GREMLIN Database
PURK - N5-carboxyaminoimidazole ribonucleotide synthase
UniProt: P12045 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (357)
Sequences: 24068 (13491)
Seq/√Len: 714.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_Q165_E3.4841.00
124_P184_S3.2151.00
164_E167_Q3.1601.00
135_K169_E2.9881.00
11_V34_K2.9701.00
238_D242_K2.9231.00
130_T133_E2.8201.00
357_K362_E2.7181.00
87_H103_L2.5291.00
143_L165_E2.5201.00
241_V245_D2.4211.00
126_S140_E2.4141.00
359_P362_E2.3641.00
60_D63_A2.3631.00
295_R300_L2.2511.00
115_I243_L2.2361.00
87_H91_D2.2331.00
239_L242_K2.1891.00
229_E232_I2.1701.00
27_S30_Q2.1651.00
117_S246_E2.1041.00
337_Y340_G2.0921.00
230_K234_Q2.0571.00
260_T264_E2.0181.00
163_K167_Q2.0021.00
88_W92_H1.9941.00
234_Q238_D1.9291.00
165_E169_E1.9221.00
235_K264_E1.8991.00
341_K344_I1.8841.00
161_V185_W1.8541.00
187_S261_E1.8531.00
335_K338_I1.8511.00
82_D106_Q1.8451.00
113_K117_S1.8241.00
110_T113_K1.8231.00
137_A141_L1.8161.00
14_I25_A1.8011.00
235_K238_D1.7891.00
137_A140_E1.7791.00
291_E295_R1.7711.00
358_Q362_E1.7421.00
109_E127_I1.7231.00
224_V284_L1.7141.00
239_L265_L1.7051.00
65_R92_H1.7031.00
109_E113_K1.6921.00
169_E173_A1.6911.00
334_A337_Y1.6821.00
41_V55_T1.6821.00
103_L110_T1.6681.00
198_R204_I1.6661.00
232_I235_K1.6611.00
340_G343_E1.6571.00
326_E329_E1.6501.00
113_K116_Q1.6401.00
292_Q303_G1.6341.00
104_I114_A1.6271.00
135_K165_E1.6271.00
335_K339_Y1.6221.00
131_K169_E1.6191.00
54_I67_L1.6121.00
61_R88_W1.5951.00
234_Q237_A1.5801.00
163_K187_S1.5761.00
29_K51_D1.5731.00
98_G101_L1.5651.00
30_Q291_E1.5641.00
115_I267_V1.5531.00
286_E306_D1.5481.00
314_V367_I1.5471.00
131_K135_K1.5451.00
335_K340_G1.5401.00
339_Y342_H1.5341.00
170_Q174_L1.5101.00
121_E264_E1.5051.00
74_I94_Y1.5041.00
286_E308_L1.5021.00
145_A182_L1.5001.00
114_A246_E1.4981.00
242_K245_D1.4941.00
131_K173_A1.4911.00
197_V292_Q1.4851.00
116_Q124_P1.4841.00
12_I95_L1.4801.00
338_I341_K1.4741.00
28_A35_V1.4711.00
118_A246_E1.4671.00
112_K183_E1.4631.00
63_A66_K1.4511.00
27_S291_E1.4511.00
232_I259_L1.4431.00
90_K99_S1.4411.00
136_Q140_E1.4241.00
237_A241_V1.4241.00
104_I110_T1.4241.00
88_W91_D1.4191.00
126_S137_A1.3961.00
197_V252_P1.3931.00
199_S203_E1.3861.00
61_R65_R1.3851.00
11_V36_A1.3701.00
111_E115_I1.3701.00
283_D354_T1.3671.00
135_K139_Q1.3631.00
150_C179_T1.3621.00
114_A118_A1.3611.00
138_V143_L1.3591.00
192_L259_L1.3561.00
114_A117_S1.3521.00
107_N150_C1.3521.00
90_K98_G1.3481.00
229_E263_G1.3351.00
184_S266_L1.3251.00
326_E331_L1.3241.00
328_P331_L1.3201.00
129_K133_E1.3181.00
47_G53_E1.3141.00
235_K239_L1.3131.00
129_K179_T1.2961.00
89_L94_Y1.2941.00
116_Q122_V1.2921.00
326_E330_L1.2881.00
62_E88_W1.2881.00
136_Q139_Q1.2821.00
100_E104_I1.2781.00
337_Y341_K1.2771.00
283_D356_M1.2761.00
13_G38_V1.2761.00
131_K172_A1.2701.00
361_D365_Q1.2591.00
