GREMLIN Database
PUR2 - Phosphoribosylamine--glycine ligase
UniProt: P12039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (380)
Sequences: 20570 (11555)
Seq/√Len: 592.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_Q159_E4.0051.00
130_K163_I3.3221.00
158_T161_E3.2551.00
119_E186_E3.1921.00
56_S60_Q3.1601.00
251_K255_K3.0581.00
125_S128_E2.9931.00
50_D53_G2.7751.00
247_E252_P2.7481.00
384_D389_A2.7231.00
80_D98_I2.6851.00
386_T389_A2.6501.00
138_A159_E2.6401.00
243_R247_E2.6191.00
310_D315_K2.5741.00
80_D84_K2.5011.00
157_M161_E2.3371.00
59_K85_A2.3041.00
18_K21_Q2.2931.00
112_K256_A2.2571.00
110_M253_A2.2101.00
121_E135_E2.2071.00
239_E243_R2.1161.00
75_I101_G2.1051.00
81_E85_A2.0671.00
238_S241_T2.0581.00
201_G265_T2.0371.00
132_Y135_E2.0351.00
105_F108_D2.0201.00
108_D112_K2.0141.00
232_S299_R1.9961.00
27_N42_Q1.9931.00
5_I16_A1.9791.00
157_M189_S1.9371.00
306_Q310_D1.9321.00
189_S276_E1.8961.00
159_E163_I1.8921.00
155_V187_Y1.8701.00
385_E389_A1.8471.00
126_F163_I1.8441.00
275_T278_G1.8421.00
55_V85_A1.8331.00
301_E320_R1.8311.00
126_F130_K1.8021.00
132_Y136_K1.7811.00
51_H81_E1.7801.00
3_V90_F1.7471.00
163_I167_H1.7421.00
98_I105_F1.7301.00
109_L256_A1.7271.00
241_T244_H1.7191.00
333_S394_V1.7091.00
126_F167_H1.7031.00
130_K159_E1.6981.00
19_A28_V1.6911.00
345_P369_E1.6851.00
301_E322_K1.6841.00
4_L31_A1.6741.00
55_V59_K1.6691.00
27_N43_L1.6631.00
93_S96_A1.6491.00
108_D111_K1.6451.00
131_A135_E1.6351.00
307_V318_D1.6291.00
198_F307_V1.6161.00
113_Y256_A1.6041.00
247_E251_K1.6031.00
341_A344_T1.6011.00
83_E94_K1.5981.00
99_I109_L1.5831.00
53_G56_S1.5671.00
66_T87_L1.5661.00
170_L180_A1.5601.00
241_T274_L1.5531.00
57_F61_N1.5531.00
18_K306_Q1.5361.00
104_Q122_T1.5261.00
81_E84_K1.5261.00
197_A250_V1.5211.00
99_I105_F1.5181.00
198_F267_V1.4971.00
82_F87_L1.4971.00
164_A168_D1.4921.00
104_Q108_D1.4841.00
330_V333_S1.4791.00
252_P255_K1.4761.00
109_L112_K1.4641.00
249_I279_S1.4591.00
243_R246_V1.4541.00
30_A41_A1.4511.00
124_T128_E1.4481.00
21_Q306_Q1.4441.00
145_D181_S1.4401.00
140_I184_I1.4401.00
52_A81_E1.4381.00
56_S59_K1.4281.00
130_K134_Q1.4241.00
133_V138_A1.4191.00
195_L245_A1.4181.00
131_A134_Q1.4051.00
3_V19_A1.4001.00
51_H55_V1.3961.00
109_L113_Y1.3951.00
20_A42_Q1.3861.00
121_E132_Y1.3751.00
124_T181_S1.3711.00
95_A99_I1.3701.00
37_M43_L1.3681.00
198_F311_L1.3681.00
244_H247_E1.3661.00
298_P381_T1.3651.00
