PUR9 - BACSU - GREMLIN Contacts

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PUR9 - Bifunctional purine biosynthesis protein PurH

UniProt:	P12048	Sequences: MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKEEGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGENPHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHMNPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSFSQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTKREPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIRHFKH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	512 (504)
Sequences:	2868 (1446)
Seq/√Len:	64.4

ECOLI - PUR9
BACSU - PUR9
HALSA - Q9HS43

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
489_E	493_K	5.276	1.00
392_K	496_D	5.256	1.00
393_R	399_E	4.067	1.00
312_E	333_S	3.795	1.00
24_T	46_D	3.766	1.00
150_D	175_K	3.746	1.00
22_E	155_L	3.675	1.00
465_P	469_E	3.593	1.00
312_E	335_S	3.536	1.00
209_K	212_S	3.343	1.00
240_E	352_T	3.275	1.00
5_R	29_E	3.271	1.00
77_A	88_I	3.254	1.00
320_A	323_N	3.124	1.00
315_K	341_V	3.115	1.00
8_I	30_V	3.081	1.00
157_Q	168_K	3.066	1.00
116_T	119_E	3.064	1.00
132_L	176_V	2.930	1.00
333_S	352_T	2.823	1.00
334_F	350_L	2.771	1.00
30_V	45_V	2.747	1.00
75_L	99_V	2.631	1.00
315_K	337_E	2.626	1.00
269_A	283_T	2.603	1.00
281_V	409_V	2.582	1.00
468_V	479_I	2.548	1.00
26_L	159_K	2.496	1.00
314_D	317_T	2.440	1.00
147_D	175_K	2.368	1.00
38_K	42_E	2.349	1.00
132_L	144_V	2.318	1.00
315_K	319_E	2.317	1.00
143_T	164_V	2.305	1.00
78_V	81_N	2.305	1.00
469_E	497_E	2.244	1.00
270_A	309_L	2.241	1.00
481_Q	502_M	2.222	1.00
86_A	90_E	2.220	1.00
8_I	20_V	2.191	1.00
157_Q	165_S	2.188	1.00
380_H	507_I	2.188	1.00
406_A	421_A	2.136	1.00
211_Q	246_E	2.128	1.00
441_K	445_E	2.099	1.00
286_T	289_E	2.095	1.00
465_P	490_D	2.063	1.00
252_I	368_V	2.047	1.00
60_M	88_I	2.014	1.00
431_A	434_M	2.011	1.00
22_E	159_K	1.971	1.00
18_P	21_K	1.964	1.00
39_L	43_N	1.952	1.00
79_R	97_D	1.931	1.00
50_I	71_I	1.922	1.00
145_I	154_V	1.921	1.00
207_F	372_L	1.915	1.00
110_I	120_A	1.914	1.00
78_V	84_H	1.910	1.00
420_L	444_I	1.892	1.00
396_N	399_E	1.870	1.00
487_R	490_D	1.846	1.00
117_Y	139_H	1.831	1.00
53_V	71_I	1.829	1.00
153_P	171_E	1.826	1.00
31_I	53_V	1.823	1.00
435_N	446_Q	1.821	1.00
80_G	85_M	1.812	1.00
440_A	467_T	1.807	1.00
493_K	497_E	1.797	1.00
