GREMLIN Database
6PGDH - 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating
UniProt: P12013 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 468 (463)
Sequences: 1774 (909)
Seq/√Len: 42.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_Y406_K4.6111.00
453_Y464_T4.1461.00
84_Q113_E3.6361.00
108_E174_K3.4881.00
4_S64_E3.3701.00
23_N134_L3.3651.00
224_E322_R3.3261.00
210_L247_P3.1821.00
56_L89_L3.0951.00
380_E390_A2.9821.00
212_E314_K2.9621.00
351_L356_I2.8961.00
202_L321_V2.8901.00
29_A62_S2.8511.00
319_E322_R2.8491.00
209_P212_E2.8041.00
214_A238_R2.7581.00
200_T204_E2.7291.00
411_G418_F2.7251.00
215_S238_R2.6761.00
340_Y351_L2.6731.00
42_I52_P2.6331.00
302_L428_Y2.6131.00
352_P355_D2.4831.00
152_A156_T2.4571.00
218_E238_R2.4571.00
3_N29_A2.4461.00
208_L216_I2.4271.00
235_E447_Y2.4141.00
213_I237_L2.4121.00
60_V89_L2.4091.00
124_V139_I2.3771.00
6_G59_F2.3611.00
202_L208_L2.3531.00
248_L252_I2.3321.00
162_V362_G2.3311.00
122_L151_A2.3281.00
95_V150_K2.3201.00
65_K91_E2.2601.00
288_L430_G2.2551.00
244_T251_V2.2121.00
39_D54_Y2.2081.00
294_E431_Y2.2041.00
408_V412_I2.1891.00
55_E58_D2.1881.00
77_K81_S2.1751.00
173_P344_S2.1651.00
26_E157_K2.1310.99
323_Q403_G2.1150.99
409_C413_S2.0750.99
211_D240_K2.0750.99
39_D43_Q2.0680.99
104_Y347_Y2.0600.99
210_L250_D2.0320.99
57_E61_Q2.0280.99
83_I96_I2.0100.99
196_A441_L1.9790.99
11_G74_T1.9790.99
327_M404_L1.9790.99
236_I443_A1.9680.99
292_K296_M1.9670.99
408_V422_T1.9300.99
68_K150_K1.8940.99
208_L318_I1.8720.99
22_A48_Q1.8560.98
190_A332_A1.8410.98
169_V355_D1.8300.98
203_R210_L1.8210.98
375_S379_S1.7970.98
219_T222_Q1.7760.98
373_V376_E1.7710.98
313_D316_T1.7640.98
395_D399_A1.7620.98
297_A385_A1.7400.98
18_A30_V1.7390.98
201_F317_W1.7340.98
202_L213_I1.7310.98
87_K117_K1.7130.97
328_G421_L1.7070.97
145_R149_E1.6930.97
319_E323_Q1.6910.97
191_D329_K1.6860.97
10_L41_L1.6850.97
79_V102_S1.6780.97
246_Q251_V1.6740.97
83_I114_L1.6710.97
410_E413_S1.6590.97
201_F321_V1.6450.97
422_T426_S1.6390.97
5_I21_M1.6310.97
87_K119_I1.6140.96
454_E461_V1.6050.96
165_D358_L1.6010.96
406_K413_S1.5950.96
405_R429_D1.5800.96
231_E367_R1.5780.96
388_L397_L1.5500.95
216_I318_I1.5450.95
304_G401_Q1.5420.95
30_V41_L1.5290.95
198_A321_V1.5290.95
113_E116_E1.5280.95
323_Q399_A1.5280.95
320_Y403_G1.5090.95
179_F268_Q1.5000.94
8_I31_Y1.4940.94
69_I96_I1.4890.94
202_L206_L1.4860.94
269_A284_F1.4820.94
