PURL - BACSU - GREMLIN Contacts

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PURL - Phosphoribosylformylglycinamidine synthase subunit PurL

UniProt:	P12042	Sequences: MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEIGIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNHPSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEIIDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYREFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLRIRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTAHITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLDAIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVKKEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKSKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	742 (710)
Sequences:	3274 (1661)
Seq/√Len:	62.3

ECOLI - PUR4
BACSU - PURL
HALSA - PURL
SULSO - PURL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
356_M	368_E	4.630	1.00
646_I	660_V	4.625	1.00
295_E	350_H	4.426	1.00
109_Y	160_G	4.390	1.00
573_F	580_V	4.330	1.00
656_L	702_V	3.970	1.00
488_I	493_A	3.899	1.00
637_V	678_V	3.599	1.00
707_I	720_H	3.586	1.00
365_V	368_E	3.544	1.00
297_N	300_L	3.466	1.00
645_A	678_V	3.457	1.00
295_E	360_T	3.271	1.00
335_I	339_D	3.209	1.00
283_S	348_V	3.135	1.00
217_K	344_E	3.081	1.00
332_Q	336_D	2.917	1.00
570_T	574_K	2.848	1.00
332_Q	335_I	2.834	1.00
581_Y	698_H	2.834	1.00
523_I	556_I	2.821	1.00
360_T	365_V	2.803	1.00
682_K	685_H	2.787	1.00
658_A	708_L	2.775	1.00
414_L	420_I	2.761	1.00
581_Y	690_E	2.760	1.00
625_A	689_F	2.753	1.00
406_D	409_E	2.744	1.00
475_V	478_K	2.708	1.00
412_K	729_V	2.704	1.00
417_Q	594_E	2.664	1.00
174_V	426_V	2.620	1.00
226_A	276_A	2.581	1.00
659_N	709_A	2.579	1.00
659_N	701_E	2.534	1.00
581_Y	689_F	2.529	1.00
569_T	626_I	2.523	1.00
440_V	570_T	2.497	1.00
299_D	362_K	2.470	1.00
474_E	525_E	2.433	1.00
580_V	658_A	2.407	1.00
212_M	326_I	2.402	1.00
516_I	541_L	2.399	1.00
679_V	689_F	2.398	1.00
330_R	333_E	2.396	1.00
479_I	674_Q	2.392	1.00
621_A	693_V	2.383	1.00
633_S	649_S	2.357	1.00
647_A	708_L	2.343	1.00
14_E	18_Y	2.332	1.00
411_L	643_G	2.330	1.00
170_V	447_G	2.291	1.00
409_E	413_A	2.284	1.00
333_E	336_D	2.266	1.00
457_A	565_T	2.226	1.00
302_P	346_V	2.217	1.00
484_A	556_I	2.164	1.00
210_T	347_S	2.160	1.00
387_E	518_K	2.142	1.00
484_A	558_M	2.138	1.00
622_L	679_V	2.108	1.00
310_A	361_H	2.098	1.00
165_I	256_L	2.082	1.00
578_D	702_V	2.060	1.00
504_F	519_A	2.057	1.00
573_F	658_A	2.054	1.00
424_E	731_K	2.046	1.00
581_Y	696_A	2.034	1.00
693_V	696_A	2.033	1.00
581_Y	686_Q	2.025	1.00
133_V	190_C	2.024	1.00
579_L	698_H	2.024	1.00
578_D	680_S	2.018	1.00
477_G	519_A	2.014	1.00
633_S	680_S	2.011	1.00
447_G	450_R	1.999	1.00
445_D	449_L	1.998	1.00
445_D	635_H	1.996	1.00
408_N	725_E	1.989	1.00
412_K	725_E	1.989	1.00
408_N	412_K	1.949	1.00
646_I	678_V	1.942	1.00
303_Q	313_M	1.941	1.00
386_Q	511_E	1.936	1.00
129_R	257_E	1.923	1.00
335_I	345_A	1.917	1.00
642_L	678_V	1.917	1.00
449_L	452_R	1.900	1.00
469_L	519_A	1.892	1.00
27_E	58_K	1.891	1.00
261_E	340_K	1.890	1.00
91_Q	195_N	1.884	1.00
93_V	458_L	1.883	1.00
518_K	521_D	1.876	1.00
468_Y	479_I	1.868	1.00
646_I	658_A	1.865	1.00
75_L	92_A	1.862	1.00
624_D	628_K	1.846	1.00
358_R	365_V	1.839	1.00
622_L	631_V	1.838	1.00
385_S	517_E	1.820	1.00
