GREMLIN Database
CTAA - Heme A synthase
UniProt: P12946 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (282)
Sequences: 2614 (1849)
Seq/√Len: 110.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_A180_A3.4891.00
178_T219_A3.1651.00
131_F287_G3.1091.00
65_G104_A3.0011.00
106_L122_L2.8971.00
21_I280_F2.8551.00
10_V138_T2.7251.00
168_I226_W2.7201.00
75_A97_I2.6251.00
171_Y226_W2.6081.00
71_V100_L2.5821.00
17_L280_F2.5071.00
22_G63_A2.4731.00
254_F288_V2.3871.00
231_A235_I2.3441.00
13_T138_T2.2011.00
102_L106_L2.1901.00
15_V70_L2.1901.00
44_G48_P2.1831.00
268_S271_A2.1731.00
20_L24_A2.1381.00
75_A79_W2.1331.00
125_G177_Y2.0971.00
224_F259_A2.0831.00
196_L203_G2.0371.00
106_L126_I2.0021.00
247_G291_Y1.9901.00
13_T135_L1.9561.00
35_C42_C1.9351.00
69_I73_S1.9161.00
260_L264_M1.8911.00
55_I59_S1.8781.00
249_I253_I1.8281.00
29_T56_I1.8211.00
19_V64_S1.8201.00
79_W90_T1.7751.00
87_R91_F1.7651.00
75_A94_I1.7431.00
193_N198_S1.7341.00
229_V233_H1.7251.00
77_W81_K1.6971.00
16_M134_V1.6911.00
8_L73_S1.6751.00
175_V223_L1.6601.00
194_V221_L1.6401.00
161_M234_A1.6201.00
235_I249_I1.6191.00
49_E52_P1.6141.00
58_W62_F1.6011.00
196_L199_P1.5971.00
202_N206_T1.5811.00
273_G277_A1.5791.00
284_C288_V1.5781.00
72_L97_I1.5711.00
228_I232_V1.5611.00
264_M268_S1.5611.00
164_H226_W1.5531.00
12_T70_L1.5511.00
234_A248_W1.5431.00
82_I90_T1.5301.00
224_F256_T1.5291.00
106_L109_L1.5091.00
231_A252_L1.4961.00
20_L283_A1.4951.00
79_W94_I1.4901.00
6_K142_F1.4901.00
68_I104_A1.4881.00
261_S277_A1.4771.00
92_L137_L1.4701.00
168_I227_I1.4701.00
261_S281_F1.4641.00
172_S289_L1.4631.00
250_S288_V1.4621.00
231_A249_I1.4481.00
91_F95_M1.4441.00
117_A185_T1.4431.00
25_L276_L1.4391.00
76_F80_R1.4341.00
168_I230_A1.4301.00
256_T260_L1.3981.00
41_L44_G1.3971.00
135_L287_G1.3941.00
251_C292_F1.3761.00
232_V235_I1.3761.00
164_H168_I1.3671.00
98_I102_L1.3631.00
8_L77_W1.3611.00
159_K163_F1.3591.00
254_F284_C1.3471.00
242_K246_W1.3391.00
163_F167_G1.3321.00
35_C40_P1.3311.00
40_P43_H1.3261.00
9_G74_L1.3080.99
25_L29_T1.2880.99
171_Y223_L1.2880.99
15_V67_S1.2870.99
227_I255_I1.2820.99
76_F79_W1.2770.99
101_F105_L1.2620.99
291_Y295_L1.2580.99
213_Q266_V1.2490.99
191_C197_C1.2400.99
109_L119_I1.2360.99
24_A279_S1.2210.99
280_F284_C1.2200.99
30_G186_E1.2070.99
213_Q217_R1.2060.99
96_S133_S1.2060.99
169_L290_C1.2020.99
22_G56_I1.2020.99
4_A7_A1.1970.99
214_M218_A1.1960.99
164_H229_V1.1840.99
168_I172_S1.1700.99
91_F94_I1.1500.99
254_F257_L1.1500.99
165_M292_F1.1460.99
166_I293_L1.1390.98
35_C44_G1.1350.98
96_S134_V1.1170.98
175_V178_T1.1100.98
108_A112_V1.1070.98
105_L109_L1.1070.98
125_G173_Y1.1010.98
128_L283_A1.0990.98
66_I70_L1.0980.98
109_L122_L1.0970.98
135_L139_L1.0940.98
102_L126_I1.0940.98
97_I100_L1.0890.98
110_A119_I1.0890.98
221_L225_V1.0880.98
132_A286_F1.0780.98
166_I170_I1.0720.98
100_L130_S1.0700.98
45_R48_P1.0680.98
286_F290_C1.0600.98
251_C289_L1.0570.98
35_C38_Q1.0420.97
65_G69_I1.0380.97
105_L108_A1.0320.97