149_E152_A1.4810.94
131_V135_T1.4780.94
384_L390_A1.4680.94
305_P401_Q1.4540.93
205_T414_T1.4470.93
15_S44_K1.4350.93
21_M70_F1.4230.93
53_Y58_D1.4190.93
224_E319_E1.4110.92
21_M154_I1.4080.92
219_T322_R1.4070.92
23_N135_T1.4030.92
300_D434_G1.4010.92
35_R39_D1.4000.92
299_Q434_G1.3990.92
24_K157_K1.3970.92
328_G404_L1.3830.92
29_A53_Y1.3820.92
380_E391_P1.3740.91
454_E459_D1.3670.91
338_A427_Y1.3650.91
97_M151_A1.3630.91
111_Y115_K1.3610.91
87_K113_E1.3550.91
263_K271_D1.3540.91
115_K144_D1.3450.90
354_K375_S1.3440.90
112_D116_E1.3390.90
304_G432_R1.3340.90
206_L321_V1.3310.90
21_M28_V1.3310.90
219_T315_D1.3280.90
82_V85_S1.3230.90
435_R456_T1.3230.90
409_C412_I1.3180.89
214_A237_L1.3180.89
277_T331_C1.3100.89
248_L251_V1.3050.89
69_I90_L1.3040.89
169_V359_I1.2960.89
123_G142_G1.2960.89
10_L30_V1.2950.89
45_L50_L1.2730.88
344_S353_L1.2680.88
53_Y59_F1.2600.87
223_G322_R1.2560.87
102_S106_D1.2520.87
53_Y62_S1.2410.86
213_I321_V1.2320.86
343_S347_Y1.2250.86
218_E222_Q1.2210.85
454_E460_G1.2200.85
198_A421_L1.2190.85
255_K454_E1.2130.85
321_V421_L1.2110.85
280_T284_F1.2110.85
327_M400_Y1.2090.85
354_K379_S1.2070.85
240_K247_P1.1980.84
11_G32_N1.1950.84
109_R113_E1.1880.84
7_V70_F1.1820.84
72_M158_I1.1790.83
344_S350_N1.1770.83
3_N51_S1.1460.82
183_V339_Q1.1430.81
455_R462_F1.1430.81
171_I359_I1.1410.81
317_W410_E1.1410.81
205_T416_I1.1380.81
33_Y74_T1.1340.81
36_D40_Q1.1300.81
38_T54_Y1.1260.80
183_V265_T1.1250.80
35_R54_Y1.1240.80
202_L216_I1.1230.80
103_H267_M1.1190.80
32_N38_T1.1170.80
22_A134_L1.1170.80
415_G432_R1.1130.80
74_T78_P1.1080.79
458_M462_F1.1070.79
236_I444_Q1.1060.79
157_K161_Q1.1020.79
341_K345_E1.0960.79
19_L134_L1.0860.78
72_M139_I1.0830.78
342_M345_E1.0800.78
201_F411_G1.0780.77
297_A300_D1.0760.77
302_L305_P1.0750.77
203_R250_D1.0680.77
302_L432_R1.0670.77
417_S433_T1.0670.77
171_I356_I1.0650.77
358_L375_S1.0650.77
418_F422_T1.0630.76
226_K369_D1.0600.76
15_S134_L1.0590.76
394_T398_H1.0580.76
5_I97_M1.0570.76
38_T52_P1.0490.75
437_N440_L1.0470.75
242_E464_T1.0470.75
22_A49_S1.0420.75
120_G144_D1.0400.75
173_P350_N1.0330.74
70_F97_M1.0310.74
272_N347_Y1.0310.74
138_S360_F1.0280.74
11_G33_Y1.0210.73
17_I158_I1.0190.73
219_T223_G1.0160.73
107_T123_G1.0140.73
412_I418_F1.0090.73
29_A59_F1.0090.73
69_I88_P1.0080.73
78_P81_S0.9970.72
108_E347_Y0.9930.71
139_I159_A0.9930.71
258_Q263_K0.9910.71
247_P250_D0.9890.71
266_S280_T0.9860.71