578_D	632_Q	1.820	1.00
187_N	555_V	1.819	1.00
31_I	47_F	1.813	1.00
295_E	358_R	1.805	1.00
331_E	347_S	1.802	1.00
655_N	727_E	1.791	1.00
131_I	449_L	1.785	1.00
649_S	680_S	1.784	1.00
632_Q	682_K	1.769	1.00
681_V	689_F	1.763	0.99
455_K	566_A	1.758	0.99
120_I	165_I	1.756	0.99
686_Q	698_H	1.754	0.99
297_N	360_T	1.744	0.99
489_I	623_L	1.741	0.99
447_G	452_R	1.720	0.99
685_H	688_A	1.720	0.99
650_V	658_A	1.715	0.99
411_L	647_A	1.704	0.99
177_D	603_I	1.696	0.99
575_Q	578_D	1.691	0.99
299_D	361_H	1.688	0.99
224_H	227_T	1.677	0.99
647_A	651_M	1.672	0.99
567_H	627_K	1.665	0.99
709_A	720_H	1.658	0.99
210_T	331_E	1.657	0.99
455_K	564_D	1.651	0.99
579_L	686_Q	1.637	0.99
576_A	704_A	1.632	0.99
512_I	549_A	1.624	0.99
635_H	648_E	1.623	0.99
210_T	350_H	1.621	0.99
120_I	190_C	1.619	0.99
727_E	731_K	1.619	0.99
616_L	620_K	1.609	0.99
732_G	736_C	1.609	0.99
728_R	732_G	1.609	0.99
446_A	449_L	1.606	0.99
580_V	680_S	1.605	0.99
445_D	450_R	1.600	0.99
618_R	677_F	1.596	0.99
567_H	629_G	1.593	0.99
141_E	178_S	1.585	0.99
632_Q	680_S	1.578	0.99
73_R	494_E	1.571	0.99
721_A	726_L	1.570	0.99
659_N	703_T	1.568	0.99
482_A	674_Q	1.565	0.99
210_T	326_I	1.557	0.99
626_I	631_V	1.554	0.99
66_K	521_D	1.553	0.99
445_D	448_V	1.552	0.99
412_K	721_A	1.547	0.99
179_S	551_Y	1.531	0.99
135_N	158_I	1.517	0.98
524_S	528_N	1.502	0.98
651_M	730_W	1.500	0.98
690_E	696_A	1.498	0.98
419_T	594_E	1.492	0.98
643_G	710_I	1.477	0.98
62_P	382_H	1.474	0.98
355_K	372_D	1.472	0.98
562_I	568_I	1.458	0.98
631_V	679_V	1.456	0.98
564_D	567_H	1.452	0.98
722_Q	725_E	1.450	0.98
228_F	233_M	1.449	0.98
420_I	644_V	1.447	0.98
173_E	423_K	1.445	0.98
573_F	649_S	1.442	0.98
347_S	350_H	1.439	0.98
416_Q	732_G	1.436	0.98
650_V	708_L	1.433	0.98
416_Q	729_V	1.431	0.98
581_Y	679_V	1.427	0.98
24_S	381_Y	1.421	0.98
66_K	524_S	1.413	0.98
411_L	644_V	1.405	0.97
417_Q	598_M	1.402	0.97
422_S	731_K	1.399	0.97
210_T	328_R	1.398	0.97
412_K	726_L	1.387	0.97
81_G	90_N	1.386	0.97
427_Y	443_G	1.375	0.97
488_I	498_V	1.372	0.97
35_L	370_P	1.369	0.97
313_M	361_H	1.368	0.97
293_G	355_K	1.368	0.97
630_F	685_H	1.364	0.97
472_D	606_K	1.358	0.97
336_D	339_D	1.356	0.97
631_V	634_A	1.354	0.97
481_V	523_I	1.351	0.97
265_C	333_E	1.351	0.97
134_L	460_M	1.350	0.97
474_E	518_K	1.347	0.97
212_M	335_I	1.341	0.97
531_S	616_L	1.341	0.97
471_L	607_A	1.336	0.97
583_I	679_V	1.334	0.96
505_G	515_Q	1.331	0.96
354_D	358_R	1.327	0.96
686_Q	690_E	1.327	0.96
721_A	725_E	1.322	0.96
358_R	368_E	1.306	0.96
634_A	677_F	1.305	0.96
71_G	85_V	1.304	0.96
207_V	353_D	1.302	0.96
274_M	282_S	1.301	0.96
105_A	233_M	1.298	0.96
92_A	196_H	1.297	0.96
589_E	673_S	1.296	0.96
625_A	631_V	1.294	0.96
90_N	196_H	1.288	0.96
187_N	462_T	1.287	0.96
450_R	565_T	1.281	0.96
45_G	311_Y	1.272	0.95
262_V	334_I	1.271	0.95
424_E	428_D	1.268	0.95
15_E	19_Q	1.268	0.95
445_D	452_R	1.264	0.95
85_V	497_A	1.262	0.95
696_A	699_I	1.260	0.95
468_Y	674_Q	1.257	0.95
525_E	529_V	1.256	0.95
326_I	331_E	1.252	0.95
448_V	568_I	1.250	0.95
213_Y	274_M	1.250	0.95
89_D	456_K	1.244	0.95
579_L	582_V	1.242	0.95
583_I	618_R	1.240	0.95
297_N	362_K	1.240	0.95
408_N	721_A	1.238	0.95
637_V	645_A	1.230	0.94
472_D	607_A	1.229	0.94
405_E	410_M	1.229	0.94
33_S	36_G	1.226	0.94
444_S	449_L	1.225	0.94
288_S	375_A	1.222	0.94
