GREMLIN Database
PURS - Phosphoribosylformylglycinamidine synthase subunit PurS
UniProt: P12049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (77)
Sequences: 1190 (648)
Seq/√Len: 73.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_K63_E3.5641.00
33_E57_L3.0011.00
60_E64_K2.8111.00
22_V39_I2.2501.00
55_D59_K2.1031.00
31_Y61_M2.0751.00
7_Y42_Y1.9991.00
14_V71_I1.9201.00
4_V78_V1.8691.00
39_I43_M1.8491.00
35_Q48_E1.8401.00
49_K54_L1.8021.00
20_S23_Q1.7551.00
5_K44_E1.6871.00
53_D56_V1.6611.00
52_R55_D1.6441.00
5_K77_E1.6070.99
62_C74_Y1.5830.99
49_K53_D1.5390.99
23_Q36_D1.5180.99
26_L37_V1.4760.99
3_K46_T1.4340.99
7_Y75_R1.4040.99
57_L60_E1.2760.97
10_L71_I1.2720.97
26_L61_M1.2660.97
9_S75_R1.2550.97
10_L70_V1.2040.96
3_K44_E1.2000.96
5_K42_Y1.1970.96
7_Y77_E1.1790.96
9_S73_D1.1680.95
19_G38_R1.1350.95
15_L20_S1.1200.94
9_S42_Y1.1200.94
59_K74_Y1.0860.93
18_Q39_I1.0810.93
4_V47_I1.0690.93
6_V45_L1.0100.90
50_S53_D1.0060.90
37_V45_L0.9900.90
40_G72_E0.9900.90
63_E69_T0.9510.88
15_L21_A0.9400.87
8_V43_M0.9330.87
55_D76_Y0.9250.86
13_S39_I0.9230.86
18_Q22_V0.9120.85
47_I54_L0.9000.85
50_S54_L0.8970.84
13_S20_S0.8950.84
53_D57_L0.8890.84
2_Y14_V0.8880.84
2_Y46_T0.8650.82
2_Y49_K0.8610.82
20_S24_H0.8390.80
36_D46_T0.8240.79
22_V41_K0.8080.78
19_G40_G0.8060.77
19_G37_V0.8010.77
23_Q27_H0.7990.77
58_V76_Y0.7970.77
22_V43_M0.7950.76
18_Q72_E0.7860.76
35_Q46_T0.7780.75
51_D54_L0.7770.75
58_V62_C0.7390.71
57_L61_M0.7170.69
62_C76_Y0.7000.67
67_A70_V0.6970.67
60_E63_E0.6940.66
13_S21_A0.6880.66
20_S36_D0.6800.65
56_V59_K0.6790.65
54_L78_V0.6700.64
25_A67_A0.6520.61
32_N48_E0.6520.61
31_Y57_L0.6470.61
21_A39_I0.6410.60
16_D72_E0.6300.59
14_V42_Y0.6100.56
11_K73_D0.6100.56
26_L45_L0.6090.56
25_A70_V0.6080.56
4_V54_L0.5970.55
23_Q35_Q0.5950.55
12_E78_V0.5930.54
43_M70_V0.5870.54
62_C78_V0.5870.54
33_E56_V0.5860.53
18_Q40_G0.5850.53
61_M65_L0.5850.53
8_V45_L0.5810.53
6_V17_P0.5800.53
10_L38_R0.5690.51
52_R78_V0.5580.50
10_L14_V0.5550.50
56_V60_E0.5510.49
12_E36_D0.5460.48
11_K18_Q0.5390.48
45_L66_L0.5360.47
34_V37_V0.5320.47
20_S28_S0.5310.47
20_S65_L0.5290.46
16_D38_R0.5240.46
35_Q60_E0.5230.46
7_Y44_E0.5220.45
21_A70_V0.5200.45
70_V73_D0.5180.45
20_S73_D0.5120.44
18_Q28_S0.5120.44
25_A29_M0.5100.44
59_K76_Y0.5050.43
21_A65_L0.5040.43
5_K62_C0.5010.43
38_R72_E0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t4aA 3 0.9524 100 0.195 Contact Map
1vq3A 4 0.9405 100 0.225 Contact Map
2dgbA 2 0.9643 100 0.233 Contact Map
2yx5A 4 0.9643 100 0.234 Contact Map
1gtdA 3 0.9881 100 0.249 Contact Map
2zw2A 2 0.9643 100 0.256 Contact Map
4lgyA 1 0.9524 93.8 0.838 Contact Map
2go8A 2 0.7738 38.5 0.904 Contact Map
1e3pA 3 0.4167 15.9 0.92 Contact Map
3u7iA 2 0.869 15 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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