GREMLIN Database
PUR5 - Phosphoribosylformylglycinamidine cyclo-ligase
UniProt: P12043 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (334)
Sequences: 3454 (1884)
Seq/√Len: 103.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_H151_Y3.6211.00
28_R128_E3.5821.00
186_L194_V3.4631.00
172_I243_G3.1451.00
215_R223_E2.8311.00
125_E129_Q2.7421.00
174_E334_K2.6921.00
54_K164_D2.6471.00
179_I326_A2.6351.00
130_S227_I2.6211.00
74_M218_G2.6021.00
125_E128_E2.5791.00
178_L304_V2.5281.00
197_V288_L2.5191.00
301_I329_I2.4931.00
267_E331_R2.4391.00
31_R98_E2.4381.00
46_D163_K2.3341.00
244_M303_F2.3331.00
178_L306_A2.3151.00
54_K163_K2.2771.00
316_I326_A2.2691.00
6_K11_D2.2221.00
267_E333_K2.2211.00
179_I316_I2.1411.00
180_G301_I2.1311.00
76_K219_E2.1131.00
21_R117_E2.0591.00
270_H290_E2.0561.00
72_F150_E2.0521.00
265_S333_K2.0501.00
17_E21_R2.0441.00
259_M306_A1.9971.00
178_L266_A1.9811.00
242_D308_K1.9651.00
266_A332_V1.9541.00
307_V315_V1.9281.00
174_E264_L1.9091.00
215_R220_E1.8991.00
176_H242_D1.8801.00
92_V157_S1.8791.00
43_G135_V1.8201.00
226_R324_E1.8151.00
171_K242_D1.7981.00
53_Q164_D1.7771.00
142_M146_Y1.7581.00
197_V282_L1.7401.00
186_L191_F1.7001.00
263_G335_G1.6831.00
252_F256_I1.6721.00
243_G259_M1.6701.00
161_A166_I1.6611.00
205_D208_T1.6471.00
16_Y254_E1.6341.00
126_G227_I1.6331.00
108_V116_I1.6331.00
78_D121_Q1.6211.00
312_L328_L1.5981.00
283_Q290_E1.5861.00
220_E223_E1.5821.00
82_V126_G1.5741.00
308_K311_H1.5711.00
294_F299_M1.5671.00
313_T317_G1.5381.00
25_H121_Q1.5381.00
265_S338_V1.5071.00
33_G45_F1.5061.00
68_L145_L1.5041.00
244_M305_L1.5031.00
239_G315_V1.5021.00
56_V166_I1.5021.00
13_E295_N1.5011.00
18_A22_M1.4951.00
252_F304_V1.4931.00
60_G92_V1.4871.00
231_P324_E1.4841.00
121_Q125_E1.4721.00
240_K311_H1.4601.00
4_A7_N1.4591.00
94_A244_M1.4561.00
316_I328_L1.4561.00
270_H294_F1.4501.00
264_L332_V1.4491.00
311_H314_D1.4451.00
69_K150_E1.4441.00
256_I268_I1.4411.00
14_A113_P1.4411.00
18_A116_I1.4311.00
82_V129_Q1.4201.00
20_K23_K1.4191.00
283_Q293_M1.4101.00
129_Q227_I1.4051.00
179_I328_L1.4001.00
21_R114_V1.3981.00
53_Q162_E1.3951.00
106_L116_I1.3891.00
274_P327_Y1.3831.00
314_D317_G1.3671.00
265_S335_G1.3620.99
235_A319_L1.3470.99
182_S327_Y1.3450.99
309_E331_R1.3290.99
115_K149_D1.3250.99
70_L206_L1.3230.99
25_H117_E1.3170.99
35_M56_V1.3140.99
274_P280_S1.3100.99
172_I259_M1.3090.99
312_L316_I1.3090.99
178_L268_I1.3050.99
238_S318_T1.2910.99
80_I153_I1.2900.99
232_V305_L1.2820.99
184_S223_E1.2700.99
75_D115_K1.2660.99
46_D54_K1.2650.99
15_G19_V1.2600.99
215_R219_E1.2560.99
70_L74_M1.2390.99
73_S199_L1.2290.99
235_A315_V1.2250.99
52_Y162_E1.2230.99