444_S	447_G	1.222	0.94
581_Y	681_V	1.212	0.94
371_V	375_A	1.210	0.94
490_C	634_A	1.209	0.94
628_K	688_A	1.208	0.94
386_Q	510_P	1.206	0.94
621_A	692_T	1.202	0.94
483_E	638_S	1.201	0.94
487_N	636_D	1.198	0.94
643_G	647_A	1.189	0.93
214_V	338_F	1.188	0.93
310_A	366_V	1.185	0.93
267_A	330_R	1.183	0.93
211_V	325_V	1.183	0.93
327_E	330_R	1.183	0.93
490_C	677_F	1.181	0.93
13_K	17_L	1.180	0.93
494_E	627_K	1.180	0.93
625_A	692_T	1.177	0.93
586_T	673_S	1.176	0.93
459_A	488_I	1.173	0.93
636_D	648_E	1.173	0.93
619_Q	677_F	1.171	0.93
472_D	518_K	1.170	0.93
646_I	699_I	1.168	0.93
209_N	269_V	1.166	0.93
659_N	711_Q	1.166	0.93
220_R	312_E	1.164	0.93
582_V	637_V	1.162	0.93
74_V	78_P	1.159	0.92
473_P	515_Q	1.158	0.92
485_A	532_T	1.156	0.92
269_V	327_E	1.155	0.92
579_L	701_E	1.152	0.92
644_V	648_E	1.149	0.92
187_N	499_T	1.147	0.92
588_P	671_S	1.145	0.92
497_A	533_P	1.143	0.92
47_F	373_A	1.142	0.92
144_S	181_E	1.142	0.92
211_V	294_I	1.142	0.92
499_T	557_G	1.141	0.92
471_L	605_G	1.138	0.92
498_V	534_V	1.137	0.92
529_V	613_D	1.135	0.92
68_P	74_V	1.134	0.92
692_T	695_D	1.132	0.92
359_L	367_C	1.128	0.91
575_Q	682_K	1.126	0.91
574_K	680_S	1.123	0.91
444_S	450_R	1.121	0.91
622_L	677_F	1.118	0.91
579_L	683_K	1.115	0.91
209_N	351_V	1.114	0.91
630_F	688_A	1.114	0.91
25_D	29_A	1.113	0.91
177_D	470_Y	1.112	0.91
688_A	691_A	1.112	0.91
446_A	452_R	1.110	0.91
352_T	355_K	1.109	0.91
448_V	452_R	1.105	0.91
153_E	156_A	1.105	0.91
573_F	680_S	1.104	0.91
472_D	475_V	1.101	0.90
415_L	647_A	1.099	0.90
97_I	462_T	1.093	0.90
459_A	493_A	1.091	0.90
446_A	491_S	1.083	0.90
446_A	450_R	1.082	0.90
577_G	702_V	1.077	0.89
563_E	627_K	1.077	0.89
572_H	654_E	1.077	0.89
425_W	429_Q	1.075	0.89
195_N	198_D	1.074	0.89
483_E	636_D	1.073	0.89
639_E	648_E	1.073	0.89
97_I	555_V	1.069	0.89
189_M	557_G	1.064	0.89
180_Y	464_C	1.064	0.89
461_T	484_A	1.062	0.89
445_D	638_S	1.062	0.89
474_E	521_D	1.061	0.89
104_S	154_V	1.059	0.89
134_L	189_M	1.054	0.88
486_R	615_E	1.052	0.88
447_G	451_I	1.052	0.88
485_A	619_Q	1.052	0.88
650_V	723_T	1.051	0.88
457_A	568_I	1.050	0.88
573_F	702_V	1.049	0.88
469_L	480_A	1.046	0.88
482_A	615_E	1.046	0.88
703_T	706_G	1.045	0.88
105_A	228_F	1.044	0.88
586_T	589_E	1.042	0.88
77_G	94_V	1.038	0.88
133_V	165_I	1.037	0.88
295_E	354_D	1.037	0.88
177_D	467_R	1.034	0.87
656_L	704_A	1.031	0.87
212_M	347_S	1.030	0.87
580_V	699_I	1.029	0.87
444_S	448_V	1.028	0.87
269_V	330_R	1.027	0.87
465_N	483_E	1.021	0.87
261_E	337_I	1.018	0.87
92_A	194_I	1.015	0.86
301_I	313_M	1.014	0.86
305_E	308_M	1.013	0.86
29_A	32_E	1.011	0.86
706_G	723_T	1.010	0.86
337_I	340_K	1.010	0.86
73_R	496_L	1.009	0.86
46_I	369_L	1.008	0.86
139_F	151_F	1.006	0.86
625_A	630_F	1.004	0.86
637_V	642_L	1.003	0.86
661_T	711_Q	1.001	0.86
64_L	67_F	0.999	0.86
571_Q	652_T	0.999	0.86
383_K	508_E	0.996	0.85
94_V	128_A	0.993	0.85
418_P	421_A	0.993	0.85
63_I	513_F	0.993	0.85
141_E	181_E	0.990	0.85
448_V	451_I	0.986	0.85
314_M	359_L	0.984	0.85
286_M	325_V	0.983	0.85
445_D	451_I	0.983	0.85
146_R	150_L	0.983	0.85
494_E	623_L	0.976	0.84
206_G	327_E	0.974	0.84
283_S	357_L	0.972	0.84
433_M	441_A	0.965	0.83
494_E	563_E	0.959	0.83
299_D	363_G	0.958	0.83
583_I	621_A	0.956	0.83
650_V	654_E	0.956	0.83
372_D	376_E	0.954	0.83
29_A	33_S	0.954	0.83
444_S	491_S	0.954	0.83
