GREMLIN Database
PUR8 - Adenylosuccinate lyase
UniProt: P12047 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 431 (388)
Sequences: 11029 (5836)
Seq/√Len: 296.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_A45_V3.9231.00
44_D87_W3.4311.00
36_E197_Y3.2471.00
32_E201_K3.2161.00
340_N343_R3.2011.00
381_E385_K3.1681.00
32_E49_R3.1641.00
111_D172_K3.1271.00
28_I53_S3.1221.00
404_S407_K2.8641.00
22_A108_Q2.8421.00
118_E165_L2.7551.00
230_A284_I2.7251.00
121_V162_K2.7191.00
114_L169_K2.6451.00
110_N222_Y2.5791.00
150_F336_V2.5301.00
174_G221_D2.5101.00
342_K346_D2.4781.00
123_I332_K2.4291.00
114_L165_L2.3981.00
18_N318_I2.3361.00
119_R328_S2.3351.00
283_V311_I2.3281.00
227_A288_M2.2911.00
127_K130_E2.2911.00
35_A42_K2.2871.00
107_K176_E2.2541.00
280_M322_Y2.2081.00
41_P44_D2.1941.00
381_E396_E2.1571.00
133_Y338_P2.1261.00
254_F335_T2.0751.00
197_Y201_K2.0481.00
287_Y316_A2.0311.00
197_Y200_E2.0261.00
121_V165_L1.9881.00
118_E169_K1.9841.00
366_L374_T1.9601.00
194_V198_V1.9551.00
340_N344_N1.9491.00
387_V395_A1.9371.00
126_E332_K1.9331.00
170_Q174_G1.9231.00
126_E130_E1.9001.00
176_E205_K1.8801.00
252_E337_F1.8791.00
343_R347_R1.8771.00
231_T285_R1.8731.00
196_Q200_E1.8621.00
237_A277_M1.8581.00
342_K415_N1.8551.00
390_R409_A1.8451.00
117_L229_I1.8411.00
167_R221_D1.8331.00
42_K46_K1.8321.00
36_E201_K1.8311.00
165_L169_K1.8161.00
178_G199_C1.8071.00
28_I49_R1.8001.00
25_E108_Q1.7941.00
46_K50_E1.7881.00
170_Q173_A1.7521.00
123_I331_V1.7211.00
394_E405_P1.7111.00
413_D416_Y1.6891.00
131_H134_T1.6891.00
125_K162_K1.6851.00
233_I277_M1.6781.00
220_A295_V1.6431.00
164_N232_S1.6411.00
57_N61_E1.6381.00
338_P342_K1.6311.00
121_V158_H1.6201.00
405_P409_A1.6031.00
163_R211_T1.5981.00
374_T377_P1.5831.00
54_F80_S1.5551.00
128_A158_H1.5251.00
407_K410_D1.5091.00
123_I328_S1.5051.00
290_T307_S1.5011.00
58_R79_E1.4941.00
387_V392_L1.4911.00
328_S332_K1.4841.00
163_R217_D1.4611.00
194_V202_L1.4531.00
191_D194_V1.4471.00
45_V49_R1.4371.00
182_G212_Q1.4361.00
227_A292_Y1.4271.00
254_F333_N1.4201.00
127_K131_H1.4181.00
21_Q25_E1.4171.00
289_M293_E1.4111.00
171_A225_T1.3881.00
216_R305_H1.3631.00
70_V74_T1.3511.00
166_E174_G1.3461.00
28_I32_E1.3451.00
125_K129_K1.3421.00
387_V391_E1.3331.00
77_V81_L1.3281.00
374_T402_R1.3261.00
339_E343_R1.3211.00
337_F340_N1.3191.00
223_M291_A1.3191.00
121_V161_M1.3161.00
24_L70_V1.3151.00
252_E335_T1.3141.00
109_A321_N1.3141.00
173_A205_K1.3111.00
