GNTK - BACSU - GREMLIN Contacts

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GNTK - Gluconokinase

UniProt:	P12011	Sequences: MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTAEQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADNRSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEYIFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCSPEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDEKGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQRVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTVFLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLYATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRGLITHK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	513 (473)
Sequences:	12487 (8500)
Seq/√Len:	390.8

ECOLI - LYXK LSRK ARAB XYLB GLPK RHAB FUCK YGCE
BACSU - GNTK ARAB XYLB YOAC GLPK RHAB
HALSA - GLPK
SULSO - GLPK1 GLPK2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_W	142_N	3.866	1.00
191_E	201_P	3.658	1.00
21_S	25_D	3.468	1.00
17_A	58_T	3.277	1.00
110_K	142_N	3.232	1.00
390_Y	485_M	2.851	1.00
123_R	190_D	2.848	1.00
390_Y	394_L	2.782	1.00
397_T	429_S	2.774	1.00
183_N	186_G	2.747	1.00
421_Q	425_D	2.711	1.00
430_E	472_T	2.706	1.00
336_V	376_H	2.702	1.00
93_L	147_I	2.701	1.00
37_Y	95_P	2.676	1.00
182_M	207_L	2.658	1.00
365_F	377_M	2.634	1.00
32_I	57_H	2.626	1.00
168_E	206_K	2.598	1.00
32_I	61_R	2.594	1.00
209_P	212_E	2.558	1.00
30_E	61_R	2.543	1.00
406_R	432_V	2.526	1.00
94_T	144_R	2.475	1.00
52_F	164_Q	2.455	1.00
87_D	150_K	2.418	1.00
417_E	469_Y	2.384	1.00
49_E	164_Q	2.376	1.00
19_L	62_I	2.368	1.00
88_E	152_K	2.345	1.00
390_Y	482_R	2.295	1.00
325_P	328_V	2.230	1.00
183_N	190_D	2.218	1.00
237_A	242_L	2.145	1.00
191_E	195_R	2.120	1.00
341_D	376_H	2.105	1.00
188_D	201_P	2.095	1.00
162_F	236_G	2.087	1.00
18_V	441_C	2.077	1.00
8_I	55_V	2.074	1.00
194_L	201_P	2.050	1.00
14_S	31_S	2.038	1.00
302_V	381_A	1.999	1.00
218_S	221_I	1.999	1.00
153_K	169_Y	1.973	1.00
345_F	365_F	1.943	1.00
49_E	91_K	1.940	1.00
110_K	114_E	1.930	1.00
474_I	477_S	1.926	1.00
263_G	299_G	1.919	1.00
428_E	478_A	1.919	1.00
344_L	487_I	1.877	1.00
397_T	403_P	1.876	1.00
35_P	50_E	1.873	1.00
5_M	449_L	1.868	1.00
373_K	376_H	1.849	1.00
409_A	420_R	1.848	1.00
328_V	331_K	1.846	1.00
335_R	375_E	1.832	1.00
61_R	65_Q	1.822	1.00
6_L	59_T	1.821	1.00
435_E	466_G	1.806	1.00
219_P	229_P	1.804	1.00
10_I	15_T	1.790	1.00
166_F	233_F	1.785	1.00
40_D	43_T	1.781	1.00
6_L	17_A	1.775	1.00
4_Y	27_V	1.773	1.00
485_M	489_I	1.770	1.00
208_V	212_E	1.721	1.00
