GREMLIN Database
GNTP - Gluconate permease
UniProt: P12012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (418)
Sequences: 5589 (3778)
Seq/√Len: 184.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_A276_M3.2841.00
304_T307_S3.2831.00
200_I204_S3.0221.00
294_P297_T2.9901.00
12_A34_G2.8781.00
237_L282_V2.8311.00
180_I184_P2.8211.00
9_G322_F2.7631.00
196_F200_I2.7531.00
87_T91_K2.7001.00
234_T238_P2.6891.00
201_V205_F2.6701.00
324_Q328_N2.6271.00
42_P45_K2.6111.00
9_G35_V2.5841.00
197_A201_V2.5351.00
418_S421_E2.5191.00
333_D337_D2.4991.00
77_D301_S2.4911.00
228_F232_V2.4361.00
204_S207_K2.3751.00
87_T228_F2.3721.00
272_A275_A2.3721.00
49_S328_N2.3701.00
200_I203_A2.3521.00
348_I438_L2.3401.00
201_V204_S2.2971.00
197_A200_I2.2731.00
342_T345_S2.2691.00
431_T435_V2.2651.00
11_L15_F2.2611.00
182_A185_T2.2601.00
197_A204_S2.2231.00
351_W434_S2.2051.00
227_G230_I2.1661.00
77_D297_T2.1661.00
229_G233_F2.1281.00
198_K201_V2.0651.00
231_S234_T2.0621.00
15_F19_G2.0491.00
337_D340_K2.0491.00
354_A371_T2.0161.00
439_G443_L2.0151.00
48_S52_A2.0021.00
435_V439_G2.0001.00
87_T90_N1.9791.00
193_F197_A1.9731.00
200_I207_K1.9541.00
176_L180_I1.9231.00
200_I205_F1.8881.00
183_V187_L1.8791.00
82_Q86_M1.8371.00
177_Y180_I1.8081.00
167_Y393_T1.7671.00
196_F204_S1.7661.00
424_A428_L1.7511.00
192_L196_F1.7401.00
250_L253_E1.7391.00
193_F200_I1.7191.00
110_I113_F1.7161.00
246_T250_L1.7081.00
190_G193_F1.6801.00
199_K203_A1.6611.00
197_A205_F1.6591.00
334_Y338_L1.6301.00
198_K204_S1.6241.00
190_G194_T1.6111.00
42_P46_V1.6001.00
178_G181_V1.5931.00
52_A56_G1.5911.00
228_F231_S1.5871.00
231_S238_P1.5781.00
379_L389_V1.5761.00
355_A399_I1.5761.00
246_T249_D1.5721.00
12_A31_V1.5721.00
176_L179_F1.5631.00
350_A393_T1.5621.00
238_P242_M1.5521.00
281_L285_Y1.5501.00
242_M246_T1.5421.00
193_F196_F1.5401.00
235_A242_M1.5151.00
105_S108_I1.5111.00
245_A249_D1.5031.00
359_I400_A1.5001.00
272_A277_I1.4961.00
174_V390_V1.4901.00
197_A207_K1.4861.00
180_I185_T1.4831.00
248_I252_Q1.4831.00
45_K48_S1.4771.00
199_K204_S1.4681.00
161_T164_A1.4671.00
193_F201_V1.4591.00
163_I368_A1.4471.00
234_T242_M1.4291.00
73_K77_D1.4291.00
202_P206_A1.4101.00
140_G415_F1.3991.00
5_I38_A1.3961.00
202_P205_F1.3921.00
175_L178_G1.3891.00
198_K202_P1.3841.00
241_I278_I1.3811.00
226_P230_I1.3731.00
198_K203_A1.3721.00
199_K205_F1.3671.00
83_R87_T1.3641.00
54_I62_A1.3581.00
170_N173_E1.3551.00
380_G386_L1.3481.00
226_P231_S1.3441.00
235_A238_P1.3401.00
230_I234_T1.3381.00
229_G234_T1.3341.00
246_T252_Q1.3241.00
152_G398_V1.3191.00
104_A107_I1.3121.00
196_F207_K1.3071.00
249_D252_Q1.3011.00
94_E131_E1.2971.00
229_G232_V1.2921.00