402_D	421_A	1.786	1.00
3_I	28_V	1.785	1.00
309_L	313_V	1.778	1.00
493_K	496_D	1.741	1.00
456_L	471_A	1.741	1.00
288_A	292_D	1.736	0.99
465_P	497_E	1.736	0.99
37_K	47_V	1.730	0.99
339_L	343_T	1.712	0.99
321_L	326_L	1.708	0.99
336_Q	340_D	1.703	0.99
287_I	309_L	1.698	0.99
402_D	422_K	1.687	0.99
210_K	227_Q	1.686	0.99
399_E	477_T	1.678	0.99
37_K	41_Q	1.673	0.99
307_I	321_L	1.671	0.99
19_F	145_I	1.668	0.99
253_K	276_M	1.664	0.99
469_E	473_K	1.659	0.99
19_F	154_V	1.656	0.99
107_K	186_L	1.650	0.99
59_I	91_H	1.641	0.99
455_A	478_A	1.636	0.99
285_K	289_E	1.634	0.99
19_F	100_V	1.632	0.99
73_G	93_I	1.626	0.99
420_L	427_V	1.616	0.99
292_D	320_A	1.615	0.99
284_G	293_R	1.602	0.99
243_H	348_L	1.571	0.99
41_Q	49_G	1.567	0.99
391_T	502_M	1.553	0.99
253_K	366_T	1.545	0.99
249_Y	364_Q	1.541	0.99
147_D	150_D	1.532	0.99
117_Y	191_L	1.530	0.99
26_L	158_I	1.527	0.99
268_P	287_I	1.520	0.99
383_D	386_E	1.513	0.99
494_K	497_E	1.508	0.99
117_Y	170_R	1.499	0.98
438_G	446_Q	1.494	0.98
454_S	476_V	1.478	0.98
284_G	289_E	1.476	0.98
82_E	86_A	1.474	0.98
469_E	498_Y	1.467	0.98
243_H	343_T	1.455	0.98
60_M	87_Q	1.443	0.98
242_L	352_T	1.441	0.98
387_I	404_K	1.437	0.98
494_K	498_Y	1.434	0.98
322_H	344_A	1.420	0.98
255_A	328_I	1.417	0.98
264_E	412_H	1.400	0.98
29_E	48_I	1.395	0.98
132_L	146_V	1.385	0.97
112_K	115_V	1.357	0.97
393_R	477_T	1.353	0.97
225_F	368_V	1.348	0.97
115_V	120_A	1.341	0.97
59_I	134_A	1.338	0.97
243_H	342_L	1.333	0.97
465_P	498_Y	1.331	0.97
272_A	302_I	1.329	0.97
152_S	156_N	1.327	0.97
37_K	49_G	1.324	0.97
402_D	423_D	1.320	0.97
17_V	39_L	1.318	0.97
222_E	376_D	1.317	0.97
403_L	478_A	1.313	0.96
398_Q	402_D	1.313	0.96
307_I	326_L	1.312	0.96
398_Q	423_D	1.312	0.96
29_E	94_Q	1.312	0.96
146_V	179_H	1.312	0.96
479_I	500_I	1.309	0.96
247_L	252_I	1.308	0.96
470_E	473_K	1.308	0.96
31_I	96_I	1.304	0.96
3_I	98_L	1.303	0.96
402_D	424_N	1.303	0.96
456_L	476_V	1.301	0.96
387_I	480_I	1.300	0.96
468_V	491_S	1.298	0.96
20_V	40_L	1.297	0.96
99_V	130_G	1.295	0.96
384_D	404_K	1.288	0.96
61_D	84_H	1.286	0.96
264_E	411_K	1.276	0.96
144_V	176_V	1.268	0.96
363_K	376_D	1.266	0.96
178_R	192_T	1.258	0.96
388_S	506_G	1.257	0.96
22_E	26_L	1.256	0.95
31_I	50_I	1.252	0.95
80_G	140_Q	1.247	0.95
401_E	424_N	1.236	0.95
174_A	178_R	1.234	0.95
365_L	372_L	1.233	0.95
289_E	293_R	1.225	0.95
79_R	141_D	1.219	0.95
