GREMLIN Database
GLNA - Glutamine synthetase
UniProt: P12425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (422)
Sequences: 6380 (3299)
Seq/√Len: 160.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
400_K422_E5.0691.00
276_A362_L4.9061.00
171_D225_H3.9771.00
248_L274_F3.8961.00
274_F354_G3.8301.00
122_L359_K3.7521.00
356_D360_N3.6881.00
118_E359_K3.4661.00
95_D113_K3.4391.00
117_K121_D3.3661.00
273_H361_K3.3021.00
406_V411_E3.2891.00
280_K360_N3.0471.00
98_N102_T2.9641.00
411_E415_E2.8431.00
11_K15_E2.7761.00
168_C172_I2.7241.00
115_I352_A2.7211.00
136_F191_A2.7101.00
284_S402_N2.6351.00
111_N413_L2.5761.00
117_K120_E2.5351.00
434_P438_E2.5151.00
202_A210_D2.5111.00
218_V229_A2.5061.00
257_A270_T2.4921.00
171_D224_K2.4451.00
129_L347_L2.4091.00
269_E361_K2.3721.00
202_A206_R2.3441.00
248_L350_L2.3441.00
397_E422_E2.2651.00
252_K255_V2.2561.00
288_V349_V2.2221.00
391_T394_E2.2101.00
281_H356_D2.1981.00
272_K363_E2.1681.00
393_A429_R2.1561.00
206_R210_D2.1501.00
273_H276_A2.1271.00
287_A399_F2.0921.00
116_L205_V2.0881.00
12_L16_E2.0791.00
125_S250_L2.0631.00
138_F236_L2.0571.00
289_T346_A2.0561.00
203_G206_R2.0261.00
40_S177_E2.0201.00
281_H402_N2.0101.00
116_L204_A1.9901.00
176_L217_V1.9591.00
179_M217_V1.9461.00
172_I218_V1.9211.00
390_A394_E1.9181.00
137_L168_C1.9021.00
283_T386_V1.8931.00
284_S404_V1.8721.00
399_F414_F1.8691.00
398_E401_S1.8491.00
105_E412_H1.8301.00
23_L94_C1.8221.00
7_E11_K1.8131.00
19_K174_L1.8051.00
273_H362_L1.7951.00
427_M439_Q1.7761.00
182_E200_K1.7651.00
267_L271_A1.7651.00
269_E273_H1.7441.00
276_A364_A1.7071.00
18_V79_I1.7061.00
281_H353_A1.7021.00
116_L203_G1.6791.00
283_T398_E1.6781.00
136_F242_S1.6711.00
359_K407_K1.6671.00
208_C347_L1.6641.00
270_T358_I1.6611.00
46_L74_L1.6511.00
393_A397_E1.6501.00
341_A346_A1.6381.00
175_E221_I1.6281.00
214_F218_V1.6191.00
288_V399_F1.6061.00
396_L418_I1.5811.00
403_E407_K1.5751.00
133_P211_I1.5671.00
111_N348_S1.5661.00
394_E397_E1.5501.00
113_K205_V1.5451.00
13_V39_V1.5401.00
71_Y97_Y1.5331.00
287_A396_L1.5201.00
175_E178_E1.5171.00
280_K362_L1.5021.00
76_T93_I1.4971.00
352_A408_A1.4971.00
120_E125_S1.4971.00
119_M355_L1.4951.00
146_P149_E1.4811.00
400_K418_I1.4591.00
404_V408_A1.4361.00
371_N374_V1.4351.00
24_Q91_R1.4201.00
115_I348_S1.4031.00
199_F207_S1.3891.00
91_R213_T1.3741.00
273_H363_E1.3701.00
207_S210_D1.3681.00
26_T212_Q1.3651.00
137_L222_A1.3611.00
397_E401_S1.3551.00
397_E400_K1.3511.00
176_L181_F1.3511.00
115_I118_E1.3231.00
113_K117_K1.3131.00
285_F289_T1.3101.00
272_K364_A1.3071.00
8_D11_K1.2961.00
139_K227_L1.2931.00
421_K424_E1.2921.00
426_D429_R1.2881.00
248_L354_G1.2861.00
