S	495_L	0.626	0.47
7_V	37_I	0.624	0.47
33_L	267_L	0.621	0.47
240_E	251_E	0.620	0.47
226_A	232_D	0.620	0.47
280_L	284_V	0.617	0.46
438_C	492_I	0.617	0.46
24_L	257_L	0.616	0.46
114_V	153_P	0.615	0.46
357_D	406_I	0.614	0.46
465_F	492_I	0.614	0.46
106_D	110_G	0.613	0.46
44_I	328_W	0.613	0.46
129_A	135_A	0.612	0.46
230_D	235_A	0.610	0.46
364_I	367_T	0.610	0.46
101_K	121_E	0.610	0.46
370_A	387_A	0.605	0.45
465_F	490_V	0.605	0.45
396_L	400_G	0.603	0.45
80_D	515_T	0.603	0.45
391_Y	396_L	0.601	0.45
380_I	521_F	0.601	0.45
296_V	366_A	0.600	0.45
418_L	431_L	0.600	0.45
378_L	504_S	0.600	0.45
506_F	518_Q	0.599	0.44
440_L	492_I	0.599	0.44
101_K	124_D	0.599	0.44
360_V	403_S	0.598	0.44
336_E	368_K	0.598	0.44
247_S	282_N	0.596	0.44
44_I	114_V	0.596	0.44
125_R	419_P	0.596	0.44
6_F	158_I	0.595	0.44
428_G	433_L	0.595	0.44
319_A	522_K	0.595	0.44
185_G	241_D	0.595	0.44
220_D	223_D	0.594	0.44
398_L	402_H	0.594	0.44
262_C	267_L	0.593	0.44
449_V	522_K	0.593	0.44
350_I	504_S	0.592	0.44
33_L	270_K	0.589	0.43
360_V	402_H	0.589	0.43
99_L	248_I	0.588	0.43
115_I	347_D	0.588	0.43
149_I	236_V	0.588	0.43
428_G	464_E	0.587	0.43
35_V	471_Q	0.587	0.43
390_E	501_F	0.585	0.43
476_Q	495_L	0.584	0.43
167_R	232_D	0.584	0.43
115_I	418_L	0.584	0.43
518_Q	521_F	0.583	0.43
420_E	427_L	0.582	0.43
283_K	319_A	0.581	0.43
386_V	406_I	0.581	0.43
500_W	520_L	0.579	0.42
313_L	326_V	0.579	0.42
303_P	309_V	0.579	0.42
70_L	111_T	0.579	0.42
384_M	506_F	0.578	0.42
162_K	205_Q	0.577	0.42
305_A	386_V	0.577	0.42
442_E	452_D	0.575	0.42
293_I	380_I	0.574	0.42
194_H	198_E	0.574	0.42
421_Q	425_E	0.574	0.42
178_V	211_V	0.573	0.42
40_F	93_K	0.573	0.42
438_C	489_L	0.573	0.42
365_V	369_Y	0.572	0.42
38_Q	74_H	0.571	0.41
232_D	235_A	0.570	0.41
368_K	390_E	0.570	0.41
402_H	406_I	0.570	0.41
194_H	197_K	0.568	0.41
384_M	492_I	0.567	0.41
34_N	270_K	0.567	0.41
262_C	268_A	0.567	0.41
29_K	82_N	0.567	0.41
24_L	210_V	0.566	0.41
436_Y	484_S	0.566	0.41
38_Q	129_A	0.566	0.41
195_S	199_L	0.565	0.41
12_V	181_I	0.565	0.41
86_F	93_K	0.564	0.41
66_A	187_L	0.563	0.41
294_G	370_A	0.563	0.41
502_V	523_G	0.563	0.41
72_L	93_K	0.562	0.41
208_I	261_V	0.561	0.40
166_G	389_I	0.560	0.40
317_G	322_T	0.560	0.40
310_V	314_R	0.560	0.40
123_K	230_D	0.560	0.40
207_N	263_E	0.559	0.40
126_V	158_I	0.559	0.40
320_F	522_K	0.559	0.40
329_I	343_T	0.558	0.40
504_S	510_F	0.558	0.40
40_F	125_R	0.557	0.40
181_I	238_E	0.557	0.40
293_I	525_I	0.557	0.40
350_I	525_I	0.557	0.40
33_L	252_L	0.557	0.40
510_F	514_P	0.557	0.40
137_V	269_C	0.557	0.40
20_V	326_V	0.557	0.40
244_N	318_Y	0.556	0.40
96_S	99_L	0.556	0.40
36_T	52_S	0.556	0.40
481_S	492_I	0.555	0.40
364_I	368_K	0.555	0.40
29_K	513_R	0.555	0.40
29_K	307_I	0.554	0.40
201_S	422_K	0.554	0.40
418_L	511_K	0.553	0.40
483_T	486_D	0.553	0.40
315_H	512_S	0.552	0.39
14_S	162_K	0.552	0.39
7_V	23_S	0.551	0.39
229_C	482_G	0.550	0.39
14_S	189_T	0.550	0.39
446_A	506_F	0.549	0.39
349_I	369_Y	0.549	0.39
344_S	530_E	0.548	0.39
55_Q	59_V	0.548	0.39
402_H	413_P	0.547	0.39
128_R	266_K	0.547	0.39
110_G	484_S	0.546	0.39
87_S	129_A	0.545	0.39
465_F	469_F	0.544	0.39
119_T	228_F	0.544	0.39
441_E	481_S	0.543	0.39
347_D	531_A	0.543	0.39
