GREMLIN Database
TMRB - Tunicamycin resistance protein
UniProt: P12921 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (170)
Sequences: 372 (219)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_Y95_R4.9191.00
141_L149_H3.5531.00
83_I92_I3.2080.99
9_F129_W2.9550.98
110_A152_T2.8410.98
66_L77_L2.7500.97
23_R162_E2.5210.96
53_Q88_Y2.4470.95
84_V137_C2.3950.94
16_T160_V2.3740.94
106_F164_I2.2640.92
75_G165_A2.2290.92
83_I90_N2.2130.91
129_W133_Q2.1830.91
112_K116_L2.1690.90
92_I150_I1.8920.83
119_L127_N1.8890.83
110_A153_D1.8600.82
81_M122_R1.8540.82
17_A78_I1.7600.78
9_F51_D1.7170.76
59_R91_E1.7100.76
5_I109_M1.6680.74
110_A114_T1.6380.73
21_H78_I1.6010.71
26_P76_I1.5990.71
123_A126_K1.5240.67
3_I112_K1.5230.67
19_E22_R1.4470.63
3_I147_E1.4240.62
57_L134_I1.4230.62
42_M49_K1.4230.62
112_K135_D1.4050.61
32_P51_D1.3990.60
62_N65_L1.3970.60
3_I157_I1.3680.58
144_P148_D1.3660.58
35_M106_F1.3510.57
16_T75_G1.3490.57
83_I164_I1.3430.57
88_Y91_E1.3380.57
9_F82_T1.3300.56
120_R130_A1.3260.56
29_V94_G1.3220.56
5_I17_A1.3140.55
4_W91_E1.3140.55
25_N115_L1.3030.55
17_A49_K1.2950.54
56_P79_V1.2760.53
21_H27_S1.2700.53
25_N156_S1.2690.53
39_L136_R1.2610.52
128_S133_Q1.2440.51
96_L103_V1.2320.50
65_L95_R1.2070.49
87_E150_I1.2030.49
41_S54_S1.1940.48
20_L155_L1.1880.48
39_L55_Y1.1840.48
13_K108_L1.1650.46
82_T129_W1.1600.46
14_T87_E1.1590.46
18_F29_V1.1570.46
89_F93_I1.1490.46
8_A30_Y1.1490.46
18_F112_K1.1350.45
52_F129_W1.1340.45
132_K161_A1.1310.44
24_L76_I1.1230.44
12_G108_L1.1090.43
11_S65_L1.1070.43
5_I131_A1.1010.43
90_N94_G1.0970.43
119_L137_C1.0720.41
5_I134_I1.0690.41
63_Y99_E1.0610.40
107_T141_L1.0570.40
70_T101_R1.0490.40
158_Q161_A1.0470.40
11_S121_T1.0370.39
115_L134_I1.0370.39
8_A11_S1.0370.39
9_F127_N1.0350.39
122_R126_K1.0320.39
38_A42_M1.0310.39
131_A134_I1.0250.38
27_S78_I1.0240.38
2_I5_I1.0130.38
84_V107_T1.0120.38
119_L130_A1.0040.37
36_G82_T1.0030.37
52_F82_T0.9990.37
97_R116_L0.9980.37
28_Y77_L0.9950.37
70_T76_I0.9860.36
78_I154_N0.9690.35
150_I155_L0.9490.34
35_M39_L0.9420.34
26_P109_M0.9410.34
164_I167_R0.9380.34
25_N98_Q0.9380.34
5_I36_G0.9340.33
89_F107_T0.9340.33
34_K37_F0.9330.33
33_E118_R0.9300.33
106_F149_H0.9300.33
133_Q136_R0.9240.33
24_L27_S0.9240.33
26_P57_L0.9160.32
97_R113_E0.9160.32
53_Q81_M0.9130.32
5_I15_Q0.9060.32
111_S157_I0.9010.32
3_I163_N0.8960.31
40_R124_E0.8920.31
42_M57_L0.8910.31
15_Q168_A0.8880.31
2_I30_Y0.8840.31
146_F149_H0.8840.31
84_V119_L0.8820.31
11_S115_L0.8800.31
125_G150_I0.8790.31
57_L74_R0.8590.30
122_R130_A0.8580.30
46_E74_R0.8480.29
34_K42_M0.8380.29
104_H121_T0.8340.28
84_V88_Y0.8250.28
67_A115_L0.8240.28
13_K36_G0.8240.28
154_N162_E0.8180.28
19_E130_A0.8110.27
96_L100_G0.8100.27
70_T161_A0.8100.27
92_I99_E0.8090.27
36_G52_F0.8050.27