7_V28_V0.9850.71
401_Q432_R0.9840.71
59_F62_S0.9750.70
304_G428_Y0.9680.69
34_T37_L0.9640.69
298_A431_Y0.9620.69
294_E386_N0.9610.69
171_I176_A0.9590.69
326_Y396_K0.9550.68
272_N346_L0.9540.68
249_I440_L0.9510.68
239_K464_T0.9500.68
7_V30_V0.9480.68
148_Y152_A0.9460.68
253_L292_K0.9390.67
278_I331_C0.9380.67
270_I283_L0.9320.66
195_I325_L0.9310.66
214_A218_E0.9310.66
190_A278_I0.9300.66
200_T437_N0.9300.66
108_E112_D0.9290.66
99_G139_I0.9290.66
148_Y169_V0.9280.66
334_A386_N0.9250.66
204_E433_T0.9250.66
71_L96_I0.9250.66
253_L455_R0.9220.66
122_L170_Y0.9210.66
27_N51_S0.9140.65
148_Y170_Y0.9120.65
195_I230_I0.9120.65
401_Q428_Y0.9100.65
163_G362_G0.9100.65
426_S429_D0.9090.64
15_S22_A0.9060.64
162_V165_D0.9040.64
124_V155_L0.9030.64
111_Y144_D0.8950.63
433_T436_S0.8950.63
323_Q400_Y0.8920.63
145_R170_Y0.8890.63
372_N376_E0.8880.63
282_S420_C0.8870.63
239_K248_L0.8850.62
412_I426_S0.8840.62
303_A398_H0.8840.62
37_L40_Q0.8820.62
27_N49_S0.8790.62
107_T121_Y0.8790.62
165_D361_R0.8780.62
74_T77_K0.8750.61
202_L318_I0.8750.61
120_G146_D0.8680.61
105_E271_D0.8670.61
294_E338_A0.8650.61
233_T444_Q0.8650.61
281_E284_F0.8620.60
457_D462_F0.8560.60
429_D432_R0.8560.60
381_Q390_A0.8530.60
417_S436_S0.8520.59
145_R350_N0.8450.59
5_I70_F0.8440.59
153_P159_A0.8430.59
194_L420_C0.8420.59
200_T203_R0.8400.58
370_F392_Y0.8400.58
221_N231_E0.8390.58
99_G126_I0.8380.58
35_R38_T0.8380.58
112_D115_K0.8370.58
278_I424_A0.8350.58
258_Q287_Y0.8350.58
142_G176_A0.8340.58
298_A389_I0.8290.57
342_M346_L0.8280.57
258_Q267_M0.8260.57
316_T320_Y0.8260.57
43_Q46_D0.8260.57
281_E420_C0.8190.56
201_F418_F0.8180.56
210_L249_I0.8170.56
118_G151_A0.8150.56
412_I425_L0.8150.56
124_V151_A0.8150.56
95_V122_L0.8120.56
126_I139_I0.8100.56
206_L317_W0.8090.55
326_Y392_Y0.8040.55
315_D319_E0.8040.55
370_F393_F0.8040.55
398_H428_Y0.8020.55
114_L119_I0.8000.55
138_S359_I0.8000.55
24_K161_Q0.8000.55
274_I342_M0.7990.55
103_H268_Q0.7980.54
6_G9_G0.7980.54
280_T349_W0.7970.54
212_E215_S0.7970.54
7_V10_L0.7970.54
60_V90_L0.7940.54
4_S27_N0.7940.54
340_Y356_I0.7890.54
3_N27_N0.7890.54
326_Y370_F0.7880.54
402_T406_K0.7870.53
23_N44_K0.7860.53
175_G349_W0.7860.53
73_V79_V0.7800.53
54_Y58_D0.7800.53
438_A441_L0.7790.53
64_E68_K0.7770.52
19_L45_L0.7750.52
70_F99_G0.7750.52
302_L398_H0.7730.52
269_A276_S0.7710.52
18_A21_M0.7680.52
18_A29_A0.7660.51
205_T410_E0.7640.51
78_P82_V0.7640.51
