GREMLIN Database
PURQ - Phosphoribosylformylglycinamidine synthase subunit PurQ
UniProt: P12041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (214)
Sequences: 3271 (1673)
Seq/√Len: 114.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_K176_S3.6041.00
17_M85_V3.3301.00
106_K146_N3.0741.00
134_E210_K3.0251.00
183_N187_N2.7591.00
149_C153_T2.6491.00
156_T184_E2.5781.00
150_D153_T2.5171.00
155_A159_E2.4961.00
44_G81_P2.4651.00
17_M46_L2.4211.00
73_K77_A2.3531.00
82_V188_V2.2771.00
158_K166_T2.2451.00
93_Q102_M2.1971.00
118_I135_S2.1691.00
21_V46_L2.1521.00
74_Q78_E2.1391.00
120_Q166_T2.0941.00
209_L213_Q2.0521.00
22_K28_E2.0221.00
155_A176_S1.9831.00
158_K163_I1.9721.00
6_I47_I1.9641.00
20_A199_V1.9521.00
4_A32_V1.9441.00
75_A80_K1.8811.00
30_E42_F1.8641.00
13_C197_R1.8361.00
164_A182_V1.7921.00
61_A94_E1.7721.00
116_E135_S1.7581.00
156_T159_E1.7401.00
81_P125_L1.7211.00
151_D155_A1.7031.00
117_L136_I1.6811.00
71_A74_Q1.6561.00
147_F181_V1.6561.00
114_P137_T1.6481.00
27_H216_V1.6181.00
124_T164_A1.6091.00
7_V31_Y1.5911.00
3_F21_V1.5891.00
129_S217_K1.5871.00
3_F44_G1.5651.00
111_I140_V1.5391.00
157_L163_I1.5351.00
129_S214_S1.5191.00
18_Y31_Y1.5001.00
130_Y136_I1.4861.00
11_S48_P1.4711.00
21_V44_G1.4261.00
103_R148_Y1.4131.00
165_F180_G1.4061.00
3_F27_H1.3631.00
18_Y22_K1.3631.00
210_K213_Q1.3531.00
2_K41_G1.3391.00
140_V171_I1.3301.00
157_L181_V1.3291.00
2_K28_E1.3231.00
119_V165_F1.3181.00
124_T182_V1.3011.00
116_E168_G1.2991.00
46_L83_L1.2971.00
13_C141_A1.2960.99
141_A197_R1.2960.99
180_G191_M1.2870.99
213_Q217_K1.2840.99
89_F190_G1.2640.99
160_N184_E1.2630.99
22_K29_V1.2440.99
139_P198_A1.2420.99
121_N131_E1.2260.99
118_I168_G1.2220.99
201_E206_A1.2090.99
40_D74_Q1.2010.99
107_D111_I1.1950.99
171_I177_D1.1810.99
183_N188_V1.1790.99
170_N177_D1.1680.99
162_Q182_V1.1670.99
156_T160_N1.1650.99
110_F141_A1.1570.99
131_E134_E1.1450.99
130_Y210_K1.1440.99
149_C154_L1.1330.99
21_V27_H1.1260.99
167_Y179_A1.1250.99
182_V186_G1.1240.99
121_N161_N1.1210.99
199_V203_L1.1130.98
151_D175_V1.1080.98
135_S168_G1.1080.98
163_I166_T1.1050.98
152_E155_A1.0990.98
103_R146_N1.0990.98
66_A70_P1.0890.98
94_E101_A1.0770.98
43_D79_G1.0760.98
40_D71_A1.0710.98
76_A97_L1.0690.98
116_E137_T1.0690.98
74_Q77_A1.0680.98
104_R108_L1.0650.98
93_Q98_L1.0620.98
154_L175_V1.0530.98
154_L158_K1.0470.98
121_N124_T1.0460.98
51_F86_C1.0450.98
25_L209_L1.0350.98
151_D176_S1.0340.98
157_L162_Q1.0310.97
89_F98_L1.0270.97
121_N186_G1.0150.97
39_L45_V0.9950.97
4_A42_F0.9930.97
6_I72_V0.9890.97
19_H199_V0.9870.97
59_C144_E0.9850.97
129_S213_Q0.9820.97
13_C138_I0.9810.97
127_T165_F0.9720.96
45_V82_V0.9650.96
156_T168_G0.9600.96
155_A158_K0.9580.96
82_V92_L0.9510.96
60_G64_R0.9510.96
182_V189_L0.9470.96
14_D31_Y0.9360.96
115_V140_V0.9250.95
163_I178_I0.9220.95
5_V21_V0.9200.95
164_A189_L0.9070.95
115_V171_I0.9040.95
98_L190_G0.9030.95
162_Q184_E0.8930.94
156_T169_S0.8910.94
2_K30_E0.8890.94
148_Y175_V0.8890.94
165_F189_L0.8860.94
149_C181_V0.8860.94
45_V80_K0.8830.94
59_C102_M0.8690.93
11_S14_D0.8680.93
45_V75_A0.8640.93
156_T162_Q0.8560.93
12_N86_C0.8550.93
92_L188_V0.8520.93
89_F102_M0.8510.93
118_I166_T0.8470.92
114_P204_G0.8460.92
5_V48_P0.8450.92
98_L188_V0.8330.92
69_M95_L0.8330.92
141_A196_E0.8280.92
30_E38_S0.8250.91
30_E41_G0.8240.91
117_L195_P0.8220.91
38_S71_A0.8190.91
129_S210_K0.8190.91
152_E159_E0.8150.91
125_L218_N0.8050.90
154_L176_S0.8030.90
205_S213_Q0.8020.90
7_V18_Y0.8010.90
119_V130_Y0.7980.90