12_I28_A1.2501.00
132_N135_K1.2481.00
197_V296_A1.2421.00
194_V236_A1.2351.00
26_V30_Q1.2311.00
113_K125_Y1.2231.00
317_L348_R1.2211.00
230_K233_Q1.2201.00
143_L164_E1.2081.00
146_V161_V1.2061.00
37_V52_V1.2021.00
109_E150_C1.2001.00
186_V268_N1.1981.00
340_G344_I1.1971.00
133_E136_Q1.1911.00
132_N136_Q1.1891.00
34_K52_V1.1841.00
196_V244_A1.1791.00
85_A89_L1.1751.00
327_D330_L1.1551.00
196_V240_A1.1471.00
339_Y343_E1.1411.00
121_E239_L1.1341.00
336_L340_G1.1311.00
337_Y343_E1.1281.00
138_V145_A1.1271.00
233_Q237_A1.1221.00
31_M295_R1.1151.00
128_V137_A1.1121.00
228_V232_I1.1081.00
24_M75_T1.1021.00
335_K343_E1.1021.00
105_T270_L1.1011.00
112_K122_V1.1011.00
357_K366_E1.1001.00
355_F367_I1.0941.00
160_F174_L1.0911.00
353_I370_K1.0901.00
33_Y298_C1.0881.00
204_I241_V1.0861.00
74_I89_L1.0811.00
13_G68_A1.0791.00
362_E366_E1.0711.00
231_G235_K1.0711.00
196_V253_L1.0691.00
116_Q125_Y1.0651.00
124_P140_E1.0641.00
336_L339_Y1.0601.00
87_H100_E1.0591.00
259_L265_L1.0591.00
206_T237_A1.0561.00
368_T372_M1.0531.00
190_M211_E1.0501.00
357_K363_W1.0401.00
364_I368_T1.0391.00
127_I179_T1.0391.00
329_E332_K1.0361.00
301_P304_K1.0341.00
146_V185_W1.0301.00
124_P141_L1.0231.00
98_G250_V1.0221.00
334_A338_I1.0151.00
243_L246_E1.0131.00
196_V255_V1.0111.00
52_V69_E1.0091.00
160_F175_L1.0091.00
68_A94_Y1.0061.00
208_P233_Q1.0041.00
188_F261_E1.0041.00
369_N372_M1.0001.00
139_Q169_E0.9921.00
166_A170_Q0.9881.00
87_H99_S0.9861.00
170_Q173_A0.9821.00
143_L168_M0.9821.00
120_C267_V0.9811.00
141_L145_A0.9801.00
134_L168_M0.9761.00
335_K342_H0.9681.00
243_L247_L0.9661.00
160_F171_A0.9611.00
65_R88_W0.9591.00
366_E369_N0.9591.00
240_A257_M0.9591.00
167_Q170_Q0.9531.00
240_A255_V0.9521.00
205_S304_K0.9511.00
327_D331_L0.9461.00
11_V72_D0.9451.00
54_I69_E0.9381.00
12_I33_Y0.9381.00
198_R245_D0.9381.00
39_D44_S0.9341.00
100_E103_L0.9301.00
212_N218_I0.9241.00
194_V237_A0.9131.00
255_V270_L0.9131.00
282_L354_T0.9131.00
328_P332_K0.9121.00
287_T292_Q0.9111.00
25_A35_V0.9051.00
138_V168_M0.9051.00
187_S260_T0.9051.00
244_A253_L0.9051.00
105_T247_L0.9051.00
198_R244_A0.9041.00
208_P224_V0.9021.00
12_I294_I0.9011.00
145_A162_I0.9001.00
162_I171_A0.9001.00
292_Q295_R0.8991.00
244_A247_L0.8981.00
274_P289_Q0.8951.00
365_Q369_N0.8931.00
147_L162_I0.8901.00
334_A340_G0.8891.00
334_A343_E0.8881.00
203_E245_D0.8801.00
28_A294_I0.8771.00
310_P358_Q0.8751.00
326_E332_K0.8741.00
330_L333_E0.8721.00
336_L341_K0.8701.00
109_E179_T0.8671.00
147_L171_A0.8661.00
62_E66_K0.8611.00
107_N151_R0.8611.00
339_Y344_I0.8601.00
87_H90_K0.8601.00
294_I298_C0.8581.00
337_Y342_H0.8571.00
355_F370_K0.8561.00
336_L344_I0.8541.00
331_L334_A0.8541.00
194_V240_A0.8501.00
146_V159_Q0.8491.00
334_A339_Y0.8461.00
231_G234_Q0.8401.00
235_K265_L0.8381.00
133_E137_A0.8361.00
31_M291_E0.8341.00
13_G71_S0.8311.00
211_E227_R0.8271.00
