PUR7 - BACSU - GREMLIN Contacts

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PUR7 - Phosphoribosylaminoimidazole-succinocarboxamide synthase

UniProt:	P12046	Sequences: MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAEISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGSMSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIVNEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFRRNLGSLTDAYEEIFNRLGGIHHV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	241 (218)
Sequences:	3379 (1719)
Seq/√Len:	116.4

ECOLI - PUR7
BACSU - PUR7
HALSA - PUR7
SULSO - PUR7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
94_V	123_Y	4.051	1.00
149_Q	184_L	3.911	1.00
169_D	206_K	3.363	1.00
7_E	19_K	2.906	1.00
25_T	73_I	2.809	1.00
69_N	189_Q	2.784	1.00
88_I	193_A	2.765	1.00
185_D	189_Q	2.688	1.00
95_V	157_T	2.609	1.00
136_E	154_K	2.538	1.00
62_H	163_E	2.530	1.00
147_P	151_E	2.425	1.00
86_V	193_A	2.372	1.00
38_N	130_G	2.320	1.00
77_S	80_E	2.247	1.00
22_D	25_T	2.220	1.00
174_R	209_N	2.110	1.00
140_W	147_P	2.095	1.00
172_H	207_E	2.091	1.00
64_H	70_N	2.088	1.00
84_K	185_D	2.065	1.00
89_V	190_V	2.031	1.00
62_H	167_I	2.026	1.00
152_T	155_S	1.999	1.00
19_K	85_K	1.966	1.00
61_K	64_H	1.820	1.00
98_V	176_I	1.784	1.00
166_S	170_D	1.760	1.00
152_T	189_Q	1.745	1.00
59_I	168_F	1.624	1.00
65_A	163_E	1.593	1.00
16_K	29_V	1.591	1.00
155_S	159_I	1.577	1.00
98_V	114_E	1.529	1.00
120_I	139_I	1.519	1.00
37_F	222_G	1.519	1.00
152_T	156_I	1.516	1.00
26_L	83_I	1.509	1.00
40_E	130_G	1.507	1.00
57_S	72_F	1.480	1.00
20_T	82_L	1.470	1.00
47_G	50_R	1.463	1.00
37_F	40_E	1.446	1.00
185_D	191_L	1.445	1.00
184_L	190_V	1.411	1.00
33_S	44_E	1.410	1.00
98_V	174_R	1.402	1.00
41_K	217_F	1.401	1.00
24_N	85_K	1.396	1.00
99_V	113_T	1.370	1.00
57_S	75_R	1.363	1.00
114_E	169_D	1.361	1.00
57_S	81_Q	1.334	1.00
8_L	16_K	1.333	1.00
114_E	165_Q	1.329	1.00
175_L	203_L	1.320	1.00
93_V	153_I	1.313	1.00
43_A	217_F	1.295	1.00
97_N	161_N	1.284	0.99
11_E	16_K	1.283	0.99
220_N	224_L	1.279	0.99
50_R	78_E	1.274	0.99
95_V	158_T	1.273	0.99
91_L	139_I	1.272	0.99
149_Q	190_V	1.271	0.99
93_V	157_T	1.268	0.99
165_Q	169_D	1.267	0.99
160_V	180_L	1.266	0.99
106_R	110_P	1.265	0.99
173_V	203_L	1.256	0.99
215_D	219_R	1.253	0.99
34_A	217_F	1.252	0.99
103_M	115_L	1.238	0.99
30_Y	53_N	1.228	0.99
168_F	203_L	1.227	0.99
56_S	60_F	1.220	0.99
50_R	54_E	1.219	0.99
138_H	143_K	1.219	0.99
89_V	149_Q	1.218	0.99
159_I	163_E	1.216	0.99
156_I	159_I	1.208	0.99
151_E	155_S	1.186	0.99
122_F	139_I	1.181	0.99
167_I	171_C	1.178	0.99
17_I	28_V	1.174	0.99
162_E	166_S	1.147	0.99
58_L	62_H	1.140	0.99
136_E	150_V	1.140	0.99
89_V	153_I	1.140	0.99
86_V	185_D	1.134	0.99
137_D	154_K	1.126	0.99
146_T	149_Q	1.113	0.99
123_Y	133_L	1.109	0.99
205_D	208_T	1.104	0.98
117_Q	162_E	1.103	0.98
69_N	156_I	1.101	0.98
20_T	25_T	1.098	0.98