61_D	81_N	1.215	0.95
78_V	141_D	1.213	0.95
313_V	334_F	1.207	0.94
25_E	159_K	1.205	0.94
452_K	477_T	1.198	0.94
259_V	353_L	1.191	0.94
174_A	191_L	1.185	0.94
465_P	494_K	1.175	0.94
157_Q	164_V	1.167	0.93
8_I	16_L	1.161	0.93
130_G	135_A	1.156	0.93
444_I	474_A	1.152	0.93
107_K	179_H	1.150	0.93
112_K	119_E	1.148	0.93
21_K	25_E	1.148	0.93
166_L	170_R	1.146	0.93
156_N	159_K	1.145	0.93
168_K	172_L	1.130	0.92
73_G	91_H	1.129	0.92
11_S	105_P	1.125	0.92
448_G	451_A	1.125	0.92
82_E	85_M	1.123	0.92
17_V	43_N	1.122	0.92
139_H	170_R	1.122	0.92
28_V	98_L	1.115	0.92
339_L	350_L	1.114	0.92
116_T	120_A	1.110	0.91
277_N	431_A	1.107	0.91
225_F	237_A	1.105	0.91
473_K	498_Y	1.102	0.91
11_S	123_N	1.102	0.91
22_E	25_E	1.100	0.91
117_Y	120_A	1.099	0.91
21_K	45_V	1.097	0.91
70_N	92_G	1.097	0.91
256_D	260_Q	1.089	0.91
420_L	454_S	1.088	0.91
143_T	172_L	1.083	0.90
154_V	168_K	1.080	0.90
198_K	222_E	1.079	0.90
53_V	70_N	1.077	0.90
337_E	340_D	1.076	0.90
420_L	476_V	1.075	0.90
397_E	401_E	1.074	0.90
470_E	474_A	1.072	0.90
157_Q	162_G	1.062	0.90
288_A	320_A	1.060	0.89
384_D	400_W	1.058	0.89
427_V	451_A	1.054	0.89
199_E	222_E	1.053	0.89
130_G	134_A	1.052	0.89
262_V	308_A	1.052	0.89
297_A	426_T	1.051	0.89
5_R	31_I	1.050	0.89
330_I	353_L	1.044	0.89
243_H	350_L	1.043	0.89
12_D	108_E	1.043	0.89
472_A	500_I	1.038	0.88
319_E	323_N	1.038	0.88
399_E	501_A	1.031	0.88
189_D	193_N	1.028	0.88
378_D	509_H	1.025	0.88
486_I	489_E	1.024	0.88
288_A	316_A	1.024	0.88
468_V	495_A	1.020	0.88
389_I	395_P	1.018	0.87
317_T	321_L	1.014	0.87
14_T	149_A	1.012	0.87
241_Q	246_E	1.010	0.87
143_T	157_Q	1.009	0.87
107_K	111_S	0.999	0.86
315_K	335_S	0.993	0.86
200_P	224_T	0.986	0.86
18_P	152_S	0.985	0.86
86_A	89_N	0.984	0.86
434_M	442_I	0.984	0.86
153_P	168_K	0.982	0.86
87_Q	90_E	0.981	0.85
295_F	299_K	0.978	0.85
389_I	503_V	0.978	0.85
334_F	352_T	0.976	0.85
316_A	319_E	0.976	0.85
80_G	141_D	0.974	0.85
236_I	239_A	0.969	0.85
296_E	425_M	0.968	0.85
287_I	317_T	0.967	0.85
107_K	182_A	0.965	0.85
492_I	504_F	0.963	0.84
59_I	93_I	0.962	0.84
292_D	296_E	0.959	0.84
22_E	158_I	0.958	0.84
146_V	150_D	0.956	0.84
131_M	134_A	0.956	0.84
77_A	95_P	0.952	0.84
265_F	269_A	0.952	0.84
259_V	263_R	0.946	0.83
303_F	486_I	0.945	0.83
297_A	425_M	0.939	0.83
199_E	224_T	0.938	0.83
72_H	134_A	0.937	0.83
426_T	429_V	0.937	0.83