7_V72_M0.7630.51
32_N74_T0.7610.51
355_D358_L0.7590.51
297_A389_I0.7550.50
81_S85_S0.7550.50
139_I346_L0.7550.50
139_I168_C0.7530.50
242_E245_G0.7530.50
405_R415_G0.7510.50
147_V151_A0.7510.50
40_Q43_Q0.7480.50
115_K146_D0.7480.50
296_M434_G0.7470.50
340_Y360_F0.7470.50
168_C258_Q0.7410.49
244_T247_P0.7390.49
18_A50_L0.7390.49
222_Q246_Q0.7360.49
248_L456_T0.7340.48
19_L23_N0.7330.48
149_E170_Y0.7320.48
22_A50_L0.7300.48
139_I151_A0.7300.48
70_F155_L0.7290.48
357_A374_I0.7280.48
208_L314_K0.7280.48
174_K347_Y0.7260.48
415_G429_D0.7240.47
149_E153_P0.7220.47
216_I237_L0.7210.47
73_V78_P0.7170.47
272_N342_M0.7160.47
174_K348_G0.7160.47
368_A427_Y0.7100.46
33_Y37_L0.7100.46
268_Q271_D0.7070.46
120_G150_K0.7060.46
210_L246_Q0.7050.46
337_F441_L0.7030.46
15_S41_L0.7030.46
281_E423_T0.7020.45
291_L294_E0.7020.45
272_N343_S0.6990.45
71_L82_V0.6980.45
69_I89_L0.6970.45
72_M228_Y0.6960.45
3_N62_S0.6960.45
298_A432_R0.6950.45
337_F349_W0.6950.45
331_C404_L0.6930.45
302_L401_Q0.6920.44
255_K441_L0.6900.44
219_T224_E0.6900.44
310_K313_D0.6880.44
92_E146_D0.6860.44
437_N441_L0.6860.44
69_I91_E0.6840.44
301_V394_T0.6830.44
374_I377_A0.6820.44
215_S219_T0.6820.44
293_E296_M0.6820.44
108_E349_W0.6810.43
79_V339_Q0.6810.43
322_R400_Y0.6800.43
314_K318_I0.6800.43
175_G191_D0.6790.43
337_F353_L0.6790.43
376_E392_Y0.6760.43
233_T440_L0.6740.43
284_F349_W0.6720.43
32_N72_M0.6720.43
37_L73_V0.6720.43
192_M444_Q0.6720.43
241_D244_T0.6710.43
81_S84_Q0.6700.42
194_L325_L0.6700.42
428_Y432_R0.6680.42
203_R378_F0.6680.42
405_R426_S0.6670.42
354_K370_F0.6670.42
331_C368_A0.6650.42
114_L424_A0.6620.42
141_P169_V0.6610.42
327_M397_L0.6600.42
44_K134_L0.6600.42
224_E400_Y0.6580.41
329_K370_F0.6560.41
120_G151_A0.6560.41
124_V168_C0.6550.41
199_Y203_R0.6550.41
55_E59_F0.6540.41
208_L212_E0.6540.41
32_N37_L0.6530.41
224_E323_Q0.6520.41
141_P171_I0.6520.41
41_L50_L0.6510.41
30_V34_T0.6500.41
139_I164_D0.6490.41
444_Q447_Y0.6490.41
218_E234_A0.6490.41
119_I144_D0.6490.41
191_D195_I0.6460.40
316_T406_K0.6460.40
61_Q64_E0.6450.40
385_A395_D0.6440.40
343_S441_L0.6430.40
50_L134_L0.6430.40
265_T276_S0.6420.40
45_L48_Q0.6410.40
391_P394_T0.6410.40
373_V396_K0.6400.40
34_T41_L0.6390.40
231_E234_A0.6380.40
74_T126_I0.6380.40
268_Q339_Q0.6370.39
20_N189_Y0.6370.39
200_T433_T0.6350.39
377_A390_A0.6340.39
253_L457_D0.6340.39
57_E89_L0.6320.39
228_Y447_Y0.6320.39
108_E111_Y0.6310.39