298_P383_F1.3611.00
186_E280_K1.3591.00
364_K367_G1.3571.00
242_V246_V1.3361.00
126_F166_L1.3331.00
83_E93_S1.3321.00
107_K185_E1.3271.00
246_V251_K1.3211.00
133_V140_I1.3201.00
102_S145_D1.3201.00
111_K119_E1.3151.00
321_W324_T1.2931.00
127_D131_A1.2871.00
396_K400_E1.2841.00
336_Y375_G1.2781.00
193_F274_L1.2731.00
167_H171_E1.2731.00
138_A158_T1.2721.00
188_L282_I1.2681.00
106_A110_M1.2641.00
197_A254_A1.2611.00
17_W21_Q1.2601.00
88_H313_D1.2531.00
123_F132_Y1.2511.00
388_E392_D1.2461.00
328_S379_N1.2451.00
58_A87_L1.2381.00
250_V270_A1.2371.00
360_H363_T1.2241.00
128_E131_A1.2231.00
100_E284_F1.2161.00
75_I78_L1.2051.00
384_D393_R1.2031.00
332_A335_G1.1941.00
366_E369_E1.1931.00
108_D120_Y1.1921.00
199_V254_A1.1891.00
80_D95_A1.1781.00
346_I349_L1.1741.00
239_E242_V1.1721.00
111_K117_T1.1701.00
26_E313_D1.1671.00
389_A393_R1.1661.00
82_F89_V1.1641.00
43_L61_N1.1641.00
197_A270_A1.1641.00
395_Y399_D1.1551.00
110_M281_V1.1541.00
46_I50_D1.1531.00
107_K117_T1.1511.00
122_T181_S1.1511.00
3_V26_E1.1461.00
141_V155_V1.1431.00
244_H278_G1.1421.00
199_V205_Y1.1401.00
119_E136_K1.1351.00
380_V401_I1.1341.00
127_D130_K1.1291.00
69_G73_P1.1181.00
288_F304_L1.1181.00
240_E244_H1.1111.00
154_T169_F1.0911.00
3_V309_L1.0861.00
104_Q145_D1.0841.00
328_S332_A1.0831.00
164_A167_H1.0811.00
93_S265_T1.0811.00
22_S303_D1.0801.00
393_R396_K1.0791.00
237_I241_T1.0781.00
384_D390_A1.0761.00
161_E164_A1.0681.00
302_S307_V1.0671.00
58_A66_T1.0631.00
382_A394_V1.0621.00
380_V397_A1.0551.00
154_T168_D1.0521.00
19_A309_L1.0511.00
329_V332_A1.0491.00
345_P348_S1.0481.00
166_L170_L1.0461.00
116_P249_I1.0451.00
353_T356_V1.0441.00
391_R395_Y1.0411.00
297_L381_T1.0391.00
330_V335_G1.0391.00
342_K345_P1.0351.00
66_T82_F1.0311.00
396_K399_D1.0261.00
4_L58_A1.0241.00
205_Y251_K1.0201.00
141_V187_Y1.0191.00
134_Q163_I1.0131.00
55_V81_E1.0091.00
189_S275_T1.0061.00
95_A98_I1.0021.00
31_A54_L0.9911.00
138_A162_A0.9901.00
15_L67_I0.9871.00
327_V332_A0.9851.00
129_A162_A0.9821.00
154_T165_C0.9821.00
307_V310_D0.9811.00
111_K120_Y0.9781.00
17_W359_F0.9781.00
160_E164_A0.9781.00
392_D396_K0.9731.00
52_A56_S0.9711.00
29_F61_N0.9691.00
236_Q274_L0.9681.00
136_K140_I0.9681.00
195_L250_V0.9601.00
209_I212_D0.9591.00
274_L279_S0.9561.00
190_G276_E0.9551.00
382_A397_A0.9541.00
126_F170_L0.9521.00
324_T385_E0.9521.00
72_V76_E0.9491.00
317_V320_R0.9441.00
83_E265_T0.9411.00