59_S101_F1.2190.99
260_L264_L1.2080.99
232_V303_F1.2060.99
209_T216_P1.1930.99
275_I280_S1.1910.99
209_T214_E1.1830.99
234_A237_K1.1820.99
44_M58_I1.1810.99
177_L312_L1.1640.98
320_E325_K1.1630.98
315_V318_T1.1510.98
87_M188_S1.1490.98
234_A322_H1.1480.98
177_L328_L1.1480.98
172_I332_V1.1480.98
335_G338_V1.1470.98
116_I119_I1.1430.98
87_M225_T1.1420.98
173_E308_K1.1380.98
118_Q121_Q1.1380.98
289_K292_D1.1360.98
186_L278_I1.1290.98
231_P234_A1.1260.98
234_A318_T1.1250.98
69_K73_S1.1230.98
31_R45_F1.1150.98
216_P219_E1.1100.98
131_G230_K1.1040.98
55_P162_E1.0980.98
293_M297_F1.0930.98
162_E165_E1.0920.98
126_G130_S1.0770.97
102_F155_G1.0710.97
181_L303_F1.0690.97
305_L315_V1.0670.97
88_C157_S1.0660.97
288_L293_M1.0620.97
53_Q165_E1.0610.97
280_S284_E1.0530.97
169_G172_I1.0520.97
239_G318_T1.0510.97
56_V161_A1.0490.97
188_S225_T1.0470.97
17_E20_K1.0420.97
25_H124_A1.0420.97
111_A116_I1.0410.97
182_S325_K1.0270.96
131_G233_L1.0260.96
106_L119_I1.0240.96
126_G129_Q1.0210.96
93_L303_F1.0150.96
238_S314_D1.0130.96
204_L217_L1.0110.96
180_G274_P1.0110.96
177_L309_E1.0050.96
182_S326_A1.0040.96
178_L332_V1.0030.96
286_G293_M0.9930.96
198_L204_L0.9920.96
13_E16_Y0.9910.96
3_E201_D0.9890.96
56_V163_K0.9880.96
229_V233_L0.9870.96
27_E30_K0.9800.95
318_T322_H0.9790.95
34_V37_S0.9790.95
89_V157_S0.9770.95
44_M166_I0.9750.95
196_K201_D0.9730.95
171_K240_K0.9670.95
101_F135_V0.9670.95
52_Y160_V0.9640.95
275_I299_M0.9630.95
4_A292_D0.9590.95
98_E131_G0.9580.95
101_F158_V0.9500.94
232_V236_V0.9480.94
292_D296_V0.9440.94
59_S158_V0.9430.94
18_A113_P0.9420.94
129_Q230_K0.9410.94
3_E7_N0.9400.94
317_G321_S0.9390.94
98_E237_K0.9380.94
199_L206_L0.9380.94
72_F145_L0.9330.94
58_I97_A0.9330.94
198_L281_F0.9300.94
42_G58_I0.9290.94
30_K34_V0.9280.94
236_V244_M0.9280.94
211_E214_E0.9250.94
253_I256_I0.9200.93
265_S337_G0.9190.93
307_V312_L0.9170.93
313_T328_L0.9150.93
86_A227_I0.9040.93
231_P319_L0.9000.93
279_F293_M0.9000.93
202_A285_Y0.8970.93
274_P277_P0.8960.93
301_I327_Y0.8950.93
181_L324_E0.8890.92
119_I153_I0.8830.92
204_L208_T0.8830.92
179_I307_V0.8820.92
280_S283_Q0.8810.92
265_S336_E0.8800.92
87_M227_I0.8760.92
93_L232_V0.8710.91
16_Y295_N0.8700.91
82_V125_E0.8690.91
198_L206_L0.8660.91
210_Y220_E0.8560.91
197_V202_A0.8520.91
232_V244_M0.8490.90
256_I266_A0.8480.90
69_K145_L0.8450.90
98_E233_L0.8420.90
176_H308_K0.8390.90
112_D149_D0.8380.90
181_L319_L0.8370.90
206_L217_L0.8340.90
254_E257_P0.8340.90
281_F285_Y0.8300.89
48_S51_S0.8280.89
48_S54_K0.8180.89
69_K72_F0.8150.89
47_L160_V0.8140.88
269_D331_R0.8120.88
274_P325_K0.8110.88
234_A238_S0.8080.88
22_M26_V0.8070.88
172_I242_D0.8070.88
299_M335_G0.7960.87