382_F	387_I	0.934	0.83
261_I	271_V	0.933	0.82
75_L	131_M	0.933	0.82
174_A	192_T	0.931	0.82
438_G	441_K	0.930	0.82
77_A	85_M	0.930	0.82
431_A	442_I	0.929	0.82
139_H	173_A	0.928	0.82
88_I	95_P	0.926	0.82
478_A	501_A	0.925	0.82
395_P	399_E	0.923	0.82
185_A	206_T	0.923	0.82
387_I	400_W	0.920	0.82
255_A	330_I	0.920	0.82
395_P	503_V	0.920	0.82
154_V	172_L	0.919	0.81
239_A	351_L	0.916	0.81
309_L	317_T	0.915	0.81
311_R	332_P	0.914	0.81
469_E	494_K	0.914	0.81
150_D	153_P	0.914	0.81
15_N	18_P	0.912	0.81
437_V	467_T	0.912	0.81
48_I	53_V	0.910	0.81
287_I	311_R	0.906	0.81
490_D	493_K	0.906	0.81
389_I	394_E	0.905	0.80
404_K	480_I	0.904	0.80
401_E	404_K	0.899	0.80
286_T	316_A	0.898	0.80
262_V	269_A	0.897	0.80
55_G	70_N	0.895	0.80
16_L	20_V	0.892	0.80
295_F	324_I	0.892	0.80
140_Q	166_L	0.890	0.79
108_E	112_K	0.890	0.79
418_I	459_D	0.889	0.79
99_V	144_V	0.888	0.79
107_K	208_E	0.888	0.79
319_E	344_A	0.887	0.79
273_V	308_A	0.886	0.79
413_V	419_V	0.884	0.79
321_L	329_I	0.878	0.78
390_P	504_F	0.877	0.78
419_V	426_T	0.874	0.78
393_R	499_G	0.874	0.78
395_P	501_A	0.873	0.78
24_T	30_V	0.872	0.78
362_E	377_L	0.872	0.78
60_M	78_V	0.869	0.78
342_L	350_L	0.868	0.78
468_V	472_A	0.862	0.77
168_K	171_E	0.861	0.77
81_N	84_H	0.860	0.77
114_D	119_E	0.860	0.77
158_I	163_S	0.860	0.77
300_T	438_G	0.859	0.77
393_R	501_A	0.858	0.77
155_L	159_K	0.858	0.77
322_H	348_L	0.857	0.77
309_L	321_L	0.857	0.77
270_A	321_L	0.856	0.77
291_F	324_I	0.855	0.77
139_H	166_L	0.854	0.76
255_A	351_L	0.850	0.76
165_S	168_K	0.850	0.76
164_V	169_K	0.846	0.76
420_L	456_L	0.845	0.76
170_R	194_V	0.845	0.76
30_V	48_I	0.845	0.76
314_D	335_S	0.842	0.75
468_V	476_V	0.838	0.75
283_T	424_N	0.835	0.75
406_A	455_A	0.834	0.75
333_S	354_D	0.831	0.75
85_M	88_I	0.830	0.74
467_T	491_S	0.828	0.74
287_I	314_D	0.827	0.74
434_M	438_G	0.827	0.74
59_I	73_G	0.826	0.74
178_R	182_A	0.824	0.74
61_D	87_Q	0.824	0.74
292_D	323_N	0.821	0.74
41_Q	46_D	0.821	0.74
120_A	190_Y	0.820	0.74
56_F	91_H	0.818	0.73
39_L	42_E	0.814	0.73
300_T	435_N	0.813	0.73
178_R	188_A	0.811	0.73
343_T	348_L	0.808	0.72
257_A	276_M	0.807	0.72
75_L	132_L	0.805	0.72
267_E	311_R	0.805	0.72
388_S	489_E	0.805	0.72
472_A	498_Y	0.801	0.72
209_K	224_T	0.799	0.72
60_M	73_G	0.798	0.71
481_Q	504_F	0.798	0.71
477_T	499_G	0.796	0.71
270_A	307_I	0.793	0.71
319_E	322_H	0.792	0.71