230_I233_F1.2911.00
233_F237_L1.2841.00
114_F117_G1.2841.00
70_M302_C1.2801.00
182_A186_V1.2801.00
179_F183_V1.2801.00
428_L432_I1.2791.00
196_F201_V1.2771.00
175_L180_I1.2751.00
177_Y181_V1.2741.00
178_G184_P1.2701.00
442_L445_S1.2701.00
181_V184_P1.2681.00
297_T300_D1.2621.00
280_L286_T1.2611.00
13_L31_V1.2591.00
192_L195_K1.2571.00
133_K204_S1.2551.00
197_A203_A1.2531.00
323_K327_I1.2521.00
249_D253_E1.2521.00
12_A16_L1.2441.00
201_V207_K1.2371.00
198_K205_F1.2351.00
69_A302_C1.2351.00
115_E406_A1.2321.00
178_G185_T1.2271.00
178_G182_A1.2261.00
274_T278_I1.2151.00
190_G195_K1.2101.00
440_F444_L1.2061.00
300_D304_T1.1981.00
166_E372_T1.1981.00
191_P194_T1.1971.00
196_F203_A1.1911.00
98_Q101_V1.1891.00
101_V104_A1.1871.00
48_S51_E1.1821.00
275_A280_L1.1821.00
22_L27_S1.1771.00
282_V286_T1.1571.00
116_V119_V1.1561.00
247_I251_L1.1521.00
429_L433_I1.1521.00
130_R136_I1.1511.00
73_K301_S1.1511.00
399_I434_S1.1461.00
77_D304_T1.1431.00
247_I250_L1.1411.00
199_K207_K1.1311.00
184_P187_L1.1301.00
192_L200_I1.1291.00
101_V105_S1.1251.00
190_G197_A1.1201.00
194_T198_K1.1151.00
273_S277_I1.1121.00
420_K424_A1.1111.00
230_I238_P1.1101.00
382_S385_N1.1071.00
57_T320_G1.1001.00
224_E228_F1.0901.00
203_A207_K1.0711.00
99_W191_P1.0671.00
395_A437_G1.0671.00
194_T197_A1.0621.00
351_W438_L1.0581.00
39_L42_P1.0571.00
175_L179_F1.0531.00
275_A286_T1.0491.00
214_L217_Q1.0471.00
193_F204_S1.0471.00
283_A286_T1.0461.00
115_E316_I1.0461.00
348_I442_L1.0441.00
276_M280_L1.0431.00
296_K300_D1.0401.00
395_A441_I1.0391.00
81_A85_A1.0381.00
228_F235_A1.0381.00
273_S276_M1.0371.00
244_V250_L1.0371.00
194_T204_S1.0361.00
74_L283_A1.0331.00
200_I206_A1.0321.00
53_G324_Q1.0311.00
279_S283_A1.0301.00
49_S324_Q1.0261.00
114_F407_G1.0261.00
227_G231_S1.0251.00
198_K207_K1.0201.00
419_M423_F1.0181.00
280_L284_V1.0181.00
399_I431_T1.0161.00
228_F234_T1.0151.00
110_I114_F1.0120.99
178_G186_V1.0080.99
272_A283_A1.0070.99
194_T200_I1.0050.99
104_A108_I1.0030.99
86_M131_E1.0000.99
40_G43_F1.0000.99
437_G441_I0.9990.99
245_A250_L0.9980.99
195_K198_K0.9970.99
190_G200_I0.9880.99
363_S366_V0.9880.99
173_E176_L0.9880.99
234_T250_L0.9880.99
34_G38_A0.9860.99
407_G411_F0.9850.99
199_K202_P0.9820.99
179_F184_P0.9800.99
181_V444_L0.9790.99
222_L225_T0.9770.99
190_G196_F0.9760.99
118_L414_Y0.9710.99
196_F199_K0.9680.99
274_T280_L0.9680.99
237_L279_S0.9680.99
330_G333_D0.9680.99
203_A206_A0.9670.99
195_K199_K0.9660.99
41_M49_S0.9660.99
50_I321_A0.9610.99
232_V235_A0.9610.99
171_I176_L0.9550.99
227_G233_F0.9510.99
246_T253_E0.9500.99
226_P234_T0.9480.99
196_F205_F0.9460.99
401_S405_D0.9450.99
412_K422_T0.9450.99