61_T156_F0.7960.87
18_A120_V0.7940.87
199_L204_L0.7920.87
267_E270_H0.7910.87
12_I295_N0.7870.87
316_I320_E0.7860.87
86_A225_T0.7850.87
260_L266_A0.7840.87
317_G320_E0.7820.86
273_W301_I0.7820.86
213_F220_E0.7800.86
173_E242_D0.7800.86
11_D14_A0.7750.86
256_I304_V0.7740.86
113_P117_E0.7720.86
30_K36_G0.7720.86
88_C102_F0.7710.86
328_L331_R0.7700.86
204_L285_Y0.7620.85
114_V118_Q0.7610.85
251_G255_N0.7610.85
93_L234_A0.7580.85
209_T212_P0.7560.85
145_L150_E0.7480.84
84_A153_I0.7470.84
42_G95_Q0.7470.84
33_G98_E0.7450.84
86_A188_S0.7450.84
78_D118_Q0.7430.83
199_L202_A0.7430.83
167_V244_M0.7420.83
188_S227_I0.7410.83
106_L153_I0.7410.83
12_I15_G0.7400.83
231_P322_H0.7380.83
172_I261_P0.7380.83
25_H28_R0.7350.83
3_E197_V0.7330.83
80_I119_I0.7320.83
45_F160_V0.7310.82
179_I315_V0.7230.82
177_L331_R0.7230.82
58_I161_A0.7220.82
48_S163_K0.7220.82
168_T171_K0.7210.82
142_M145_L0.7190.81
206_L218_G0.7170.81
49_E54_K0.7150.81
180_G327_Y0.7150.81
245_A304_V0.7150.81
60_G93_L0.7130.81
124_A128_E0.7130.81
235_A239_G0.7110.81
12_I16_Y0.7100.81
283_Q288_L0.7090.81
233_L237_K0.7040.80
45_F101_F0.7020.80
14_A110_K0.7020.80
3_E296_V0.7000.80
213_F281_F0.6980.79
253_I295_N0.6960.79
234_A240_K0.6950.79
14_A17_E0.6930.79
147_T150_E0.6930.79
110_K148_A0.6910.79
30_K37_S0.6900.79
172_I264_L0.6880.79
309_E312_L0.6860.78
319_L324_E0.6740.77
18_A26_V0.6730.77
199_L281_F0.6690.77
253_I291_E0.6670.76
86_A126_G0.6670.76
292_D295_N0.6640.76
17_E114_V0.6640.76
304_V329_I0.6620.76
59_S135_V0.6610.76
73_S206_L0.6590.76
17_E113_P0.6580.75
127_C134_L0.6580.75
34_V133_A0.6560.75
21_R113_P0.6520.75
235_A241_I0.6510.75
165_E240_K0.6500.75
144_G192_S0.6490.74
112_D115_K0.6490.74
180_G329_I0.6490.74
126_G229_V0.6490.74
46_D160_V0.6480.74
239_G314_D0.6470.74
309_E328_L0.6410.73
245_A252_F0.6400.73
198_L202_A0.6380.73
48_S162_E0.6370.73
271_G274_P0.6370.73
314_D318_T0.6360.73
27_E37_S0.6350.73
198_L282_L0.6350.73
252_F294_F0.6350.73
28_R125_E0.6340.73
19_V141_E0.6340.73
15_G141_E0.6340.73
18_A106_L0.6340.73
264_L267_E0.6310.72
33_G46_D0.6310.72
194_V282_L0.6300.72
178_L305_L0.6220.71
18_A84_A0.6220.71
76_K218_G0.6220.71
109_G147_T0.6200.71
75_D118_Q0.6200.71
275_I283_Q0.6180.71
217_L221_L0.6170.71
18_A119_I0.6160.71
235_A305_L0.6150.70
167_V243_G0.6150.70
49_E160_V0.6100.70
52_Y164_D0.6100.70
71_A80_I0.6090.70
293_M299_M0.6090.70
115_K119_I0.6070.69
92_V159_G0.6070.69
275_I290_E0.6070.69
87_M157_S0.6060.69
70_L194_V0.6060.69
275_I294_F0.6050.69
5_Y9_G0.6040.69
241_I315_V0.6030.69
245_A253_I0.6010.69
167_V303_F0.5970.68
93_L233_L0.5970.68
119_I123_V0.5960.68
80_I145_L0.5950.68
74_M206_L0.5950.68
12_I292_D0.5940.68