114_L172_K1.3101.00
388_P391_E1.3081.00
381_E392_L1.3071.00
77_V80_S1.3061.00
274_S330_I1.2871.00
119_R332_K1.2821.00
327_F332_K1.2811.00
287_Y315_D1.2661.00
116_D325_N1.2661.00
220_A228_L1.2621.00
198_V202_L1.2621.00
224_A228_L1.2601.00
231_T295_V1.2481.00
150_F154_L1.2441.00
76_A80_S1.2411.00
39_V90_Y1.2401.00
106_L222_Y1.2391.00
154_L157_W1.2321.00
285_R293_E1.2271.00
76_A79_E1.2251.00
23_W97_V1.2241.00
123_I126_E1.2121.00
78_S85_R1.2091.00
194_V203_G1.2071.00
47_V50_E1.2041.00
116_D324_L1.2031.00
18_N109_A1.1991.00
191_D198_V1.1981.00
33_A197_Y1.1971.00
157_W300_E1.1751.00
134_T338_P1.1701.00
117_L161_M1.1691.00
222_Y317_T1.1691.00
129_K132_K1.1591.00
120_F161_M1.1561.00
58_R80_S1.1551.00
31_C40_I1.1551.00
131_H338_P1.1541.00
132_K151_G1.1481.00
385_K392_L1.1471.00
180_I198_V1.1431.00
26_V97_V1.1401.00
229_I320_L1.1381.00
291_A312_I1.1351.00
46_K49_R1.1241.00
144_H247_E1.1181.00
150_F341_M1.1101.00
202_L206_A1.1051.00
286_G290_T1.1051.00
183_A264_A1.1041.00
157_W236_F1.0971.00
125_K158_H1.0921.00
223_M316_A1.0911.00
296_P299_H1.0901.00
136_M341_M1.0891.00
240_I274_S1.0841.00
47_V51_N1.0821.00
281_A285_R1.0801.00
168_F229_I1.0791.00
45_V52_A1.0781.00
114_L118_E1.0701.00
120_F331_V1.0701.00
116_D119_R1.0601.00
249_R340_N1.0601.00
116_D321_N1.0561.00
124_I236_F1.0561.00
58_R76_A1.0511.00
288_M292_Y1.0451.00
55_D58_R1.0441.00
234_E278_T1.0431.00
138_G148_T1.0421.00
155_A208_P1.0401.00
380_M384_E1.0401.00
147_P345_M1.0301.00
118_E122_D1.0251.00
233_I323_M1.0161.00
120_F328_S1.0151.00
107_K172_K1.0141.00
133_Y151_G1.0121.00
37_L197_Y1.0121.00
100_T178_G1.0111.00
166_E173_A1.0101.00
110_N172_K1.0051.00
102_L219_H1.0051.00
119_R327_F1.0041.00
144_H246_S1.0021.00
236_F327_F1.0011.00
110_N168_F1.0001.00
225_T229_I0.9961.00
109_A112_I0.9871.00
127_K154_L0.9841.00
172_K176_E0.9831.00
377_P396_E0.9811.00
107_K111_D0.9791.00
177_V206_A0.9781.00
41_P87_W0.9771.00
42_K45_V0.9691.00
381_E384_E0.9611.00
22_A104_Y0.9601.00
123_I327_F0.9601.00
381_E395_A0.9591.00
226_L320_L0.9581.00
366_L375_V0.9571.00
67_R72_A0.9571.00
21_Q108_Q0.9571.00
23_W26_V0.9531.00
134_T341_M0.9521.00
159_E163_R0.9491.00
132_K149_T0.9481.00
365_G411_C0.9421.00
365_G407_K0.9411.00
153_K300_E0.9371.00
378_K392_L0.9361.00
113_L320_L0.9301.00
127_K331_V0.9301.00
17_E21_Q0.9301.00
35_A46_K0.9251.00
117_L165_L0.9241.00
149_T418_L0.9191.00
141_H275_E0.9181.00
43_E46_K0.9171.00
102_L313_L0.9131.00
26_V100_T0.9131.00