224_F255_I1.0280.97
165_M230_A1.0270.97
224_F228_I1.0250.97
251_C288_V1.0230.97
203_G218_A1.0230.97
41_L46_F1.0190.97
163_F166_I1.0160.97
43_H54_S1.0120.97
95_M133_S1.0120.97
227_I231_A1.0090.97
169_L293_L1.0030.97
259_A263_I0.9930.96
110_A120_M0.9920.96
19_V67_S0.9850.96
57_E111_V0.9800.96
165_M293_L0.9740.96
247_G295_L0.9690.96
160_K163_F0.9670.96
104_A108_A0.9650.96
25_L56_I0.9530.95
18_I22_G0.9500.95
251_C285_L0.9480.95
261_S274_F0.9480.95
128_L176_V0.9450.95
225_V229_V0.9420.95
265_I275_A0.9340.95
102_L105_L0.9330.95
218_A222_L0.9310.95
114_G184_H0.9260.95
116_N119_I0.9230.95
138_T142_F0.9200.95
139_L294_L0.9200.95
28_K33_Q0.9180.94
135_L291_Y0.9150.94
115_S120_M0.9140.94
167_G170_I0.9110.94
216_H278_H0.9100.94
247_G288_V0.9080.94
132_A290_C0.9060.94
18_I63_A0.9020.94
17_L131_F0.8970.94
145_D154_P0.8960.94
64_S68_I0.8950.94
193_N196_L0.8950.94
246_W249_I0.8920.94
72_L104_A0.8890.93
88_E140_L0.8860.93
161_M165_M0.8810.93
229_V232_V0.8800.93
250_S257_L0.8710.93
140_L294_L0.8680.93
26_V64_S0.8680.93
7_A11_L0.8650.93
96_S137_L0.8640.92
170_I174_I0.8620.92
38_Q43_H0.8590.92
113_F116_N0.8580.92
27_T33_Q0.8570.92
242_K245_F0.8550.92
113_F119_I0.8550.92
89_T137_L0.8540.92
22_G59_S0.8490.92
252_L256_T0.8490.92
254_F285_L0.8460.92
271_A274_F0.8430.92
174_I219_A0.8390.91
109_L113_F0.8330.91
169_L173_Y0.8330.91
10_V142_F0.8300.91
27_T120_M0.8270.91
35_C58_W0.8250.91
172_S223_L0.8250.91
72_L76_F0.8200.90
73_S77_W0.8180.90
211_W215_G0.8130.90
194_V198_S0.8130.90
194_V197_C0.8120.90
254_F281_F0.8110.90
15_V63_A0.8080.90
234_A240_D0.8080.90
264_M274_F0.8010.89
243_Q295_L0.8010.89
177_Y181_Y0.7870.88
232_V236_T0.7820.88
131_F283_A0.7790.88
11_L70_L0.7760.88
202_N205_P0.7730.88
63_A66_I0.7710.87
65_G108_A0.7680.87
26_V116_N0.7630.87
196_L205_P0.7620.87
235_I252_L0.7610.87
11_L15_V0.7600.87
37_R43_H0.7570.86
122_L126_I0.7550.86
230_A292_F0.7550.86
178_T215_G0.7530.86
216_H258_Q0.7520.86
89_T141_I0.7520.86
185_T190_A0.7520.86
268_S273_G0.7520.86
218_A221_L0.7510.86
26_V56_I0.7480.86
75_A98_I0.7430.85
253_I257_L0.7370.85
65_G127_S0.7360.85
34_G54_S0.7340.85
186_E189_L0.7330.85
250_S254_F0.7270.84
5_L141_I0.7260.84
34_G53_A0.7250.84
31_S56_I0.7240.84
27_T32_G0.7220.84
255_I259_A0.7180.83
221_L259_A0.7170.83
161_M233_H0.7170.83
199_P202_N0.7130.83
121_A184_H0.7120.83
204_L207_Q0.7080.83
188_S191_C0.7020.82
96_S130_S0.6990.82
129_I133_S0.6970.82
124_F134_V0.6930.81
176_V286_F0.6900.81
230_A233_H0.6890.81
171_Y219_A0.6870.81
159_K162_Q0.6830.80
86_F89_T0.6810.80
215_G218_A0.6800.80
180_A186_E0.6780.80
161_M164_H0.6690.79
110_A115_S0.6690.79
16_M20_L0.6690.79
8_L74_L0.6690.79
35_C43_H0.6680.79
92_L133_S0.6670.79
189_L275_A0.6630.78
63_A70_L0.6620.78
164_H233_H0.6580.78
72_L101_F0.6570.78
172_S227_I0.6570.78
5_L78_S0.6570.78
185_T212_V0.6570.78
99_F133_S0.6560.78
27_T271_A0.6540.77
272_L276_L0.6510.77
129_I173_Y0.6500.77
235_I245_F0.6460.77
92_L140_L0.6460.77
146_K154_P0.6450.76
71_V93_A0.6420.76
222_L225_V0.6420.76