103_M	107_L	1.096	0.98
50_R	79_T	1.092	0.98
192_L	196_I	1.090	0.98
99_V	104_S	1.089	0.98
58_L	167_I	1.069	0.98
87_T	184_L	1.069	0.98
16_K	31_K	1.061	0.98
116_E	143_K	1.060	0.98
53_N	81_Q	1.059	0.98
162_E	165_Q	1.057	0.98
25_T	82_L	1.046	0.98
29_V	79_T	1.043	0.98
8_L	11_E	1.030	0.98
54_E	78_E	1.027	0.98
106_R	111_E	1.023	0.97
134_I	144_A	1.022	0.97
91_L	134_I	1.021	0.97
57_S	61_K	1.015	0.97
105_K	222_G	1.012	0.97
29_V	80_E	1.006	0.97
51_L	55_I	0.998	0.97
61_K	72_F	0.996	0.97
140_W	150_V	0.996	0.97
93_V	120_I	0.983	0.97
223_S	226_D	0.979	0.97
54_E	75_R	0.978	0.97
152_T	190_V	0.976	0.97
156_I	160_V	0.972	0.97
54_E	57_S	0.965	0.96
63_L	67_G	0.961	0.96
100_A	112_G	0.958	0.96
26_L	85_K	0.952	0.96
11_E	31_K	0.950	0.96
174_R	206_K	0.946	0.96
224_L	227_A	0.944	0.96
89_V	184_L	0.943	0.96
223_S	227_A	0.938	0.96
24_N	186_A	0.938	0.96
99_V	115_L	0.934	0.96
84_K	191_L	0.931	0.96
73_I	84_K	0.929	0.96
159_I	162_E	0.928	0.96
154_K	158_T	0.928	0.96
76_I	80_E	0.918	0.95
62_H	65_A	0.917	0.95
93_V	182_F	0.911	0.95
72_F	81_Q	0.907	0.95
32_D	46_S	0.901	0.95
196_I	200_T	0.901	0.95
61_K	65_A	0.895	0.95
167_I	170_D	0.892	0.94
17_I	26_L	0.888	0.94
139_I	150_V	0.880	0.94
28_V	83_I	0.878	0.94
156_I	190_V	0.874	0.94
126_D	130_G	0.873	0.94
116_E	165_Q	0.866	0.94
69_N	191_L	0.864	0.93
135_T	138_H	0.863	0.93
137_D	140_W	0.860	0.93
122_F	150_V	0.858	0.93
87_T	186_A	0.857	0.93
27_Y	76_I	0.855	0.93
136_E	151_E	0.850	0.93
111_E	211_K	0.837	0.92
149_Q	152_T	0.831	0.92
102_S	133_L	0.830	0.92
119_I	135_T	0.830	0.92
21_D	24_N	0.829	0.92
185_D	188_G	0.829	0.92
55_I	198_P	0.826	0.92
160_V	196_I	0.826	0.92
29_V	77_S	0.826	0.92
211_K	219_R	0.824	0.92
86_V	191_L	0.820	0.92
59_I	203_L	0.820	0.92
145_A	153_I	0.811	0.91
87_T	188_G	0.810	0.91
140_W	143_K	0.806	0.91
21_D	25_T	0.802	0.91
45_I	225_T	0.800	0.91
104_S	109_I	0.792	0.90
60_F	81_Q	0.784	0.90
120_I	157_T	0.782	0.90
166_S	169_D	0.778	0.89
8_L	18_Y	0.777	0.89
138_H	144_A	0.775	0.89
76_I	82_L	0.773	0.89
84_K	186_A	0.767	0.89
106_R	138_H	0.763	0.88
37_F	130_G	0.760	0.88
36_A	221_L	0.760	0.88
10_Y	17_I	0.753	0.88
68_I	156_I	0.750	0.88
122_F	154_K	0.745	0.87
72_F	75_R	0.744	0.87
180_L	200_T	0.743	0.87
107_L	138_H	0.743	0.87
104_S	113_T	0.740	0.87
34_A	45_I	0.738	0.87
205_D	210_E	0.737	0.87
104_S	219_R	0.730	0.86
109_I	113_T	0.725	0.86
73_I	82_L	0.721	0.85
120_I	158_T	0.720	0.85
19_K	26_L	0.720	0.85
90_P	127_D	0.717	0.85
126_D	132_P	0.716	0.85
120_I	153_I	0.716	0.85
32_D	44_E	0.714	0.85
151_E	154_K	0.714	0.85
37_F	41_K	0.712	0.85
43_A	225_T	0.700	0.84
145_A	149_Q	0.700	0.84
136_E	147_P	0.697	0.83
60_F	71_H	0.697	0.83
99_V	103_M	0.690	0.83
61_K	74_E	0.687	0.83
20_T	27_Y	0.683	0.82
119_I	137_D	0.682	0.82
69_N	84_K	0.677	0.82
103_M	109_I	0.676	0.82
6_N	19_K	0.675	0.81
134_I	138_H	0.674	0.81
115_L	118_P	0.673	0.81
96_R	177_D	0.672	0.81
90_P	193_A	0.670	0.81