143_T	154_V	0.792	0.71
337_E	341_V	0.792	0.71
268_P	311_R	0.787	0.70
8_I	17_V	0.781	0.70
225_F	252_I	0.780	0.70
363_K	374_I	0.779	0.70
19_F	155_L	0.776	0.69
75_L	144_V	0.775	0.69
208_E	227_Q	0.774	0.69
383_D	404_K	0.773	0.69
456_L	468_V	0.771	0.69
109_T	120_A	0.770	0.69
289_E	292_D	0.769	0.69
85_M	141_D	0.767	0.68
109_T	115_V	0.764	0.68
164_V	168_K	0.764	0.68
441_K	470_E	0.764	0.68
205_V	372_L	0.763	0.68
72_H	130_G	0.760	0.68
316_A	335_S	0.759	0.68
261_I	409_V	0.754	0.67
72_H	131_M	0.752	0.67
465_P	491_S	0.751	0.67
434_M	446_Q	0.751	0.67
451_A	454_S	0.750	0.67
240_E	333_S	0.750	0.67
265_F	409_V	0.749	0.67
245_K	327_E	0.748	0.67
420_L	440_A	0.748	0.67
17_V	21_K	0.746	0.66
109_T	123_N	0.744	0.66
269_A	281_V	0.741	0.66
83_E	87_Q	0.740	0.66
440_A	456_L	0.740	0.66
153_P	157_Q	0.738	0.65
448_G	474_A	0.738	0.65
117_Y	194_V	0.737	0.65
109_T	112_K	0.736	0.65
257_A	277_N	0.735	0.65
148_P	151_Y	0.734	0.65
182_A	186_L	0.734	0.65
49_G	52_E	0.733	0.65
276_M	366_T	0.730	0.65
192_T	202_Q	0.729	0.65
391_T	481_Q	0.728	0.64
84_H	87_Q	0.728	0.64
277_N	434_M	0.726	0.64
16_L	39_L	0.725	0.64
73_G	96_I	0.723	0.64
85_M	89_N	0.723	0.64
489_E	497_E	0.723	0.64
440_A	468_V	0.723	0.64
28_V	158_I	0.722	0.64
167_Q	170_R	0.722	0.64
24_T	40_L	0.722	0.64
59_I	87_Q	0.721	0.64
228_T	367_S	0.720	0.64
153_P	156_N	0.718	0.63
388_S	394_E	0.717	0.63
11_S	179_H	0.714	0.63
181_A	188_A	0.712	0.63
300_T	441_K	0.710	0.62
435_N	438_G	0.710	0.62
135_A	142_V	0.707	0.62
272_A	295_F	0.706	0.62
255_A	308_A	0.706	0.62
489_E	496_D	0.706	0.62
114_D	120_A	0.705	0.62
438_G	449_E	0.703	0.62
334_F	351_L	0.702	0.62
73_G	88_I	0.701	0.61
287_I	313_V	0.701	0.61
334_F	339_L	0.700	0.61
429_V	434_M	0.699	0.61
121_I	140_Q	0.699	0.61
108_E	111_S	0.696	0.61
300_T	449_E	0.695	0.61
267_E	283_T	0.695	0.61
276_M	328_I	0.695	0.61
209_K	226_Y	0.692	0.60
38_K	41_Q	0.692	0.60
282_G	302_I	0.689	0.60
112_K	123_N	0.687	0.60
364_Q	367_S	0.684	0.60
250_N	327_E	0.684	0.60
434_M	439_S	0.683	0.59
132_L	143_T	0.683	0.59
329_I	342_L	0.682	0.59
438_G	467_T	0.682	0.59
439_S	442_I	0.682	0.59
185_A	204_T	0.680	0.59
425_M	450_K	0.679	0.59
110_I	190_Y	0.679	0.59
390_P	492_I	0.678	0.59
202_Q	206_T	0.678	0.59
64_L	69_P	0.677	0.59
285_K	311_R	0.676	0.59
340_D	343_T	0.676	0.59
154_V	164_V	0.676	0.59
154_V	158_I	0.676	0.59