456_D	460_A	1.719	1.00
306_I	381_A	1.713	1.00
138_A	142_N	1.708	1.00
234_V	451_A	1.700	1.00
123_R	192_E	1.700	1.00
324_D	328_V	1.690	1.00
90_D	163_K	1.683	1.00
85_A	140_I	1.675	1.00
425_D	477_S	1.672	1.00
425_D	474_I	1.657	1.00
87_D	91_K	1.650	1.00
432_V	470_R	1.649	1.00
119_E	122_K	1.639	1.00
251_K	462_S	1.638	1.00
109_H	113_E	1.625	1.00
170_V	208_V	1.623	1.00
254_E	406_R	1.623	1.00
19_L	66_H	1.614	1.00
332_I	335_R	1.609	1.00
4_Y	19_L	1.596	1.00
332_I	375_E	1.580	1.00
84_I	157_I	1.560	1.00
387_Y	484_L	1.559	1.00
106_G	110_K	1.538	1.00
213_I	216_H	1.532	1.00
85_A	203_H	1.523	1.00
304_R	308_D	1.522	1.00
213_I	234_V	1.516	1.00
478_A	482_R	1.515	1.00
362_R	369_T	1.511	1.00
490_N	494_L	1.497	1.00
394_L	489_I	1.495	1.00
185_K	272_P	1.487	1.00
47_N	50_E	1.486	1.00
119_E	123_R	1.475	1.00
476_D	479_K	1.472	1.00
430_E	470_R	1.457	1.00
252_K	270_D	1.454	1.00
62_I	66_H	1.450	1.00
228_D	231_T	1.442	1.00
394_L	397_T	1.442	1.00
30_E	62_I	1.438	1.00
5_M	454_K	1.436	1.00
63_T	68_E	1.429	1.00
379_R	383_E	1.429	1.00
146_E	149_S	1.428	1.00
37_Y	50_E	1.416	1.00
30_E	58_T	1.414	1.00
162_F	214_F	1.408	1.00
28_Q	65_Q	1.405	1.00
333_A	418_V	1.396	1.00
49_E	53_Q	1.390	1.00
119_E	192_E	1.387	1.00
139_W	143_E	1.385	1.00
331_K	335_R	1.385	1.00
329_L	378_I	1.381	1.00
435_E	468_T	1.375	1.00
417_E	471_H	1.374	1.00
28_Q	62_I	1.372	1.00
80_M	238_S	1.363	1.00
418_V	422_M	1.363	1.00
417_E	433_V	1.360	1.00
166_F	215_Q	1.353	1.00
73_F	448_G	1.352	1.00
449_L	455_I	1.352	1.00
259_I	423_M	1.351	1.00
345_F	349_L	1.351	1.00
330_T	334_Q	1.344	1.00
112_K	117_G	1.335	1.00
270_D	287_D	1.334	1.00
52_F	56_I	1.319	1.00
332_I	374_K	1.318	1.00
296_V	388_N	1.312	1.00
28_Q	66_H	1.311	1.00
386_I	422_M	1.298	1.00
86_I	155_I	1.298	1.00
173_Y	187_L	1.296	1.00
67_P	70_R	1.290	1.00
216_H	230_E	1.288	1.00
257_V	423_M	1.286	1.00
406_R	430_E	1.285	1.00
255_I	404_V	1.283	1.00
479_K	483_T	1.275	1.00
8_I	59_T	1.271	1.00
433_V	471_H	1.259	1.00
160_Y	164_Q	1.259	1.00
200_T	203_H	1.256	1.00
208_V	214_F	1.255	1.00
457_S	460_A	1.246	1.00
386_I	423_M	1.245	1.00
386_I	426_I	1.242	1.00
15_T	55_V	1.241	1.00
345_F	381_A	1.220	1.00
105_E	109_H	1.213	1.00
162_F	170_V	1.213	1.00
194_L	204_L	1.212	1.00
22_E	454_K	1.212	1.00
120_V	128_I	1.210	1.00
270_D	289_H	1.198	1.00
82_S	96_C	1.193	1.00
415_R	437_Y	1.191	1.00
107_W	138_A	1.188	1.00
330_T	416_S	1.187	1.00
141_T	148_A	1.181	1.00
134_L	197_A	1.176	1.00
251_K	254_E	1.167	1.00
422_M	426_I	1.167	1.00
15_T	54_A	1.164	1.00
420_R	471_H	1.157	1.00
394_L	485_M	1.154	1.00
330_T	417_E	1.154	1.00