314_R	318_Y	0.543	0.39
418_L	424_V	0.542	0.38
495_L	499_P	0.541	0.38
165_I	172_Y	0.541	0.38
119_T	123_K	0.540	0.38
51_M	55_Q	0.539	0.38
48_P	140_T	0.539	0.38
274_M	278_K	0.538	0.38
279_E	282_N	0.538	0.38
205_Q	230_D	0.537	0.38
88_N	91_T	0.537	0.38
5_I	60_F	0.536	0.38
309_V	318_Y	0.536	0.38
2_T	138_V	0.535	0.38
436_Y	485_P	0.535	0.38
378_L	503_A	0.534	0.38
128_R	419_P	0.534	0.38
445_K	496_K	0.534	0.38
302_L	378_L	0.533	0.38
159_R	177_L	0.531	0.37
62_T	74_H	0.531	0.37
101_K	125_R	0.531	0.37
20_V	26_R	0.530	0.37
199_L	204_I	0.529	0.37
55_Q	352_P	0.529	0.37
438_C	455_V	0.528	0.37
259_K	262_C	0.528	0.37
280_L	353_G	0.528	0.37
400_G	472_Q	0.528	0.37
146_V	242_A	0.528	0.37
211_V	217_I	0.527	0.37
395_V	473_M	0.527	0.37
446_A	520_L	0.526	0.37
363_K	455_V	0.526	0.37
15_L	165_I	0.526	0.37
50_T	429_G	0.526	0.37
178_V	241_D	0.525	0.37
187_L	213_T	0.524	0.37
334_V	340_A	0.524	0.37
228_F	236_V	0.523	0.37
446_A	479_V	0.522	0.36
126_V	138_V	0.521	0.36
372_E	390_E	0.521	0.36
197_K	205_Q	0.521	0.36
479_V	495_L	0.521	0.36
175_C	230_D	0.520	0.36
89_V	94_I	0.520	0.36
350_I	366_A	0.520	0.36
129_A	134_N	0.520	0.36
253_Q	274_M	0.519	0.36
82_N	175_C	0.519	0.36
66_A	177_L	0.519	0.36
37_I	84_N	0.519	0.36
2_T	135_A	0.518	0.36
89_V	146_V	0.518	0.36
225_I	238_E	0.518	0.36
110_G	281_V	0.518	0.36
185_G	302_L	0.518	0.36
259_K	271_E	0.518	0.36
243_D	394_N	0.517	0.36
275_S	279_E	0.517	0.36
436_Y	489_L	0.517	0.36
493_I	504_S	0.516	0.36
182_K	503_A	0.516	0.36
87_S	307_I	0.515	0.36
368_K	531_A	0.515	0.36
52_S	506_F	0.515	0.36
229_C	296_V	0.514	0.36
333_E	337_N	0.514	0.36
439_K	486_D	0.514	0.36
237_I	256_G	0.514	0.36
162_K	449_V	0.514	0.36
19_I	295_L	0.514	0.36
72_L	111_T	0.513	0.36
353_G	406_I	0.513	0.36
428_G	461_H	0.513	0.36
14_S	258_D	0.512	0.35
28_L	261_V	0.512	0.35
125_R	162_K	0.512	0.35
344_S	375_I	0.512	0.35
396_L	496_K	0.512	0.35
48_P	184_A	0.511	0.35
202_L	226_A	0.511	0.35
34_N	133_T	0.511	0.35
101_K	183_A	0.511	0.35
74_H	493_I	0.510	0.35
287_L	318_Y	0.510	0.35
20_V	307_I	0.510	0.35
242_A	247_S	0.509	0.35
170_V	302_L	0.508	0.35
495_L	502_V	0.508	0.35
253_Q	256_G	0.508	0.35
360_V	495_L	0.508	0.35
173_I	329_I	0.507	0.35
279_E	399_K	0.507	0.35
148_D	160_Q	0.507	0.35
211_V	377_F	0.506	0.35
105_G	148_D	0.506	0.35
93_K	101_K	0.505	0.35
448_E	451_Q	0.505	0.35
74_H	180_Y	0.505	0.35
420_E	440_L	0.505	0.35
513_R	517_P	0.504	0.35
366_A	390_E	0.504	0.35
498_H	521_F	0.503	0.35
88_N	101_K	0.503	0.35
442_E	529_V	0.503	0.35
135_A	209_I	0.503	0.35
8_T	12_V	0.503	0.35
253_Q	278_K	0.503	0.35
459_H	464_E	0.502	0.34
25_G	79_I	0.502	0.34
528_S	531_A	0.502	0.34
335_T	340_A	0.501	0.34
384_M	503_A	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zdjA	4	0.9813	100	0.387	Contact Map
3nvaA	2	0.9888	100	0.413	Contact Map
1vcoA	4	0.9813	100	0.443	Contact Map
2vo1A	4	0.4262	100	0.471	Contact Map
1s1mA	4	0.9794	100	0.507	Contact Map
2v4uA	1	0.4598	100	0.785	Contact Map
2w7tA	1	0.4542	100	0.81	Contact Map
1l9xA	1	0.4206	100	0.897	Contact Map
4l8fC	3	0.415	100	0.897	Contact Map
3uowA	2	0.3963	99.9	0.898	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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