328_S333_S0.9411.00
253_A284_F0.9341.00
79_V89_V0.9321.00
197_A268_L0.9301.00
5_I19_A0.9301.00
142_I182_V0.9291.00
195_L246_V0.9261.00
16_A28_V0.9251.00
88_H201_G0.9241.00
80_D94_K0.9221.00
350_A368_G0.9151.00
22_S306_Q0.9141.00
16_A41_A0.9131.00
240_E243_R0.9101.00
309_L313_D0.9081.00
250_V272_L0.9061.00
119_E135_E0.9051.00
202_E314_D0.9051.00
129_A166_L0.9041.00
331_L398_V0.9001.00
78_L82_F0.8971.00
146_G179_S0.8921.00
93_S263_S0.8901.00
133_V162_A0.8891.00
67_I308_L0.8891.00
270_A284_F0.8831.00
199_V204_V0.8821.00
199_V255_K0.8821.00
244_H279_S0.8761.00
32_P44_V0.8731.00
207_M246_V0.8731.00
317_V321_W0.8711.00
111_K121_E0.8701.00
327_V330_V0.8701.00
41_A44_V0.8691.00
166_L182_V0.8631.00
20_A28_V0.8611.00
32_P37_M0.8561.00
244_H249_I0.8541.00
22_S310_D0.8531.00
318_D321_W0.8531.00
249_I272_L0.8531.00
344_T348_S0.8531.00
57_F63_V0.8511.00
204_V254_A0.8501.00
204_V255_K0.8501.00
188_L280_K0.8481.00
115_I281_V0.8451.00
397_A400_E0.8401.00
254_A268_L0.8401.00
160_E163_I0.8371.00
347_G402_F0.8371.00
316_E321_W0.8311.00
191_E274_L0.8301.00
104_Q181_S0.8291.00
330_V334_E0.8261.00
203_K255_K0.8261.00
307_V319_L0.8211.00
54_L82_F0.8191.00
140_I156_A0.8181.00
82_F85_A0.8171.00
352_E355_Q0.8061.00
316_E319_L0.8051.00
231_Y387_F0.8041.00
77_G98_I0.8031.00
80_D83_E0.8021.00
344_T347_G0.7991.00
207_M321_W0.7971.00
71_E74_L0.7951.00
100_E257_M0.7951.00
339_S342_K0.7941.00
345_P349_L0.7941.00
340_Y344_T0.7891.00
79_V83_E0.7871.00
156_A165_C0.7851.00
382_A390_A0.7821.00
55_V84_K0.7821.00
102_S181_S0.7791.00
252_P256_A0.7791.00
320_R323_D0.7771.00
200_K204_V0.7761.00
316_E320_R0.7761.00
19_A67_I0.7751.00
30_A37_M0.7741.00
210_A242_V0.7741.00
207_M212_D0.7681.00
123_F129_A0.7651.00
77_G81_E0.7631.00
29_F57_F0.7621.00
324_T383_F0.7581.00
76_E98_I0.7571.00
83_E95_A0.7571.00
245_A279_S0.7541.00
128_E132_Y0.7541.00
211_Q214_K0.7511.00
329_V333_S0.7501.00
341_A348_S0.7431.00
133_V137_G0.7431.00
208_V212_D0.7401.00
141_V153_V0.7401.00
308_L312_L0.7391.00
389_A392_D0.7391.00
90_F309_L0.7381.00
70_P73_P0.7341.00
142_I165_C0.7281.00
208_V211_Q0.7261.00
136_K186_E0.7251.00
299_R326_A0.7211.00
273_M282_I0.7211.00
29_F63_V0.7201.00
232_S295_V0.7191.00
142_I156_A0.7181.00
344_T349_L0.7181.00
13_H40_S0.7141.00
47_E50_D0.7131.00
196_M267_V0.7131.00
16_A30_A0.7111.00
328_S331_L0.7081.00
126_F162_A0.7081.00
58_A82_F0.7061.00
29_F44_V0.7061.00
357_V382_A0.7061.00