237_A	447_L	1.153	1.00
192_E	195_R	1.151	1.00
90_D	169_Y	1.149	1.00
331_K	334_Q	1.149	1.00
53_Q	57_H	1.149	1.00
8_I	17_A	1.147	1.00
213_I	232_P	1.146	1.00
391_T	489_I	1.146	1.00
20_F	26_V	1.145	1.00
47_N	95_P	1.143	1.00
390_Y	427_F	1.134	1.00
85_A	151_A	1.134	1.00
144_R	147_I	1.131	1.00
343_L	372_H	1.130	1.00
428_E	482_R	1.127	1.00
368_L	372_H	1.126	1.00
310_F	377_M	1.126	1.00
327_D	330_T	1.125	1.00
57_H	61_R	1.120	1.00
168_E	208_V	1.118	1.00
173_Y	207_L	1.113	1.00
328_V	332_I	1.113	1.00
4_Y	70_R	1.111	1.00
114_E	196_I	1.110	1.00
55_V	161_I	1.106	1.00
366_F	491_L	1.103	1.00
148_A	151_A	1.097	1.00
51_I	157_I	1.096	1.00
63_T	66_H	1.094	1.00
352_E	355_P	1.092	1.00
155_I	169_Y	1.090	1.00
170_V	214_F	1.088	1.00
213_I	451_A	1.082	1.00
482_R	486_P	1.079	1.00
85_A	137_I	1.074	1.00
408_Q	432_V	1.071	1.00
151_A	203_H	1.070	1.00
36_L	46_Q	1.069	1.00
106_G	109_H	1.069	1.00
298_N	302_V	1.066	1.00
108_A	128_I	1.066	1.00
477_S	480_E	1.064	1.00
76_F	162_F	1.062	1.00
173_Y	182_M	1.052	1.00
73_F	452_T	1.046	1.00
48_P	84_I	1.045	1.00
103_R	139_W	1.041	1.00
393_F	427_F	1.037	1.00
146_E	150_K	1.036	1.00
5_M	452_T	1.035	1.00
253_G	405_T	1.035	1.00
339_G	342_G	1.033	1.00
456_D	459_D	1.032	1.00
372_H	376_H	1.026	1.00
487_I	490_N	1.023	1.00
109_H	112_K	1.021	1.00
20_F	445_C	1.020	1.00
119_E	196_I	1.019	1.00
254_E	408_Q	1.017	1.00
122_K	274_T	1.011	1.00
332_I	378_I	1.008	1.00
61_R	64_K	1.008	1.00
385_V	413_F	1.008	1.00
44_A	100_A	0.992	1.00
34_Y	54_A	0.989	1.00
194_L	199_I	0.986	1.00
107_W	143_E	0.983	1.00
94_T	147_I	0.980	1.00
336_V	340_S	0.979	1.00
17_A	62_I	0.975	1.00
107_W	110_K	0.972	1.00
363_G	368_L	0.971	1.00
446_I	464_M	0.966	1.00
216_H	232_P	0.965	1.00
449_L	454_K	0.965	1.00
387_Y	426_I	0.964	1.00
413_F	419_W	0.964	1.00
55_V	59_T	0.961	1.00
74_I	231_T	0.959	1.00
279_R	283_Y	0.957	1.00
73_F	234_V	0.956	1.00
467_S	470_R	0.955	1.00
474_I	478_A	0.955	1.00
256_A	410_T	0.953	1.00
50_E	53_Q	0.952	1.00
134_L	180_G	0.950	1.00
45_E	95_P	0.950	1.00
281_F	284_A	0.949	1.00
182_M	186_G	0.949	1.00
120_V	180_G	0.948	1.00
122_K	185_K	0.947	1.00
30_E	65_Q	0.945	1.00
118_H	122_K	0.944	1.00
298_N	301_I	0.944	1.00
163_K	169_Y	0.937	1.00
379_R	418_V	0.937	1.00
137_I	154_Y	0.936	1.00
39_P	43_T	0.934	1.00
56_I	60_A	0.928	1.00
368_L	377_M	0.928	1.00
60_A	64_K	0.928	1.00
334_Q	418_V	0.927	1.00
251_K	405_T	0.927	1.00
77_S	440_S	0.923	1.00
63_T	71_I	0.922	1.00
145_K	149_S	0.921	1.00
302_V	345_F	0.921	1.00
72_S	452_T	0.917	1.00
110_K	113_E	0.916	1.00
187_L	209_P	0.916	1.00