170_Q221_D0.9111.00
258_G329_N0.9081.00
21_Q60_L0.9031.00
166_E170_Q0.9021.00
194_V199_C0.8991.00
237_A330_I0.8981.00
91_G192_P0.8961.00
283_V315_D0.8951.00
224_A288_M0.8941.00
242_G298_W0.8931.00
254_F337_F0.8831.00
142_G242_G0.8801.00
242_G248_T0.8801.00
134_T336_V0.8801.00
33_A37_L0.8791.00
173_A176_E0.8781.00
152_L209_I0.8781.00
43_E47_V0.8781.00
223_M288_M0.8771.00
22_A105_L0.8751.00
199_C207_A0.8741.00
124_I154_L0.8691.00
148_T184_V0.8681.00
139_R144_H0.8681.00
135_V418_L0.8671.00
128_A155_A0.8651.00
191_D202_L0.8651.00
107_K204_L0.8641.00
119_R324_L0.8631.00
233_I327_F0.8631.00
284_I320_L0.8631.00
249_R337_F0.8631.00
230_A320_L0.8621.00
32_E197_Y0.8601.00
382_A392_L0.8571.00
36_E42_K0.8551.00
121_V125_K0.8521.00
20_F59_I0.8491.00
57_N60_L0.8451.00
18_N108_Q0.8421.00
124_I331_V0.8411.00
199_C202_L0.8371.00
55_D80_S0.8341.00
199_C203_G0.8321.00
242_G299_H0.8311.00
378_K393_V0.8301.00
254_F257_K0.8291.00
391_E395_A0.8271.00
47_V84_E0.8241.00
394_E409_A0.8171.00
231_T292_Y0.8171.00
130_E335_T0.8161.00
397_E402_R0.8151.00
390_R405_P0.8141.00
215_Q232_S0.8131.00
224_A292_Y0.8131.00
106_L313_L0.8121.00
131_H336_V0.8111.00
198_V203_G0.8021.00
109_A317_T0.8011.00
406_E410_D0.8011.00
67_R75_R0.8011.00
387_V396_E0.8011.00
312_I316_A0.8001.00
124_I158_H0.7960.99
194_V197_Y0.7950.99
122_D126_E0.7950.99
408_I412_F0.7950.99
35_A40_I0.7940.99
58_R63_E0.7930.99
135_V345_M0.7920.99
381_E387_V0.7880.99
163_R177_V0.7870.99
31_C45_V0.7840.99
324_L328_S0.7840.99
123_I127_K0.7830.99
158_H162_K0.7830.99
30_A92_L0.7790.99
285_R289_M0.7760.99
282_R290_T0.7760.99
378_K389_F0.7740.99
178_G198_V0.7730.99
148_T210_S0.7720.99
142_G245_K0.7700.99
112_I321_N0.7680.99
198_V201_K0.7680.99
23_W70_V0.7670.99
58_R62_I0.7630.99
29_L201_K0.7610.99
31_C48_M0.7570.99
47_V81_L0.7560.99
221_D224_A0.7550.99
133_Y415_N0.7500.99
32_E36_E0.7500.99
153_K243_L0.7500.99
390_R394_E0.7490.99
217_D232_S0.7460.99
144_H348_T0.7450.99
219_H313_L0.7450.99
283_V287_Y0.7440.99
75_R79_E0.7440.99
177_V218_R0.7430.99
32_E45_V0.7430.99
51_N81_L0.7400.99
283_V314_P0.7400.99
159_E208_P0.7370.99
277_M327_F0.7350.99
137_M345_M0.7290.99
74_T88_V0.7290.99
116_D328_S0.7220.99
55_D62_I0.7210.99
136_M153_K0.7200.99
139_R247_E0.7180.99
179_K212_Q0.7160.99
56_I60_L0.7100.99
222_Y226_L0.7100.99
82_G85_R0.7100.99
277_M330_I0.7090.99
110_N171_A0.7080.99
284_I319_A0.7070.99
19_R98_V0.7050.99
116_D320_L0.7040.99
378_K396_E0.7030.99
83_E86_K0.7030.99