244_V248_I0.9430.99
101_V107_I0.9430.99
86_M90_N0.9420.99
40_G45_K0.9410.99
44_D48_S0.9400.99
275_A283_A0.9390.99
237_L241_I0.9350.99
248_I251_L0.9280.99
177_Y184_P0.9250.99
359_I399_I0.9210.99
150_T157_H0.9170.99
238_P241_I0.9160.99
6_V10_I0.9150.99
169_A174_V0.9150.99
102_V105_S0.9130.99
245_A248_I0.9090.99
220_F224_E0.9080.99
421_E424_A0.9070.99
150_T154_L0.9050.99
194_T205_F0.9050.99
113_F116_V0.9030.99
316_I406_A0.9000.99
226_P238_P0.8990.99
191_P195_K0.8980.99
234_T241_I0.8890.99
64_I316_I0.8880.99
190_G205_F0.8860.99
438_L442_L0.8830.99
193_F205_F0.8820.99
25_F314_L0.8780.99
281_L287_M0.8750.99
40_G44_D0.8740.98
160_P164_A0.8730.98
192_L201_V0.8710.98
377_P382_S0.8700.98
427_T431_T0.8690.98
177_Y391_L0.8670.98
245_A251_L0.8660.98
364_A401_S0.8660.98
276_M279_S0.8660.98
179_F182_A0.8630.98
225_T228_F0.8620.98
283_A287_M0.8600.98
391_L441_I0.8600.98
400_A427_T0.8570.98
35_V322_F0.8560.98
238_P246_T0.8530.98
248_I253_E0.8530.98
233_F240_I0.8480.98
401_S426_W0.8480.98
169_A172_G0.8480.98
358_R364_A0.8470.98
80_G231_S0.8400.98
102_V186_V0.8390.98
201_V206_A0.8360.98
194_T201_V0.8350.98
383_D386_L0.8320.98
274_T277_I0.8310.98
189_A193_F0.8290.98
228_F238_P0.8250.98
145_A190_G0.8250.98
268_L271_N0.8230.98
324_Q327_I0.8230.98
273_S283_A0.8220.98
177_Y183_V0.8210.98
9_G34_G0.8200.98
241_I245_A0.8200.98
293_I298_V0.8190.98
78_S287_M0.8190.98
280_L287_M0.8150.98
181_V440_F0.8120.98
233_F286_T0.8110.98
63_L67_L0.8100.98
242_M250_L0.8090.98
174_V177_Y0.8070.97
377_P381_H0.8060.97
144_V408_F0.8060.97
342_T346_P0.8050.97
361_L370_S0.8050.97
7_A11_L0.8030.97
162_A167_Y0.7980.97
430_E433_I0.7960.97
181_V185_T0.7940.97
163_I167_Y0.7930.97
425_T428_L0.7900.97
193_F198_K0.7890.97
191_P196_F0.7890.97
99_W102_V0.7880.97
426_W430_E0.7860.97
31_V34_G0.7810.97
171_I175_L0.7790.97
376_I380_G0.7780.97
134_I138_F0.7750.97
224_E227_G0.7730.97
47_V51_E0.7720.97
273_S281_L0.7710.97
214_L219_T0.7690.97
358_R405_D0.7680.97
284_V287_M0.7650.97
16_L30_V0.7620.96
391_L395_A0.7580.96
234_T286_T0.7570.96
116_V159_G0.7560.96
189_A200_I0.7550.96
230_I286_T0.7550.96
52_A328_N0.7530.96
180_I183_V0.7530.96
243_S247_I0.7510.96
174_V178_G0.7500.96
27_S31_V0.7430.96
354_A367_A0.7420.96
245_A252_Q0.7420.96
367_A405_D0.7410.96
270_G275_A0.7400.96
190_G204_S0.7390.96
170_N175_L0.7350.96
231_S242_M0.7310.96
101_V108_I0.7300.95
364_A397_S0.7290.95
196_F202_P0.7270.95
109_G117_G0.7270.95
193_F432_I0.7260.95
148_S430_E0.7240.95
141_I145_A0.7230.95
368_A397_S0.7220.95
442_L446_L0.7210.95
115_E118_L0.7210.95
10_I13_L0.7180.95
227_G234_T0.7160.95
228_F242_M0.7140.95
86_M225_T0.7120.95
273_S278_I0.7120.95
