GREMLIN Database
RL5 - 50S ribosomal protein L5
UniProt: P12877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (176)
Sequences: 2715 (1149)
Seq/√Len: 86.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_R101_D4.7581.00
6_E10_K4.1891.00
36_I61_A3.5891.00
129_T155_V3.1991.00
19_K168_E3.1921.00
7_K11_E3.1101.00
108_L111_V2.4471.00
13_A28_V2.4391.00
34_I100_L2.3631.00
117_V175_M2.3441.00
22_Y165_E2.2761.00
15_A18_T2.2551.00
35_V157_V2.2201.00
168_E172_Q2.1891.00
132_I137_I2.1431.00
58_T64_K2.1381.00
68_T88_K2.1231.00
31_I156_I2.1141.00
98_D102_K1.9661.00
100_L156_I1.9601.00
103_L130_L1.9261.00
38_M53_A1.9081.00
11_E15_A1.9071.00
124_G163_D1.9061.00
7_K12_I1.8881.00
5_K9_N1.8791.00
119_K167_R1.8751.00
168_E171_T1.7911.00
142_D145_K1.7871.00
17_M28_V1.7731.00
97_Y173_V1.7681.00
9_N13_A1.7661.00
100_L104_I1.7521.00
167_R171_T1.7441.00
58_T65_P1.7241.00
22_Y162_T1.7151.00
69_R84_P1.6831.00
20_F168_E1.6771.00
101_D105_S1.6401.00
57_L87_A1.6251.00
15_A172_Q1.6221.00
38_M57_L1.6221.00
70_A73_S1.6191.00
12_I173_V1.6041.00
27_Q161_N1.5711.00
123_D127_N1.5331.00
40_V53_A1.5261.00
36_I152_M1.4680.99
19_K172_Q1.4440.99
79_L85_I1.4280.99
54_V67_V1.4170.99
162_T165_E1.4060.99
67_V84_P1.3970.99
108_L117_V1.3950.99
34_I104_I1.3860.99
68_T86_G1.3510.99
70_A82_G1.3470.99
50_I87_A1.3400.99
164_E167_R1.3370.99
88_K153_D1.2670.98
32_E159_T1.2620.98
44_V85_I1.2560.98
17_M25_V1.2250.98
73_S81_E1.2240.98
54_V58_T1.1990.98
14_P18_T1.1620.97
52_S56_E1.1520.97
34_I173_V1.1450.97
5_K94_E1.1340.97
36_I57_L1.1300.97
135_Q150_R1.1240.96
121_S153_D1.1160.96
147_T150_R1.1130.96
46_N49_A1.1070.96
56_E150_R1.1020.96
19_K164_E1.0980.96
51_D55_E1.0640.95
55_E58_T1.0500.95
32_E35_V1.0270.94
14_P17_M1.0230.94
55_E59_F1.0170.94
117_V130_L1.0100.94
38_M87_A0.9940.93
15_A19_K0.9730.92
38_M150_R0.9720.92
134_E149_V0.9710.92
37_N153_D0.9440.91
18_T21_N0.9350.91
3_R105_S0.9330.91
22_Y27_Q0.9310.91
52_S147_T0.9280.90
136_L143_Y0.9240.90
136_L149_V0.9210.90
121_S130_L0.9150.90
104_I173_V0.9080.89
13_A17_M0.9060.89
20_F165_E0.9040.89
44_V50_I0.9040.89
7_K173_V0.8990.89
158_T166_A0.8930.89
54_V87_A0.8910.88
91_L99_F0.8900.88
42_D148_K0.8810.88
9_N14_P0.8810.88
52_S143_Y0.8750.88
31_I100_L0.8740.88
19_K171_T0.8710.87
44_V79_L0.8700.87
119_K178_Q0.8670.87
125_R163_D0.8590.87
73_S82_G0.8530.86
31_I34_I0.8520.86
107_S132_I0.8290.85
10_K18_T0.8270.84
121_S128_Y0.8260.84
40_V50_I0.8250.84
132_I153_D0.8230.84
100_L173_V0.8230.84
7_K174_G0.8210.84
42_D150_R0.8100.83
143_Y150_R0.7990.82
33_K90_T0.7990.82
57_L89_V0.7930.82
13_A25_V0.7920.82
31_I96_M0.7830.81
7_K15_A0.7790.81
98_D101_D0.7700.80
33_K92_R0.7670.80
47_A84_P0.7660.80
103_L108_L0.7660.80
44_V83_M0.7650.80
131_G151_G0.7410.77
40_V49_A0.7400.77
74_I129_T0.7380.77
66_V88_K0.7350.77
107_S137_I0.7340.77
160_A165_E0.7290.76
42_D46_N0.7190.75
10_K14_P0.7180.75