53_D61_V1.2841.00
269_E272_K1.2741.00
334_V350_L1.2661.00
107_D110_N1.2551.00
270_T273_H1.2521.00
269_E363_E1.2501.00
77_F90_A1.2471.00
320_I332_V1.2361.00
285_F349_V1.2351.00
400_K415_E1.2311.00
276_A365_P1.2311.00
290_N295_S1.2251.00
19_K177_E1.2231.00
202_A207_S1.2151.00
189_E196_E1.2111.00
191_A240_N1.2111.00
171_D175_E1.2091.00
275_I332_V1.2021.00
140_L223_R1.1981.00
165_G195_H1.1981.00
53_D57_I1.1941.00
13_V42_L1.1811.00
10_E43_G1.1811.00
284_S398_E1.1751.00
118_E352_A1.1671.00
418_I422_E1.1601.00
32_I93_I1.1601.00
283_T286_T1.1441.00
124_F257_A1.1441.00
406_V415_E1.1331.00
428_F435_W1.1311.00
73_D95_D1.1311.00
426_D430_T1.1301.00
232_M294_N1.1301.00
53_D56_S1.1181.00
281_H360_N1.1171.00
221_I225_H1.1151.00
185_A198_D1.1141.00
284_S405_M1.1131.00
406_V414_F1.1071.00
217_V221_I1.1061.00
119_M127_F1.1061.00
402_N406_V1.1031.00
286_T336_S1.1021.00
98_N105_E1.1011.00
18_V90_A1.0991.00
246_C350_L1.0991.00
279_V320_I1.0991.00
283_T394_E1.0981.00
274_F350_L1.0971.00
275_I320_I1.0941.00
119_M122_L1.0941.00
21_I42_L1.0880.99
356_D407_K1.0830.99
402_N405_M1.0830.99
296_Y392_L1.0790.99
285_F353_A1.0790.99
137_L229_A1.0780.99
70_L96_I1.0760.99
57_I60_F1.0650.99
192_P239_V1.0610.99
11_K14_K1.0550.99
279_V365_P1.0480.99
70_L94_C1.0440.99
297_K436_E1.0380.99
432_V436_E1.0320.99
54_G57_I1.0320.99
112_L204_A1.0300.99
175_E217_V1.0290.99
423_I427_M1.0280.99
175_E224_K1.0270.99
399_F405_M1.0230.99
295_S338_D1.0210.99
103_P110_N1.0200.99
138_F230_T1.0180.99
282_A319_L1.0160.99
190_V240_N1.0090.99
313_A367_P1.0090.99
246_C346_A1.0060.99
425_W429_R0.9980.99
287_A417_F0.9980.99
237_F432_V0.9970.99
64_E371_N0.9920.99
184_E200_K0.9920.99
428_F433_H0.9900.99
278_I320_I0.9870.99
19_K85_E0.9780.99
196_E245_H0.9770.99
399_F418_I0.9770.99
53_D58_E0.9760.99
136_F240_N0.9760.99
222_A229_A0.9740.99
9_I92_F0.9700.99
319_L336_S0.9610.99
273_H358_I0.9580.99
9_I77_F0.9580.99
168_C227_L0.9550.99
404_V407_K0.9540.99
310_A385_I0.9530.99
32_I212_Q0.9490.99
276_A363_E0.9350.98
124_F270_T0.9330.98
400_K411_E0.9330.98
292_T340_A0.9320.98
78_V91_R0.9320.98
315_N373_Y0.9320.98
199_F214_F0.9310.98
8_D12_L0.9240.98
415_E419_E0.9210.98
260_D266_Q0.9170.98
433_H436_E0.9120.98
197_I214_F0.9100.98
396_L425_W0.9090.98
127_F250_L0.9010.98
233_P340_A0.9010.98
259_F266_Q0.9000.98
179_M213_T0.8990.98
189_E245_H0.8980.98
326_R329_S0.8980.98
168_C221_I0.8970.98
211_I244_M0.8970.98
233_P338_D0.8960.98
27_D33_K0.8950.98
422_E426_D0.8900.98
62_R65_E0.8880.98
283_T309_V0.8840.98
173_V186_S0.8830.98
132_E189_E0.8830.98
119_M250_L0.8820.98
53_D60_F0.8800.98
250_L257_A0.8760.98
10_E14_K0.8740.98
83_T89_V0.8730.98
431_Q435_W0.8730.98
166_E170_R0.8690.98