64_H	69_N	0.665	0.80
150_V	154_K	0.665	0.80
161_N	165_Q	0.664	0.80
216_L	224_L	0.663	0.80
136_E	139_I	0.662	0.80
9_L	26_L	0.659	0.80
107_L	134_I	0.656	0.80
67_G	159_I	0.653	0.79
205_D	212_L	0.648	0.79
137_D	158_T	0.647	0.79
110_P	113_T	0.643	0.78
153_I	190_V	0.642	0.78
59_I	164_L	0.638	0.78
95_V	120_I	0.637	0.78
112_G	204_W	0.634	0.77
92_E	131_D	0.633	0.77
120_I	154_K	0.633	0.77
8_L	17_I	0.632	0.77
32_D	79_T	0.632	0.77
87_T	149_Q	0.629	0.77
20_T	24_N	0.627	0.76
100_A	104_S	0.627	0.76
41_K	220_N	0.626	0.76
182_F	190_V	0.625	0.76
145_A	150_V	0.622	0.76
172_H	206_K	0.621	0.76
70_N	191_L	0.618	0.75
74_E	77_S	0.614	0.75
98_V	209_N	0.613	0.75
122_F	153_I	0.612	0.75
134_I	139_I	0.609	0.74
91_L	144_A	0.608	0.74
56_S	195_E	0.606	0.74
136_E	140_W	0.605	0.74
122_F	140_W	0.605	0.74
94_V	153_I	0.603	0.74
8_L	19_K	0.597	0.73
99_V	109_I	0.590	0.72
103_M	106_R	0.590	0.72
53_N	57_S	0.590	0.72
43_A	224_L	0.588	0.72
105_K	215_D	0.587	0.72
148_E	151_E	0.582	0.71
163_E	167_I	0.578	0.71
111_E	219_R	0.577	0.70
100_A	222_G	0.577	0.70
173_V	212_L	0.573	0.70
74_E	82_L	0.571	0.70
104_S	108_G	0.570	0.69
63_L	163_E	0.568	0.69
24_N	84_K	0.566	0.69
118_P	158_T	0.565	0.69
211_K	221_L	0.565	0.69
19_K	24_N	0.565	0.69
67_G	70_N	0.565	0.69
63_L	70_N	0.564	0.69
64_H	67_G	0.564	0.69
195_E	198_P	0.563	0.69
53_N	80_E	0.560	0.68
160_V	192_L	0.559	0.68
100_A	111_E	0.557	0.68
169_D	174_R	0.556	0.68
63_L	160_V	0.556	0.68
180_L	196_I	0.554	0.67
10_Y	127_D	0.552	0.67
22_D	85_K	0.549	0.67
59_I	204_W	0.547	0.66
107_L	133_L	0.547	0.66
114_E	152_T	0.547	0.66
178_F	201_C	0.545	0.66
106_R	121_E	0.544	0.66
132_P	138_H	0.543	0.66
211_K	216_L	0.542	0.66
171_C	203_L	0.542	0.66
176_I	204_W	0.542	0.66
7_E	20_T	0.536	0.65
197_S	201_C	0.536	0.65
113_T	116_E	0.535	0.65
126_D	144_A	0.534	0.64
126_D	129_L	0.534	0.64
14_A	200_T	0.530	0.64
98_V	201_C	0.530	0.64
48_K	199_D	0.526	0.63
170_D	189_Q	0.525	0.63
63_L	196_I	0.524	0.63
39_G	42_K	0.524	0.63
216_L	227_A	0.522	0.63
27_Y	80_E	0.520	0.62
6_N	21_D	0.519	0.62
205_D	216_L	0.519	0.62
214_K	218_R	0.518	0.62
106_R	133_L	0.517	0.62
47_G	51_L	0.513	0.61
28_V	81_Q	0.511	0.61
100_A	219_R	0.508	0.61
53_N	60_F	0.508	0.61
215_D	222_G	0.506	0.60
59_I	167_I	0.505	0.60
152_T	159_I	0.505	0.60
86_V	186_A	0.502	0.60
105_K	108_G	0.502	0.60
89_V	193_A	0.501	0.60
58_L	61_K	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kreA	2	0.971	100	0.039	Contact Map
2gqrA	2	0.9834	100	0.045	Contact Map
2ywvA	2	0.9834	100	0.047	Contact Map
3nuaA	2	0.9751	100	0.048	Contact Map
2z02A	2	0.9834	100	0.053	Contact Map
4fe2A	2	0.971	100	0.058	Contact Map
1kutA	2	0.9295	100	0.078	Contact Map
3u55A	2	0.9378	100	0.085	Contact Map
2h31A	6	0.8755	100	0.09	Contact Map
4ja0A	6	0.9544	100	0.091	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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