244_V249_D0.7120.95
272_A278_I0.7110.95
83_R228_F0.7100.95
106_F110_I0.7090.95
242_M249_D0.7070.95
272_A285_Y0.7070.95
39_L329_G0.7060.95
347_I384_V0.7060.95
214_L220_F0.7040.94
73_K76_A0.7030.94
270_G283_A0.7020.94
276_M284_V0.7010.94
12_A15_F0.7000.94
115_E119_V0.6960.94
309_I313_L0.6960.94
239_I242_M0.6950.94
187_L192_L0.6940.94
190_G201_V0.6920.94
220_F223_E0.6910.94
293_I297_T0.6880.94
272_A279_S0.6850.94
175_L182_A0.6840.94
433_I437_G0.6830.94
38_A43_F0.6830.94
243_S246_T0.6820.94
385_N388_L0.6810.93
367_A371_T0.6810.93
109_G113_F0.6780.93
220_F227_G0.6770.93
111_A114_F0.6770.93
52_A55_G0.6760.93
422_T426_W0.6760.93
355_A434_S0.6740.93
102_V108_I0.6700.93
436_A439_G0.6690.93
174_V387_A0.6690.93
234_T237_L0.6690.93
364_A406_A0.6680.93
392_A396_G0.6670.93
175_L184_P0.6670.93
215_G219_T0.6670.93
109_G114_F0.6670.93
129_S139_L0.6640.93
41_M45_K0.6640.93
246_T251_L0.6630.93
82_Q223_E0.6630.93
180_I187_L0.6610.92
8_L12_A0.6610.92
358_R401_S0.6600.92
195_K205_F0.6600.92
388_L444_L0.6600.92
339_F353_I0.6590.92
237_L240_I0.6590.92
117_G147_L0.6590.92
349_L379_L0.6560.92
361_L366_V0.6560.92
73_K304_T0.6550.92
172_G176_L0.6540.92
232_V236_M0.6530.92
229_G238_P0.6530.92
5_I9_G0.6500.92
45_K49_S0.6490.92
182_A187_L0.6480.92
213_S217_Q0.6480.92
195_K200_I0.6480.92
214_L222_L0.6480.92
232_V238_P0.6480.92
183_V186_V0.6470.92
225_T231_S0.6470.92
355_A400_A0.6460.92
280_L283_A0.6460.92
162_A369_L0.6450.92
218_K221_N0.6450.92
16_L27_S0.6420.91
294_P298_V0.6420.91
297_T301_S0.6390.91
84_I231_S0.6370.91
185_T189_A0.6370.91
217_Q220_F0.6360.91
284_V302_C0.6360.91
217_Q221_N0.6360.91
235_A246_T0.6350.91
225_T229_G0.6340.91
94_E132_L0.6340.91
277_I281_L0.6300.91
222_L227_G0.6300.91
277_I285_Y0.6290.90
425_T429_L0.6260.90
49_S52_A0.6230.90
350_A375_V0.6230.90
275_A279_S0.6220.90
177_Y387_A0.6220.90
180_I186_V0.6180.90
16_L22_L0.6180.90
215_G218_K0.6160.90
12_A19_G0.6150.89
23_N26_I0.6150.89
80_G83_R0.6130.89
100_A108_I0.6110.89
214_L218_K0.6100.89
103_I107_I0.6100.89
162_A166_E0.6100.89
173_E387_A0.6100.89
272_A281_L0.6070.89
229_G240_I0.6070.89
358_R367_A0.6060.89
227_G238_P0.6060.89
388_L441_I0.6050.89
275_A278_I0.6040.89
224_E229_G0.6040.89
153_F395_A0.6040.89
5_I31_V0.6040.89
345_S348_I0.6030.89
146_A150_T0.6030.89
178_G183_V0.6020.88
192_L197_A0.6010.88
272_A287_M0.6000.88
5_I39_L0.5970.88
244_V251_L0.5970.88
195_K201_V0.5970.88
222_L226_P0.5960.88
151_H155_P0.5960.88
358_R397_S0.5950.88
390_V433_I0.5940.88
228_F233_F0.5940.88
30_V34_G0.5940.88
149_V182_A0.5940.88
223_E231_S0.5900.87
366_V370_S0.5900.87
189_A192_L0.5890.87
233_F236_M0.5880.87
189_A194_T0.5870.87
242_M245_A0.5860.87