147_I	150_K	0.915	1.00
140_I	147_I	0.909	1.00
345_F	380_A	0.907	1.00
234_V	452_T	0.907	1.00
116_N	119_E	0.905	1.00
6_L	71_I	0.904	1.00
85_A	154_Y	0.904	1.00
171_I	176_A	0.902	1.00
6_L	19_L	0.899	1.00
151_A	154_Y	0.898	1.00
21_S	27_V	0.898	1.00
19_L	71_I	0.896	1.00
390_Y	426_I	0.896	1.00
5_M	73_F	0.895	1.00
76_F	161_I	0.894	1.00
91_K	164_Q	0.893	1.00
116_N	196_I	0.893	1.00
406_R	470_R	0.892	1.00
427_F	430_E	0.889	1.00
460_A	464_M	0.886	1.00
110_K	138_A	0.884	1.00
159_E	171_I	0.881	1.00
387_Y	485_M	0.878	1.00
428_E	480_E	0.878	1.00
81_H	178_A	0.877	1.00
152_K	202_D	0.872	1.00
407_I	427_F	0.869	1.00
94_T	140_I	0.864	1.00
173_Y	209_P	0.863	1.00
20_F	442_L	0.862	1.00
75_S	234_V	0.861	1.00
185_K	274_T	0.860	1.00
475_E	478_A	0.858	1.00
475_E	480_E	0.856	1.00
10_I	161_I	0.856	1.00
333_A	379_R	0.855	1.00
336_V	341_D	0.853	1.00
327_D	331_K	0.852	1.00
187_L	288_K	0.852	1.00
134_L	181_M	0.851	1.00
71_I	231_T	0.851	1.00
263_G	389_L	0.850	1.00
460_A	463_D	0.848	1.00
365_F	381_A	0.844	1.00
461_V	465_I	0.843	1.00
265_I	393_F	0.842	1.00
277_K	398_E	0.842	1.00
243_S	410_T	0.840	1.00
83_V	154_Y	0.840	1.00
80_M	293_G	0.839	1.00
176_A	189_W	0.837	1.00
69_K	228_D	0.835	1.00
185_K	271_K	0.833	1.00
281_F	285_L	0.833	1.00
86_I	90_D	0.826	1.00
330_T	333_A	0.825	1.00
475_E	479_K	0.823	1.00
394_L	398_E	0.822	1.00
59_T	63_T	0.822	1.00
189_W	204_L	0.822	1.00
156_G	179_T	0.822	1.00
264_A	295_P	0.822	1.00
188_D	206_K	0.820	1.00
10_I	55_V	0.819	1.00
76_F	165_L	0.819	1.00
32_I	58_T	0.818	1.00
170_V	206_K	0.817	1.00
33_G	304_R	0.812	1.00
167_N	218_S	0.812	1.00
450_Y	458_F	0.812	1.00
344_L	366_F	0.810	1.00
80_M	175_L	0.810	1.00
102_N	129_H	0.809	1.00
108_A	130_P	0.807	1.00
217_C	231_T	0.807	1.00
450_Y	460_A	0.805	1.00
171_I	205_S	0.805	1.00
240_G	264_A	0.799	1.00
279_R	284_A	0.798	1.00
29_K	438_E	0.796	1.00
305_W	308_D	0.794	1.00
108_A	135_S	0.792	1.00
483_T	486_P	0.791	1.00
216_H	229_P	0.789	1.00
393_F	397_T	0.788	1.00
326_Y	329_L	0.785	1.00
255_I	407_I	0.785	1.00
99_W	262_S	0.783	1.00
138_A	141_T	0.783	1.00
137_I	181_M	0.777	1.00
490_N	493_R	0.777	1.00
123_R	183_N	0.775	1.00
382_L	422_M	0.774	1.00
307_R	326_Y	0.773	1.00
208_V	235_I	0.770	1.00
409_A	423_M	0.770	1.00
20_F	436_S	0.768	1.00
247_V	410_T	0.768	1.00
432_V	467_S	0.765	1.00
72_S	454_K	0.765	1.00
182_M	187_L	0.764	1.00
45_E	103_R	0.763	1.00
311_A	374_K	0.761	1.00
112_K	128_I	0.759	1.00
409_A	433_V	0.756	1.00
188_D	191_E	0.755	1.00
106_G	142_N	0.755	1.00
450_Y	457_S	0.754	1.00
303_L	330_T	0.752	1.00
93_L	150_K	0.752	1.00
73_F	232_P	0.751	1.00