25_N83_I0.8000.27
124_E130_A0.7940.26
114_T160_V0.7940.26
42_M55_Y0.7920.26
111_S156_S0.7780.26
37_F40_R0.7760.26
79_V101_R0.7750.26
23_R66_L0.7740.26
82_T122_R0.7740.26
71_D79_V0.7730.25
33_E159_D0.7710.25
54_S72_T0.7660.25
10_G130_A0.7620.25
156_S162_E0.7620.25
12_G36_G0.7620.25
89_F122_R0.7610.25
114_T152_T0.7600.25
16_T130_A0.7600.25
9_F53_Q0.7580.25
148_D167_R0.7560.25
60_A94_G0.7540.25
29_V51_D0.7540.25
141_L146_F0.7500.24
154_N164_I0.7470.24
17_A154_N0.7300.24
66_L70_T0.7240.23
44_P116_L0.7240.23
127_N131_A0.7200.23
111_S153_D0.7160.23
14_T117_K0.7160.23
61_F77_L0.7160.23
39_L42_M0.7140.23
106_F113_E0.7120.23
89_F146_F0.7080.23
44_P81_M0.7050.23
100_G103_V0.7050.23
114_T153_D0.7030.22
89_F119_L0.7020.22
8_A137_C0.7010.22
93_I97_R0.6970.22
152_T160_V0.6960.22
36_G108_L0.6880.22
29_V83_I0.6870.22
98_Q159_D0.6860.22
45_Q116_L0.6820.22
27_S113_E0.6790.21
160_V164_I0.6740.21
114_T117_K0.6680.21
75_G103_V0.6680.21
110_A134_I0.6670.21
75_G161_A0.6630.21
5_I63_Y0.6620.21
141_L165_A0.6610.21
116_L131_A0.6580.21
11_S37_F0.6570.21
16_T165_A0.6560.21
138_V153_D0.6550.21
78_I153_D0.6520.20
78_I162_E0.6450.20
11_S61_F0.6350.20
17_A51_D0.6340.20
74_R95_R0.6330.20
30_Y112_K0.6300.20
24_L165_A0.6290.20
40_R52_F0.6270.19
153_D160_V0.6170.19
53_Q129_W0.6120.19
82_T119_L0.6100.19
104_H166_A0.6080.19
29_V99_E0.6070.19
13_K118_R0.6060.19
25_N151_Q0.5980.18
37_F159_D0.5980.18
38_A61_F0.5960.18
120_R166_A0.5940.18
53_Q62_N0.5930.18
60_A64_S0.5910.18
101_R144_P0.5880.18
15_Q109_M0.5870.18
113_E135_D0.5830.18
33_E36_G0.5780.18
60_A72_T0.5770.18
30_Y38_A0.5740.18
4_W59_R0.5700.17
26_P42_M0.5660.17
120_R123_A0.5630.17
98_Q139_E0.5600.17
41_S165_A0.5560.17
84_V136_R0.5550.17
54_S81_M0.5520.17
68_S140_G0.5510.17
9_F128_S0.5490.17
12_G118_R0.5490.17
57_L147_E0.5460.17
32_P81_M0.5430.17
43_V68_S0.5420.17
61_F66_L0.5390.16
66_L96_L0.5390.16
8_A134_I0.5380.16
60_A67_A0.5370.16
53_Q105_H0.5370.16
9_F32_P0.5340.16
24_L57_L0.5300.16
74_R78_I0.5270.16
64_S68_S0.5230.16
52_F122_R0.5190.16
51_D88_Y0.5170.16
29_V44_P0.5160.16
42_M71_D0.5160.16
60_A69_L0.5150.16
8_A97_R0.5110.16
54_S88_Y0.5080.15
117_K154_N0.5070.15
66_L79_V0.5060.15
15_Q131_A0.5050.15
30_Y77_L0.5050.15
163_N167_R0.5040.15
47_I101_R0.5010.15
28_Y69_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vliA 2 0.868 100 0.666 Contact Map
1qhxA 4 0.8122 99.6 0.791 Contact Map
2yvuA 2 0.8376 99.6 0.799 Contact Map
2cdnA 1 0.8376 99.6 0.799 Contact Map
1m8pA 5 0.8528 99.5 0.804 Contact Map
2p5tB 1 0.9391 99.5 0.805 Contact Map
2gksA 2 0.8426 99.5 0.806 Contact Map
3a4mA 2 0.9036 99.5 0.808 Contact Map
2iyvA 1 0.8579 99.5 0.809 Contact Map
2rhmA 2 0.8629 99.5 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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