282_R294_N0.7030.99
124_I161_M0.7010.99
44_D84_E0.7000.99
237_A274_S0.6990.99
52_A74_T0.6980.99
21_Q56_I0.6970.99
385_K396_E0.6940.99
160_E214_L0.6920.99
373_D377_P0.6910.99
131_H150_F0.6900.99
112_I116_D0.6900.99
336_V341_M0.6870.99
166_E169_K0.6870.99
223_M312_I0.6840.98
210_S298_W0.6830.98
240_I334_L0.6820.98
36_E194_V0.6810.98
327_F331_V0.6810.98
366_L403_L0.6790.98
130_E338_P0.6790.98
161_M164_N0.6780.98
346_D390_R0.6760.98
415_N419_K0.6750.98
50_E81_L0.6750.98
222_Y312_I0.6750.98
29_L32_E0.6750.98
160_E232_S0.6680.98
177_V207_A0.6680.98
294_N307_S0.6660.98
103_S218_R0.6660.98
256_A333_N0.6660.98
77_V88_V0.6660.98
219_H291_A0.6650.98
39_V91_G0.6650.98
229_I323_M0.6640.98
134_T149_T0.6630.98
116_D327_F0.6620.98
339_E342_K0.6620.98
31_C88_V0.6620.98
237_A326_R0.6590.98
44_D47_V0.6530.98
238_V278_T0.6520.98
393_V396_E0.6480.98
122_D125_K0.6480.98
164_N228_L0.6480.98
119_R123_I0.6470.98
28_I45_V0.6450.98
387_V393_V0.6430.98
311_I314_P0.6410.98
33_A198_V0.6400.98
251_V334_L0.6400.98
24_L52_A0.6400.98
403_L411_C0.6400.98
377_P381_E0.6390.98
391_E405_P0.6390.98
120_F327_F0.6390.98
106_L312_I0.6380.98
146_E184_V0.6380.98
118_E121_V0.6360.98
392_L396_E0.6350.98
40_I90_Y0.6350.98
196_Q206_A0.6340.97
160_E215_Q0.6340.97
360_A407_K0.6330.97
199_C206_A0.6320.97
290_T312_I0.6320.97
55_D59_I0.6300.97
136_M148_T0.6280.97
128_A132_K0.6280.97
204_L207_A0.6270.97
154_L341_M0.6270.97
211_T232_S0.6260.97
330_I334_L0.6250.97
156_L235_K0.6240.97
176_E204_L0.6230.97
220_A291_A0.6230.97
392_L395_A0.6210.97
110_N175_I0.6210.97
245_K248_T0.6200.97
137_M249_R0.6190.97
129_K133_Y0.6180.97
167_R170_Q0.6170.97
375_V379_A0.6160.97
49_R52_A0.6150.97
323_M327_F0.6140.97
167_R217_D0.6140.97
211_T217_D0.6120.97
360_A363_D0.6120.97
273_G326_R0.6110.97
118_E162_K0.6090.97
14_W109_A0.6080.97
126_E129_K0.6080.97
374_T396_E0.6080.97
220_A292_Y0.6070.97
195_E202_L0.6050.97
110_N114_L0.6050.97
180_I194_V0.6050.97
148_T186_T0.6050.97
214_L300_E0.6030.97
171_A175_I0.6030.97
220_A224_A0.6020.97
134_T342_K0.6020.97
20_F60_L0.6020.97
40_I44_D0.6010.97
219_H312_I0.6000.97
353_Y417_H0.5990.96
111_D169_K0.5980.96
166_E177_V0.5980.96
407_K411_C0.5950.96
403_L407_K0.5940.96
282_R293_E0.5940.96
234_E293_E0.5930.96
277_M322_Y0.5920.96
227_A231_T0.5920.96
33_A201_K0.5920.96
28_I52_A0.5910.96
311_I315_D0.5890.96
199_C205_K0.5870.96
167_R174_G0.5860.96
410_D416_Y0.5860.96
35_A49_R0.5830.96
285_R292_Y0.5830.96
79_E83_E0.5810.96