228_Y232_I0.6310.39
7_V18_A0.6300.39
320_Y323_Q0.6290.39
373_V392_Y0.6280.39
99_G155_L0.6270.39
322_R403_G0.6250.38
287_Y290_S0.6250.38
111_Y174_K0.6240.38
153_P157_K0.6230.38
337_F392_Y0.6220.38
24_K135_T0.6210.38
241_D455_R0.6200.38
72_M134_L0.6190.38
195_I329_K0.6190.38
30_V53_Y0.6190.38
169_V176_A0.6190.38
331_C334_A0.6180.38
132_G189_Y0.6180.38
206_L318_I0.6170.38
126_I444_Q0.6170.38
22_A47_G0.6150.37
114_L121_Y0.6140.37
73_V82_V0.6140.37
317_W407_V0.6130.37
84_Q87_K0.6130.37
155_L168_C0.6120.37
191_D349_W0.6120.37
329_K349_W0.6090.37
90_L96_I0.6090.37
281_E430_G0.6090.37
274_I338_A0.6080.37
301_V391_P0.6080.37
200_T205_T0.6060.37
194_L278_I0.6060.37
134_L268_Q0.6050.37
102_S121_Y0.6050.37
8_I56_L0.6050.37
211_D222_Q0.6050.37
230_I233_T0.6040.37
26_E154_I0.6030.36
132_G140_M0.6030.36
15_S23_N0.6020.36
107_T174_K0.6010.36
294_E322_R0.6010.36
141_P168_C0.6010.36
36_D39_D0.6010.36
241_D247_P0.6000.36
254_D295_R0.6000.36
24_K84_Q0.6000.36
375_S397_L0.6000.36
410_E414_T0.5980.36
159_A168_C0.5980.36
114_L117_K0.5980.36
403_G406_K0.5960.36
210_L237_L0.5960.36
397_L404_L0.5940.36
276_S331_C0.5930.36
23_N48_Q0.5920.35
319_E403_G0.5920.35
179_F343_S0.5920.35
41_L45_L0.5910.35
56_L85_S0.5900.35
63_L69_I0.5890.35
113_E117_K0.5890.35
241_D251_V0.5890.35
209_P314_K0.5880.35
305_P432_R0.5880.35
267_M277_T0.5880.35
228_Y357_A0.5880.35
327_M428_Y0.5870.35
281_E285_A0.5850.35
159_A165_D0.5850.35
178_H258_Q0.5840.35
92_E117_K0.5840.35
72_M285_A0.5830.35
198_A201_F0.5820.35
350_N353_L0.5820.35
148_Y156_T0.5820.35
173_P356_I0.5800.34
154_I157_K0.5800.34
162_V375_S0.5800.34
257_G290_S0.5790.34
11_G78_P0.5780.34
396_K399_A0.5780.34
199_Y437_N0.5770.34
57_E88_P0.5760.34
442_Q445_R0.5760.34
58_D61_Q0.5760.34
211_D247_P0.5760.34
38_T55_E0.5750.34
452_T464_T0.5750.34
88_P92_E0.5740.34
138_S324_A0.5740.34
11_G16_N0.5730.34
87_K114_L0.5720.34
234_A255_K0.5700.34
333_Y393_F0.5670.33
418_F426_S0.5670.33
267_M271_D0.5660.33
10_L32_N0.5660.33
31_Y56_L0.5650.33
60_V86_L0.5650.33
377_A393_F0.5640.33
156_T169_V0.5640.33
203_R213_I0.5630.33
344_S355_D0.5630.33
373_V390_A0.5630.33
409_C417_S0.5620.33
115_K459_D0.5610.33
68_K154_I0.5600.33
257_G444_Q0.5580.33
56_L86_L0.5580.33
374_I393_F0.5580.33
278_I420_C0.5580.33
195_I225_L0.5570.33
204_E416_I0.5550.32
337_F357_A0.5550.32
30_V50_L0.5520.32
296_M299_Q0.5510.32
163_G372_N0.5500.32
21_M97_M0.5500.32
30_V165_D0.5480.32