690_E	698_H	0.953	0.83
461_T	488_I	0.952	0.83
474_E	519_A	0.952	0.83
151_F	426_V	0.951	0.83
451_I	456_K	0.949	0.82
228_F	243_A	0.947	0.82
105_A	184_P	0.946	0.82
638_S	648_E	0.946	0.82
414_L	644_V	0.944	0.82
267_A	333_E	0.942	0.82
689_F	693_V	0.941	0.82
171_G	461_T	0.938	0.82
688_A	692_T	0.938	0.82
326_I	334_I	0.933	0.81
206_G	269_V	0.932	0.81
413_A	599_T	0.930	0.81
159_A	188_A	0.927	0.81
514_W	518_K	0.925	0.81
611_D	614_V	0.925	0.81
575_Q	632_Q	0.923	0.81
651_M	727_E	0.923	0.81
156_A	160_G	0.922	0.81
120_I	167_I	0.921	0.81
725_E	729_V	0.920	0.80
396_E	605_G	0.920	0.80
573_F	656_L	0.919	0.80
415_L	420_I	0.918	0.80
298_L	361_H	0.917	0.80
408_N	719_I	0.914	0.80
492_G	563_E	0.912	0.80
21_M	44_I	0.907	0.80
42_T	367_C	0.904	0.79
30_L	33_S	0.902	0.79
303_Q	308_M	0.900	0.79
70_S	74_V	0.900	0.79
360_T	363_G	0.897	0.79
74_V	77_G	0.896	0.79
662_V	668_L	0.896	0.79
724_K	727_E	0.895	0.79
206_G	209_N	0.894	0.79
142_L	151_F	0.893	0.78
613_D	624_D	0.893	0.78
62_P	69_T	0.893	0.78
147_V	151_F	0.893	0.78
628_K	692_T	0.892	0.78
212_M	345_A	0.889	0.78
580_V	660_V	0.887	0.78
212_M	331_E	0.886	0.78
336_D	340_K	0.884	0.78
80_E	93_V	0.884	0.78
689_F	696_A	0.883	0.78
625_A	679_V	0.883	0.78
411_L	719_I	0.883	0.78
729_V	732_G	0.882	0.78
92_A	199_I	0.879	0.77
487_N	648_E	0.879	0.77
220_R	305_E	0.876	0.77
421_A	734_I	0.874	0.77
622_L	626_I	0.872	0.77
120_I	133_V	0.871	0.77
324_L	334_I	0.871	0.77
83_G	128_A	0.869	0.77
232_E	509_K	0.869	0.77
489_I	626_I	0.869	0.77
412_K	416_Q	0.867	0.76
369_L	375_A	0.867	0.76
415_L	726_L	0.867	0.76
578_D	683_K	0.864	0.76
681_V	685_H	0.860	0.76
500_D	556_I	0.857	0.76
191_V	559_V	0.856	0.75
28_F	32_E	0.854	0.75
497_A	532_T	0.853	0.75
397_T	602_R	0.852	0.75
11_Q	14_E	0.851	0.75
678_V	699_I	0.850	0.75
624_D	692_T	0.850	0.75
725_E	728_R	0.849	0.75
373_A	377_E	0.849	0.75
621_A	625_A	0.847	0.75
19_Q	25_D	0.845	0.74
235_D	546_N	0.845	0.74
687_A	690_E	0.843	0.74
70_S	528_N	0.843	0.74
466_A	555_V	0.842	0.74
62_P	70_S	0.841	0.74
81_G	125_S	0.840	0.74
614_V	617_S	0.839	0.74
437_N	452_R	0.837	0.74
630_F	692_T	0.836	0.74
109_Y	247_G	0.836	0.74
128_A	191_V	0.836	0.74
698_H	701_E	0.835	0.74
204_A	209_N	0.834	0.74
140_G	181_E	0.833	0.73
690_E	694_K	0.830	0.73
623_L	627_K	0.829	0.73
66_K	70_S	0.828	0.73
134_L	171_G	0.823	0.73
228_F	513_F	0.822	0.72
498_V	558_M	0.821	0.72
207_V	292_S	0.821	0.72
483_E	648_E	0.820	0.72
395_L	398_D	0.820	0.72
651_M	654_E	0.819	0.72
339_D	345_A	0.819	0.72
144_S	147_V	0.818	0.72
469_L	476_G	0.818	0.72
234_S	237_S	0.817	0.72
328_R	350_H	0.817	0.72
311_Y	315_L	0.815	0.72
644_V	647_A	0.814	0.72
650_V	680_S	0.814	0.72
446_A	568_I	0.813	0.72
483_E	487_N	0.813	0.72
23_V	31_I	0.813	0.72
131_I	458_L	0.811	0.71
89_D	195_N	0.811	0.71
91_Q	193_L	0.810	0.71
187_N	503_N	0.810	0.71
527_C	534_V	0.808	0.71
525_E	528_N	0.808	0.71
569_T	631_V	0.807	0.71
488_I	558_M	0.806	0.71
683_K	686_Q	0.805	0.71
288_S	372_D	0.803	0.71
485_A	496_L	0.802	0.71
407_A	411_L	0.801	0.70
333_E	337_I	0.799	0.70
720_H	725_E	0.798	0.70
384_P	510_P	0.798	0.70
93_V	561_L	0.798	0.70
487_N	635_H	0.797	0.70
68_P	533_P	0.796	0.70
169_T	447_G	0.792	0.70
300_L	362_K	0.792	0.70
579_L	684_E	0.791	0.70
620_K	624_D	0.791	0.70
59_N	513_F	0.789	0.69
688_A	711_Q	0.789	0.69
407_A	670_F	0.785	0.69