34_H66_A0.7970.90
35_E66_A0.7960.90
178_I181_V0.7890.90
128_A217_K0.7860.89
113_R140_V0.7850.89
168_G177_D0.7840.89
59_C104_R0.7830.89
46_L85_V0.7740.89
104_R143_G0.7740.89
153_T156_T0.7600.88
123_E161_N0.7570.88
70_P73_K0.7570.88
130_Y134_E0.7560.87
152_E156_T0.7540.87
102_M147_F0.7520.87
104_R109_K0.7520.87
181_V190_G0.7510.87
165_F168_G0.7480.87
37_T71_A0.7450.87
75_A81_P0.7390.86
8_L63_A0.7380.86
86_C172_N0.7380.86
5_V18_Y0.7340.86
25_L212_F0.7300.86
13_C203_L0.7260.85
48_P112_C0.7260.85
69_M72_V0.7250.85
142_H172_N0.7200.85
124_T127_T0.7150.84
130_Y211_L0.7120.84
60_G91_I0.7110.84
170_N174_S0.7090.84
61_A101_A0.7070.84
102_M190_G0.7020.83
154_L178_I0.6960.83
65_F68_I0.6940.83
161_N186_G0.6940.83
68_I71_A0.6880.82
37_T40_D0.6860.82
180_G190_G0.6860.82
155_A175_V0.6860.82
4_A35_E0.6850.82
128_A214_S0.6820.82
51_F172_N0.6820.82
44_G215_I0.6790.81
25_L216_V0.6760.81
124_T186_G0.6760.81
110_F196_E0.6740.81
69_M73_K0.6720.81
12_N141_A0.6660.80
70_P74_Q0.6640.80
79_G218_N0.6620.80
166_T176_S0.6610.79
51_F142_H0.6600.79
18_Y29_V0.6600.79
200_D203_L0.6580.79
76_A82_V0.6520.79
120_Q133_G0.6510.78
12_N142_H0.6500.78
55_D86_C0.6450.78
51_F194_H0.6360.77
41_G71_A0.6330.76
86_C144_E0.6290.76
77_A185_K0.6280.76
21_V29_V0.6270.76
87_N90_Q0.6260.76
112_C141_A0.6210.75
19_H22_K0.6200.75
37_T68_I0.6190.75
158_K161_N0.6180.75
20_A26_G0.6080.74
138_I207_D0.6050.73
126_F189_L0.6030.73
79_G187_N0.6030.73
164_A186_G0.6020.73
117_L179_A0.6010.73
75_A78_E0.6000.73
81_P215_I0.5990.72
198_A204_G0.5980.72
47_I72_V0.5960.72
42_F75_A0.5950.72
32_V38_S0.5950.72
122_D125_L0.5940.72
37_T70_P0.5920.72
8_L11_S0.5910.71
12_N197_R0.5850.71
162_Q169_S0.5850.71
86_C142_H0.5850.71
52_S172_N0.5840.71
38_S41_G0.5780.70
72_V76_A0.5720.69
165_F169_S0.5710.69
39_L71_A0.5680.68
12_N51_F0.5680.68
195_P208_G0.5670.68
44_G126_F0.5670.68
147_F175_V0.5670.68
138_I197_R0.5650.68
192_M196_E0.5650.68
126_F211_L0.5640.68
44_G83_L0.5610.68
58_R61_A0.5600.67
111_I171_I0.5580.67
15_I31_Y0.5520.66
130_Y214_S0.5510.66
3_F25_L0.5500.66
127_T189_L0.5500.66
136_I139_P0.5480.66
158_K168_G0.5480.66
123_E182_V0.5470.66
25_L35_E0.5470.66
122_D131_E0.5460.65
127_T164_A0.5450.65
2_K212_F0.5430.65
149_C175_V0.5420.65
26_G29_V0.5420.65
64_R73_K0.5410.65
58_R94_E0.5400.65
14_D112_C0.5400.65
169_S177_D0.5380.64
125_L128_A0.5380.64
163_I176_S0.5380.64
86_C194_H0.5370.64
136_I209_L0.5360.64
57_L61_A0.5340.64
47_I92_L0.5310.63
58_R100_G0.5290.63
51_F192_M0.5290.63
39_L68_I0.5280.63
5_V29_V0.5280.63
38_S68_I0.5280.63
86_C90_Q0.5270.63
97_L188_V0.5260.63
60_G188_V0.5260.63
92_L190_G0.5250.62
94_E97_L0.5240.62
59_C143_G0.5200.62
49_G194_H0.5180.61
49_G90_Q0.5180.61
8_L58_R0.5140.61
8_L95_L0.5130.61
119_V136_I0.5130.61
3_F29_V0.5120.61
147_F157_L0.5120.61
13_C17_M0.5110.60
25_L29_V0.5110.60
3_F46_L0.5110.60
114_P138_I0.5090.60
164_A169_S0.5090.60
92_L180_G0.5080.60
142_H194_H0.5070.60
81_P187_N0.5060.60
130_Y208_G0.5030.59
83_L189_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lgyA 1 0.9604 100 0.433 Contact Map
3d54D 1 0.9251 100 0.615 Contact Map
1l9xA 1 0.9471 99.9 0.747 Contact Map
2w7tA 1 0.9207 99.9 0.749 Contact Map
3fijA 4 0.8502 99.9 0.759 Contact Map
2vxoA 2 0.8194 99.9 0.766 Contact Map
4l8fC 3 0.9427 99.9 0.767 Contact Map
2vpiA 1 0.793 99.8 0.768 Contact Map
1wl8A 1 0.8062 99.8 0.768 Contact Map
1qdlB 2 0.8194 99.8 0.769 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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