265_T311_L0.7061.00
46_I53_G0.7041.00
121_E128_E0.7031.00
130_K167_H0.6981.00
104_Q183_V0.6971.00
359_F378_A0.6961.00
283_E287_R0.6961.00
6_I78_L0.6961.00
51_H78_L0.6931.00
193_F245_A0.6921.00
227_G230_A0.6921.00
359_F363_T0.6921.00
156_A162_A0.6911.00
237_I242_V0.6881.00
142_I166_L0.6881.00
388_E391_R0.6871.00
207_M214_K0.6861.00
34_N37_M0.6861.00
108_D122_T0.6841.00
168_D171_E0.6821.00
18_K22_S0.6811.00
83_E89_V0.6791.00
96_A265_T0.6781.00
88_H265_T0.6771.00
198_F207_M0.6771.00
222_G227_G0.6761.00
177_D180_A0.6751.00
133_V166_L0.6741.00
208_V232_S0.6741.00
230_A295_V0.6731.00
19_A26_E0.6711.00
275_T280_K0.6691.00
363_T367_G0.6681.00
355_Q393_R0.6661.00
326_A329_V0.6641.00
208_V300_M0.6631.00
264_F268_L0.6621.00
36_G39_A0.6621.00
188_L275_T0.6591.00
96_A263_S0.6571.00
114_D252_P0.6571.00
199_V265_T0.6531.00
274_L277_N0.6531.00
211_Q231_Y0.6501.00
378_A401_I0.6501.00
337_P340_Y0.6491.00
394_V398_V0.6481.00
191_E236_Q0.6471.00
75_I79_V0.6451.00
229_G333_S0.6451.00
129_A184_I0.6451.00
79_V82_F0.6451.00
206_P319_L0.6441.00
65_L312_L0.6441.00
294_Q297_L0.6431.00
210_A214_K0.6411.00
193_F234_V0.6401.00
333_S336_Y0.6391.00
209_I299_R0.6361.00
105_F109_L0.6351.00
253_A256_A0.6341.00
208_V299_R0.6331.00
250_V254_A0.6321.00
294_Q332_A0.6311.00
22_S309_L0.6301.00
332_A336_Y0.6291.00
209_I326_A0.6291.00
35_D370_F0.6261.00
58_A63_V0.6261.00
277_N280_K0.6231.00
212_D234_V0.6211.00
107_K118_A0.6201.00
170_L182_V0.6201.00
28_V32_P0.6201.00
222_G226_G0.6191.00
4_L63_V0.6191.00
94_K98_I0.6181.00
347_G350_A0.6171.00
332_A337_P0.6161.00
244_H252_P0.6141.00
341_A346_I0.6131.00
340_Y343_G0.6131.00
126_F129_A0.6131.00
209_I213_H0.6111.00
110_M115_I0.6091.00
359_F364_K0.6071.00
90_F312_L0.6041.00
204_V208_V0.6031.00
207_M210_A0.6021.00
77_G80_D0.6021.00
257_M263_S0.6011.00
102_S105_F0.6011.00
310_D318_D0.6001.00
193_F272_L0.5991.00
327_V385_E0.5991.00
358_V361_A0.5981.00
145_D183_V0.5961.00
238_S278_G0.5961.00
399_D402_F0.5941.00
142_I184_I0.5941.00
319_L323_D0.5931.00
165_C169_F0.5931.00
325_A328_S0.5921.00
169_F182_V0.5901.00
103_K143_K0.5891.00
328_S335_G0.5871.00
137_G159_E0.5861.00
361_A364_K0.5841.00
200_K314_D0.5841.00
76_E79_V0.5831.00
326_A330_V0.5831.00
274_L278_G0.5821.00
6_I54_L0.5821.00
3_V28_V0.5821.00
132_Y184_I0.5801.00
59_K84_K0.5791.00
88_H91_G0.5791.00
210_A213_H0.5781.00
193_F237_I0.5781.00
55_V87_L0.5771.00
165_C168_D0.5771.00
