GREMLIN Database
GNTK - Gluconokinase
UniProt: P12011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 513 (473)
Sequences: 12487 (8500)
Seq/√Len: 390.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_W142_N3.8661.00
191_E201_P3.6581.00
21_S25_D3.4681.00
17_A58_T3.2771.00
110_K142_N3.2321.00
390_Y485_M2.8511.00
123_R190_D2.8481.00
390_Y394_L2.7821.00
397_T429_S2.7741.00
183_N186_G2.7471.00
421_Q425_D2.7111.00
430_E472_T2.7061.00
336_V376_H2.7021.00
93_L147_I2.7011.00
37_Y95_P2.6761.00
182_M207_L2.6581.00
365_F377_M2.6341.00
32_I57_H2.6261.00
168_E206_K2.5981.00
32_I61_R2.5941.00
209_P212_E2.5581.00
30_E61_R2.5431.00
406_R432_V2.5261.00
94_T144_R2.4751.00
52_F164_Q2.4551.00
87_D150_K2.4181.00
417_E469_Y2.3841.00
49_E164_Q2.3761.00
19_L62_I2.3681.00
88_E152_K2.3451.00
390_Y482_R2.2951.00
325_P328_V2.2301.00
183_N190_D2.2181.00
237_A242_L2.1451.00
191_E195_R2.1201.00
341_D376_H2.1051.00
188_D201_P2.0951.00
162_F236_G2.0871.00
18_V441_C2.0771.00
8_I55_V2.0741.00
194_L201_P2.0501.00
14_S31_S2.0381.00
302_V381_A1.9991.00
218_S221_I1.9991.00
153_K169_Y1.9731.00
345_F365_F1.9431.00
49_E91_K1.9401.00
110_K114_E1.9301.00
474_I477_S1.9261.00
263_G299_G1.9191.00
428_E478_A1.9191.00
344_L487_I1.8771.00
397_T403_P1.8761.00
35_P50_E1.8731.00
5_M449_L1.8681.00
373_K376_H1.8491.00
409_A420_R1.8481.00
328_V331_K1.8461.00
335_R375_E1.8321.00
61_R65_Q1.8221.00
6_L59_T1.8211.00
435_E466_G1.8061.00
219_P229_P1.8041.00
10_I15_T1.7901.00
166_F233_F1.7851.00
40_D43_T1.7811.00
6_L17_A1.7751.00
4_Y27_V1.7731.00
485_M489_I1.7701.00
208_V212_E1.7211.00
456_D460_A1.7191.00
306_I381_A1.7131.00
138_A142_N1.7081.00
234_V451_A1.7001.00
123_R192_E1.7001.00
324_D328_V1.6901.00
90_D163_K1.6831.00
85_A140_I1.6751.00
425_D477_S1.6721.00
425_D474_I1.6571.00
87_D91_K1.6501.00
432_V470_R1.6491.00
119_E122_K1.6391.00
251_K462_S1.6381.00
109_H113_E1.6251.00
170_V208_V1.6231.00
254_E406_R1.6231.00
19_L66_H1.6141.00
332_I335_R1.6091.00
4_Y19_L1.5961.00
332_I375_E1.5801.00
84_I157_I1.5601.00
387_Y484_L1.5591.00
106_G110_K1.5381.00
213_I216_H1.5321.00
85_A203_H1.5231.00
304_R308_D1.5221.00
213_I234_V1.5161.00
478_A482_R1.5151.00
362_R369_T1.5111.00
490_N494_L1.4971.00
394_L489_I1.4951.00
185_K272_P1.4871.00
47_N50_E1.4861.00
119_E123_R1.4751.00
476_D479_K1.4721.00
430_E470_R1.4571.00
252_K270_D1.4541.00
62_I66_H1.4501.00
228_D231_T1.4421.00
394_L397_T1.4421.00
30_E62_I1.4381.00
5_M454_K1.4361.00
63_T68_E1.4291.00
379_R383_E1.4291.00