206_L221_L0.5940.68
213_F278_I0.5930.68
174_E331_R0.5920.68
157_S225_T0.5910.67
165_E237_K0.5900.67
88_C254_E0.5890.67
26_V38_L0.5890.67
52_Y98_E0.5880.67
46_D56_V0.5880.67
3_E288_L0.5880.67
79_T122_G0.5870.67
165_E236_V0.5870.67
40_G95_Q0.5870.67
12_I296_V0.5840.66
210_Y281_F0.5790.66
239_G311_H0.5790.66
269_D328_L0.5780.66
236_V241_I0.5780.66
202_A208_T0.5760.65
312_L326_A0.5740.65
123_V157_S0.5730.65
36_G43_G0.5720.65
35_M166_I0.5710.65
220_E278_I0.5700.65
4_A295_N0.5690.64
44_M56_V0.5690.64
260_L332_V0.5690.64
103_L156_F0.5680.64
102_F156_F0.5670.64
282_L293_M0.5660.64
282_L288_L0.5630.64
74_M222_L0.5620.64
209_T213_F0.5620.64
76_K79_T0.5600.63
268_I329_I0.5590.63
51_S98_E0.5580.63
22_M25_H0.5570.63
266_A306_A0.5550.63
198_L203_E0.5530.62
204_L281_F0.5530.62
24_K27_E0.5530.62
68_L146_Y0.5520.62
253_I294_F0.5520.62
72_F151_Y0.5510.62
184_S220_E0.5510.62
84_A252_F0.5500.62
86_A130_S0.5490.62
320_E326_A0.5470.61
240_K308_K0.5460.61
180_G304_V0.5420.61
181_L231_P0.5420.61
235_A318_T0.5420.61
230_K233_L0.5410.61
313_T316_I0.5410.61
279_F286_G0.5400.60
253_I257_P0.5400.60
86_A224_P0.5390.60
232_V235_A0.5380.60
173_E238_S0.5350.60
66_T142_M0.5350.60
26_V30_K0.5330.59
318_T321_S0.5320.59
256_I260_L0.5310.59
4_A289_K0.5310.59
139_T142_M0.5310.59
178_L259_M0.5300.59
198_L221_L0.5300.59
186_L221_L0.5300.59
189_N249_G0.5290.59
277_P280_S0.5290.59
157_S188_S0.5270.59
105_Y152_D0.5270.59
106_L150_E0.5270.59
60_G88_C0.5240.58
35_M46_D0.5240.58
177_L180_G0.5240.58
87_M224_P0.5230.58
194_V199_L0.5230.58
51_S237_K0.5220.58
196_K199_L0.5220.58
235_A322_H0.5210.58
26_V124_A0.5210.58
82_V86_A0.5190.57
4_A288_L0.5160.57
15_G38_L0.5160.57
46_D49_E0.5150.57
130_S186_L0.5130.57
42_G92_V0.5090.56
72_F77_H0.5080.56
117_E121_Q0.5080.56
84_A111_A0.5080.56
275_I293_M0.5080.56
236_V315_V0.5080.56
194_V197_V0.5080.56
18_A299_M0.5070.56
4_A296_V0.5070.56
111_A153_I0.5060.56
217_L278_I0.5060.56
70_L218_G0.5050.55
80_I84_A0.5050.55
113_P116_I0.5030.55
16_Y92_V0.5030.55
174_E333_K0.5030.55
216_P220_E0.5020.55
236_V240_K0.5020.55
33_G133_A0.5020.55
108_V115_K0.5010.55
93_L236_V0.5000.55
186_L279_F0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kizA 2 0.8931 100 0.412 Contact Map
2btuA 2 0.9422 100 0.427 Contact Map
3mdoA 2 0.896 100 0.428 Contact Map
2z01A 2 0.9046 100 0.44 Contact Map
3m84A 2 0.9855 100 0.46 Contact Map
3p4eA 2 0.9277 100 0.469 Contact Map
2v9yA 2 0.8699 100 0.526 Contact Map
3wjpA 2 0.896 100 0.653 Contact Map
4lgyA 1 0.8988 100 0.654 Contact Map
2zodA 2 0.8497 100 0.663 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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