160_A166_A0.7110.74
54_V65_P0.7100.74
143_Y147_T0.7090.74
58_T61_A0.7080.74
5_K93_G0.7060.74
118_S121_S0.7020.73
53_A87_A0.6950.73
49_A150_R0.6930.73
25_V28_V0.6910.72
4_L7_K0.6900.72
38_M56_E0.6900.72
6_E9_N0.6840.72
129_T153_D0.6780.71
47_A178_Q0.6760.71
34_I156_I0.6760.71
27_Q160_A0.6710.70
94_E98_D0.6700.70
145_K148_K0.6700.70
17_M24_S0.6670.70
39_G86_G0.6650.69
68_T74_I0.6620.69
156_I173_V0.6610.69
12_I20_F0.6600.69
79_L83_M0.6590.69
59_F145_K0.6430.67
161_N165_E0.6430.67
3_R98_D0.6420.67
56_E147_T0.6410.67
61_A65_P0.6400.66
134_E144_D0.6300.65
108_L130_L0.6280.65
57_L61_A0.6250.65
135_Q156_I0.6220.64
36_I103_L0.6220.64
124_G158_T0.6220.64
19_K22_Y0.6210.64
70_A79_L0.6200.64
5_K17_M0.6200.64
44_V129_T0.6190.64
130_L139_P0.6170.64
53_A57_L0.6150.63
9_N17_M0.6140.63
120_K164_E0.6130.63
17_M20_F0.6110.63
4_L104_I0.6100.63
99_F138_F0.6050.62
39_G77_F0.6030.62
35_V88_K0.6010.62
122_F127_N0.5940.61
45_Q76_G0.5930.61
13_A172_Q0.5930.61
24_S132_I0.5930.61
117_V128_Y0.5930.61
40_V58_T0.5890.60
45_Q132_I0.5860.60
46_N147_T0.5820.59
33_K157_V0.5790.59
158_T169_L0.5790.59
40_V68_T0.5750.58
132_I154_I0.5720.58
150_R153_D0.5710.58
9_N12_I0.5690.57
102_K140_E0.5670.57
80_R144_D0.5670.57
47_A51_D0.5660.57
32_E157_V0.5660.57
34_I99_F0.5650.57
9_N30_K0.5620.57
10_K21_N0.5600.56
29_P123_D0.5600.56
46_N175_M0.5590.56
123_D126_G0.5580.56
9_N15_A0.5570.56
94_E97_Y0.5560.56
101_D115_R0.5550.56
156_I175_M0.5550.56
46_N50_I0.5540.55
61_A135_Q0.5540.55
23_D27_Q0.5520.55
44_V47_A0.5510.55
20_F24_S0.5430.54
69_R82_G0.5420.54
41_G80_R0.5420.54
7_K10_K0.5410.54
11_E164_E0.5400.54
47_A85_I0.5400.54
132_I152_M0.5390.53
121_S157_V0.5380.53
34_I96_M0.5370.53
115_R178_Q0.5370.53
45_Q178_Q0.5370.53
45_Q175_M0.5360.53
63_Q77_F0.5350.53
93_G117_V0.5340.53
76_G79_L0.5330.53
16_L172_Q0.5330.53
44_V51_D0.5320.53
143_Y148_K0.5320.53
104_I175_M0.5310.52
29_P99_F0.5300.52
26_M38_M0.5300.52
108_L132_I0.5290.52
95_R98_D0.5290.52
103_L117_V0.5270.52
56_E146_V0.5270.52
63_Q95_R0.5270.52
102_K107_S0.5260.52
29_P140_E0.5250.52
65_P88_K0.5240.51
37_N133_K0.5210.51
31_I97_Y0.5200.51
31_I173_V0.5170.51
20_F172_Q0.5140.50
47_A50_I0.5130.50
17_M93_G0.5130.50
37_N65_P0.5110.50
27_Q144_D0.5090.49
63_Q92_R0.5080.49
56_E135_Q0.5070.49
16_L19_K0.5070.49
143_Y149_V0.5070.49
112_R172_Q0.5050.49
122_F170_L0.5040.49
38_M153_D0.5040.49
29_P158_T0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboH 1 0.9777 100 0.015 Contact Map
1iq4A 1 1 100 0.015 Contact Map
4rb6G 1 1 100 0.022 Contact Map
4tp9F 1 0.9888 100 0.028 Contact Map
1vw4E 1 1 100 0.091 Contact Map
3j21E 1 0.9162 100 0.267 Contact Map
1vq8D 1 0.6648 100 0.276 Contact Map
3zf7L 1 0.8212 100 0.293 Contact Map
4ujqM 1 0.8212 100 0.301 Contact Map
4a17D 1 0.8324 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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