146_E149_S1.4281.00
37_Y50_E1.4161.00
30_E58_T1.4141.00
162_F214_F1.4081.00
28_Q65_Q1.4051.00
333_A418_V1.3961.00
49_E53_Q1.3901.00
119_E192_E1.3871.00
139_W143_E1.3851.00
331_K335_R1.3851.00
329_L378_I1.3811.00
435_E468_T1.3751.00
417_E471_H1.3741.00
28_Q62_I1.3721.00
80_M238_S1.3631.00
418_V422_M1.3631.00
417_E433_V1.3601.00
166_F215_Q1.3531.00
73_F448_G1.3521.00
449_L455_I1.3521.00
259_I423_M1.3511.00
345_F349_L1.3511.00
330_T334_Q1.3441.00
112_K117_G1.3351.00
270_D287_D1.3341.00
52_F56_I1.3191.00
332_I374_K1.3181.00
296_V388_N1.3121.00
28_Q66_H1.3111.00
386_I422_M1.2981.00
86_I155_I1.2981.00
173_Y187_L1.2961.00
67_P70_R1.2901.00
216_H230_E1.2881.00
257_V423_M1.2861.00
406_R430_E1.2851.00
255_I404_V1.2831.00
479_K483_T1.2751.00
8_I59_T1.2711.00
433_V471_H1.2591.00
160_Y164_Q1.2591.00
200_T203_H1.2561.00
208_V214_F1.2551.00
457_S460_A1.2461.00
386_I423_M1.2451.00
386_I426_I1.2421.00
15_T55_V1.2411.00
345_F381_A1.2201.00
105_E109_H1.2131.00
162_F170_V1.2131.00
194_L204_L1.2121.00
22_E454_K1.2121.00
120_V128_I1.2101.00
270_D289_H1.1981.00
82_S96_C1.1931.00
415_R437_Y1.1911.00
107_W138_A1.1881.00
330_T416_S1.1871.00
141_T148_A1.1811.00
134_L197_A1.1761.00
251_K254_E1.1671.00
422_M426_I1.1671.00
15_T54_A1.1641.00
420_R471_H1.1571.00
394_L485_M1.1541.00
330_T417_E1.1541.00
237_A447_L1.1531.00
192_E195_R1.1511.00
90_D169_Y1.1491.00
331_K334_Q1.1491.00
53_Q57_H1.1491.00
8_I17_A1.1471.00
213_I232_P1.1461.00
391_T489_I1.1461.00
20_F26_V1.1451.00
47_N95_P1.1431.00
390_Y427_F1.1341.00
85_A151_A1.1341.00
144_R147_I1.1311.00
343_L372_H1.1301.00
428_E482_R1.1271.00
368_L372_H1.1261.00
310_F377_M1.1261.00
327_D330_T1.1251.00
57_H61_R1.1201.00
168_E208_V1.1181.00
173_Y207_L1.1131.00
328_V332_I1.1131.00
4_Y70_R1.1111.00
114_E196_I1.1101.00
55_V161_I1.1061.00
366_F491_L1.1031.00
148_A151_A1.0971.00
51_I157_I1.0961.00
63_T66_H1.0941.00
352_E355_P1.0921.00
155_I169_Y1.0901.00
170_V214_F1.0881.00
213_I451_A1.0821.00
482_R486_P1.0791.00
85_A137_I1.0741.00
408_Q432_V1.0711.00
151_A203_H1.0701.00
36_L46_Q1.0691.00
106_G109_H1.0691.00
298_N302_V1.0661.00
108_A128_I1.0661.00
477_S480_E1.0641.00
76_F162_F1.0621.00
173_Y182_M1.0521.00
73_F452_T1.0461.00
48_P84_I1.0451.00
103_R139_W1.0411.00
393_F427_F1.0371.00
146_E150_K1.0361.00
5_M452_T1.0351.00
253_G405_T1.0351.00
339_G342_G1.0331.00
456_D459_D1.0321.00
372_H376_H1.0261.00
487_I490_N1.0231.00
109_H112_K1.0211.00
20_F445_C1.0201.00
119_E196_I1.0191.00