49_R53_S0.5810.96
58_R61_E0.5800.96
161_M233_I0.5800.96
397_E404_S0.5780.96
230_A323_M0.5760.96
284_I316_A0.5760.96
25_E201_K0.5760.96
37_L194_V0.5740.96
70_V101_A0.5730.95
26_V101_A0.5720.95
113_L226_L0.5720.95
290_T294_N0.5700.95
135_V414_Y0.5700.95
388_P392_L0.5700.95
157_W160_E0.5690.95
410_D413_D0.5690.95
127_K334_L0.5680.95
171_A222_Y0.5660.95
202_L207_A0.5650.95
117_L323_M0.5640.95
87_W90_Y0.5640.95
289_M292_Y0.5630.95
383_W386_Q0.5630.95
161_M327_F0.5630.95
159_E162_K0.5610.95
250_E344_N0.5600.95
164_N167_R0.5600.95
280_M319_A0.5590.95
240_I326_R0.5580.95
290_T308_A0.5570.95
171_A221_D0.5570.95
228_L295_V0.5550.95
237_A278_T0.5530.95
161_M229_I0.5530.95
173_A177_V0.5510.94
139_R248_T0.5500.94
350_G354_S0.5490.94
287_Y314_P0.5450.94
226_L229_I0.5450.94
84_E87_W0.5440.94
162_K166_E0.5440.94
115_K119_R0.5440.94
120_F123_I0.5440.94
25_E29_L0.5430.94
168_F225_T0.5420.94
136_M243_L0.5420.94
382_A387_V0.5410.94
81_L84_E0.5410.94
107_K205_K0.5400.94
149_T419_K0.5400.94
322_Y326_R0.5400.94
258_G333_N0.5400.94
164_N225_T0.5400.94
31_C49_R0.5390.94
191_D195_E0.5390.94
195_E199_C0.5390.94
286_G289_M0.5390.94
114_L225_T0.5380.94
106_L175_I0.5360.94
192_P202_L0.5350.94
338_P341_M0.5350.94
238_V296_P0.5350.94
67_R256_A0.5340.93
125_K128_A0.5320.93
415_N418_L0.5310.93
105_L317_T0.5300.93
167_R228_L0.5290.93
243_L299_H0.5280.93
59_I62_I0.5280.93
154_L334_L0.5270.93
176_E206_A0.5250.93
377_P384_E0.5250.93
44_D48_M0.5240.93
26_V180_I0.5220.93
246_S249_R0.5220.93
94_S179_K0.5210.93
54_F58_R0.5210.93
273_G330_I0.5200.93
179_K213_T0.5200.93
221_D228_L0.5190.92
148_T152_L0.5170.92
234_E296_P0.5160.92
278_T304_S0.5150.92
344_N347_R0.5130.92
394_E408_I0.5130.92
117_L168_F0.5120.92
394_E410_D0.5100.92
153_K239_E0.5090.92
163_R174_G0.5080.92
66_T71_V0.5080.92
24_L77_V0.5050.91
141_H303_I0.5050.91
138_G185_G0.5050.91
351_L382_A0.5050.91
242_G245_K0.5040.91
36_E200_E0.5020.91
48_M77_V0.5010.91
150_F334_L0.5010.91
22_A25_E0.5000.91
91_G191_D0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pfmA 4 0.9977 100 0.103 Contact Map
1c3cA 4 0.9838 100 0.104 Contact Map
4eeiA 4 0.9582 100 0.113 Contact Map
1re5A 4 0.9954 100 0.122 Contact Map
3c8tA 4 0.9606 100 0.125 Contact Map
1q5nA 4 0.9652 100 0.128 Contact Map
1dofA 4 0.877 100 0.164 Contact Map
1k7wA 4 0.9652 100 0.192 Contact Map
2e9fA 4 0.9675 100 0.193 Contact Map
1tj7A 4 0.9838 100 0.193 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.