444_I	467_T	0.675	0.59
111_S	186_L	0.675	0.59
382_F	507_I	0.675	0.59
284_G	425_M	0.672	0.58
236_I	255_A	0.672	0.58
406_A	457_G	0.672	0.58
380_H	386_E	0.671	0.58
291_F	320_A	0.670	0.58
119_E	123_N	0.669	0.58
60_M	84_H	0.668	0.58
83_E	86_A	0.667	0.58
8_I	100_V	0.666	0.58
178_R	202_Q	0.665	0.57
89_N	94_Q	0.665	0.57
326_L	348_L	0.664	0.57
329_I	348_L	0.664	0.57
5_R	28_V	0.664	0.57
420_L	451_A	0.663	0.57
339_L	352_T	0.662	0.57
88_I	92_G	0.662	0.57
344_A	348_L	0.661	0.57
56_F	87_Q	0.661	0.57
213_L	252_I	0.660	0.57
75_L	176_V	0.658	0.57
16_L	30_V	0.657	0.57
235_S	239_A	0.657	0.57
465_P	487_R	0.657	0.57
420_L	435_N	0.656	0.56
3_I	158_I	0.655	0.56
259_V	356_S	0.654	0.56
269_A	284_G	0.653	0.56
400_W	480_I	0.653	0.56
11_S	108_E	0.651	0.56
30_V	246_E	0.651	0.56
271_V	281_V	0.650	0.56
272_A	414_K	0.647	0.55
400_W	404_K	0.646	0.55
472_A	494_K	0.645	0.55
322_H	341_V	0.644	0.55
413_V	434_M	0.643	0.55
272_A	282_G	0.642	0.55
398_Q	401_E	0.642	0.55
303_F	323_N	0.639	0.54
50_I	75_L	0.639	0.54
339_L	342_L	0.636	0.54
174_A	195_V	0.636	0.54
253_K	256_D	0.633	0.54
302_I	326_L	0.632	0.54
140_Q	170_R	0.631	0.54
259_V	354_D	0.631	0.54
4_K	28_V	0.631	0.54
256_D	371_G	0.630	0.53
121_I	134_A	0.630	0.53
82_E	89_N	0.630	0.53
421_A	455_A	0.630	0.53
438_G	444_I	0.629	0.53
20_V	45_V	0.629	0.53
265_F	268_P	0.627	0.53
115_V	190_Y	0.626	0.53
270_A	291_F	0.625	0.53
305_G	326_L	0.624	0.53
235_S	369_Q	0.624	0.53
266_T	311_R	0.624	0.53
376_D	379_M	0.623	0.53
438_G	442_I	0.623	0.53
472_A	497_E	0.623	0.53
405_L	421_A	0.621	0.52
447_A	451_A	0.620	0.52
196_G	199_E	0.619	0.52
41_Q	52_E	0.619	0.52
336_Q	339_L	0.619	0.52
17_V	42_E	0.618	0.52
31_I	48_I	0.618	0.52
313_V	317_T	0.617	0.52
384_D	401_E	0.617	0.52
85_M	95_P	0.617	0.52
79_R	85_M	0.616	0.52
110_I	115_V	0.614	0.52
448_G	454_S	0.613	0.51
8_I	45_V	0.613	0.51
284_G	317_T	0.611	0.51
392_K	499_G	0.610	0.51
75_L	136_S	0.609	0.51
57_P	91_H	0.609	0.51
60_M	81_N	0.609	0.51
201_E	208_E	0.608	0.51
81_N	85_M	0.608	0.51
239_A	255_A	0.606	0.51
109_T	114_D	0.606	0.51
112_K	120_A	0.606	0.51
67_L	72_H	0.604	0.50
71_I	134_A	0.604	0.50
14_T	148_P	0.604	0.50
60_M	77_A	0.603	0.50
59_I	79_R	0.602	0.50
445_E	449_E	0.602	0.50
191_L	195_V	0.602	0.50
203_F	207_F	0.602	0.50
491_S	495_A	0.602	0.50
471_A	476_V	0.601	0.50
431_A	446_Q	0.600	0.50
81_N	141_D	0.600	0.50
