GREMLIN Database
RL14 - 50S ribosomal protein L14
UniProt: P12875 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 122 (122)
Sequences: 1580 (587)
Seq/√Len: 53.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_C58_V4.7841.00
19_V84_C4.1661.00
21_T39_I3.6261.00
19_V41_C3.1711.00
7_R18_E2.9071.00
5_E20_L2.6871.00
20_L44_K2.5351.00
2_I21_T2.4271.00
60_A84_C2.3121.00
25_L40_V2.2931.00
70_R76_Y2.2741.00
18_E45_Q2.1611.00
40_V59_K2.1011.00
33_A62_I2.0751.00
42_T55_G1.9901.00
19_V43_V1.9301.00
51_V94_R1.8860.99
88_R92_S1.8850.99
86_I94_R1.8650.99
9_K81_E1.8040.99
7_R20_L1.7770.99
10_V19_V1.7690.99
106_L115_V1.7440.99
34_N69_A1.7150.99
59_K89_D1.6590.99
4_Q23_K1.6120.98
9_K18_E1.6080.98
34_N68_G1.5770.98
2_I6_T1.5240.97
20_L42_T1.5040.97
91_K110_N1.4630.97
71_R105_E1.4490.96
77_I122_I1.3270.94
38_V111_F1.3080.94
94_R108_E1.2520.92
102_V106_L1.2320.92
7_R44_K1.1930.90
10_V84_C1.1820.90
38_V87_I1.1750.90
113_K116_S1.1720.90
91_K111_F1.1640.89
35_I69_A1.1550.89
50_G55_G1.1230.87
4_Q20_L1.1210.87
2_I8_L1.1110.87
8_L19_V1.1020.86
83_A108_E1.1000.86
24_V33_A1.0910.86
3_Q6_T1.0850.86
107_R112_M1.0790.85
22_I122_I1.0500.84
112_M115_V1.0430.83
39_I62_I1.0420.83
63_V102_V1.0360.83
14_S94_R0.9710.78
71_R74_G0.9540.77
23_K29_G0.9450.77
19_V62_I0.9190.75
87_I91_K0.9140.74
110_N115_V0.9120.74
64_R83_A0.9060.73
64_R100_G0.9040.73
102_V114_I0.9010.73
64_R81_E0.8860.72
60_A86_I0.8850.72
11_A101_P0.8810.71
38_V91_K0.8750.71
53_K56_E0.8720.71
11_A63_V0.8690.70
8_L39_I0.8530.69
68_G76_Y0.8520.69
45_Q101_P0.8500.69
8_L84_C0.8500.69
72_S108_E0.8480.68
35_I68_G0.8310.67
88_R94_R0.8240.66
63_V85_V0.8230.66
18_E44_K0.8180.66
41_C60_A0.8140.65
115_V122_I0.8030.64
16_A52_V0.8000.64
41_C86_I0.7980.64
97_R117_L0.7790.62
14_S23_K0.7770.62
32_T95_G0.7750.61
52_V57_V0.7710.61
51_V90_D0.7690.61
22_I56_E0.7680.61
27_G31_K0.7640.60
68_G78_S0.7600.60
58_V94_R0.7580.60
46_A50_G0.7580.60
7_R42_T0.7530.59
90_D94_R0.7470.59
23_K28_S0.7350.57
105_E114_I0.7240.56
41_C84_C0.7240.56
6_T51_V0.7110.55
103_A108_E0.7100.55
22_I29_G0.7080.55
61_V114_I0.7070.54
14_S51_V0.7050.54
17_R22_I0.6940.53
17_R47_T0.6930.53
27_G30_R0.6930.53
55_G65_T0.6870.52
51_V86_I0.6830.52
30_R62_I0.6830.52
88_R91_K0.6810.52
28_S31_K0.6810.52
14_S47_T0.6780.51
65_T69_A0.6680.50
119_P122_I0.6640.50
52_V72_S0.6570.49
51_V108_E0.6560.49
106_L109_N0.6510.49
16_A87_I0.6500.48
58_V86_I0.6490.48
25_L59_K0.6480.48
3_Q31_K0.6460.48
12_D15_G0.6450.48
99_F120_E0.6440.48
79_F101_P0.6430.48
102_V107_R0.6410.47
45_Q54_K0.6400.47
54_K101_P0.6390.47
117_L120_E0.6380.47
69_A76_Y0.6310.46
93_P117_L0.6310.46
10_V16_A0.6270.46
21_T25_L0.6270.46
8_L21_T0.6250.46
35_I65_T0.6230.46
42_T57_V0.6190.45
64_R101_P0.6190.45
52_V56_E0.6160.45
19_V58_V0.6150.45
95_G98_I0.6120.44
61_V111_F0.6120.44
26_G104_R0.6080.44
14_S95_G0.6070.44
55_G75_S0.6060.44
115_V119_P0.6020.43
11_A93_P0.5950.43
63_V83_A0.5910.42
50_G75_S0.5860.42
61_V99_F0.5810.41
74_G77_I0.5800.41
68_G77_I0.5800.41
62_I89_D0.5750.41
11_A64_R0.5750.41
64_R104_R0.5740.41
34_N65_T0.5670.40
107_R121_V0.5660.40
51_V110_N0.5620.39
81_E101_P0.5620.39
47_T50_G0.5570.39
21_T88_R0.5560.39
5_E23_K0.5560.39
61_V103_A0.5550.39
6_T21_T0.5540.38
23_K55_G0.5520.38
4_Q42_T0.5500.38
59_K96_T0.5480.38
104_R111_F0.5470.38
104_R120_E0.5460.38
92_S110_N0.5420.37
21_T84_C0.5350.37
9_K49_G0.5320.36
116_S120_E0.5310.36
4_Q66_K0.5310.36
72_S75_S0.5260.36
97_R113_K0.5250.36
42_T60_A0.5240.36
114_I117_L0.5230.35
64_R71_R0.5220.35
20_L122_I0.5210.35
41_C51_V0.5170.35
16_A46_A0.5160.35
88_R113_K0.5110.34
5_E45_Q0.5050.34
23_K33_A0.5010.33
49_G56_E0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1whiA 2 1 100 0.01 Contact Map
4rb6O 1 1 100 0.01 Contact Map
3bboM 1 0.9918 100 0.018 Contact Map
4tp9K 1 0.9918 100 0.021 Contact Map
1vw4I 1 0.9754 100 0.039 Contact Map
3zf7W 1 0.9672 100 0.06 Contact Map
3j21J 1 0.9672 100 0.064 Contact Map
1vq8K 1 0.9672 100 0.067 Contact Map
4ujrI 1 0.9672 100 0.076 Contact Map
1vx7M 1 0.9672 100 0.076 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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