202_E255_K0.5761.00
342_K348_S0.5761.00
309_L312_L0.5751.00
200_K203_K0.5751.00
133_V184_I0.5741.00
304_L308_L0.5741.00
210_A234_V0.5741.00
115_I249_I0.5741.00
352_E356_V0.5731.00
142_I162_A0.5731.00
331_L336_Y0.5731.00
343_G346_I0.5721.00
359_F401_I0.5721.00
19_A305_V0.5711.00
53_G57_F0.5711.00
70_P74_L0.5701.00
356_V397_A0.5691.00
390_A394_V0.5681.00
95_A105_F0.5661.00
224_N227_G0.5661.00
338_E341_A0.5651.00
359_F362_G0.5631.00
327_V383_F0.5621.00
51_H76_E0.5621.00
334_E341_A0.5600.99
331_L334_E0.5590.99
118_A282_I0.5580.99
327_V333_S0.5570.99
44_V57_F0.5570.99
195_L272_L0.5570.99
133_V136_K0.5560.99
334_E337_P0.5540.99
125_S166_L0.5540.99
344_T390_A0.5540.99
37_M40_S0.5540.99
134_Q138_A0.5510.99
195_L210_A0.5510.99
238_S274_L0.5490.99
331_L335_G0.5480.99
118_A188_L0.5470.99
270_A281_V0.5470.99
238_S242_V0.5450.99
157_M187_Y0.5420.99
59_K87_L0.5410.99
196_M269_Y0.5400.99
209_I242_V0.5400.99
364_K371_V0.5390.99
331_L390_A0.5390.99
341_A347_G0.5380.99
199_V263_S0.5380.99
138_A157_M0.5370.99
362_G365_A0.5360.99
5_I30_A0.5340.99
206_P246_V0.5340.99
155_V225_T0.5340.99
186_E275_T0.5330.99
130_K162_A0.5300.99
208_V213_H0.5290.99
253_A281_V0.5280.99
102_S146_G0.5280.99
140_I186_E0.5280.99
365_A368_G0.5280.99
302_S319_L0.5280.99
196_M210_A0.5270.99
209_I324_T0.5270.99
319_L324_T0.5260.99
57_F60_Q0.5240.99
107_K111_K0.5230.99
353_T357_V0.5230.99
264_F286_A0.5220.99
16_A20_A0.5210.99
387_F391_R0.5210.99
297_L303_D0.5200.99
267_V288_F0.5180.99
241_T279_S0.5170.99
202_E265_T0.5170.99
129_A132_Y0.5170.99
109_L257_M0.5160.99
307_V317_V0.5140.99
318_D322_K0.5140.99
56_S85_A0.5110.99
69_G72_V0.5110.99
106_A281_V0.5100.99
343_G349_L0.5090.99
362_G367_G0.5090.99
245_A272_L0.5090.99
151_K176_G0.5060.99
211_Q234_V0.5050.99
115_I252_P0.5040.99
3_V305_V0.5020.99
54_L66_T0.5020.99
51_H77_G0.5020.99
106_A285_N0.5010.99
205_Y255_K0.5010.99
161_E165_C0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xclA 1 0.9976 100 0.293 Contact Map
2yw2A 2 0.9929 100 0.295 Contact Map
2yrxA 1 0.9739 100 0.296 Contact Map
2ip4A 1 0.9716 100 0.303 Contact Map
3lp8A 1 0.9692 100 0.314 Contact Map
3mjfA 1 0.9858 100 0.317 Contact Map
2qk4A 1 0.9739 100 0.326 Contact Map
3n6rA 1 0.8057 100 0.332 Contact Map
3u9tA 3 0.9289 100 0.335 Contact Map
3va7A 1 0.7938 100 0.338 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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