9_I74_L0.8680.97
278_I332_V0.8670.97
375_M385_I0.8610.97
405_M414_F0.8610.97
127_F351_L0.8610.97
288_V409_L0.8600.97
37_I45_A0.8600.97
168_C225_H0.8570.97
306_P335_R0.8550.97
252_K257_A0.8530.97
129_L207_S0.8520.97
258_F271_A0.8510.97
139_K149_E0.8500.97
417_F421_K0.8480.97
150_L154_G0.8480.97
111_N115_I0.8440.97
285_F405_M0.8430.97
370_R375_M0.8400.97
288_V414_F0.8400.97
393_A425_W0.8360.97
356_D404_V0.8360.97
132_E196_E0.8350.97
396_L421_K0.8330.97
414_F418_I0.8280.97
106_G412_H0.8270.97
131_P211_I0.8270.97
413_L416_H0.8250.97
317_S372_I0.8250.97
317_S373_Y0.8240.97
310_A318_P0.8240.97
21_I39_V0.8230.97
164_L223_R0.8230.97
75_N206_R0.8220.97
56_S60_F0.8190.96
119_M124_F0.8170.96
129_L274_F0.8170.96
97_Y103_P0.8170.96
151_N154_G0.8160.96
248_L334_V0.8140.96
122_L355_L0.8130.96
393_A422_E0.8120.96
432_V435_W0.8100.96
237_F431_Q0.8070.96
56_S61_V0.8060.96
409_L414_F0.8050.96
396_L422_E0.7990.96
115_I119_M0.7980.96
174_L178_E0.7930.96
16_E79_I0.7930.96
40_S182_E0.7910.96
107_D111_N0.7850.95
97_Y110_N0.7840.95
410_G413_L0.7820.95
41_Q44_K0.7810.95
276_A280_K0.7800.95
282_A309_V0.7790.95
174_L177_E0.7740.95
278_I350_L0.7740.95
349_V409_L0.7730.95
251_F257_A0.7700.95
366_A369_D0.7690.95
43_G47_D0.7680.95
300_V307_C0.7670.95
167_N225_H0.7660.95
281_H284_S0.7650.95
413_L417_F0.7650.95
282_A320_I0.7650.95
80_F91_R0.7650.95
278_I334_V0.7630.95
408_A413_L0.7620.95
323_P331_R0.7620.95
423_I426_D0.7610.95
124_F250_L0.7590.95
105_E410_G0.7580.95
115_I408_A0.7560.94
134_E189_E0.7550.94
132_E247_N0.7550.94
110_N114_R0.7530.94
129_L208_C0.7530.94
286_T388_L0.7480.94
274_F355_L0.7480.94
35_V157_F0.7460.94
293_V392_L0.7460.94
95_D107_D0.7430.94
232_M297_K0.7400.94
348_S409_L0.7400.94
289_T402_N0.7400.94
315_N371_N0.7370.94
171_D221_I0.7350.94
233_P295_S0.7330.94
427_M430_T0.7330.94
416_H419_E0.7330.94
73_D113_K0.7320.93
33_K158_D0.7320.93
103_P113_K0.7310.93
23_L45_A0.7300.93
7_E10_E0.7270.93
272_K276_A0.7270.93
173_V183_I0.7260.93
84_A167_N0.7250.93
111_N114_R0.7230.93
20_Y173_V0.7230.93
310_A372_I0.7220.93
403_E406_V0.7210.93
398_E402_N0.7180.93
152_D156_Y0.7160.93
428_F431_Q0.7150.93
135_F172_I0.7130.93
428_F439_Q0.7120.93
45_A50_V0.7100.92
249_S331_R0.7090.92
122_L257_A0.7060.92
110_N113_K0.7050.92
105_E110_N0.7050.92
16_E77_F0.7050.92
181_F199_F0.7040.92
382_E385_I0.7030.92
356_D362_L0.7010.92
182_E210_D0.7010.92
190_V304_E0.6990.92
346_A349_V0.6970.92
246_C347_L0.6930.91
301_P307_C0.6920.91
293_V428_F0.6910.91
83_T167_N0.6900.91
260_D264_D0.6870.91
176_L214_F0.6870.91
13_V18_V0.6860.91
250_L351_L0.6850.91
73_D76_T0.6820.91
411_E414_F0.6780.91
13_V21_I0.6760.90
384_G387_D0.6750.90