106_G	143_E	0.750	1.00
461_V	464_M	0.748	1.00
158_K	236_G	0.748	1.00
257_V	263_G	0.747	1.00
306_I	378_I	0.747	1.00
446_I	461_V	0.746	1.00
7_G	75_S	0.746	1.00
227_I	230_E	0.745	1.00
299_G	385_V	0.743	1.00
414_A	437_Y	0.743	1.00
171_I	207_L	0.743	1.00
304_R	326_Y	0.739	1.00
15_T	34_Y	0.738	1.00
32_I	54_A	0.737	1.00
306_I	377_M	0.736	1.00
382_L	416_S	0.734	1.00
26_V	29_K	0.733	1.00
294_G	392_V	0.733	1.00
342_G	484_L	0.732	1.00
34_Y	46_Q	0.732	1.00
257_V	389_L	0.730	1.00
219_P	230_E	0.730	1.00
48_P	95_P	0.728	1.00
33_G	307_R	0.728	1.00
450_Y	461_V	0.727	1.00
174_S	237_A	0.727	1.00
386_I	419_W	0.726	1.00
340_S	344_L	0.726	1.00
391_T	485_M	0.726	1.00
459_D	462_S	0.722	1.00
483_T	487_I	0.721	1.00
12_T	98_T	0.720	1.00
243_S	440_S	0.719	1.00
192_E	196_I	0.719	1.00
414_A	420_R	0.718	1.00
334_Q	421_Q	0.715	1.00
479_K	484_L	0.715	1.00
56_I	221_I	0.713	1.00
174_S	285_L	0.713	1.00
74_I	217_C	0.712	1.00
86_I	169_Y	0.712	1.00
5_M	72_S	0.711	1.00
421_Q	474_I	0.709	1.00
109_H	360_D	0.708	1.00
85_A	93_L	0.706	1.00
336_V	375_E	0.706	1.00
395_A	398_E	0.705	1.00
10_I	54_A	0.702	1.00
280_I	285_L	0.702	1.00
484_L	487_I	0.701	1.00
50_E	54_A	0.701	1.00
49_E	160_Y	0.699	1.00
120_V	193_A	0.698	1.00
56_I	164_Q	0.698	1.00
336_V	339_G	0.698	1.00
334_Q	417_E	0.697	1.00
390_Y	489_I	0.695	1.00
87_D	93_L	0.694	1.00
90_D	152_K	0.693	1.00
247_V	256_A	0.693	1.00
459_D	463_D	0.692	0.99
87_D	152_K	0.691	0.99
272_P	281_F	0.691	0.99
462_S	465_I	0.690	0.99
489_I	493_R	0.689	0.99
55_V	58_T	0.689	0.99
190_D	193_A	0.689	0.99
337_R	340_S	0.688	0.99
342_G	383_E	0.687	0.99
88_E	150_K	0.687	0.99
183_N	188_D	0.686	0.99
138_A	198_G	0.684	0.99
407_I	429_S	0.682	0.99
79_A	99_W	0.680	0.99
53_Q	56_I	0.679	0.99
472_T	475_E	0.678	0.99
333_A	336_V	0.678	0.99
214_F	235_I	0.677	0.99
229_P	232_P	0.677	0.99
86_I	153_K	0.675	0.99
477_S	482_R	0.674	0.99
341_D	372_H	0.674	0.99
221_I	230_E	0.674	0.99
84_I	96_C	0.673	0.99
404_V	429_S	0.670	0.99
405_T	429_S	0.669	0.99
409_A	431_V	0.666	0.99
342_G	379_R	0.665	0.99
97_I	103_R	0.665	0.99
275_D	279_R	0.664	0.99
333_A	378_I	0.664	0.99
22_E	72_S	0.663	0.99
86_I	160_Y	0.662	0.99
227_I	231_T	0.661	0.99
18_V	26_V	0.660	0.99
49_E	92_P	0.660	0.99
254_E	405_T	0.660	0.99
162_F	166_F	0.659	0.99
52_F	221_I	0.658	0.99
210_T	236_G	0.658	0.99
383_E	422_M	0.658	0.99
430_E	473_P	0.657	0.99
306_I	310_F	0.656	0.99
78_S	175_L	0.655	0.99
59_T	62_I	0.654	0.99
111_I	197_A	0.653	0.99
296_V	392_V	0.652	0.99
213_I	452_T	0.651	0.99
348_Y	352_E	0.650	0.99
249_A	254_E	0.649	0.99