258_F268_N0.8271.00
67_L71_S0.8261.00
312_M363_W0.8251.00
172_A180_C0.8251.00
75_T293_H0.8191.00
314_V322_K0.8161.00
236_A265_L0.8151.00
151_R177_H0.8141.00
308_L356_M0.8111.00
338_I343_E0.8071.00
31_M288_S0.8051.00
128_V134_L0.7981.00
28_A33_Y0.7971.00
28_A75_T0.7971.00
242_K246_E0.7961.00
186_V266_L0.7911.00
79_E82_D0.7901.00
288_S291_E0.7901.00
238_D241_V0.7851.00
33_Y294_I0.7831.00
189_K261_E0.7831.00
147_L180_C0.7821.00
175_L180_C0.7811.00
25_A50_A0.7801.00
89_L92_H0.7771.00
37_V50_A0.7771.00
334_A341_K0.7761.00
134_L172_A0.7761.00
334_A342_H0.7701.00
166_A169_E0.7701.00
313_M321_V0.7671.00
314_V352_H0.7651.00
317_L321_V0.7631.00
202_G245_D0.7631.00
121_E266_L0.7611.00
194_V209_T0.7611.00
116_Q126_S0.7571.00
39_D53_E0.7561.00
107_N179_T0.7561.00
90_K100_E0.7551.00
209_T233_Q0.7551.00
335_K344_I0.7501.00
201_N301_P0.7481.00
223_I360_E0.7481.00
295_R298_C0.7461.00
101_L248_N0.7451.00
11_V52_V0.7451.00
197_V207_F0.7451.00
231_G263_G0.7441.00
362_E365_Q0.7421.00
126_S133_E0.7411.00
90_K250_V0.7401.00
184_S260_T0.7391.00
98_G248_N0.7381.00
204_I245_D0.7371.00
215_H218_I0.7361.00
206_T241_V0.7351.00
328_P333_E0.7331.00
85_A88_W0.7291.00
14_I28_A0.7271.00
232_I263_G0.7261.00
335_K341_K0.7251.00
279_H282_L0.7251.00
355_F363_W0.7211.00
312_M364_I0.7201.00
338_I342_H0.7141.00
317_L322_K0.7121.00
41_V44_S0.7111.00
312_M322_K0.7061.00
314_V319_D0.7011.00
86_L89_L0.7001.00
110_T114_A0.6971.00
329_E363_W0.6961.00
68_A74_I0.6951.00
313_M316_L0.6911.00
228_V233_Q0.6901.00
319_D322_K0.6901.00
312_M321_V0.6881.00
186_V260_T0.6881.00
313_M322_K0.6841.00
315_N318_G0.6831.00
22_K48_Q0.6821.00
12_I35_V0.6811.00
214_H219_L0.6771.00
44_S47_G0.6751.00
138_V142_R0.6741.00
61_R85_A0.6731.00
56_A63_A0.6721.00
34_K51_D0.6711.00
50_A53_E0.6711.00
243_L270_L0.6701.00
367_I371_W0.6651.00
361_D364_I0.6631.00
86_L90_K0.6621.00
162_I168_M0.6611.00
38_V56_A0.6601.00
314_V321_V0.6591.00
147_L172_A0.6541.00
107_N110_T0.6541.00
15_I85_A0.6541.00
310_P356_M0.6541.00
260_T266_L0.6541.00
171_A175_L0.6531.00
11_V37_V0.6521.00
109_E181_I0.6511.00
138_V165_E0.6511.00
236_A242_K0.6511.00
337_Y344_I0.6511.00
333_E366_E0.6501.00
300_L304_K0.6501.00
141_L184_S0.6481.00
150_C181_I0.6481.00
323_L327_D0.6481.00
192_L236_A0.6481.00
190_M259_L0.6471.00
316_L319_D0.6451.00
210_A222_S0.6451.00
209_T226_A0.6441.00
198_R250_V0.6431.00
216_N219_L0.6411.00
329_E333_E0.6411.00
135_K173_A0.6401.00
314_V317_L0.6391.00
250_V296_A0.6381.00
135_K138_V0.6371.00
184_S264_E0.6371.00
195_I252_P0.6361.00
29_K35_V0.6341.00
204_I244_A0.6321.00
249_L253_L0.6291.00
203_E303_G0.6281.00
292_Q304_K0.6281.00
280_Y283_D0.6271.00
239_L257_M0.6261.00
261_E264_E0.6261.00
323_L331_L0.6241.00
259_L263_G0.6231.00
236_A239_L0.6231.00
240_A244_A0.6201.00
192_L226_A0.6201.00
36_A54_I0.6191.00
37_V48_Q0.6151.00
327_D332_K0.6141.00
293_H297_V0.6121.00