254_E408_Q1.0171.00
122_K274_T1.0111.00
332_I378_I1.0081.00
61_R64_K1.0081.00
385_V413_F1.0081.00
44_A100_A0.9921.00
34_Y54_A0.9891.00
194_L199_I0.9861.00
107_W143_E0.9831.00
94_T147_I0.9801.00
336_V340_S0.9791.00
17_A62_I0.9751.00
107_W110_K0.9721.00
363_G368_L0.9711.00
446_I464_M0.9661.00
216_H232_P0.9651.00
449_L454_K0.9651.00
387_Y426_I0.9641.00
413_F419_W0.9641.00
55_V59_T0.9611.00
74_I231_T0.9591.00
279_R283_Y0.9571.00
73_F234_V0.9561.00
467_S470_R0.9551.00
474_I478_A0.9551.00
256_A410_T0.9531.00
50_E53_Q0.9521.00
134_L180_G0.9501.00
45_E95_P0.9501.00
281_F284_A0.9491.00
182_M186_G0.9491.00
120_V180_G0.9481.00
122_K185_K0.9471.00
30_E65_Q0.9451.00
118_H122_K0.9441.00
298_N301_I0.9441.00
163_K169_Y0.9371.00
379_R418_V0.9371.00
137_I154_Y0.9361.00
39_P43_T0.9341.00
56_I60_A0.9281.00
368_L377_M0.9281.00
60_A64_K0.9281.00
334_Q418_V0.9271.00
251_K405_T0.9271.00
77_S440_S0.9231.00
63_T71_I0.9221.00
145_K149_S0.9211.00
302_V345_F0.9211.00
72_S452_T0.9171.00
110_K113_E0.9161.00
187_L209_P0.9161.00
147_I150_K0.9151.00
140_I147_I0.9091.00
345_F380_A0.9071.00
234_V452_T0.9071.00
116_N119_E0.9051.00
6_L71_I0.9041.00
85_A154_Y0.9041.00
171_I176_A0.9021.00
6_L19_L0.8991.00
151_A154_Y0.8981.00
21_S27_V0.8981.00
19_L71_I0.8961.00
390_Y426_I0.8961.00
5_M73_F0.8951.00
76_F161_I0.8941.00
91_K164_Q0.8931.00
116_N196_I0.8931.00
406_R470_R0.8921.00
427_F430_E0.8891.00
460_A464_M0.8861.00
110_K138_A0.8841.00
159_E171_I0.8811.00
387_Y485_M0.8781.00
428_E480_E0.8781.00
81_H178_A0.8771.00
152_K202_D0.8721.00
407_I427_F0.8691.00
94_T140_I0.8641.00
173_Y209_P0.8631.00
20_F442_L0.8621.00
75_S234_V0.8611.00
185_K274_T0.8601.00
475_E478_A0.8581.00
475_E480_E0.8561.00
10_I161_I0.8561.00
333_A379_R0.8551.00
336_V341_D0.8531.00
327_D331_K0.8521.00
187_L288_K0.8521.00
134_L181_M0.8511.00
71_I231_T0.8511.00
263_G389_L0.8501.00
460_A463_D0.8481.00
365_F381_A0.8441.00
461_V465_I0.8431.00
265_I393_F0.8421.00
277_K398_E0.8421.00
243_S410_T0.8401.00
83_V154_Y0.8401.00
80_M293_G0.8391.00
176_A189_W0.8371.00
69_K228_D0.8351.00
185_K271_K0.8331.00
281_F285_L0.8331.00
86_I90_D0.8261.00
330_T333_A0.8251.00
475_E479_K0.8231.00
394_L398_E0.8221.00
59_T63_T0.8221.00
189_W204_L0.8221.00
156_G179_T0.8221.00
264_A295_P0.8221.00
188_D206_K0.8201.00
10_I55_V0.8191.00
76_F165_L0.8191.00
32_I58_T0.8181.00
170_V206_K0.8171.00
33_G304_R0.8121.00
167_N218_S0.8121.00
450_Y458_F0.8121.00
344_L366_F0.8101.00
80_M175_L0.8101.00
102_N129_H0.8091.00
