GREMLIN Database
PURE - N5-carboxyaminoimidazole ribonucleotide mutase
UniProt: P12044 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 162 (152)
Sequences: 3198 (1450)
Seq/√Len: 117.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_T157_S2.5131.00
6_G49_Y2.4921.00
54_R144_D2.4311.00
114_T127_L2.3541.00
130_Q147_R2.3341.00
72_P102_I2.3171.00
84_I114_T2.2641.00
96_M100_L2.2261.00
107_G122_V2.2001.00
4_L59_K2.1511.00
59_K135_F2.1451.00
8_I75_T2.1221.00
28_L129_A2.1201.00
47_F78_K2.0811.00
44_D51_E2.0671.00
7_I22_C2.0651.00
35_K45_F1.9581.00
54_R140_A1.9431.00
26_D32_Y1.9281.00
22_C32_Y1.8151.00
6_G58_I1.7911.00
132_L139_L1.7631.00
18_M64_G1.7581.00
30_V129_A1.7141.00
18_M86_V1.7081.00
89_Q92_A1.6991.00
27_E149_N1.6881.00
48_E52_T1.6781.00
19_K23_D1.6541.00
152_Q156_E1.6221.00
84_I131_I1.6181.00
33_E56_R1.6171.00
115_S120_G1.6031.00
89_Q94_N1.6011.00
54_R80_T1.5791.00
4_L31_P1.5641.00
148_E152_Q1.5561.00
45_F155_L1.5431.00
146_R150_T1.5261.00
93_L116_I1.5071.00
89_Q117_G1.5001.00
37_V46_M1.4861.00
42_T154_V1.4731.00
52_T55_E1.4701.00
145_E149_N1.4581.00
129_A139_L1.4361.00
24_I125_G1.4311.00
99_L103_V1.4281.00
133_S139_L1.4111.00
138_D142_K1.4011.00
80_T144_D1.3831.00
141_R145_E1.3811.00
22_C34_K1.3641.00
84_I112_A1.2991.00
149_N153_T1.2921.00
148_E151_K1.2881.00
20_H23_D1.2730.99
29_N142_K1.2380.99
61_I81_L1.2300.99
80_T140_A1.2230.99
33_E58_I1.2100.99
51_E78_K1.1540.99
24_I122_V1.1460.99
28_L142_K1.1380.99
20_H122_V1.1380.99
42_T45_F1.1260.99
49_Y58_I1.1220.99
50_A61_I1.1220.99
59_K136_D1.1170.99
44_D78_K1.1010.98
99_L116_I1.0970.98
24_I27_E1.0880.98
46_M75_T1.0850.98
90_S94_N1.0720.98
23_D27_E1.0590.98
16_E19_K1.0550.98
67_G91_K1.0550.98
126_L129_A1.0360.98
22_C26_D1.0190.98
131_I134_A1.0080.97
44_D48_E1.0050.97
153_T157_S1.0050.97
17_T89_Q0.9740.97
59_K134_A0.9720.97
17_T117_G0.9600.96
15_W22_C0.9570.96
46_M50_A0.9540.96
24_I126_L0.9530.96
112_A127_L0.9350.96
5_V60_V0.9340.96
125_G129_A0.9330.96
37_V45_F0.9300.96
15_W34_K0.9230.96
107_G120_G0.9210.95
139_L142_K0.9070.95
17_T88_V0.9030.95
149_N152_Q0.8960.95
21_A64_G0.8950.95
80_T143_L0.8930.95
122_V146_R0.8880.94
144_D148_E0.8880.94
141_R144_D0.8850.94
46_M74_M0.8840.94
91_K98_S0.8820.94
64_G88_V0.8780.94
74_M77_A0.8730.94
24_I28_L0.8570.93
50_A75_T0.8560.93
50_A53_A0.8550.93
151_K155_L0.8540.93
12_T36_V0.8500.93
52_T56_R0.8470.93
85_G102_I0.8430.93
143_L147_R0.8350.92
92_A96_M0.8260.92
44_D151_K0.8220.92
67_G98_S0.8110.91
44_D47_F0.8110.91
33_E49_Y0.8100.91
4_L136_D0.8060.91
21_A62_I0.7960.91