213_I221_Q0.6091.00
195_I254_A0.6091.00
134_L182_L0.6071.00
237_A242_K0.6071.00
317_L371_W0.6051.00
131_K168_M0.6051.00
171_A174_L0.6041.00
214_H218_I0.6011.00
212_N215_H0.6011.00
142_R165_E0.6011.00
34_K294_I0.6011.00
221_Q314_V0.6011.00
294_I297_V0.5971.00
336_L343_E0.5951.00
224_V280_Y0.5941.00
196_V206_T0.5921.00
11_V70_I0.5911.00
239_L243_L0.5891.00
101_L250_V0.5881.00
131_K134_L0.5861.00
295_R303_G0.5851.00
147_L182_L0.5851.00
192_L209_T0.5831.00
35_V290_F0.5831.00
260_T263_G0.5831.00
27_S31_M0.5811.00
338_I344_I0.5811.00
125_Y183_E0.5801.00
39_D67_L0.5801.00
113_K127_I0.5781.00
269_E273_R0.5781.00
201_N299_G0.5781.00
68_A71_S0.5781.00
40_P51_D0.5781.00
194_V206_T0.5771.00
255_V267_V0.5771.00
100_E110_T0.5761.00
334_A344_I0.5751.00
279_H313_M0.5741.00
65_R91_D0.5731.00
323_L326_E0.5731.00
252_P274_P0.5731.00
235_K242_K0.5721.00
162_I167_Q0.5711.00
205_S305_T0.5711.00
336_L342_H0.5711.00
208_P284_L0.5691.00
163_K185_W0.5671.00
199_S302_L0.5671.00
318_G321_V0.5661.00
220_F317_L0.5651.00
123_A186_V0.5651.00
211_E226_A0.5651.00
309_K358_Q0.5651.00
363_W367_I0.5641.00
34_K291_E0.5631.00
31_M294_I0.5621.00
100_E248_N0.5611.00
130_T172_A0.5601.00
147_L168_M0.5571.00
207_F285_C0.5571.00
36_A52_V0.5561.00
99_S103_L0.5561.00
360_E364_I0.5551.00
195_I210_A0.5551.00
203_E301_P0.5551.00
316_L321_V0.5531.00
66_K92_H0.5531.00
192_L257_M0.5511.00
210_A226_A0.5511.00
313_M318_G0.5511.00
56_A67_L0.5501.00
215_H220_F0.5501.00
252_P273_R0.5501.00
201_N250_V0.5491.00
64_I89_L0.5471.00
313_M317_L0.5461.00
114_A247_L0.5461.00
211_E223_I0.5461.00
229_E259_L0.5461.00
29_K50_A0.5461.00
102_L272_P0.5451.00
62_E65_R0.5431.00
289_Q293_H0.5431.00
137_A182_L0.5431.00
63_A67_L0.5431.00
121_E235_K0.5421.00
27_S288_S0.5401.00
318_G322_K0.5391.00
104_I117_S0.5391.00
38_V64_I0.5371.00
355_F366_E0.5341.00
143_L163_K0.5301.00
309_K356_M0.5281.00
232_I265_L0.5281.00
115_I270_L0.5261.00
119_G242_K0.5231.00
192_L228_V0.5231.00
186_V189_K0.5231.00
199_S299_G0.5231.00
86_L99_S0.5231.00
329_E334_A0.5221.00
80_N83_Y0.5211.00
138_V172_A0.5191.00
199_S202_G0.5181.00
193_S210_A0.5171.00
312_M317_L0.5151.00
68_A89_L0.5151.00
160_F170_Q0.5131.00
194_V257_M0.5111.00
185_W258_F0.5111.00
243_L267_V0.5101.00
196_V204_I0.5090.99
167_Q171_A0.5080.99
307_L310_P0.5060.99
249_L272_P0.5050.99
134_L137_A0.5020.99
112_K116_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3orqA 2 0.9763 100 0.277 Contact Map
3aw8A 2 0.9447 100 0.279 Contact Map
4mamA 2 0.9474 100 0.28 Contact Map
3q2oA 2 0.9842 100 0.285 Contact Map
2dwcA 4 0.9763 100 0.286 Contact Map
4e4tA 2 0.9789 100 0.289 Contact Map
3ax6A 2 0.9211 100 0.292 Contact Map
1kjqA 2 0.9763 100 0.295 Contact Map
3u9tA 3 0.9632 100 0.305 Contact Map
3n6rA 1 0.8158 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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