232_E	544_E	0.785	0.69
147_V	181_E	0.784	0.69
73_R	85_V	0.783	0.69
526_A	610_I	0.779	0.68
487_N	638_S	0.779	0.68
499_T	555_V	0.778	0.68
136_S	173_E	0.776	0.68
635_H	638_S	0.776	0.68
574_K	577_G	0.775	0.68
86_D	90_N	0.775	0.68
281_S	536_G	0.774	0.68
575_Q	702_V	0.773	0.68
516_I	520_A	0.772	0.68
59_N	383_K	0.771	0.68
658_A	700_G	0.770	0.67
483_E	635_H	0.768	0.67
455_K	565_T	0.764	0.67
270_G	541_L	0.764	0.67
569_T	634_A	0.763	0.67
75_L	199_I	0.763	0.67
63_I	67_F	0.762	0.67
165_I	190_C	0.762	0.67
141_E	597_K	0.759	0.66
444_S	571_Q	0.759	0.66
707_I	722_Q	0.758	0.66
414_L	643_G	0.758	0.66
526_A	612_L	0.757	0.66
475_V	609_Q	0.757	0.66
589_E	609_Q	0.755	0.66
422_S	734_I	0.755	0.66
485_A	558_M	0.754	0.66
617_S	699_I	0.753	0.66
482_A	486_R	0.753	0.66
440_V	568_I	0.753	0.66
574_K	578_D	0.753	0.66
691_A	694_K	0.752	0.66
198_D	264_Q	0.751	0.66
82_A	85_V	0.751	0.66
632_Q	685_H	0.751	0.66
636_D	639_E	0.750	0.65
656_L	703_T	0.750	0.65
587_K	673_S	0.747	0.65
179_S	470_Y	0.747	0.65
432_Y	442_P	0.746	0.65
109_Y	159_A	0.746	0.65
464_C	469_L	0.745	0.65
577_G	701_E	0.745	0.65
356_M	370_P	0.745	0.65
681_V	684_E	0.744	0.65
287_A	294_I	0.744	0.65
388_P	511_E	0.744	0.65
68_P	72_E	0.743	0.65
578_D	682_K	0.742	0.65
572_H	652_T	0.742	0.65
615_E	675_S	0.738	0.64
432_Y	441_A	0.738	0.64
730_W	733_A	0.737	0.64
262_V	324_L	0.737	0.64
594_E	597_K	0.736	0.64
149_Y	153_E	0.735	0.64
576_A	656_L	0.735	0.64
593_S	608_P	0.734	0.64
582_V	699_I	0.733	0.64
461_T	491_S	0.726	0.63
484_A	500_D	0.726	0.63
96_K	188_A	0.724	0.63
424_E	734_I	0.724	0.63
208_G	350_H	0.723	0.63
160_G	164_C	0.722	0.62
578_D	633_S	0.721	0.62
106_L	228_F	0.721	0.62
724_K	728_R	0.721	0.62
189_M	460_M	0.720	0.62
624_D	695_D	0.720	0.62
353_D	412_K	0.720	0.62
461_T	557_G	0.720	0.62
623_L	626_I	0.719	0.62
388_P	391_Y	0.718	0.62
93_V	497_A	0.718	0.62
143_T	148_K	0.717	0.62
621_A	624_D	0.717	0.62
63_I	66_K	0.717	0.62
21_M	48_S	0.717	0.62
247_G	304_R	0.715	0.62
506_N	509_K	0.714	0.62
585_E	614_V	0.713	0.61
489_I	619_Q	0.713	0.61
500_D	523_I	0.711	0.61
474_E	477_G	0.711	0.61
22_G	231_E	0.710	0.61
104_S	153_E	0.708	0.61
411_L	721_A	0.708	0.61
117_G	161_Y	0.708	0.61
81_G	272_Q	0.707	0.61
61_K	380_V	0.705	0.61
338_F	345_A	0.705	0.61
178_S	601_G	0.702	0.60
481_V	526_A	0.701	0.60
687_A	691_A	0.701	0.60
156_A	429_Q	0.700	0.60
288_S	376_E	0.700	0.60
589_E	608_P	0.699	0.60
583_I	677_F	0.699	0.60
372_D	375_A	0.698	0.60
338_F	343_L	0.696	0.60
372_D	377_E	0.696	0.60
446_A	461_T	0.695	0.60
489_I	675_S	0.694	0.59
191_V	460_M	0.693	0.59
304_R	318_S	0.693	0.59
13_K	32_E	0.692	0.59
175_Q	639_E	0.692	0.59
331_E	335_I	0.692	0.59
288_S	355_K	0.691	0.59
509_K	544_E	0.691	0.59
563_E	567_H	0.691	0.59
440_V	444_S	0.690	0.59
410_M	599_T	0.690	0.59
650_V	710_I	0.689	0.59
131_I	193_L	0.689	0.59
213_Y	283_S	0.689	0.59
587_K	611_D	0.686	0.59
703_T	709_A	0.683	0.58
706_G	722_Q	0.683	0.58
301_I	348_V	0.682	0.58
150_L	184_P	0.682	0.58
276_A	279_L	0.681	0.58
459_A	562_I	0.680	0.58
574_K	656_L	0.680	0.58
463_D	487_N	0.679	0.58
298_L	359_L	0.678	0.58
573_F	650_V	0.677	0.58
686_Q	689_F	0.677	0.58
683_K	687_A	0.677	0.58
625_A	629_G	0.676	0.57
719_I	726_L	0.676	0.57
57_Y	60_S	0.675	0.57
445_D	636_D	0.675	0.57
93_V	191_V	0.674	0.57
361_H	366_V	0.674	0.57