502_M	505_T	0.600	0.50
346_K	486_I	0.599	0.50
110_I	116_T	0.598	0.50
313_V	321_L	0.596	0.49
158_I	161_E	0.596	0.49
291_F	326_L	0.594	0.49
469_E	490_D	0.594	0.49
253_K	302_I	0.592	0.49
130_G	170_R	0.591	0.49
384_D	387_I	0.590	0.49
456_L	479_I	0.590	0.49
282_G	402_D	0.590	0.49
240_E	339_L	0.589	0.49
265_F	408_K	0.588	0.49
393_R	496_D	0.586	0.48
402_D	455_A	0.584	0.48
5_R	94_Q	0.584	0.48
73_G	134_A	0.584	0.48
259_V	369_Q	0.584	0.48
16_L	45_V	0.583	0.48
98_L	143_T	0.583	0.48
48_I	52_E	0.582	0.48
170_R	174_A	0.582	0.48
199_E	209_K	0.581	0.48
403_L	503_V	0.579	0.48
236_I	252_I	0.578	0.47
105_P	108_E	0.577	0.47
261_I	281_V	0.577	0.47
49_G	53_V	0.574	0.47
422_K	477_T	0.574	0.47
421_A	424_N	0.574	0.47
297_A	438_G	0.571	0.47
413_V	429_V	0.570	0.46
84_H	438_G	0.570	0.46
258_A	308_A	0.569	0.46
261_I	511_K	0.568	0.46
40_L	45_V	0.567	0.46
446_Q	467_T	0.566	0.46
479_I	491_S	0.566	0.46
53_V	94_Q	0.566	0.46
50_I	134_A	0.565	0.46
249_Y	367_S	0.565	0.46
192_T	255_A	0.563	0.46
171_E	174_A	0.563	0.46
427_V	450_K	0.563	0.46
207_F	228_T	0.561	0.45
243_H	339_L	0.559	0.45
225_F	247_L	0.559	0.45
234_G	259_V	0.558	0.45
20_V	24_T	0.558	0.45
364_Q	377_L	0.558	0.45
382_F	404_K	0.557	0.45
303_F	462_F	0.556	0.45
117_Y	476_V	0.556	0.45
462_F	467_T	0.556	0.45
468_V	500_I	0.555	0.45
69_P	73_G	0.554	0.45
227_Q	238_Q	0.553	0.44
143_T	168_K	0.552	0.44
421_A	457_G	0.552	0.44
40_L	43_N	0.552	0.44
255_A	259_V	0.551	0.44
455_A	501_A	0.551	0.44
295_F	320_A	0.551	0.44
272_A	328_I	0.550	0.44
291_F	321_L	0.550	0.44
293_R	424_N	0.549	0.44
276_M	464_M	0.549	0.44
30_V	43_N	0.548	0.44
295_F	302_I	0.548	0.44
238_Q	354_D	0.547	0.44
288_A	314_D	0.547	0.44
217_E	250_N	0.547	0.44
62_G	65_K	0.546	0.44
268_P	310_N	0.546	0.44
115_V	119_E	0.544	0.43
444_I	470_E	0.544	0.43
102_N	148_P	0.544	0.43
203_F	374_I	0.543	0.43
220_H	378_D	0.543	0.43
291_F	295_F	0.542	0.43
319_E	341_V	0.541	0.43
465_P	493_K	0.541	0.43
61_D	78_V	0.540	0.43
140_Q	169_K	0.539	0.43
79_R	96_I	0.538	0.43
5_R	53_V	0.538	0.43
150_D	429_V	0.538	0.43
207_F	365_L	0.537	0.43
143_T	169_K	0.536	0.43
433_Q	459_D	0.536	0.43
41_Q	47_V	0.536	0.43
262_V	273_V	0.535	0.42
293_R	423_D	0.535	0.42
409_V	426_T	0.535	0.42
234_G	238_Q	0.534	0.42
314_D	337_E	0.534	0.42
448_G	452_K	0.534	0.42
211_Q	247_L	0.534	0.42
117_Y	190_Y	0.533	0.42
261_I	264_E	0.533	0.42
