GREMLIN Database
PUR3 - Phosphoribosylglycinamide formyltransferase
UniProt: P12040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (177)
Sequences: 10725 (6580)
Seq/√Len: 494.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_V154_A3.7331.00
95_D142_E2.9531.00
143_G146_T2.9021.00
141_D146_T2.7731.00
95_D99_Q2.7471.00
161_D169_R2.7151.00
115_A130_V2.5731.00
116_F130_V2.5221.00
33_L79_H2.4461.00
8_A43_V2.3821.00
116_F128_A2.2611.00
137_V181_V2.2471.00
153_K180_S2.2371.00
136_T149_I2.2111.00
161_D165_T2.1641.00
123_G163_L2.1191.00
184_Q189_N2.0421.00
75_Q78_L1.9851.00
77_R100_A1.9281.00
139_Y150_I1.9191.00
23_K50_F1.9001.00
120_D123_G1.8801.00
16_E20_T1.8071.00
74_E78_L1.8031.00
123_G127_R1.7591.00
153_K173_L1.7481.00
151_A177_W1.7471.00
42_K45_E1.7291.00
151_A181_V1.7081.00
153_K176_K1.6941.00
158_D169_R1.6671.00
92_L144_M1.6541.00
162_T165_T1.6341.00
55_F75_Q1.6091.00
155_I173_L1.5761.00
71_A74_E1.5531.00
139_Y185_L1.5511.00
124_Q127_R1.5051.00
45_E48_E1.4661.00
158_D161_D1.4471.00
83_L182_I1.4281.00
180_S184_Q1.3991.00
53_P79_H1.3971.00
132_V156_E1.3921.00
183_K187_G1.3771.00
29_A186_L1.3581.00
136_T152_Q1.3541.00
106_I150_I1.3401.00
112_L134_G1.3051.00
151_A184_Q1.3051.00
70_Q96_T1.3011.00
58_E61_S1.3001.00
15_F34_L1.2751.00
155_I169_R1.2751.00
120_D124_Q1.2591.00
153_K177_W1.2581.00
6_V15_F1.2571.00
42_K46_R1.2541.00
98_L105_I1.2401.00
81_V84_I1.2271.00
21_R179_P1.2241.00
84_I105_I1.2131.00
121_A124_Q1.2091.00
73_I77_R1.1791.00
124_Q128_A1.1781.00
149_I152_Q1.1621.00
163_L167_E1.1541.00
28_D183_K1.1521.00
151_A180_S1.1511.00
73_I100_A1.1471.00
70_Q74_E1.1361.00
126_F166_I1.1351.00
55_F79_H1.1331.00
16_E46_R1.1321.00
35_V55_F1.1311.00
185_L190_N1.1221.00
33_L55_F1.1211.00
99_Q142_E1.0991.00
44_I54_S1.0921.00
19_V50_F1.0911.00
75_Q79_H1.0891.00
173_L176_K1.0691.00
184_Q190_N1.0671.00
39_P56_A1.0661.00
73_I101_Y1.0571.00
18_I108_I1.0561.00
18_I182_I1.0541.00
141_D148_P1.0531.00
85_A182_I1.0481.00
176_K180_S1.0351.00
133_A166_I1.0331.00
32_A79_H1.0161.00
112_L152_Q1.0161.00
137_V177_W1.0131.00
33_L81_V1.0131.00
53_P75_Q1.0021.00
20_T50_F1.0021.00
167_E171_H0.9941.00
34_L47_A0.9881.00
76_L81_V0.9791.00
59_P91_R0.9741.00
74_E77_R0.9741.00
133_A157_I0.9731.00
35_V72_I0.9561.00
45_E49_A0.9511.00
22_L29_A0.9491.00
29_A183_K0.9401.00
108_I178_Y0.9271.00
122_V167_E0.9131.00
137_V151_A0.9001.00
73_I96_T0.8951.00
17_A20_T0.8941.00
57_F68_F0.8901.00
86_L140_V0.8901.00
157_I161_D0.8831.00
106_I185_L0.8821.00
101_Y105_I0.8791.00
122_V170_I0.8761.00
105_I140_V0.8711.00
85_A178_Y0.8641.00
22_L27_W0.8581.00
19_V52_I0.8521.00
135_I173_L0.8461.00
113_L117_P0.8421.00
39_P42_K0.8421.00
15_F19_V0.8391.00
81_V100_A0.8381.00
32_A81_V0.8301.00
18_I178_Y0.8291.00
11_N42_K0.8261.00
158_D165_T0.8171.00
73_I97_L0.8151.00
183_K186_L0.8091.00
16_E50_F0.8071.00
93_I105_I0.8031.00
171_H175_H0.8031.00
21_R176_K0.8021.00
106_I178_Y0.8011.00
8_A36_C0.7921.00