270_G	292_S	0.673	0.57
635_H	645_A	0.673	0.57
478_K	525_E	0.672	0.57
147_V	150_L	0.672	0.57
410_M	414_L	0.672	0.57
706_G	724_K	0.671	0.57
218_T	303_Q	0.670	0.57
202_G	289_K	0.670	0.57
124_F	322_M	0.669	0.57
194_I	199_I	0.669	0.57
16_K	28_F	0.668	0.56
284_A	357_L	0.668	0.56
138_R	173_E	0.668	0.56
432_Y	438_T	0.667	0.56
488_I	491_S	0.666	0.56
180_Y	553_T	0.666	0.56
68_P	71_G	0.665	0.56
262_V	333_E	0.664	0.56
241_R	305_E	0.664	0.56
75_L	242_S	0.664	0.56
357_L	369_L	0.664	0.56
142_L	418_P	0.663	0.56
683_K	688_A	0.663	0.56
630_F	683_K	0.662	0.56
102_H	229_A	0.662	0.56
448_V	459_A	0.661	0.56
274_M	323_L	0.660	0.56
107_E	110_Q	0.659	0.55
131_I	451_I	0.659	0.55
680_S	702_V	0.658	0.55
81_G	88_G	0.658	0.55
296_M	348_V	0.658	0.55
211_V	296_M	0.658	0.55
678_V	682_K	0.657	0.55
593_S	611_D	0.656	0.55
617_S	692_T	0.656	0.55
643_G	670_F	0.655	0.55
668_L	697_V	0.654	0.55
65_R	69_T	0.652	0.55
325_V	351_V	0.652	0.55
267_A	337_I	0.652	0.55
219_G	304_R	0.651	0.55
63_I	516_I	0.650	0.54
595_L	599_T	0.650	0.54
613_D	616_L	0.650	0.54
424_E	727_E	0.649	0.54
689_F	698_H	0.649	0.54
640_G	672_E	0.647	0.54
498_V	527_C	0.647	0.54
586_T	637_V	0.647	0.54
328_R	331_E	0.646	0.54
573_F	654_E	0.646	0.54
582_V	678_V	0.645	0.54
356_M	369_L	0.645	0.54
95_F	557_G	0.645	0.54
87_I	451_I	0.644	0.54
395_L	606_K	0.644	0.54
457_A	564_D	0.642	0.54
681_V	686_Q	0.642	0.54
266_D	327_E	0.642	0.54
522_G	526_A	0.641	0.53
49_V	227_T	0.641	0.53
57_Y	99_S	0.640	0.53
287_A	351_V	0.640	0.53
211_V	283_S	0.640	0.53
658_A	702_V	0.639	0.53
76_Q	213_Y	0.636	0.53
459_A	491_S	0.636	0.53
303_Q	361_H	0.635	0.53
26_D	382_H	0.635	0.53
80_E	83_G	0.634	0.53
95_F	559_V	0.634	0.53
661_T	664_G	0.633	0.53
733_A	737_L	0.631	0.52
596_Q	604_Y	0.630	0.52
76_Q	125_S	0.630	0.52
465_N	639_E	0.630	0.52
195_N	355_K	0.630	0.52
647_A	658_A	0.629	0.52
84_I	87_I	0.629	0.52
66_K	528_N	0.627	0.52
575_Q	709_A	0.626	0.52
56_S	59_N	0.625	0.52
617_S	621_A	0.625	0.52
171_G	462_T	0.625	0.52
467_R	470_Y	0.625	0.52
189_M	462_T	0.624	0.51
109_Y	249_P	0.623	0.51
34_I	372_D	0.623	0.51
615_E	619_Q	0.623	0.51
283_S	296_M	0.623	0.51
49_V	52_S	0.623	0.51
138_R	466_A	0.623	0.51
387_E	514_W	0.621	0.51
584_G	588_P	0.621	0.51
97_I	500_D	0.621	0.51
84_I	199_I	0.621	0.51
658_A	699_I	0.621	0.51
109_Y	156_A	0.620	0.51
478_K	612_L	0.619	0.51
635_H	639_E	0.619	0.51
288_S	371_V	0.619	0.51
109_Y	164_C	0.619	0.51
231_E	240_K	0.619	0.51
651_M	723_T	0.619	0.51
471_L	591_A	0.617	0.51
303_Q	306_T	0.617	0.51
124_F	256_L	0.616	0.51
240_K	243_A	0.616	0.51
176_F	182_G	0.616	0.51
137_L	158_I	0.615	0.50
336_D	659_N	0.615	0.50
579_L	681_V	0.614	0.50
302_P	345_A	0.614	0.50
655_N	724_K	0.614	0.50
74_V	218_T	0.614	0.50
252_E	318_S	0.613	0.50
481_V	556_I	0.612	0.50
491_S	569_T	0.612	0.50
209_N	277_A	0.611	0.50
49_V	224_H	0.611	0.50
185_L	553_T	0.610	0.50
440_V	448_V	0.610	0.50
625_A	628_K	0.608	0.50
484_A	532_T	0.608	0.50
352_T	358_R	0.608	0.50
218_T	318_S	0.608	0.50
445_D	487_N	0.608	0.50
581_Y	632_Q	0.608	0.50
85_V	451_I	0.607	0.50
421_A	447_G	0.606	0.49
465_N	636_D	0.605	0.49
204_A	207_V	0.605	0.49
299_D	310_A	0.605	0.49
14_E	17_L	0.604	0.49
136_S	171_G	0.601	0.49
596_Q	602_R	0.601	0.49
391_Y	395_L	0.601	0.49
577_G	656_L	0.601	0.49
446_A	451_I	0.601	0.49
723_T	727_E	0.601	0.49
224_H	254_L	0.600	0.49