261_I	412_H	0.532	0.42
389_I	400_W	0.532	0.42
100_V	234_G	0.532	0.42
178_R	206_T	0.531	0.42
243_H	322_H	0.531	0.42
178_R	191_L	0.531	0.42
413_V	417_A	0.531	0.42
143_T	162_G	0.530	0.42
451_A	474_A	0.530	0.42
288_A	317_T	0.530	0.42
272_A	326_L	0.530	0.42
41_Q	213_L	0.529	0.42
456_L	491_S	0.528	0.42
249_Y	374_I	0.528	0.42
240_E	354_D	0.528	0.42
38_K	49_G	0.527	0.42
433_Q	442_I	0.526	0.41
318_A	341_V	0.526	0.41
456_L	467_T	0.526	0.41
281_V	426_T	0.526	0.41
178_R	201_E	0.525	0.41
419_V	431_A	0.525	0.41
100_V	151_Y	0.525	0.41
409_V	434_M	0.525	0.41
23_L	28_V	0.524	0.41
391_T	496_D	0.524	0.41
401_E	423_D	0.523	0.41
365_L	374_I	0.523	0.41
438_G	470_E	0.522	0.41
31_I	94_Q	0.522	0.41
268_P	317_T	0.521	0.41
395_P	496_D	0.521	0.41
33_T	225_F	0.520	0.41
270_A	405_L	0.520	0.41
236_I	330_I	0.519	0.41
407_W	505_T	0.519	0.41
75_L	134_A	0.518	0.41
368_V	371_G	0.518	0.41
182_A	204_T	0.517	0.40
419_V	429_V	0.517	0.40
77_A	130_G	0.516	0.40
10_V	151_Y	0.516	0.40
191_L	212_S	0.515	0.40
295_F	300_T	0.514	0.40
253_K	272_A	0.514	0.40
100_V	145_I	0.514	0.40
32_S	35_G	0.514	0.40
467_T	495_A	0.513	0.40
222_E	386_E	0.513	0.40
103_L	132_L	0.513	0.40
239_A	271_V	0.513	0.40
188_A	202_Q	0.512	0.40
417_A	459_D	0.511	0.40
307_I	324_I	0.511	0.40
353_L	356_S	0.510	0.40
384_D	397_E	0.509	0.40
428_G	434_M	0.509	0.40
64_L	67_L	0.508	0.39
75_L	93_I	0.508	0.39
343_T	350_L	0.508	0.39
32_S	129_P	0.508	0.39
30_V	47_V	0.507	0.39
265_F	310_N	0.507	0.39
110_I	186_L	0.507	0.39
265_F	281_V	0.507	0.39
50_I	130_G	0.506	0.39
11_S	39_L	0.506	0.39
75_L	130_G	0.506	0.39
211_Q	252_I	0.505	0.39
109_T	257_A	0.504	0.39
286_T	314_D	0.504	0.39
403_L	455_A	0.504	0.39
17_V	40_L	0.503	0.39
17_V	45_V	0.503	0.39
34_G	129_P	0.503	0.39
322_H	342_L	0.502	0.39
444_I	454_S	0.502	0.39
281_V	297_A	0.502	0.39
394_E	400_W	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ehiA	2	0.9648	100	0.078	Contact Map
3zzmA	2	0.9902	100	0.079	Contact Map
1g8mA	2	0.9668	100	0.126	Contact Map
1zczA	2	0.8848	100	0.134	Contact Map
4j6eA	2	0.4258	100	0.842	Contact Map
2yvqA	2	0.2246	99.3	0.94	Contact Map
1a9xA	3	0.2559	99.2	0.942	Contact Map
2xw6A	5	0.2402	98.7	0.953	Contact Map
1b93A	5	0.2617	98.5	0.955	Contact Map
1vmdA	5	0.2773	98.4	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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