108_A130_P0.8071.00
217_C231_T0.8071.00
450_Y460_A0.8051.00
171_I205_S0.8051.00
240_G264_A0.7991.00
279_R284_A0.7981.00
29_K438_E0.7961.00
305_W308_D0.7941.00
108_A135_S0.7921.00
483_T486_P0.7911.00
216_H229_P0.7891.00
393_F397_T0.7881.00
326_Y329_L0.7851.00
255_I407_I0.7851.00
99_W262_S0.7831.00
138_A141_T0.7831.00
137_I181_M0.7771.00
490_N493_R0.7771.00
123_R183_N0.7751.00
382_L422_M0.7741.00
307_R326_Y0.7731.00
208_V235_I0.7701.00
409_A423_M0.7701.00
20_F436_S0.7681.00
247_V410_T0.7681.00
432_V467_S0.7651.00
72_S454_K0.7651.00
182_M187_L0.7641.00
45_E103_R0.7631.00
311_A374_K0.7611.00
112_K128_I0.7591.00
409_A433_V0.7561.00
188_D191_E0.7551.00
106_G142_N0.7551.00
450_Y457_S0.7541.00
303_L330_T0.7521.00
93_L150_K0.7521.00
73_F232_P0.7511.00
106_G143_E0.7501.00
461_V464_M0.7481.00
158_K236_G0.7481.00
257_V263_G0.7471.00
306_I378_I0.7471.00
446_I461_V0.7461.00
7_G75_S0.7461.00
227_I230_E0.7451.00
299_G385_V0.7431.00
414_A437_Y0.7431.00
171_I207_L0.7431.00
304_R326_Y0.7391.00
15_T34_Y0.7381.00
32_I54_A0.7371.00
306_I377_M0.7361.00
382_L416_S0.7341.00
26_V29_K0.7331.00
294_G392_V0.7331.00
342_G484_L0.7321.00
34_Y46_Q0.7321.00
257_V389_L0.7301.00
219_P230_E0.7301.00
48_P95_P0.7281.00
33_G307_R0.7281.00
450_Y461_V0.7271.00
174_S237_A0.7271.00
386_I419_W0.7261.00
340_S344_L0.7261.00
391_T485_M0.7261.00
459_D462_S0.7221.00
483_T487_I0.7211.00
12_T98_T0.7201.00
243_S440_S0.7191.00
192_E196_I0.7191.00
414_A420_R0.7181.00
334_Q421_Q0.7151.00
479_K484_L0.7151.00
56_I221_I0.7131.00
174_S285_L0.7131.00
74_I217_C0.7121.00
86_I169_Y0.7121.00
5_M72_S0.7111.00
421_Q474_I0.7091.00
109_H360_D0.7081.00
85_A93_L0.7061.00
336_V375_E0.7061.00
395_A398_E0.7051.00
10_I54_A0.7021.00
280_I285_L0.7021.00
484_L487_I0.7011.00
50_E54_A0.7011.00
49_E160_Y0.6991.00
120_V193_A0.6981.00
56_I164_Q0.6981.00
336_V339_G0.6981.00
334_Q417_E0.6971.00
390_Y489_I0.6951.00
87_D93_L0.6941.00
90_D152_K0.6931.00
247_V256_A0.6931.00
459_D463_D0.6920.99
87_D152_K0.6910.99
272_P281_F0.6910.99
462_S465_I0.6900.99
489_I493_R0.6890.99
55_V58_T0.6890.99
190_D193_A0.6890.99
337_R340_S0.6880.99
342_G383_E0.6870.99
88_E150_K0.6870.99
183_N188_D0.6860.99
138_A198_G0.6840.99
407_I429_S0.6820.99
79_A99_W0.6800.99
53_Q56_I0.6790.99
472_T475_E0.6780.99
333_A336_V0.6780.99
214_F235_I0.6770.99
229_P232_P0.6770.99
86_I153_K0.6750.99
477_S482_R0.6740.99
341_D372_H0.6740.99
221_I230_E0.6740.99
84_I96_C0.6730.99
404_V429_S0.6700.99
405_T429_S0.6690.99