64_S69_I0.6410.76
219_A223_L0.6390.76
162_Q296_I0.6390.76
186_E275_A0.6360.75
21_I276_L0.6360.75
103_Q123_H0.6350.75
165_M296_I0.6330.75
27_T110_A0.6280.74
124_F128_L0.6280.74
53_A108_A0.6270.74
195_P217_R0.6230.74
19_V24_A0.6220.74
195_P198_S0.6220.74
111_V123_H0.6220.74
9_G138_T0.6210.74
47_F54_S0.6210.74
165_M229_V0.6200.74
17_L284_C0.6180.73
196_L214_M0.6130.73
33_Q37_R0.6120.73
133_S137_L0.6100.72
124_F184_H0.6100.72
54_S279_S0.6100.72
19_V100_L0.6090.72
97_I101_F0.6060.72
60_H180_A0.6020.71
45_R62_F0.6010.71
221_L263_I0.5980.71
88_E92_L0.5980.71
202_N207_Q0.5970.71
12_T74_L0.5960.71
192_P198_S0.5920.70
14_F18_I0.5920.70
60_H188_S0.5910.70
273_G276_L0.5900.70
23_G57_E0.5900.70
233_H237_S0.5890.70
94_I97_I0.5880.70
121_A181_Y0.5880.70
51_N54_S0.5840.69
27_T184_H0.5830.69
110_A114_G0.5830.69
34_G47_F0.5810.69
241_Q245_F0.5810.69
92_L136_I0.5790.68
258_Q278_H0.5780.68
28_K276_L0.5770.68
67_S100_L0.5770.68
144_A156_Q0.5770.68
195_P213_Q0.5750.68
198_S202_N0.5750.68
54_S58_W0.5750.68
161_M230_A0.5740.68
27_T115_S0.5730.68
84_P90_T0.5720.68
23_G123_H0.5720.68
64_S67_S0.5710.67
35_C45_R0.5700.67
27_T123_H0.5700.67
277_A281_F0.5680.67
22_G26_V0.5670.67
26_V29_T0.5670.67
24_A28_K0.5660.67
158_G162_Q0.5660.67
28_K184_H0.5650.67
94_I98_I0.5630.66
38_Q112_V0.5620.66
214_M221_L0.5620.66
232_V252_L0.5620.66
8_L47_F0.5580.66
228_I256_T0.5570.65
60_H187_S0.5570.65
90_T94_I0.5540.65
233_H236_T0.5520.65
37_R120_M0.5520.65
44_G54_S0.5510.65
77_W83_T0.5500.65
220_A223_L0.5490.64
11_L254_F0.5490.64
62_F65_G0.5480.64
124_F180_A0.5460.64
76_F242_K0.5450.64
84_P93_A0.5440.64
50_L55_I0.5440.64
26_V184_H0.5440.64
6_K141_I0.5410.63
252_L255_I0.5390.63
41_L47_F0.5380.63
80_R83_T0.5380.63
93_A97_I0.5370.63
5_L9_G0.5360.63
199_P203_G0.5360.63
206_T210_E0.5360.63
71_V74_L0.5360.63
7_A10_V0.5360.63
9_G93_A0.5330.62
100_L104_A0.5310.62
34_G115_S0.5300.62
220_A258_Q0.5290.62
125_G180_A0.5290.62
65_G68_I0.5280.61
15_V19_V0.5270.61
160_K233_H0.5260.61
231_A248_W0.5260.61
28_K53_A0.5250.61
166_I169_L0.5210.60
194_V263_I0.5210.60
167_G174_I0.5200.60
78_S89_T0.5180.60
11_L14_F0.5180.60
140_L143_E0.5170.60
28_K272_L0.5160.60
156_Q167_G0.5160.60
32_G111_V0.5150.59
125_G129_I0.5150.59
250_S260_L0.5130.59
207_Q210_E0.5130.59
180_A183_R0.5110.59
173_Y177_Y0.5100.59
225_V273_G0.5090.59
57_E258_Q0.5070.58
30_G67_S0.5060.58
53_A115_S0.5050.58
141_I145_D0.5040.58
260_L269_E0.5040.58
43_H48_P0.5030.58
124_F183_R0.5030.58
28_K275_A0.5010.57
136_I140_L0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.2124 44.7 0.95 Contact Map
4gd3A 2 0.4444 37.3 0.953 Contact Map
1kqfC 3 0.4771 25.1 0.957 Contact Map
4i0uA 4 0.2059 24 0.957 Contact Map
2jwaA 2 0.1405 21.2 0.958 Contact Map
2ks1B 1 0.1438 20.7 0.958 Contact Map
2l8sA 1 0.1405 15.1 0.961 Contact Map
4o6yA 2 0.549 11.1 0.963 Contact Map
2m3eA 1 0.1503 8.1 0.965 Contact Map
3cx5C 2 0.5327 7.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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