284_V298_V0.5860.87
103_I106_F0.5840.87
113_F119_V0.5840.87
231_S250_L0.5840.87
337_D341_G0.5840.87
162_A165_G0.5840.87
221_N224_E0.5830.87
228_F236_M0.5810.87
408_F412_K0.5800.87
49_S53_G0.5790.86
35_V325_V0.5790.86
176_L181_V0.5780.86
176_L187_L0.5780.86
129_S134_I0.5770.86
344_L348_I0.5760.86
284_V288_G0.5750.86
334_Y337_D0.5730.86
99_W103_I0.5720.86
148_S398_V0.5710.86
125_V129_S0.5710.86
193_F428_L0.5700.86
436_A440_F0.5700.86
233_F238_P0.5690.86
315_I369_L0.5690.86
152_G364_A0.5680.85
110_I150_T0.5680.85
427_T434_S0.5660.85
114_F118_L0.5660.85
287_M298_V0.5630.85
190_G206_A0.5620.85
355_A359_I0.5610.85
143_M146_A0.5600.85
102_V106_F0.5600.85
216_T219_T0.5590.85
357_L361_L0.5580.84
181_V391_L0.5570.84
33_F274_T0.5570.84
5_I35_V0.5560.84
194_T199_K0.5560.84
434_S437_G0.5560.84
406_A411_F0.5550.84
332_G336_A0.5550.84
176_L184_P0.5530.84
224_E230_I0.5530.84
227_G232_V0.5520.84
239_I243_S0.5480.83
231_S235_A0.5480.83
275_A287_M0.5450.83
368_A371_T0.5450.83
163_I166_E0.5420.83
243_S250_L0.5410.83
172_G175_L0.5400.82
274_T279_S0.5400.82
166_E373_G0.5390.82
174_V180_I0.5380.82
109_G115_E0.5380.82
98_Q102_V0.5380.82
402_H430_E0.5370.82
138_F142_P0.5360.82
191_P198_K0.5350.82
141_I425_T0.5330.82
68_G305_A0.5330.82
63_L66_G0.5310.81
238_P243_S0.5290.81
26_I280_L0.5280.81
185_T440_F0.5280.81
359_I427_T0.5270.81
38_A45_K0.5260.81
219_T222_L0.5260.81
91_K94_E0.5260.81
173_E177_Y0.5250.81
350_A354_A0.5250.81
194_T206_A0.5230.80
83_R227_G0.5220.80
387_A390_V0.5220.80
106_F149_V0.5210.80
275_A285_Y0.5190.80
32_S318_G0.5190.80
41_M46_V0.5180.80
401_S430_E0.5180.80
223_E229_G0.5170.80
101_V106_F0.5170.80
403_V423_F0.5170.80
97_I105_S0.5160.80
318_G322_F0.5150.79
33_F217_Q0.5150.79
189_A196_F0.5140.79
99_W106_F0.5140.79
224_E232_V0.5130.79
140_G417_L0.5130.79
106_F150_T0.5120.79
189_A197_A0.5120.79
111_A115_E0.5110.79
441_I445_S0.5100.79
335_V360_S0.5100.79
157_H368_A0.5090.79
5_I331_V0.5080.79
378_L382_S0.5080.79
434_S438_L0.5070.78
75_I80_G0.5050.78
242_M252_Q0.5040.78
117_G157_H0.5030.78
273_S287_M0.5030.78
417_L421_E0.5020.78
367_A404_N0.5020.78
195_K203_A0.5010.78
173_E178_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.971 100 0.567 Contact Map
4r0cA 3 0.9531 100 0.587 Contact Map
4f35D 2 0.8817 100 0.636 Contact Map
2cfqA 1 0.8259 76.9 0.946 Contact Map
4pd6A 3 0.7522 72.7 0.947 Contact Map
4dx5A 3 0.3527 61.5 0.951 Contact Map
2a65A 2 0.5938 49.2 0.955 Contact Map
3aqpA 1 0.3237 47.3 0.955 Contact Map
4m64A 1 0.8705 42.5 0.956 Contact Map
4k0jA 3 0.3103 38.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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