GREMLIN Database
RS8 - 30S ribosomal protein S8
UniProt: P12879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (129)
Sequences: 2445 (1161)
Seq/√Len: 102.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_K48_D3.5911.00
110_Q121_K3.4201.00
12_T15_R3.3511.00
91_S122_Q3.2841.00
35_E38_E2.9561.00
38_E42_R2.9001.00
26_E61_R2.6901.00
10_M37_A2.6141.00
42_R117_E2.5051.00
115_D119_R2.4141.00
117_E121_K2.3181.00
76_G132_W2.3071.00
18_N72_R2.2791.00
9_D13_R2.1061.00
11_L129_A2.0761.00
52_V61_R1.9161.00
7_I36_I1.9141.00
34_R51_F1.8861.00
6_P33_K1.8091.00
26_E59_I1.7621.00
46_I49_V1.7541.00
53_E58_G1.7491.00
24_K61_R1.7271.00
37_A62_V1.7161.00
5_D79_R1.6821.00
17_A25_L1.6061.00
10_M27_I1.5391.00
40_L131_V1.5251.00
90_K93_E1.5221.00
41_K46_I1.4671.00
78_K130_Y1.4311.00
117_E120_A1.4051.00
36_I112_V1.4041.00
94_V115_D1.3981.00
39_I112_V1.3871.00
32_L128_L1.3811.00
30_S33_K1.3550.99
38_E49_V1.3390.99
104_A130_Y1.3330.99
29_A34_R1.3130.99
7_I32_L1.3060.99
27_I60_I1.2810.99
89_A94_V1.2800.99
97_V104_A1.2680.99
50_E61_R1.2260.99
67_G70_N1.2130.99
50_E63_F1.1740.98
17_A20_V1.1420.98
21_R70_N1.1370.98
67_G71_E1.1230.98
27_I62_V1.0870.97
28_P33_K1.0760.97
45_F103_I1.0720.97
105_I129_A1.0690.97
24_K63_F1.0560.97
85_L130_Y1.0430.97
80_I87_V1.0380.97
44_G65_K1.0330.96
29_A58_G1.0200.96
38_E41_K1.0120.96
56_K59_I1.0100.96
6_P30_S1.0070.96
94_V106_I1.0070.96
34_R58_G1.0030.96
34_R38_E0.9930.96
89_A106_I0.9870.95
41_K49_V0.9840.95
94_V127_V0.9710.95
127_V130_Y0.9710.95
76_G98_L0.9630.95
29_A51_F0.9420.94
53_E56_K0.9200.93
34_R60_I0.9150.93
18_N132_W0.8990.93
113_L117_E0.8850.92
39_I105_I0.8800.92
76_G130_Y0.8760.92
95_P104_A0.8680.91
51_F58_G0.8670.91
43_E117_E0.8520.90
89_A127_V0.8480.90
79_R86_R0.8410.90
54_D59_I0.8340.89
52_V59_I0.8330.89
113_L121_K0.8270.89
45_F101_L0.8150.88
96_R115_D0.8010.87
10_M36_I0.8000.87
65_K74_I0.7980.87
86_R126_E0.7970.87
7_I132_W0.7960.87
54_D58_G0.7940.87
10_M33_K0.7800.86
8_A33_K0.7790.86
110_Q113_L0.7780.86
54_D57_Q0.7670.85
104_A115_D0.7660.85
32_L112_V0.7600.85
108_T113_L0.7560.84
47_R63_F0.7550.84
95_P130_Y0.7550.84
80_I127_V0.7540.84
31_K34_R0.7530.84
48_D63_F0.7530.84
36_I105_I0.7510.84
53_E57_Q0.7500.84
107_S112_V0.7460.83
34_R41_K0.7430.83
14_I74_I0.7410.83
21_R72_R0.7390.83
110_Q123_A0.7390.83
66_Y72_R0.7310.82
98_L132_W0.7300.82
36_I129_A0.7200.81
100_G115_D0.7180.81
55_S58_G0.7170.81
14_I77_L0.7080.80
112_V128_L0.7060.80
52_V56_K0.6950.79
40_L103_I0.6890.78
18_N77_L0.6890.78
26_E52_V0.6820.78
89_A93_E0.6720.77
94_V104_A0.6550.75
4_T109_S0.6480.74
66_Y74_I0.6280.72
42_R113_L0.6240.71
51_F60_I0.6240.71
113_L123_A0.6210.71
68_Q71_E0.6210.71
18_N67_G0.6200.71
32_L35_E0.6200.71
97_V103_I0.6140.70
34_R49_V0.6140.70
11_L15_R0.6130.70
39_I129_A0.6050.69
10_M87_V0.6020.68
13_R28_P0.6000.68
18_N73_V0.5930.67
97_V130_Y0.5930.67
55_S112_V0.5880.67
108_T111_G0.5860.66
92_N109_S0.5850.66
97_V100_G0.5840.66
113_L118_A0.5810.66
71_E75_T0.5800.66
3_M26_E0.5790.65
10_M43_E0.5790.65
106_I127_V0.5730.65
37_A60_I0.5700.64
96_R119_R0.5700.64
73_V101_L0.5690.64
89_A132_W0.5680.64
23_E47_R0.5630.63
42_R120_A0.5610.63
32_L37_A0.5600.63
64_L72_R0.5550.62
18_N74_I0.5540.62
23_E72_R0.5520.62
28_P101_L0.5510.62
22_H25_L0.5470.61
15_R129_A0.5460.61
85_L89_A0.5430.61
49_V62_V0.5430.61
46_I105_I0.5410.60
6_P10_M0.5400.60
98_L116_K0.5400.60
35_E50_E0.5380.60
35_E42_R0.5370.60
27_I33_K0.5350.59
24_K50_E0.5330.59
84_G126_E0.5330.59
13_R22_H0.5320.59
109_S123_A0.5320.59
14_I62_V0.5310.59
24_K47_R0.5300.59
103_I131_V0.5300.59
80_I130_Y0.5290.59
112_V121_K0.5270.58
82_K112_V0.5260.58
4_T33_K0.5240.58
75_T98_L0.5230.58
30_S45_F0.5220.58
4_T8_A0.5200.57
36_I39_I0.5190.57
18_N82_K0.5180.57
76_G129_A0.5180.57
3_M20_V0.5130.56
43_E114_T0.5110.56
15_R77_L0.5100.56
95_P119_R0.5090.56
12_T77_L0.5040.55
23_E31_K0.5020.55
39_I103_I0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdbA 1 0.9773 100 0.104 Contact Map
4rb5H 1 0.9848 100 0.115 Contact Map
1seiA 2 0.9848 100 0.128 Contact Map
1s03H 1 0.9621 100 0.138 Contact Map
3bbnH 1 0.9924 100 0.146 Contact Map
3rf2A 1 0.9773 100 0.165 Contact Map
1i6uA 1 0.9318 100 0.242 Contact Map
4bpeH 1 0.9242 100 0.258 Contact Map
4ujpX 1 0.9242 100 0.285 Contact Map
3qd7X 1 0.5 38.1 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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