187_N	538_N	0.600	0.49
489_I	677_F	0.600	0.49
420_I	483_E	0.600	0.49
444_S	452_R	0.600	0.49
630_F	693_V	0.600	0.49
577_G	683_K	0.600	0.49
42_T	314_M	0.599	0.49
464_C	555_V	0.599	0.49
314_M	357_L	0.598	0.49
420_I	640_G	0.598	0.49
461_T	558_M	0.597	0.48
583_I	622_L	0.596	0.48
578_D	649_S	0.594	0.48
622_L	693_V	0.593	0.48
494_E	620_K	0.592	0.48
259_C	262_V	0.591	0.48
679_V	696_A	0.590	0.48
529_V	612_L	0.590	0.48
240_K	421_A	0.589	0.47
532_T	558_M	0.587	0.47
76_Q	80_E	0.587	0.47
659_N	732_G	0.587	0.47
139_F	154_V	0.587	0.47
449_L	458_L	0.586	0.47
264_Q	337_I	0.586	0.47
398_D	401_A	0.586	0.47
249_P	584_G	0.585	0.47
690_E	693_V	0.585	0.47
207_V	350_H	0.585	0.47
406_D	644_V	0.584	0.47
477_G	523_I	0.584	0.47
732_G	735_P	0.584	0.47
485_A	498_V	0.583	0.47
336_D	628_K	0.581	0.47
614_V	628_K	0.581	0.47
65_R	68_P	0.581	0.47
69_T	78_P	0.580	0.46
602_R	605_G	0.579	0.46
588_P	667_A	0.579	0.46
662_V	699_I	0.579	0.46
445_D	648_E	0.579	0.46
596_Q	603_I	0.579	0.46
262_V	266_D	0.578	0.46
415_L	644_V	0.578	0.46
155_V	429_Q	0.578	0.46
649_S	654_E	0.577	0.46
709_A	722_Q	0.577	0.46
581_Y	685_H	0.577	0.46
627_K	630_F	0.577	0.46
478_K	609_Q	0.575	0.46
152_E	156_A	0.575	0.46
13_K	25_D	0.574	0.46
203_Q	270_G	0.574	0.46
252_E	282_S	0.573	0.46
219_G	322_M	0.573	0.46
220_R	541_L	0.573	0.46
258_A	556_I	0.572	0.46
293_G	354_D	0.572	0.46
141_E	147_V	0.571	0.45
575_Q	659_N	0.571	0.45
262_V	337_I	0.571	0.45
204_A	247_G	0.569	0.45
280_T	334_I	0.569	0.45
662_V	669_L	0.569	0.45
167_I	435_R	0.569	0.45
339_D	705_D	0.569	0.45
408_N	411_L	0.568	0.45
177_D	551_Y	0.568	0.45
193_L	451_I	0.567	0.45
281_S	535_I	0.566	0.45
660_V	710_I	0.566	0.45
350_H	360_T	0.565	0.45
705_D	709_A	0.565	0.45
668_L	729_V	0.564	0.45
70_S	73_R	0.564	0.45
427_Y	730_W	0.564	0.45
695_D	698_H	0.563	0.45
21_M	41_Y	0.563	0.45
147_V	152_E	0.562	0.44
446_A	490_C	0.562	0.44
300_L	346_V	0.562	0.44
74_V	85_V	0.562	0.44
200_K	271_I	0.560	0.44
42_T	311_Y	0.560	0.44
634_A	679_V	0.559	0.44
478_K	529_V	0.558	0.44
701_E	711_Q	0.558	0.44
586_T	671_S	0.558	0.44
650_V	656_L	0.558	0.44
705_D	722_Q	0.557	0.44
457_A	562_I	0.557	0.44
681_V	692_T	0.556	0.44
223_I	240_K	0.556	0.44
220_R	311_Y	0.556	0.44
62_P	67_F	0.556	0.44
194_I	198_D	0.555	0.44
682_K	698_H	0.555	0.44
353_D	356_M	0.554	0.44
574_K	702_V	0.553	0.43
30_L	379_P	0.553	0.43
575_Q	579_L	0.553	0.43
399_V	666_A	0.553	0.43
67_F	70_S	0.552	0.43
293_G	353_D	0.552	0.43
590_F	671_S	0.552	0.43
124_F	130_P	0.552	0.43
261_E	341_Y	0.551	0.43
146_R	151_F	0.551	0.43
520_A	556_I	0.551	0.43
632_Q	649_S	0.551	0.43
12_I	15_E	0.550	0.43
148_K	152_E	0.549	0.43
62_P	517_E	0.548	0.43
658_A	726_L	0.548	0.43
46_I	374_L	0.547	0.43
699_I	724_K	0.546	0.43
579_L	702_V	0.545	0.43
621_A	696_A	0.545	0.43
486_R	650_V	0.545	0.43
659_N	720_H	0.545	0.43
690_E	699_I	0.544	0.42
388_P	514_W	0.543	0.42
498_V	532_T	0.543	0.42
308_M	508_E	0.543	0.42
64_L	78_P	0.543	0.42
335_I	346_V	0.542	0.42
211_V	274_M	0.542	0.42
41_Y	309_T	0.541	0.42
595_L	666_A	0.541	0.42
583_I	696_A	0.539	0.42
632_Q	702_V	0.539	0.42
46_I	376_E	0.539	0.42
62_P	74_V	0.538	0.42
477_G	554_P	0.537	0.42
126_M	202_G	0.537	0.42
226_A	279_L	0.537	0.42
406_D	410_M	0.536	0.42
132_A	460_M	0.535	0.41
478_K	610_I	0.535	0.41
631_V	691_A	0.535	0.41