405_R432_R0.5480.32
276_S339_Q0.5450.32
60_V67_R0.5430.31
80_D110_R0.5430.31
16_N37_L0.5430.31
26_E153_P0.5420.31
244_T248_L0.5420.31
430_G436_S0.5410.31
257_G267_M0.5410.31
17_I70_F0.5410.31
277_T368_A0.5410.31
196_A353_L0.5390.31
130_E450_A0.5390.31
395_D398_H0.5390.31
268_Q274_I0.5380.31
36_D328_G0.5380.31
187_I336_G0.5380.31
386_N431_Y0.5370.31
215_S293_E0.5370.31
248_L465_N0.5360.31
191_D333_Y0.5360.31
107_T114_L0.5360.31
20_N445_R0.5350.31
270_I280_T0.5350.31
298_A405_R0.5340.31
270_I284_F0.5340.31
224_E326_Y0.5340.31
276_S280_T0.5330.31
176_A209_P0.5330.31
145_R173_P0.5330.31
152_A169_V0.5330.31
161_Q362_G0.5320.30
104_Y268_Q0.5320.30
207_R435_R0.5310.30
323_Q327_M0.5310.30
200_T417_S0.5310.30
19_L190_A0.5310.30
213_I230_I0.5310.30
115_K119_I0.5300.30
215_S315_D0.5300.30
312_L414_T0.5290.30
30_V52_P0.5290.30
77_K416_I0.5290.30
313_D317_W0.5280.30
11_G34_T0.5270.30
263_K443_A0.5260.30
212_E313_D0.5250.30
115_K420_C0.5250.30
292_K434_G0.5240.30
173_P348_G0.5240.30
202_L317_W0.5240.30
44_K48_Q0.5230.30
92_E222_Q0.5210.30
306_E315_D0.5210.30
71_L147_V0.5200.30
222_Q383_N0.5200.30
16_N34_T0.5190.29
96_I158_I0.5190.29
292_K431_Y0.5190.29
156_T359_I0.5180.29
225_L374_I0.5180.29
218_E307_A0.5170.29
199_Y439_N0.5170.29
59_F421_L0.5160.29
69_I87_K0.5160.29
134_L427_Y0.5150.29
22_A427_Y0.5150.29
93_G118_G0.5150.29
126_I249_I0.5150.29
381_Q385_A0.5150.29
11_G82_V0.5150.29
103_H272_N0.5130.29
23_N427_Y0.5120.29
333_Y371_L0.5120.29
19_L50_L0.5110.29
78_P102_S0.5110.29
43_Q196_A0.5110.29
30_V59_F0.5100.29
78_P266_S0.5100.29
337_F370_F0.5090.29
301_V389_I0.5070.29
71_L102_S0.5070.29
273_G287_Y0.5060.28
189_Y262_G0.5060.28
219_T319_E0.5060.28
285_A430_G0.5060.28
15_S99_G0.5050.28
18_A70_F0.5040.28
189_Y445_R0.5030.28
50_L111_Y0.5020.28
182_M452_T0.5020.28
168_C359_I0.5020.28
11_G68_K0.5010.28
296_M300_D0.5010.28
168_C430_G0.5000.28
448_F451_H0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p4qA 2 0.9936 100 0.346 Contact Map
2zydA 2 0.9936 100 0.347 Contact Map
1pgjA 2 0.9872 100 0.359 Contact Map
4gwgA 2 0.9915 100 0.363 Contact Map
2iz1A 2 0.9957 100 0.366 Contact Map
4e21A 4 0.6453 100 0.788 Contact Map
3dojA 3 0.6068 100 0.853 Contact Map
3pduA 4 0.6047 100 0.854 Contact Map
3pefA 5 0.6047 100 0.855 Contact Map
3ckyA 4 0.6175 100 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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