49_E	95_P	0.647	0.99
248_N	465_I	0.646	0.99
160_Y	163_K	0.645	0.99
421_Q	471_H	0.643	0.99
217_C	228_D	0.642	0.99
124_T	193_A	0.641	0.99
449_L	453_G	0.641	0.99
20_F	441_C	0.639	0.99
86_I	163_K	0.639	0.99
263_G	423_M	0.639	0.99
195_R	200_T	0.638	0.99
356_L	391_T	0.637	0.99
138_A	197_A	0.634	0.99
362_R	366_F	0.634	0.99
149_S	153_K	0.632	0.99
330_T	418_V	0.632	0.99
280_I	283_Y	0.631	0.99
280_I	284_A	0.631	0.99
407_I	431_V	0.630	0.99
406_R	429_S	0.630	0.99
216_H	219_P	0.630	0.99
83_V	133_P	0.628	0.99
361_V	364_S	0.628	0.99
468_T	473_P	0.627	0.99
351_G	355_P	0.627	0.99
482_R	485_M	0.627	0.99
358_N	361_V	0.625	0.99
464_M	467_S	0.625	0.99
345_F	384_G	0.624	0.99
78_S	157_I	0.624	0.99
239_D	261_T	0.623	0.99
158_K	175_L	0.621	0.99
257_V	407_I	0.621	0.99
174_S	210_T	0.621	0.99
71_I	227_I	0.620	0.99
480_E	484_L	0.618	0.99
206_K	212_E	0.616	0.99
92_P	95_P	0.615	0.99
416_S	419_W	0.614	0.99
455_I	464_M	0.613	0.99
137_I	203_H	0.611	0.99
460_A	465_I	0.610	0.99
348_Y	365_F	0.610	0.99
217_C	227_I	0.610	0.99
24_G	464_M	0.608	0.99
238_S	241_V	0.608	0.99
128_I	180_G	0.608	0.99
150_K	153_K	0.607	0.99
57_H	60_A	0.607	0.99
259_I	409_A	0.607	0.99
303_L	329_L	0.607	0.99
279_R	285_L	0.606	0.99
379_R	422_M	0.606	0.99
346_H	364_S	0.599	0.99
141_T	198_G	0.599	0.99
417_E	421_Q	0.598	0.99
132_A	178_A	0.598	0.99
5_M	455_I	0.598	0.99
159_E	169_Y	0.597	0.99
56_I	59_T	0.597	0.99
84_I	92_P	0.595	0.98
337_R	341_D	0.594	0.98
428_E	475_E	0.594	0.98
193_A	197_A	0.592	0.98
138_A	148_A	0.590	0.98
455_I	460_A	0.590	0.98
433_V	468_T	0.589	0.98
339_G	343_L	0.587	0.98
130_P	359_P	0.587	0.98
446_I	450_Y	0.587	0.98
47_N	53_Q	0.584	0.98
336_V	379_R	0.584	0.98
349_L	352_E	0.583	0.98
181_M	204_L	0.581	0.98
267_T	404_V	0.581	0.98
398_E	489_I	0.580	0.98
126_T	132_A	0.580	0.98
414_A	433_V	0.579	0.98
104_S	135_S	0.579	0.98
333_A	382_L	0.578	0.98
450_Y	455_I	0.578	0.98
486_P	489_I	0.578	0.98
340_S	379_R	0.577	0.98
68_E	71_I	0.577	0.98
278_G	283_Y	0.576	0.98
49_E	52_F	0.575	0.98
383_E	387_Y	0.574	0.98
81_H	99_W	0.573	0.98
179_T	189_W	0.572	0.98
330_T	382_L	0.572	0.98
29_K	65_Q	0.572	0.98
339_G	379_R	0.571	0.98
211_T	451_A	0.570	0.98
240_G	258_T	0.570	0.98
135_S	180_G	0.569	0.98
105_E	130_P	0.567	0.98
446_I	465_I	0.566	0.98
340_S	383_E	0.566	0.98
97_I	140_I	0.565	0.98
255_I	267_T	0.565	0.98
4_Y	69_K	0.564	0.98
38_T	44_A	0.564	0.98
120_V	197_A	0.563	0.98
356_L	489_I	0.562	0.98
48_P	96_C	0.562	0.98
263_G	296_V	0.561	0.98
23_N	463_D	0.561	0.98
80_M	178_A	0.561	0.98
420_R	433_V	0.560	0.98
385_V	419_W	0.560	0.98