140_A144_D0.7880.90
37_V74_M0.7860.90
84_I127_L0.7810.90
133_S143_L0.7800.90
147_R150_T0.7750.89
23_D26_D0.7740.89
18_M121_A0.7720.89
109_V147_R0.7590.88
28_L146_R0.7580.88
60_V132_L0.7560.88
6_G33_E0.7550.88
145_E148_E0.7480.88
48_E51_E0.7400.87
90_S98_S0.7340.87
47_F51_E0.7200.86
6_G61_I0.7180.85
137_E140_A0.7160.85
136_D139_L0.7160.85
54_R133_S0.7090.85
45_F154_V0.7040.84
63_A75_T0.7010.84
152_Q155_L0.6900.83
126_L147_R0.6900.83
17_T20_H0.6800.82
8_I49_Y0.6780.82
153_T156_E0.6740.82
96_M116_I0.6720.81
9_M18_M0.6690.81
45_F48_E0.6670.81
25_L129_A0.6640.81
45_F151_K0.6590.80
59_K140_A0.6570.80
150_T153_T0.6560.80
8_I61_I0.6440.79
93_L103_V0.6440.79
64_G86_V0.6420.78
114_T120_G0.6380.78
110_P143_L0.6320.77
63_A72_P0.6300.77
60_V131_I0.6280.77
49_Y56_R0.6220.76
5_V30_V0.6210.76
27_E146_R0.6210.76
30_V139_L0.6190.76
6_G56_R0.6170.76
125_G130_Q0.6170.76
107_G115_S0.6160.76
130_Q143_L0.6120.75
46_M72_P0.6120.75
4_L58_I0.6110.75
67_G107_G0.6090.75
129_A132_L0.6040.74
114_T131_I0.6040.74
47_F50_A0.5960.73
93_L99_L0.5960.73
127_L131_I0.5920.73
63_A102_I0.5910.73
15_W19_K0.5860.72
43_P77_A0.5860.72
7_I34_K0.5860.72
50_A78_K0.5830.72
93_L96_M0.5810.71
51_E55_E0.5780.71
136_D142_K0.5780.71
90_S115_S0.5770.71
50_A81_L0.5770.71
20_H117_G0.5750.71
90_S100_L0.5730.70
96_M103_V0.5700.70
12_T109_V0.5700.70
60_V114_T0.5690.70
53_A61_I0.5670.69
58_I81_L0.5620.69
138_D141_R0.5560.68
26_D29_N0.5560.68
10_G14_D0.5550.68
12_T15_W0.5550.68
98_S101_S0.5500.67
92_A116_I0.5480.67
72_P85_G0.5480.67
138_D148_E0.5470.67
35_K157_S0.5460.67
46_M102_I0.5460.67
85_G110_P0.5450.66
94_N100_L0.5390.66
84_I134_A0.5350.65
58_I61_I0.5340.65
16_E20_H0.5330.65
12_T16_E0.5270.64
6_G37_V0.5260.64
139_L143_L0.5250.64
133_S140_A0.5220.63
11_S14_D0.5220.63
64_G125_G0.5210.63
26_D34_K0.5210.63
24_I146_R0.5190.63
27_E142_K0.5190.63
36_V157_S0.5180.63
50_A58_I0.5170.62
54_R137_E0.5170.62
109_V143_L0.5140.62
75_T78_K0.5090.61
129_A142_K0.5060.61
137_E141_R0.5050.61
121_A125_G0.5030.60
91_K96_M0.5010.60
40_H71_L0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ay3A 2 0.9877 100 0.118 Contact Map
3trhA 5 1 100 0.126 Contact Map
3oowA 5 0.9877 100 0.129 Contact Map
3kuuA 5 1 100 0.129 Contact Map
3orsA 5 0.9938 100 0.129 Contact Map
4grdA 5 1 100 0.134 Contact Map
3lp6A 5 0.9877 100 0.136 Contact Map
1u11A 6 0.9938 100 0.137 Contact Map
1o4vA 5 0.9753 100 0.142 Contact Map
3rg8A 6 0.9691 100 0.167 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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