621_A	695_D	0.535	0.41
94_V	194_I	0.535	0.41
213_Y	282_S	0.535	0.41
493_A	560_G	0.534	0.41
270_G	294_I	0.534	0.41
617_S	620_K	0.533	0.41
71_G	270_G	0.533	0.41
78_P	81_G	0.533	0.41
396_E	399_V	0.532	0.41
369_L	374_L	0.532	0.41
485_A	530_L	0.531	0.41
637_V	669_L	0.531	0.41
12_I	16_K	0.531	0.41
146_R	152_E	0.531	0.41
731_K	735_P	0.531	0.41
528_N	582_V	0.530	0.41
60_S	99_S	0.530	0.41
297_N	310_A	0.530	0.41
167_I	256_L	0.529	0.41
439_V	457_A	0.528	0.41
465_N	468_Y	0.528	0.41
619_Q	675_S	0.528	0.41
32_E	38_L	0.528	0.41
251_M	254_L	0.527	0.41
492_G	567_H	0.527	0.41
577_G	704_A	0.527	0.41
433_M	442_P	0.527	0.41
257_E	430_Y	0.526	0.40
70_S	76_Q	0.526	0.40
59_N	384_P	0.526	0.40
617_S	631_V	0.526	0.40
224_H	523_I	0.526	0.40
209_N	283_S	0.525	0.40
91_Q	563_E	0.525	0.40
99_S	539_V	0.525	0.40
93_V	451_I	0.525	0.40
468_Y	591_A	0.523	0.40
61_K	65_R	0.523	0.40
173_E	462_T	0.523	0.40
318_S	348_V	0.522	0.40
57_Y	539_V	0.521	0.40
491_S	626_I	0.521	0.40
555_V	701_E	0.520	0.40
59_N	63_I	0.520	0.40
658_A	710_I	0.520	0.40
164_C	430_Y	0.520	0.40
74_V	533_P	0.519	0.40
178_S	688_A	0.519	0.40
619_Q	626_I	0.518	0.40
647_A	660_V	0.518	0.40
214_V	324_L	0.518	0.40
468_Y	608_P	0.518	0.40
575_Q	720_H	0.517	0.39
59_N	105_A	0.517	0.39
76_Q	281_S	0.516	0.39
58_K	96_K	0.516	0.39
501_N	555_V	0.516	0.39
296_M	359_L	0.516	0.39
728_R	731_K	0.515	0.39
462_T	555_V	0.515	0.39
104_S	186_V	0.515	0.39
249_P	477_G	0.514	0.39
276_A	541_L	0.514	0.39
287_A	355_K	0.514	0.39
140_G	177_D	0.514	0.39
266_D	333_E	0.513	0.39
102_H	113_A	0.513	0.39
129_R	435_R	0.513	0.39
220_R	315_L	0.513	0.39
84_I	194_I	0.513	0.39
46_I	314_M	0.513	0.39
686_Q	692_T	0.512	0.39
614_V	682_K	0.512	0.39
420_I	594_E	0.512	0.39
601_G	664_G	0.512	0.39
279_L	301_I	0.511	0.39
106_L	513_F	0.511	0.39
75_L	78_P	0.511	0.39
295_E	365_V	0.511	0.39
580_V	637_V	0.511	0.39
576_A	579_L	0.511	0.39
387_E	391_Y	0.510	0.39
723_T	726_L	0.510	0.39
72_E	533_P	0.510	0.39
183_N	542_Y	0.509	0.39
701_E	705_D	0.509	0.39
510_P	645_A	0.509	0.39
397_T	596_Q	0.509	0.39
664_G	691_A	0.509	0.39
407_A	669_L	0.509	0.39
75_L	79_G	0.507	0.38
501_N	523_I	0.507	0.38
204_A	269_V	0.506	0.38
621_A	631_V	0.506	0.38
390_Y	515_Q	0.506	0.38
659_N	725_E	0.506	0.38
589_E	674_Q	0.505	0.38
382_H	385_S	0.505	0.38
663_E	668_L	0.505	0.38
116_V	161_Y	0.504	0.38
63_I	517_E	0.504	0.38
706_G	728_R	0.504	0.38
133_V	158_I	0.504	0.38
492_G	626_I	0.504	0.38
579_L	682_K	0.504	0.38
567_H	682_K	0.504	0.38
105_A	134_L	0.504	0.38
283_S	287_A	0.503	0.38
614_V	675_S	0.503	0.38
419_T	597_K	0.503	0.38
161_Y	252_E	0.503	0.38
159_A	164_C	0.502	0.38
27_E	224_H	0.502	0.38
280_T	357_L	0.502	0.38
303_Q	434_V	0.501	0.38
84_I	94_V	0.501	0.38
77_G	80_E	0.500	0.38
686_Q	696_A	0.500	0.38
71_G	203_Q	0.500	0.38
685_H	701_E	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lgyA	1	0.965	100	0.34	Contact Map
3viuA	1	0.9394	100	0.347	Contact Map
1vk3A	1	0.779	100	0.465	Contact Map
2zodA	2	0.3895	100	0.847	Contact Map
3u0oA	2	0.3989	100	0.854	Contact Map
3vtiC	2	0.3774	100	0.861	Contact Map
2rb9A	2	0.4057	100	0.863	Contact Map
3fd5A	2	0.434	100	0.863	Contact Map
3wjpA	2	0.4218	100	0.869	Contact Map
2z01A	2	0.3774	100	0.87	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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