409_A431_V0.6660.99
342_G379_R0.6650.99
97_I103_R0.6650.99
275_D279_R0.6640.99
333_A378_I0.6640.99
22_E72_S0.6630.99
86_I160_Y0.6620.99
227_I231_T0.6610.99
18_V26_V0.6600.99
49_E92_P0.6600.99
254_E405_T0.6600.99
162_F166_F0.6590.99
52_F221_I0.6580.99
210_T236_G0.6580.99
383_E422_M0.6580.99
430_E473_P0.6570.99
306_I310_F0.6560.99
78_S175_L0.6550.99
59_T62_I0.6540.99
111_I197_A0.6530.99
296_V392_V0.6520.99
213_I452_T0.6510.99
348_Y352_E0.6500.99
249_A254_E0.6490.99
49_E95_P0.6470.99
248_N465_I0.6460.99
160_Y163_K0.6450.99
421_Q471_H0.6430.99
217_C228_D0.6420.99
124_T193_A0.6410.99
449_L453_G0.6410.99
20_F441_C0.6390.99
86_I163_K0.6390.99
263_G423_M0.6390.99
195_R200_T0.6380.99
356_L391_T0.6370.99
138_A197_A0.6340.99
362_R366_F0.6340.99
149_S153_K0.6320.99
330_T418_V0.6320.99
280_I283_Y0.6310.99
280_I284_A0.6310.99
407_I431_V0.6300.99
406_R429_S0.6300.99
216_H219_P0.6300.99
83_V133_P0.6280.99
361_V364_S0.6280.99
468_T473_P0.6270.99
351_G355_P0.6270.99
482_R485_M0.6270.99
358_N361_V0.6250.99
464_M467_S0.6250.99
345_F384_G0.6240.99
78_S157_I0.6240.99
239_D261_T0.6230.99
158_K175_L0.6210.99
257_V407_I0.6210.99
174_S210_T0.6210.99
71_I227_I0.6200.99
480_E484_L0.6180.99
206_K212_E0.6160.99
92_P95_P0.6150.99
416_S419_W0.6140.99
455_I464_M0.6130.99
137_I203_H0.6110.99
460_A465_I0.6100.99
348_Y365_F0.6100.99
217_C227_I0.6100.99
24_G464_M0.6080.99
238_S241_V0.6080.99
128_I180_G0.6080.99
150_K153_K0.6070.99
57_H60_A0.6070.99
259_I409_A0.6070.99
303_L329_L0.6070.99
279_R285_L0.6060.99
379_R422_M0.6060.99
346_H364_S0.5990.99
141_T198_G0.5990.99
417_E421_Q0.5980.99
132_A178_A0.5980.99
5_M455_I0.5980.99
159_E169_Y0.5970.99
56_I59_T0.5970.99
84_I92_P0.5950.98
337_R341_D0.5940.98
428_E475_E0.5940.98
193_A197_A0.5920.98
138_A148_A0.5900.98
455_I460_A0.5900.98
433_V468_T0.5890.98
339_G343_L0.5870.98
130_P359_P0.5870.98
446_I450_Y0.5870.98
47_N53_Q0.5840.98
336_V379_R0.5840.98
349_L352_E0.5830.98
181_M204_L0.5810.98
267_T404_V0.5810.98
398_E489_I0.5800.98
126_T132_A0.5800.98
414_A433_V0.5790.98
104_S135_S0.5790.98
333_A382_L0.5780.98
450_Y455_I0.5780.98
486_P489_I0.5780.98
340_S379_R0.5770.98
68_E71_I0.5770.98
278_G283_Y0.5760.98
49_E52_F0.5750.98
383_E387_Y0.5740.98
81_H99_W0.5730.98
179_T189_W0.5720.98
330_T382_L0.5720.98
29_K65_Q0.5720.98
339_G379_R0.5710.98
211_T451_A0.5700.98
240_G258_T0.5700.98
135_S180_G0.5690.98
105_E130_P0.5670.98
446_I465_I0.5660.98
340_S383_E0.5660.98
97_I140_I0.5650.98