305_A373_Y0.6750.90
276_A357_G0.6750.90
318_P372_I0.6720.90
138_F235_P0.6710.90
169_R186_S0.6710.90
36_E83_T0.6710.90
20_Y174_L0.6680.90
137_L165_G0.6660.90
288_V417_F0.6650.90
183_I197_I0.6640.90
37_I50_V0.6630.90
325_S329_S0.6610.89
311_W322_I0.6600.89
291_P340_A0.6590.89
130_G198_D0.6570.89
262_N266_Q0.6550.89
316_R335_R0.6550.89
51_M69_Y0.6550.89
42_L92_F0.6540.89
54_G60_F0.6540.89
286_T389_P0.6540.89
302_G305_A0.6530.89
163_D220_T0.6530.89
385_I388_L0.6520.89
297_K428_F0.6520.89
22_R34_N0.6510.89
102_T105_E0.6510.89
29_L420_A0.6500.89
84_A89_V0.6500.89
248_L278_I0.6480.89
58_E61_V0.6460.88
129_L248_L0.6450.88
114_R117_K0.6420.88
133_P199_F0.6420.88
134_E245_H0.6420.88
359_K362_L0.6400.88
215_K219_K0.6400.88
281_H362_L0.6390.88
155_G158_D0.6380.88
189_E247_N0.6380.88
265_L313_A0.6370.88
372_I375_M0.6360.88
119_M351_L0.6360.88
134_E196_E0.6360.88
208_C343_P0.6330.87
137_L172_I0.6320.87
184_E201_Y0.6290.87
420_A423_I0.6290.87
294_N436_E0.6280.87
25_F57_I0.6280.87
51_M325_S0.6280.87
98_N104_F0.6260.87
293_V433_H0.6240.87
24_Q32_I0.6230.87
80_F179_M0.6230.87
284_S399_F0.6220.86
201_Y249_S0.6210.86
289_T334_V0.6210.86
293_V436_E0.6210.86
233_P292_T0.6200.86
172_I197_I0.6180.86
181_F213_T0.6180.86
331_R335_R0.6170.86
211_I347_L0.6160.86
165_G227_L0.6150.86
281_H285_F0.6140.86
78_V213_T0.6140.86
141_D145_E0.6130.86
114_R118_E0.6130.86
306_P317_S0.6120.86
56_S59_G0.6120.86
57_I61_V0.6110.85
291_P295_S0.6100.85
435_W439_Q0.6090.85
116_L120_E0.6070.85
251_F254_G0.6030.85
427_M435_W0.6020.85
129_L204_A0.6010.85
280_K386_V0.6010.85
355_L359_K0.6000.84
274_F278_I0.6000.84
289_T336_S0.6000.84
12_L79_I0.5990.84
409_L413_L0.5990.84
337_V346_A0.5990.84
399_F409_L0.5980.84
289_T353_A0.5970.84
82_W217_V0.5960.84
28_I413_L0.5960.84
187_H190_V0.5950.84
221_I224_K0.5940.84
54_G58_E0.5940.84
309_V319_L0.5920.84
216_L220_T0.5920.84
273_H364_A0.5910.84
317_S371_N0.5890.83
293_V425_W0.5880.83
25_F70_L0.5880.83
368_I372_I0.5880.83
281_H404_V0.5870.83
258_F351_L0.5870.83
46_L49_K0.5850.83
89_V170_R0.5850.83
118_E122_L0.5850.83
236_L239_V0.5850.83
22_R216_L0.5840.83
234_K241_G0.5830.83
91_R179_M0.5830.83
136_F239_V0.5820.83
12_L77_F0.5820.83
315_N368_I0.5820.83
201_Y204_A0.5810.83
252_K270_T0.5780.82
130_G249_S0.5780.82
130_G187_H0.5770.82
19_K178_E0.5770.82
220_T223_R0.5770.82
132_E245_H0.5760.82
140_L228_H0.5750.82
63_I66_S0.5740.82
375_M383_N0.5730.82
172_I217_V0.5730.82
354_G357_G0.5690.81
81_P179_M0.5680.81
78_V206_R0.5680.81
127_F248_L0.5670.81
122_L361_K0.5670.81
415_E418_I0.5670.81
351_L355_L0.5660.81
42_L74_L0.5660.81
12_L17_N0.5660.81
312_S318_P0.5650.81
372_I387_D0.5650.81
410_G414_F0.5640.81
