GREMLIN Database
PUR7 - Phosphoribosylaminoimidazole-succinocarboxamide synthase
UniProt: P12046 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (218)
Sequences: 3379 (1719)
Seq/√Len: 116.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_V123_Y4.0511.00
149_Q184_L3.9111.00
169_D206_K3.3631.00
7_E19_K2.9061.00
25_T73_I2.8091.00
69_N189_Q2.7841.00
88_I193_A2.7651.00
185_D189_Q2.6881.00
95_V157_T2.6091.00
136_E154_K2.5381.00
62_H163_E2.5301.00
147_P151_E2.4251.00
86_V193_A2.3721.00
38_N130_G2.3201.00
77_S80_E2.2471.00
22_D25_T2.2201.00
174_R209_N2.1101.00
140_W147_P2.0951.00
172_H207_E2.0911.00
64_H70_N2.0881.00
84_K185_D2.0651.00
89_V190_V2.0311.00
62_H167_I2.0261.00
152_T155_S1.9991.00
19_K85_K1.9661.00
61_K64_H1.8201.00
98_V176_I1.7841.00
166_S170_D1.7601.00
152_T189_Q1.7451.00
59_I168_F1.6241.00
65_A163_E1.5931.00
16_K29_V1.5911.00
155_S159_I1.5771.00
98_V114_E1.5291.00
120_I139_I1.5191.00
37_F222_G1.5191.00
152_T156_I1.5161.00
26_L83_I1.5091.00
40_E130_G1.5071.00
57_S72_F1.4801.00
20_T82_L1.4701.00
47_G50_R1.4631.00
37_F40_E1.4461.00
185_D191_L1.4451.00
184_L190_V1.4111.00
33_S44_E1.4101.00
98_V174_R1.4021.00
41_K217_F1.4011.00
24_N85_K1.3961.00
99_V113_T1.3701.00
57_S75_R1.3631.00
114_E169_D1.3611.00
57_S81_Q1.3341.00
8_L16_K1.3331.00
114_E165_Q1.3291.00
175_L203_L1.3201.00
93_V153_I1.3131.00
43_A217_F1.2951.00
97_N161_N1.2840.99
11_E16_K1.2830.99
220_N224_L1.2790.99
50_R78_E1.2740.99
95_V158_T1.2730.99
91_L139_I1.2720.99
149_Q190_V1.2710.99
93_V157_T1.2680.99
165_Q169_D1.2670.99
160_V180_L1.2660.99
106_R110_P1.2650.99
173_V203_L1.2560.99
215_D219_R1.2530.99
34_A217_F1.2520.99
103_M115_L1.2380.99
30_Y53_N1.2280.99
168_F203_L1.2270.99
56_S60_F1.2200.99
50_R54_E1.2190.99
138_H143_K1.2190.99
89_V149_Q1.2180.99
159_I163_E1.2160.99
156_I159_I1.2080.99
151_E155_S1.1860.99
122_F139_I1.1810.99
167_I171_C1.1780.99
17_I28_V1.1740.99
162_E166_S1.1470.99
58_L62_H1.1400.99
136_E150_V1.1400.99
89_V153_I1.1400.99
86_V185_D1.1340.99
137_D154_K1.1260.99
146_T149_Q1.1130.99
123_Y133_L1.1090.99
205_D208_T1.1040.98
117_Q162_E1.1030.98
69_N156_I1.1010.98
20_T25_T1.0980.98
103_M107_L1.0960.98
50_R79_T1.0920.98
192_L196_I1.0900.98
99_V104_S1.0890.98
58_L167_I1.0690.98
87_T184_L1.0690.98
16_K31_K1.0610.98
116_E143_K1.0600.98
53_N81_Q1.0590.98
162_E165_Q1.0570.98
25_T82_L1.0460.98
29_V79_T1.0430.98
8_L11_E1.0300.98
54_E78_E1.0270.98
106_R111_E1.0230.97
134_I144_A1.0220.97
91_L134_I1.0210.97
57_S61_K1.0150.97
105_K222_G1.0120.97
29_V80_E1.0060.97
51_L55_I0.9980.97
61_K72_F0.9960.97
140_W150_V0.9960.97
93_V120_I0.9830.97
223_S226_D0.9790.97
54_E75_R0.9780.97
152_T190_V0.9760.97
156_I160_V0.9720.97
54_E57_S0.9650.96
63_L67_G0.9610.96
100_A112_G0.9580.96
26_L85_K0.9520.96
11_E31_K0.9500.96
174_R206_K0.9460.96
224_L227_A0.9440.96
89_V184_L0.9430.96
223_S227_A0.9380.96
24_N186_A0.9380.96
99_V115_L0.9340.96
84_K191_L0.9310.96
73_I84_K0.9290.96
159_I162_E0.9280.96
154_K158_T0.9280.96
76_I80_E0.9180.95
62_H65_A0.9170.95
93_V182_F0.9110.95
72_F81_Q0.9070.95
32_D46_S0.9010.95
196_I200_T0.9010.95
61_K65_A0.8950.95
167_I170_D0.8920.94
17_I26_L0.8880.94
139_I150_V0.8800.94
28_V83_I0.8780.94
156_I190_V0.8740.94
126_D130_G0.8730.94
116_E165_Q0.8660.94
69_N191_L0.8640.93
135_T138_H0.8630.93
137_D140_W0.8600.93
122_F150_V0.8580.93
87_T186_A0.8570.93
27_Y76_I0.8550.93
136_E151_E0.8500.93
111_E211_K0.8370.92
149_Q152_T0.8310.92
102_S133_L0.8300.92
119_I135_T0.8300.92
21_D24_N0.8290.92
185_D188_G0.8290.92
55_I198_P0.8260.92
160_V196_I0.8260.92
29_V77_S0.8260.92
211_K219_R0.8240.92