255_I267_T0.5650.98
4_Y69_K0.5640.98
38_T44_A0.5640.98
120_V197_A0.5630.98
356_L489_I0.5620.98
48_P96_C0.5620.98
263_G296_V0.5610.98
23_N463_D0.5610.98
80_M178_A0.5610.98
420_R433_V0.5600.98
385_V419_W0.5600.98
467_S473_P0.5600.98
339_G344_L0.5600.98
43_T97_I0.5590.98
267_T396_L0.5580.98
51_I96_C0.5570.98
198_G201_P0.5560.98
111_I135_S0.5550.98
103_R143_E0.5540.98
26_V436_S0.5540.98
25_D435_E0.5540.98
421_Q424_S0.5540.98
12_T99_W0.5530.98
232_P452_T0.5520.98
254_E462_S0.5520.98
450_Y453_G0.5520.98
148_A152_K0.5520.98
257_V265_I0.5480.97
479_K482_R0.5470.97
74_I233_F0.5470.97
329_L416_S0.5470.97
91_K150_K0.5460.97
115_L193_A0.5460.97
272_P290_W0.5460.97
221_I227_I0.5440.97
114_E138_A0.5420.97
217_C226_G0.5410.97
346_H492_S0.5400.97
173_Y210_T0.5400.97
13_T16_K0.5400.97
268_I289_H0.5390.97
90_D153_K0.5390.97
436_S442_L0.5370.97
81_H262_S0.5360.97
244_N284_A0.5360.97
174_S241_V0.5360.97
79_A238_S0.5320.97
424_S431_V0.5310.97
261_T301_I0.5310.97
423_M427_F0.5300.97
265_I392_V0.5300.97
435_E467_S0.5290.97
199_I204_L0.5270.97
326_Y330_T0.5260.97
211_T450_Y0.5250.97
82_S98_T0.5240.97
332_I336_V0.5240.97
387_Y487_I0.5230.97
210_T237_A0.5230.97
155_I163_K0.5220.97
246_G439_S0.5220.97
350_A370_M0.5220.97
422_M484_L0.5210.97
44_A98_T0.5200.96
156_G175_L0.5190.96
339_G376_H0.5190.96
184_L290_W0.5180.96
159_E205_S0.5180.96
341_D371_S0.5160.96
258_T410_T0.5160.96
347_P384_G0.5160.96
7_G441_C0.5150.96
482_R489_I0.5140.96
258_T264_A0.5130.96
4_Y66_H0.5130.96
77_S444_A0.5130.96
79_A96_C0.5120.96
441_C444_A0.5110.96
269_I292_I0.5110.96
328_V374_K0.5100.96
199_I203_H0.5100.96
148_A200_T0.5100.96
356_L492_S0.5090.96
54_A57_H0.5080.96
245_L285_L0.5080.96
309_E373_K0.5060.96
342_G487_I0.5060.96
354_A357_W0.5050.96
442_L446_I0.5050.96
397_T404_V0.5050.96
342_G376_H0.5050.96
296_V389_L0.5030.96
31_S438_E0.5030.96
168_E216_H0.5030.96
389_L423_M0.5020.96
239_D412_G0.5010.96
329_L418_V0.5010.96
93_L151_A0.5000.96
148_A198_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9571 100 0.099 Contact Map
2itmA 2 0.922 100 0.139 Contact Map
3ifrA 2 0.9454 100 0.145 Contact Map
3qdkA 2 0.9883 100 0.145 Contact Map
3hz6A 1 0.9357 100 0.149 Contact Map
3wxlA 2 0.9493 100 0.155 Contact Map
3ezwA 3 0.9474 100 0.16 Contact Map
3g25A 3 0.9454 100 0.163 Contact Map
3h3nX 3 0.9474 100 0.164 Contact Map
3l0qA 2 0.9688 100 0.166 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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