125_A130_V0.7901.00
115_A132_V0.7881.00
83_L185_L0.7881.00
96_T99_Q0.7841.00
165_T169_R0.7801.00
33_L75_Q0.7781.00
177_W181_V0.7731.00
101_Y104_K0.7721.00
18_I87_A0.7701.00
172_K176_K0.7691.00
21_R27_W0.7661.00
11_N171_H0.7641.00
37_D59_P0.7621.00
16_E49_A0.7611.00
151_A156_E0.7531.00
168_Q172_K0.7521.00
126_F163_L0.7521.00
131_K156_E0.7491.00
71_A75_Q0.7491.00
135_I177_W0.7481.00
122_V125_A0.7471.00
76_L84_I0.7381.00
18_I22_L0.7331.00
184_Q187_G0.7331.00
47_A51_H0.7311.00
161_D166_I0.7281.00
69_E94_G0.7271.00
168_Q171_H0.7211.00
125_A133_A0.7181.00
37_D91_R0.7161.00
17_A175_H0.7121.00
17_A171_H0.6971.00
21_R26_N0.6921.00
28_D187_G0.6881.00
17_A21_R0.6861.00
160_H165_T0.6761.00
155_I161_D0.6691.00
27_W179_P0.6691.00
98_L140_V0.6691.00
15_F18_I0.6661.00
164_E168_Q0.6631.00
61_S94_G0.6621.00
36_C44_I0.6621.00
19_V31_A0.6541.00
119_I124_Q0.6541.00
119_I144_M0.6511.00
157_I166_I0.6501.00
106_I137_V0.6471.00
94_G97_L0.6451.00
108_I174_E0.6411.00
59_P68_F0.6381.00
37_D40_Q0.6361.00
150_I185_L0.6351.00
117_P146_T0.6341.00
47_A52_I0.6341.00
20_T23_K0.6321.00
8_A15_F0.6311.00
84_I101_Y0.6301.00
108_I135_I0.6301.00
11_N46_R0.6241.00
22_L31_A0.6231.00
69_E72_I0.6231.00
126_F157_I0.6231.00
44_I56_A0.6221.00
27_W183_K0.6181.00
173_L177_W0.6100.99
26_N183_K0.6090.99
7_F72_I0.6070.99
181_V184_Q0.6070.99
133_A155_I0.6060.99
112_L154_A0.6050.99
91_R94_G0.6040.99
110_P122_V0.6040.99
94_G98_L0.6030.99
125_A157_I0.5990.99
20_T26_N0.5960.99
68_F89_Y0.5940.99
139_Y148_P0.5920.99
42_K48_E0.5840.99
77_R101_Y0.5770.99
7_F84_I0.5760.99
155_I170_I0.5760.99
36_C41_A0.5710.99
83_L106_I0.5710.99
15_F22_L0.5690.99
131_K159_E0.5690.99
19_V46_R0.5670.99
121_A125_A0.5660.99
110_P170_I0.5650.99
77_R80_E0.5630.99
93_I97_L0.5630.99
20_T49_A0.5610.99
150_I190_N0.5600.99
47_A50_F0.5600.99
7_F81_V0.5590.99
19_V22_L0.5540.99
57_F60_K0.5540.99
41_A46_R0.5510.99
123_G167_E0.5490.99
40_Q58_E0.5480.99
76_L97_L0.5470.99
34_L43_V0.5450.99
9_S84_I0.5440.99
72_I75_Q0.5420.99
8_A34_L0.5410.99
111_S144_M0.5400.99
111_S121_A0.5390.99
57_F61_S0.5370.99
136_T150_I0.5360.99
121_A133_A0.5350.99
120_D163_L0.5350.99
41_A44_I0.5300.99
115_A128_A0.5280.98
131_K154_A0.5270.98
155_I166_I0.5240.98
122_V126_F0.5240.98
96_T100_A0.5240.98
70_Q73_I0.5240.98
180_S183_K0.5200.98
87_A174_E0.5140.98
12_G41_A0.5070.98
48_E54_S0.5070.98
46_R50_F0.5060.98
60_K72_I0.5060.98
155_I158_D0.5050.98
7_F35_V0.5040.98
35_V84_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ywrA 2 1 100 0.082 Contact Map
4ew1A 2 0.9949 100 0.083 Contact Map
3tqrA 2 0.9897 100 0.086 Contact Map
1jkxA 2 0.9949 100 0.086 Contact Map
3aufA 2 1 100 0.086 Contact Map
4ds3A 2 0.9487 100 0.089 Contact Map
3p9xA 2 0.9949 100 0.094 Contact Map
3av3A 1 0.959 100 0.096 Contact Map
3kcqA 2 0.9744 100 0.1 Contact Map
3da8A 2 0.9897 100 0.105 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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