86_V191_L0.8200.92
59_I203_L0.8200.92
145_A153_I0.8110.91
87_T188_G0.8100.91
140_W143_K0.8060.91
21_D25_T0.8020.91
45_I225_T0.8000.91
104_S109_I0.7920.90
60_F81_Q0.7840.90
120_I157_T0.7820.90
166_S169_D0.7780.89
8_L18_Y0.7770.89
138_H144_A0.7750.89
76_I82_L0.7730.89
84_K186_A0.7670.89
106_R138_H0.7630.88
37_F130_G0.7600.88
36_A221_L0.7600.88
10_Y17_I0.7530.88
68_I156_I0.7500.88
122_F154_K0.7450.87
72_F75_R0.7440.87
180_L200_T0.7430.87
107_L138_H0.7430.87
104_S113_T0.7400.87
34_A45_I0.7380.87
205_D210_E0.7370.87
104_S219_R0.7300.86
109_I113_T0.7250.86
73_I82_L0.7210.85
120_I158_T0.7200.85
19_K26_L0.7200.85
90_P127_D0.7170.85
126_D132_P0.7160.85
120_I153_I0.7160.85
32_D44_E0.7140.85
151_E154_K0.7140.85
37_F41_K0.7120.85
43_A225_T0.7000.84
145_A149_Q0.7000.84
136_E147_P0.6970.83
60_F71_H0.6970.83
99_V103_M0.6900.83
61_K74_E0.6870.83
20_T27_Y0.6830.82
119_I137_D0.6820.82
69_N84_K0.6770.82
103_M109_I0.6760.82
6_N19_K0.6750.81
134_I138_H0.6740.81
115_L118_P0.6730.81
96_R177_D0.6720.81
90_P193_A0.6700.81
64_H69_N0.6650.80
150_V154_K0.6650.80
161_N165_Q0.6640.80
216_L224_L0.6630.80
136_E139_I0.6620.80
9_L26_L0.6590.80
107_L134_I0.6560.80
67_G159_I0.6530.79
205_D212_L0.6480.79
137_D158_T0.6470.79
110_P113_T0.6430.78
153_I190_V0.6420.78
59_I164_L0.6380.78
95_V120_I0.6370.78
112_G204_W0.6340.77
92_E131_D0.6330.77
120_I154_K0.6330.77
8_L17_I0.6320.77
32_D79_T0.6320.77
87_T149_Q0.6290.77
20_T24_N0.6270.76
100_A104_S0.6270.76
41_K220_N0.6260.76
182_F190_V0.6250.76
145_A150_V0.6220.76
172_H206_K0.6210.76
70_N191_L0.6180.75
74_E77_S0.6140.75
98_V209_N0.6130.75
122_F153_I0.6120.75
134_I139_I0.6090.74
91_L144_A0.6080.74
56_S195_E0.6060.74
136_E140_W0.6050.74
122_F140_W0.6050.74
94_V153_I0.6030.74
8_L19_K0.5970.73
99_V109_I0.5900.72
103_M106_R0.5900.72
53_N57_S0.5900.72
43_A224_L0.5880.72
105_K215_D0.5870.72
148_E151_E0.5820.71
163_E167_I0.5780.71
111_E219_R0.5770.70
100_A222_G0.5770.70
173_V212_L0.5730.70
74_E82_L0.5710.70
104_S108_G0.5700.69
63_L163_E0.5680.69
24_N84_K0.5660.69
118_P158_T0.5650.69
211_K221_L0.5650.69
19_K24_N0.5650.69
67_G70_N0.5650.69
63_L70_N0.5640.69
64_H67_G0.5640.69
195_E198_P0.5630.69
53_N80_E0.5600.68
160_V192_L0.5590.68
100_A111_E0.5570.68
169_D174_R0.5560.68
63_L160_V0.5560.68
180_L196_I0.5540.67
10_Y127_D0.5520.67
22_D85_K0.5490.67
59_I204_W0.5470.66
107_L133_L0.5470.66
114_E152_T0.5470.66
178_F201_C0.5450.66
106_R121_E0.5440.66
132_P138_H0.5430.66
211_K216_L0.5420.66
171_C203_L0.5420.66
176_I204_W0.5420.66
7_E20_T0.5360.65
197_S201_C0.5360.65
113_T116_E0.5350.65
126_D144_A0.5340.64
126_D129_L0.5340.64
14_A200_T0.5300.64
98_V201_C0.5300.64
48_K199_D0.5260.63
170_D189_Q0.5250.63
63_L196_I0.5240.63
39_G42_K0.5240.63
216_L227_A0.5220.63
27_Y80_E0.5200.62
6_N21_D0.5190.62
205_D216_L0.5190.62
214_K218_R0.5180.62
106_R133_L0.5170.62
47_G51_L0.5130.61
28_V81_Q0.5110.61
100_A219_R0.5080.61
53_N60_F0.5080.61
215_D222_G0.5060.60
59_I167_I0.5050.60
152_T159_I0.5050.60
86_V186_A0.5020.60
105_K108_G0.5020.60
89_V193_A0.5010.60
58_L61_K0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kreA 2 0.971 100 0.039 Contact Map
2gqrA 2 0.9834 100 0.045 Contact Map
2ywvA 2 0.9834 100 0.047 Contact Map
3nuaA 2 0.9751 100 0.048 Contact Map
2z02A 2 0.9834 100 0.053 Contact Map
4fe2A 2 0.971 100 0.058 Contact Map
1kutA 2 0.9295 100 0.078 Contact Map
3u55A 2 0.9378 100 0.085 Contact Map
2h31A 6 0.8755 100 0.09 Contact Map
4ja0A 6 0.9544 100 0.091 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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