467_S	473_P	0.560	0.98
339_G	344_L	0.560	0.98
43_T	97_I	0.559	0.98
267_T	396_L	0.558	0.98
51_I	96_C	0.557	0.98
198_G	201_P	0.556	0.98
111_I	135_S	0.555	0.98
103_R	143_E	0.554	0.98
26_V	436_S	0.554	0.98
25_D	435_E	0.554	0.98
421_Q	424_S	0.554	0.98
12_T	99_W	0.553	0.98
232_P	452_T	0.552	0.98
254_E	462_S	0.552	0.98
450_Y	453_G	0.552	0.98
148_A	152_K	0.552	0.98
257_V	265_I	0.548	0.97
479_K	482_R	0.547	0.97
74_I	233_F	0.547	0.97
329_L	416_S	0.547	0.97
91_K	150_K	0.546	0.97
115_L	193_A	0.546	0.97
272_P	290_W	0.546	0.97
221_I	227_I	0.544	0.97
114_E	138_A	0.542	0.97
217_C	226_G	0.541	0.97
346_H	492_S	0.540	0.97
173_Y	210_T	0.540	0.97
13_T	16_K	0.540	0.97
268_I	289_H	0.539	0.97
90_D	153_K	0.539	0.97
436_S	442_L	0.537	0.97
81_H	262_S	0.536	0.97
244_N	284_A	0.536	0.97
174_S	241_V	0.536	0.97
79_A	238_S	0.532	0.97
424_S	431_V	0.531	0.97
261_T	301_I	0.531	0.97
423_M	427_F	0.530	0.97
265_I	392_V	0.530	0.97
435_E	467_S	0.529	0.97
199_I	204_L	0.527	0.97
326_Y	330_T	0.526	0.97
211_T	450_Y	0.525	0.97
82_S	98_T	0.524	0.97
332_I	336_V	0.524	0.97
387_Y	487_I	0.523	0.97
210_T	237_A	0.523	0.97
155_I	163_K	0.522	0.97
246_G	439_S	0.522	0.97
350_A	370_M	0.522	0.97
422_M	484_L	0.521	0.97
44_A	98_T	0.520	0.96
156_G	175_L	0.519	0.96
339_G	376_H	0.519	0.96
184_L	290_W	0.518	0.96
159_E	205_S	0.518	0.96
341_D	371_S	0.516	0.96
258_T	410_T	0.516	0.96
347_P	384_G	0.516	0.96
7_G	441_C	0.515	0.96
482_R	489_I	0.514	0.96
258_T	264_A	0.513	0.96
4_Y	66_H	0.513	0.96
77_S	444_A	0.513	0.96
79_A	96_C	0.512	0.96
441_C	444_A	0.511	0.96
269_I	292_I	0.511	0.96
328_V	374_K	0.510	0.96
199_I	203_H	0.510	0.96
148_A	200_T	0.510	0.96
356_L	492_S	0.509	0.96
54_A	57_H	0.508	0.96
245_L	285_L	0.508	0.96
309_E	373_K	0.506	0.96
342_G	487_I	0.506	0.96
354_A	357_W	0.505	0.96
442_L	446_I	0.505	0.96
397_T	404_V	0.505	0.96
342_G	376_H	0.505	0.96
296_V	389_L	0.503	0.96
31_S	438_E	0.503	0.96
168_E	216_H	0.503	0.96
389_L	423_M	0.502	0.96
239_D	412_G	0.501	0.96
329_L	418_V	0.501	0.96
93_L	151_A	0.500	0.96
148_A	198_G	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ll3A	2	0.9571	100	0.099	Contact Map
2itmA	2	0.922	100	0.139	Contact Map
3ifrA	2	0.9454	100	0.145	Contact Map
3qdkA	2	0.9883	100	0.145	Contact Map
3hz6A	1	0.9357	100	0.149	Contact Map
3wxlA	2	0.9493	100	0.155	Contact Map
3ezwA	3	0.9474	100	0.16	Contact Map
3g25A	3	0.9454	100	0.163	Contact Map
3h3nX	3	0.9474	100	0.164	Contact Map
3l0qA	2	0.9688	100	0.166	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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