133_P214_F0.5640.81
247_N331_R0.5640.81
280_K356_D0.5630.81
399_F402_N0.5630.81
265_L367_P0.5630.81
140_L146_P0.5630.81
31_T219_K0.5620.80
183_I186_S0.5620.80
242_S339_P0.5610.80
112_L348_S0.5600.80
137_L227_L0.5600.80
176_L183_I0.5590.80
25_F96_I0.5580.80
205_V278_I0.5570.80
20_Y36_E0.5570.80
41_Q182_E0.5550.80
400_K406_V0.5550.80
125_S252_K0.5550.80
289_T337_V0.5540.79
184_E198_D0.5540.79
8_D13_V0.5540.79
310_A375_M0.5530.79
131_P244_M0.5520.79
74_L92_F0.5520.79
194_Q242_S0.5520.79
337_V341_A0.5500.79
72_P92_F0.5500.79
296_Y395_A0.5490.79
181_F214_F0.5480.79
132_E316_R0.5470.79
308_Y384_G0.5470.79
55_S58_E0.5460.78
238_G430_T0.5450.78
139_K151_N0.5440.78
432_V437_R0.5430.78
241_G298_R0.5420.78
20_Y83_T0.5410.78
265_L272_K0.5410.78
93_I213_T0.5410.78
272_K311_W0.5400.78
156_Y190_V0.5400.78
401_S404_V0.5390.78
55_S60_F0.5380.77
114_R410_G0.5360.77
112_L205_V0.5350.77
198_D331_R0.5350.77
121_D359_K0.5330.77
353_A357_G0.5320.77
428_F436_E0.5310.77
156_Y187_H0.5310.77
83_T170_R0.5300.76
79_I90_A0.5300.76
45_A48_N0.5300.76
392_L396_L0.5300.76
389_P392_L0.5280.76
363_E366_A0.5270.76
370_R373_Y0.5260.76
268_S271_A0.5260.76
267_L330_T0.5260.76
168_C222_A0.5260.76
131_P347_L0.5250.76
391_T429_R0.5250.76
316_R333_E0.5240.76
284_S287_A0.5240.76
130_G201_Y0.5240.76
24_Q213_T0.5240.76
184_E249_S0.5230.75
276_A354_G0.5230.75
313_A369_D0.5230.75
196_E243_G0.5230.75
360_N363_E0.5220.75
300_V303_Y0.5210.75
181_F211_I0.5210.75
127_F204_A0.5200.75
237_F430_T0.5190.75
7_E14_K0.5180.75
354_G358_I0.5170.75
196_E333_E0.5160.75
416_H420_A0.5150.74
428_F432_V0.5150.74
190_V303_Y0.5140.74
189_E243_G0.5130.74
412_H415_E0.5130.74
170_R174_L0.5130.74
135_F197_I0.5120.74
10_E46_L0.5120.74
275_I311_W0.5120.74
52_F70_L0.5110.74
368_I385_I0.5110.74
291_P341_A0.5100.74
41_Q184_E0.5090.74
181_F210_D0.5090.74
405_M417_F0.5070.73
293_V435_W0.5070.73
56_S190_V0.5070.73
22_R36_E0.5060.73
290_N296_Y0.5050.73
136_F234_K0.5050.73
402_N414_F0.5050.73
288_V345_L0.5040.73
150_L156_Y0.5040.73
407_K411_E0.5030.73
37_I42_L0.5030.73
297_K433_H0.5020.73
77_F92_F0.5020.73
384_G401_S0.5010.72
384_G388_L0.5000.72
277_G354_G0.5000.72
23_L37_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lniA 5 0.9977 100 0.067 Contact Map
4s17A 5 0.9369 100 0.093 Contact Map
4acfA 5 0.9797 100 0.093 Contact Map
1f52A 5 0.9775 100 0.1 Contact Map
3ng0A 5 0.964 100 0.102 Contact Map
4hppA 3 0.9144 100 0.121 Contact Map
2j9iA 5 0.9234 100 0.159 Contact Map
3o6xA 3 0.8423 100 0.317 Contact Map
3fkyA 8 0.7275 100 0.34 Contact Map
2ojwA 5 0.7658 100 0.35 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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